Gene

KWMTBOMO03406

Pre Gene Modal

BGIBMGA006500

Annotation

PREDICTED:_E3_ubiquitin-protein_ligase_RNF181-like_[Amyelois_transitella]

Location

Bomo_Chr6(+):7067572-7069329      View in EpiBrowser

Full name

E3 ubiquitin-protein ligase RNF181      

Alternative Name

RING finger protein 181
RING-type E3 ubiquitin transferase RNF181

Location in the cell

Nuclear   Reliability : 2.888

CDS

ATGGCTGGTTATTTTGAAGAAATGGGTTGGAGAGAATTGGGTGATGGGGAACAACCAAATCATCTCTTACATTTTGCAAGATTTCTCATAGATTCTGGCTTAGATCGAACTGGTGCAGCGGAGTGGCCAAGCTTACCTCCGCCTGCATCGAAAGAGGCAGTACAAAAATTACAAGATGTTGTAATAGAAAATCAAAAGAAAGGTTGCCCAATATGTTTGAAGAACTTAGAAGCTGGAGAAAAGGTTAAAAAGATGCCTTGTAATCATATTTTCCATCCAAGGTGTATTTTGACATGGTTAGACAAGACAAACTCATGCCCGTTTTGTAGACATGAGATGCCTACTGATGACGAAAATTATGAAGCCTACAAGAAAGCAAAGAAACGAGCTGAACAGTCACAAAATGATCTTGATGCATTACACAATTCAATGTTTAGTTAG

Protein

MAGYFEEMGWRELGDGEQPNHLLHFARFLIDSGLDRTGAAEWPSLPPPASKEAVQKLQDVVIENQKKGCPICLKNLEAGEKVKKMPCNHIFHPRCILTWLDKTNSCPFCRHEMPTDDENYEAYKKAKKRAEQSQNDLDALHNSMFS

Description

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Catalytic Activity

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.

Similarity

Belongs to the RNF181 family.

Keywords

Metal-binding   Transferase   Ubl conjugation   Ubl conjugation pathway   Zinc   Zinc-finger   Complete proteome   Reference proteome  

Feature

chain  E3 ubiquitin-protein ligase RNF181

Uniprot

H9JAF5   A0A212FBQ6   A0A2A4JWS1   A0A2H1V3R5   S4PLT2   A0A194Q934   + More
A0A194RNI7   I4DPP5   A0A1W4X5A9   A0A158NMS3   A0A2P8ZGG9   A0A151I1W7   F4X671   A0A0J7KGS4   A0A195DBQ0   A0A151JZK1   A0A151X1G7   E2ALP3   A0A195C5S4   J3JX87   E2C9J7   A0A026W143   D6WCU0   E0VW18   A0A2R7WWP9   A0A0C9PYT6   A0A067R5N6   A0A1E1W5T0   A0A1B6ICM0   A0A1B6MDZ7   A0A232F2N0   A0A0A9WDR0   A0A0A9WAR0   A0A154P6H7   K7J0B5   A0A1E1XRV6   A0A224YS89   A0A131Z6N5   A0A0C9R8E1   A0A1B6FAE8   A0A1B6IF64   A0A1S3D3J3   A0A1S3HD81   G0ZJE5   A0A0K8RJ27   A0A0P4VKV1   R4G523   A0A0P4WDM2   R7TJ77   A0A1B6EE45   A0A023FSB1   A0A2J7PNF3   A0A2P2I619   A0A131XN00   A0A293N6K9   A0A3B3Z933   C3ZWH0   A0A3B4EZR3   I3JYV0   A0A3P8QN16   A0A3P9CSA8   A0A1W5AYF1   W5NE42   A0A1S4FU02   U4UV61   A0A182H4D9   A0A2R5LBP4   H2ZRM0   Q16PN6   A0A1L8DSI5   A0A1L8GRZ4   Q6GPV5   N6UCL4   A0A0T6AV93   A0A060WBE7   A7RSU5   Q5M974   A0A1W7RBV3   A0A3B5KN48   A0A0F7Z3A4   A0A0L8FTI7   A0A3B3CEJ2   A0A3B5AGT4   W5QH69   A0A0S7IFL6   A0A3P8S8V8   A0A3B3Q8P9   A0A146P668   A0A087Y3W0   A0A3B3UEY3   A0A3P9Q5X1   H3D1L9   T1DK95   A0A1U7SGC7   A0A1A8H6I2   A0A1A7Z0N1   A0A3B4Y2D7   A0A3B4T7B3   B5XCA0  

