Gene

KWMTBOMO03347  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA006403

Annotation

PREDICTED:_leucine-rich_repeat_protein_soc-2_homolog_[Papilio_xuthus]

Location

Bomo_Chr6(-):5013017-5014922      View in EpiBrowser

Full name

Leucine-rich repeat protein soc-2 homolog      

Alternative Name

Protein Sur-8 homolog
Protein soc-2 homolog

Location in the cell

Nuclear   Reliability : 2.722

CDS

ATGAATCTCGACAACTCGTCACGAGAAAACTCTGAAGCTTTGGATTCCGTCGGTACGGTAAGCCCCAGGGAAAAATATCACACAATGAGGGAAAAGAAATTGTCCGCAGCATCGATCACTACGACTGAGGGTGCTCGTCCCAAAGTTGTTACTGTTAAACATCCGGAGTCCAATAAACCGAAACCTACAGCTAAGAAAAACAAACCAATACAGGCTGATCTTGACGTTATTAAAGAATTCATTAGATGCCGTGAAGAAGGTGTAATACGATTGGATCTCAGCAAATCATCGATTACTTCTCTTCCGCCAAATGTTAGAGATCTTACACATTTAGTAGAGTTTTATTTGTATGGGAATAAGCTGGTTGCACTTCCATCAGAATTTGGTTGTTTGTCCAATCTACAAACACTCGCATTAAATGAAAACTCATTAACAAGCCTACCAGATTCTCTTGCTAACTTAAAATCTTTAAAGGTTCTTGATTTACGACATAATAAATTAAATGATATACCTGAAGTGGTTTATAAATTGACATCTCTCACAACTTTATATCTACGGTTCAATAGAATCAGAGTTGTAGGAGATGGGATTGAAAACCTCACTAATTTAACTATGCTGAGTCTTCGAGAAAACAAGATTAAGGAATTGTCTGCAGGAATTGGCAAATTGATAAACCTTGTAACATTTGATGTGTCGCACAACCACTTAGAGCATCTGCCCCAAGAGATTGGAAATTGTCTAAATTTGTCTACATTAGACTTACAACATAATGACTTATTGGATATTCCTGAAAGTATTGGGAATCTTACAGCAGTTACTAGATTGGGACTTAGATACAATGGGCTTTCGACTATCCCTGCCACTCTAAGCAATTTGAAACATATGGATGAATTTAATGTTGAAGGAAACTCAATATCTCAGCTGCCTGAAGGTCTCTTGGCTAGATTGAGTGAACTCACCAGTATAACTCTCTCCCGTAATTCTTTCACCAGCTACCCTTCAGGTGGTCCTGCTCAATTTACTAATGTCTTTACTATAAACCTAGAACATAATCAAATTGATAAAATACCATATGGTATATTTTCAAGAGCTAAAAACTTAACAAAACTGAATATGAAGGAAAATCTTTTGACTGCACTTCCTTTAGATGTTGGGACTTGGTTAAATATGGTTGAACTTAATTTGGGGACTAATCAGCTTTCAAAACTACCTGATGATGTTCAATGTCTGCAAAATTTAGAAGTTCTGATATTGTCAAACAACCTGTTAAAAAGAATACCACCTAGTATTGGAAATTTGAGGAAGCTACGAGTACTCGACTTGGAAGAGAATAAGCTTGAAGTTCTCCCGAATGAAATAGGATTCTTACATGAATTGCAAAAGTTGATAGTGCAGTCAAACCAGTTATCAACTTTGCCTCGCTCAATAGGCCATCTGACAAATTTGACATCTTTAAGCGTGGGAGAGAATAACTTACAATATGTACCAGAAGAAATAGGCACACTGGAGAATTTGGAATCTTTATACTTGAATGATAATCCTAATTTATGCAATTTGCCATTTGAGTTAGCTTTGTGTGTAAACTTGCAAATAATGAGCATTGAGAATTGTCCATTGACTTCTATTCCTTCAGAAGTAGTAAGTTCAGGACCATCTTTGGTAATCCAGTATTTGAAAACCCAAGGGCCATACAGAGCTATGTGA