EC Number

2.3.2.27

Pubmed

19121390    22118469    23622113    26354079    22651552    21347285    + More
29403074    21719571    20798317    22516182    24508170    30249741    18362917    19820115    20566863    24845553    28648823    25401762    26823975    20075255    29209593    28797301    26830274    21396955    27129103    23254933    28049606    25463417    18563158    25186727    23537049    26483478    9215903    17510324    27762356    24755649    17615350    26358130    21551351    29451363    20809919    29240929    15496914    23758969    20433749   

EMBL

BABH01009250    AGBW02009294    OWR51147.1    NWSH01000532    PCG75850.1    ODYU01000517    + More
SOQ35416.1    GAIX01003870    JAA88690.1    KQ459551    KPI99930.1    KQ459896    KPJ19403.1    AK403706    BAM19885.1    ADTU01020717    PYGN01000064    PSN55588.1    KQ976560    KYM80626.1    GL888788    EGI58040.1    LBMM01007753    KMQ89449.1    KQ981010    KYN10345.1    KQ981374    KYN42431.1    KQ982588    KYQ54094.1    GL440609    EFN65652.1    KQ978231    KYM96204.1    BT127856    AEE62818.1    GL453868    EFN75399.1    KK107499    QOIP01000007    EZA49733.1    RLU21094.1    KQ971311    EEZ99061.1    DS235816    EEB17574.1    KK855815    PTY23968.1    GBYB01006683    JAG76450.1    KK852680    KDR18580.1    GDQN01008721    GDQN01001788    JAT82333.1    JAT89266.1    GECU01023083    JAS84623.1    GEBQ01005831    JAT34146.1    NNAY01001179    OXU24842.1    GBHO01038078    GDHC01012576    GDHC01002128    JAG05526.1    JAQ06053.1    JAQ16501.1    GBHO01038077    GBRD01013513    GBRD01008046    JAG05527.1    JAG52313.1    KQ434810    KZC06740.1    GFAA01001389    JAU02046.1    GFPF01007463    MAA18609.1    GEDV01002461    JAP86096.1    GBYB01009147    JAG78914.1    GECZ01022533    JAS47236.1    GECU01022142    JAS85564.1    JF284596    AEL23142.1    GADI01003264    JAA70544.1    GDKW01000868    JAI55727.1    ACPB03013747    GAHY01000865    JAA76645.1    GDRN01060444    JAI65363.1    AMQN01012581    KB309618    ELT93759.1    GEDC01001096    JAS36202.1    GBBL01002818    JAC24502.1    NEVH01023953    PNF17872.1    IACF01003746    LAB69356.1    GEFH01000594    JAP67987.1    GFWV01023094    MAA47821.1    GG666699    EEN43099.1    AERX01013779    AHAT01006090    KB632379    ERL94121.1    JXUM01109200    KQ565298    KXJ71116.1    GGLE01002818    MBY06944.1    AFYH01062827    AFYH01062828    CH477776    EAT36320.1    GFDF01004662    JAV09422.1    CM004471    OCT86610.1    BC073002    APGK01040357    KB740979    ENN76392.1    LJIG01022719    KRT79071.1    FR904411    CDQ62554.1    DS470817    DS469535    EDO29210.1    EDO45479.1    CR762012    BC087570    GDAY02002846    JAV48621.1    GBEX01003862    JAI10698.1    KQ426670    KOF67953.1    AMGL01076927    GBYX01429391    JAO51900.1    GCES01147005    JAQ39317.1    AYCK01006763    GAAZ01002847    JAA95096.1    HAEB01004297    HAEC01010119    SBQ78335.1    HADX01013689    SBP35921.1    BT048669    BT049472    ACI68470.1   

Proteomes

UP000005204    UP000007151    UP000218220    UP000053268    UP000053240    UP000192223    + More
UP000005205    UP000245037    UP000078540    UP000007755    UP000036403    UP000078492    UP000078541    UP000075809    UP000000311    UP000078542    UP000008237    UP000053097    UP000279307    UP000007266    UP000009046    UP000027135    UP000215335    UP000076502    UP000002358    UP000079169    UP000085678    UP000015103    UP000014760    UP000235965    UP000261520    UP000001554    UP000261460    UP000005207    UP000265100    UP000265160    UP000192224    UP000018468    UP000030742    UP000069940    UP000249989    UP000008672    UP000008820    UP000186698    UP000019118    UP000193380    UP000001593    UP000008143    UP000005226    UP000053454    UP000261560    UP000261400    UP000002356    UP000265080    UP000261540    UP000265000    UP000028760    UP000261500    UP000242638    UP000007303    UP000189704    UP000261360    UP000261420    UP000087266   

PRIDE

H9JAF5   

Pfam

PF13639   zf-RING_2        + More
PF16113   ECH_2

Interpro

IPR001841   Znf_RING        + More
IPR013083   Znf_RING/FYVE/PHD       
IPR011016   Znf_RING-CH       
IPR032259   HIBYL-CoA-H       
IPR029045   ClpP/crotonase-like_dom_sf       

SUPFAM

SSF52096   SSF52096       

Gene 3D

3.30.40.10    

ProteinModelPortal

H9JAF5   A0A212FBQ6   A0A2A4JWS1   A0A2H1V3R5   S4PLT2   A0A194Q934   + More
A0A194RNI7   I4DPP5   A0A1W4X5A9   A0A158NMS3   A0A2P8ZGG9   A0A151I1W7   F4X671   A0A0J7KGS4   A0A195DBQ0   A0A151JZK1   A0A151X1G7   E2ALP3   A0A195C5S4   J3JX87   E2C9J7   A0A026W143   D6WCU0   E0VW18   A0A2R7WWP9   A0A0C9PYT6   A0A067R5N6   A0A1E1W5T0   A0A1B6ICM0   A0A1B6MDZ7   A0A232F2N0   A0A0A9WDR0   A0A0A9WAR0   A0A154P6H7   K7J0B5   A0A1E1XRV6   A0A224YS89   A0A131Z6N5   A0A0C9R8E1   A0A1B6FAE8   A0A1B6IF64   A0A1S3D3J3   A0A1S3HD81   G0ZJE5   A0A0K8RJ27   A0A0P4VKV1   R4G523   A0A0P4WDM2   R7TJ77   A0A1B6EE45   A0A023FSB1   A0A2J7PNF3   A0A2P2I619   A0A131XN00   A0A293N6K9   A0A3B3Z933   C3ZWH0   A0A3B4EZR3   I3JYV0   A0A3P8QN16   A0A3P9CSA8   A0A1W5AYF1   W5NE42   A0A1S4FU02   U4UV61   A0A182H4D9   A0A2R5LBP4   H2ZRM0   Q16PN6   A0A1L8DSI5   A0A1L8GRZ4   Q6GPV5   N6UCL4   A0A0T6AV93   A0A060WBE7   A7RSU5   Q5M974   A0A1W7RBV3   A0A3B5KN48   A0A0F7Z3A4   A0A0L8FTI7   A0A3B3CEJ2   A0A3B5AGT4   W5QH69   A0A0S7IFL6   A0A3P8S8V8   A0A3B3Q8P9   A0A146P668   A0A087Y3W0   A0A3B3UEY3   A0A3P9Q5X1   H3D1L9   T1DK95   A0A1U7SGC7   A0A1A8H6I2   A0A1A7Z0N1   A0A3B4Y2D7   A0A3B4T7B3   B5XCA0  

PDB

2ECT     E-value=6.88049e-10,     Score=147

KEGG

101743467    K22378 E3 ubiquitin-protein ligase RNF181 [EC:2.3.2.27] | (RefSeq) E3 ubiquitin-protein ligase RNF18

GO

GO:0016874   GO:0008270   GO:0061630   GO:0005737   GO:0016567   GO:0003860   GO:0016740   GO:0046872   GO:0004842   GO:0051865   GO:0005515   GO:0003700   GO:0005634   GO:0000287   GO:0003723   GO:0006270   GO:0042555   GO:0048384  

Length:

146

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0

Exp number, first 60 AAs:

0

Total prob of N-in:

0.06354

outside

1  -  146

 

 

Pi

175.929355

Theta

147.538126

Tajima's D

0.748224

CLR

0

CSRT

0.592220388980551

Interpretation

Uncertain