Protein

MNLDNSSRENSEALDSVGTVSPREKYHTMREKKLSAASITTTEGARPKVVTVKHPESNKPKPTAKKNKPIQADLDVIKEFIRCREEGVIRLDLSKSSITSLPPNVRDLTHLVEFYLYGNKLVALPSEFGCLSNLQTLALNENSLTSLPDSLANLKSLKVLDLRHNKLNDIPEVVYKLTSLTTLYLRFNRIRVVGDGIENLTNLTMLSLRENKIKELSAGIGKLINLVTFDVSHNHLEHLPQEIGNCLNLSTLDLQHNDLLDIPESIGNLTAVTRLGLRYNGLSTIPATLSNLKHMDEFNVEGNSISQLPEGLLARLSELTSITLSRNSFTSYPSGGPAQFTNVFTINLEHNQIDKIPYGIFSRAKNLTKLNMKENLLTALPLDVGTWLNMVELNLGTNQLSKLPDDVQCLQNLEVLILSNNLLKRIPPSIGNLRKLRVLDLEENKLEVLPNEIGFLHELQKLIVQSNQLSTLPRSIGHLTNLTSLSVGENNLQYVPEEIGTLENLESLYLNDNPNLCNLPFELALCVNLQIMSIENCPLTSIPSEVVSSGPSLVIQYLKTQGPYRAM

Description

Acts as a Ras effector and participates in MAPK pathway activation. Probably acts as a regulatory subunit of protein phosphatase that specifically dephosphorylates Raf kinase and stimulate Raf activity at specialized signaling complexes upon Ras activation (By similarity).

Similarity

Belongs to the SHOC2 family.

Keywords

Complete proteome   Leucine-rich repeat   Reference proteome   Repeat  

Feature

chain  Leucine-rich repeat protein soc-2 homolog

Uniprot

H9JA58   A0A194Q976   A0A194R9L0   A0A2A4JD83   A0A2H1VTP0   A0A0L7LCD8   + More
A0A1D2NBR3   A0A2P8YTB0   A0A1B6IL23   A0A1B6K9E6   A0A0A9W2I1   A0A154PSN5   V9II03   A0A067R2G6   A0A310SV97   A0A0K8SWQ0   A0A1B6FYU5   A0A2J7QAL1   A0A0M8ZYB6   A0A226E8A8   D6X3X5   K7J0K0   A0A232FKB3   A0A0T6BD25   A0A0J7L5S1   A0A1B6DFD5   A0A224XA77   A0A1W4XMK1   A0A023FAN6   A0A182PP87   E2AHX9   A0A182M6C8   A0A2A3EPZ2   A0A088ADP4   A0A3L8DFY7   A0A1Y1MF31   A0A026WT58   A0A182S6L9   A0A069DZ99   A0A182W3F0   A0A182UA70   A0A182Y8T4   A0A182JXL1   A0A182NGE5   A0A182QWM0   A0A182UVL6   A0A1Z5LIP0   A0A2J7QAE2   A0A293LG92   A0A182XIJ8   A0A182KZK2   Q7PHC6   A0A182HYN0   A0A2M4AMU5   A0A182FSS8   R4FLM7   A0A084WA13   A0A2M4BJU0   W5J760   A0A182IL63   Q16FL4   A0A2M4BJM8   A0A2R7WZQ6   A0A2R5L978   A0A182RZK8   B0W6M9   A0A182GJX0   U4UUX9   A0A336MM82   A0A1Q3F2F9   A0A1Q3F2G2   N6TZ72   A0A1Q3F2E6   A0A0P5UEV3   A0A162Q167   A0A0P5Z7X5   A0A0P5X010   A0A0P5EMC5   A0A0P5WYX2   A0A0P6FHP4   A0A0P5VY54   A0A0N8DGS4   E9GB72   A0A0P6A5B5   E9J602   E0VD19   V5IE26   A0A0P6CT31   A0A0K8VLP1   A0A0A1WEL7   A0A131YKG7   A0A224YSL6   W8C6M8   E2BAG5   L7LZY1   A0A0N8E9Q6   A0A2M3Z975   A0A1E1X801   A0A3B0JEX1   A0A1I8PH85  

Pubmed

19121390    26354079    26227816    27289101    29403074    25401762    + More
26823975    24845553    18362917    19820115    20075255    28648823    25474469    20798317    30249741    28004739    24508170    26334808    25244985    28528879    20966253    12364791    14747013    17210077    24438588    20920257    23761445    17510324    26483478    23537049    21292972    21282665    20566863    25765539    25830018    26830274    28797301    24495485    25576852    28503490   

EMBL

BABH01009113    KQ459551    KPI99975.1    KQ460473    KPJ14518.1    NWSH01001882    + More
PCG69809.1    ODYU01004378    SOQ44195.1    JTDY01001728    KOB73060.1    LJIJ01000099    ODN02687.1    PYGN01000372    PSN47483.1    GECU01020093    JAS87613.1    GEBQ01032163    JAT07814.1    GBHO01042941    GDHC01020070    GDHC01010676    JAG00663.1    JAP98558.1    JAQ07953.1    KQ435037    KZC14120.1    JR048751    AEY60753.1    KK852804    KDR16192.1    KQ759820    OAD62749.1    GBRD01008187    JAG57634.1    GECZ01014412    JAS55357.1    NEVH01016330    PNF25628.1    KQ435824    KOX72069.1    LNIX01000006    OXA53237.1    KQ971379    EEZ97481.1    NNAY01000079    OXU31181.1    LJIG01001705    KRT85235.1    LBMM01000666    KMQ97844.1    GEDC01012911    JAS24387.1    GFTR01007201    JAW09225.1    GBBI01000613    JAC18099.1    GL439602    EFN66969.1    AXCM01001884    KZ288206    PBC33111.1    QOIP01000008    RLU19367.1    GEZM01033102    JAV84412.1    KK107109    EZA59123.1    GBGD01001010    JAC87879.1    AXCN02001612    GFJQ02000159    JAW06811.1    PNF25570.1    GFWV01002121    MAA26851.1    AAAB01008898    EAA44595.5    APCN01005391    GGFK01008778    MBW42099.1    ACPB03005528    GAHY01001318    JAA76192.1    ATLV01021997    KE525327    KFB47057.1    GGFJ01004184    MBW53325.1    ADMH02002125    ETN58700.1    CH478416    EAT33029.1    GGFJ01004138    MBW53279.1    KK856153    PTY25039.1    GGLE01001928    MBY06054.1    DS231848    JXUM01013045    JXUM01013046    KQ560367    KXJ82780.1    KB632375    ERL94026.1    UFQT01001591    SSX31090.1    GFDL01013301    JAV21744.1    GFDL01013295    JAV21750.1    APGK01055361    KB741263    ENN71552.1    GFDL01013377    JAV21668.1    GDIP01114043    GDIQ01016949    JAL89671.1    JAN77788.1    LRGB01000389    KZS19313.1    GDIP01047555    JAM56160.1    GDIP01079594    JAM24121.1    GDIP01157646    JAJ65756.1    GDIP01079593    JAM24122.1    GDIQ01049318    JAN45419.1    GDIP01093530    JAM10185.1    GDIP01035255    JAM68460.1    GL732537    EFX83378.1    GDIP01034346    JAM69369.1    GL768221    EFZ11742.1    DS235070    EEB11275.1    GANP01010922    JAB73546.1    GDIQ01087750    JAN06987.1    GDHF01027887    GDHF01017235    GDHF01012551    GDHF01010613    JAI24427.1    JAI35079.1    JAI39763.1    JAI41701.1    GBXI01017439    GBXI01007264    JAC96852.1    JAD07028.1    GEDV01009991    JAP78566.1    GFPF01009430    MAA20576.1    GAMC01004150    GAMC01004149    JAC02407.1    GL446721    EFN87327.1    GACK01007669    JAA57365.1    GDIQ01048020    JAN46717.1    GGFM01004322    MBW25073.1    GFAC01003806    JAT95382.1    OUUW01000005    SPP80665.1   

Proteomes

UP000005204    UP000053268    UP000053240    UP000218220    UP000037510    UP000094527    + More
UP000245037    UP000076502    UP000027135    UP000235965    UP000053105    UP000198287    UP000007266    UP000002358    UP000215335    UP000036403    UP000192223    UP000075885    UP000000311    UP000075883    UP000242457    UP000005203    UP000279307    UP000053097    UP000075901    UP000075920    UP000075902    UP000076408    UP000075881    UP000075884    UP000075886    UP000075903    UP000076407    UP000075882    UP000007062    UP000075840    UP000069272    UP000015103    UP000030765    UP000000673    UP000075880    UP000008820    UP000075900    UP000002320    UP000069940    UP000249989    UP000030742    UP000019118    UP000076858    UP000000305    UP000009046    UP000008237    UP000268350    UP000095300   

PRIDE

H9JA58   

Pfam

PF13855   LRR_8        + More
PF13306   LRR_5
PF12799   LRR_4
PF06239   ECSIT
PF14784   ECSIT_C
PF00560   LRR_1

Interpro

IPR001611   Leu-rich_rpt        + More
IPR003591   Leu-rich_rpt_typical-subtyp       
IPR032675   LRR_dom_sf       
IPR026906   LRR_5       
IPR025875   Leu-rich_rpt_4       
IPR029342   ECIST_C       
IPR010418   ECSIT       

Gene 3D

3.80.10.10    

ProteinModelPortal

H9JA58   A0A194Q976   A0A194R9L0   A0A2A4JD83   A0A2H1VTP0   A0A0L7LCD8   + More
A0A1D2NBR3   A0A2P8YTB0   A0A1B6IL23   A0A1B6K9E6   A0A0A9W2I1   A0A154PSN5   V9II03   A0A067R2G6   A0A310SV97   A0A0K8SWQ0   A0A1B6FYU5   A0A2J7QAL1   A0A0M8ZYB6   A0A226E8A8   D6X3X5   K7J0K0   A0A232FKB3   A0A0T6BD25   A0A0J7L5S1   A0A1B6DFD5   A0A224XA77   A0A1W4XMK1   A0A023FAN6   A0A182PP87   E2AHX9   A0A182M6C8   A0A2A3EPZ2   A0A088ADP4   A0A3L8DFY7   A0A1Y1MF31   A0A026WT58   A0A182S6L9   A0A069DZ99   A0A182W3F0   A0A182UA70   A0A182Y8T4   A0A182JXL1   A0A182NGE5   A0A182QWM0   A0A182UVL6   A0A1Z5LIP0   A0A2J7QAE2   A0A293LG92   A0A182XIJ8   A0A182KZK2   Q7PHC6   A0A182HYN0   A0A2M4AMU5   A0A182FSS8   R4FLM7   A0A084WA13   A0A2M4BJU0   W5J760   A0A182IL63   Q16FL4   A0A2M4BJM8   A0A2R7WZQ6   A0A2R5L978   A0A182RZK8   B0W6M9   A0A182GJX0   U4UUX9   A0A336MM82   A0A1Q3F2F9   A0A1Q3F2G2   N6TZ72   A0A1Q3F2E6   A0A0P5UEV3   A0A162Q167   A0A0P5Z7X5   A0A0P5X010   A0A0P5EMC5   A0A0P5WYX2   A0A0P6FHP4   A0A0P5VY54   A0A0N8DGS4   E9GB72   A0A0P6A5B5   E9J602   E0VD19   V5IE26   A0A0P6CT31   A0A0K8VLP1   A0A0A1WEL7   A0A131YKG7   A0A224YSL6   W8C6M8   E2BAG5   L7LZY1   A0A0N8E9Q6   A0A2M3Z975   A0A1E1X801   A0A3B0JEX1   A0A1I8PH85  

PDB

4U08     E-value=9.74335e-42,     Score=429

KEGG

101740066    K19613 leucine-rich repeat protein SHOC2 | (RefSeq) leucine-rich repeat protein soc-2 homolog

GO

GO:0005886   GO:0006470   GO:0001917   GO:0004722   GO:0042622   GO:0004721   GO:0005515   GO:0007264   GO:0051082   GO:0008270   GO:0033177   GO:0000287   GO:0003723   GO:0006270   GO:0042555   GO:0048384  

Length:

567

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00589000000000001

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00286

outside

1  -  567

 

 

Pi

180.515219

Theta

205.98807

Tajima's D

-0.414787

CLR

36.925245

CSRT

0.265286735663217

Interpretation

Uncertain