Gene

KWMTBOMO03310

Pre Gene Modal

BGIBMGA006417

Annotation

PREDICTED:_tyrosine-protein_kinase_Fps85D_isoform_X2_[Amyelois_transitella]

Location

Bomo_Chr6(-):4057337-4099260      View in EpiBrowser

Full name

Tyrosine-protein kinase       + More
Tyrosine-protein kinase Fer      
Non-specific protein-tyrosine kinase      

Location in the cell

Cytoplasmic   Reliability : 1.655 Nuclear   Reliability : 1.947

CDS

ATGGGATACACTACGAATGGCGCGGGTCGGGCAGCGCACGAGGCGCTGTTGGCGCGACAGGATGCTGAGCTAAGGCTCATGGAAGCTATGAAGAGAAGCCTCCAAGCAAAGATGAAAAGCGACAGAGAATATGCTCTGGCGCTAAGTGCTGCGGCTGCGCAGGGGCAGAAGATGGACAAATGCGAAGAGCTAAATGGATCGGTGATAGCGGCAGCATGGCGTACCATGACCGAGGAGTGGGATAACACAAGTCGTCTCATCAAATTGAATGCCGAAGCTCTCGAGTCTCGAGCTCTTGATCGCCTCACCACACTGATGACAGAACGAAGGAAGGCGCGCAAAATGTACCAGGAGGATCATACAAAAATCTCTTCTCAGTTCACACAGCTATCCGAAGAAGTGCAGAGAAAACAGAGCGAGTACCAAAAGTGCCTTGAGTCTTACAAACAGATGCGGGCCAAGTTCGAAGAGAATTATCTCAAATGTCCAACTAGCAGGGGAGGGAGGAAATTAGATGAGACGAGAGACAAATATGGCAAAGCGTGCAGGAGACTCCATCGGGCACACAACGAGTATGTGTTATTGTTGGCTGAGGCGACCGAATGCGAACGAGCCCTTCGGACTGCAGCCATCCCTGCGCTTTTAGAACAGCAACGTCGCCAGGGGGAAGCTACTGCTACTTCTTGGAAAGGGATCCTTTTAGAAGTGGTGCAGCGGTCAGACTATAGTACCGAAAAGTTCAGGGAGATCCAGACCAAAGTCGAGACTACAGTGCAGAATCTGAGGCCACAAGACGAGTACAAAGAGTTCTTAGAGAAGTATAAATCGCCTCCATCGACACCAGTGATATTTACATTTGACGAAAGCCTAGTGGAAGACACGAGCGGTAAATTACAACCAAATCAACTGACAGTCGATAATCTCACAGTTGAGTGGCTGAAAGAGAAACTCACAGAGCTGGAGGCAACATTGCAGGACAACAGAGAGAAACAGACCGCTTTGCAGGGACCAGAAATTATAGGGAATGGGGTTTGCAAAAACAACAATACCGGACTCACGAACGGCGTAAATGGAATCGACAGGCATTCTCCTCCGCCGATTCCCGTCACAACATCGGAGCCCATAAAGTTGTTAGAGCTACGCGTAGCAGAACGCAAATGTGCGAAACAAGCGGAGATGATACGATCCGCGTTGGCCGAACTAGGATGTGAAGAAGCGCCCAGCGGCTGCCCGGATCTGTCGGCCGAGACAGTCGGCGTTGATAGCTTAGACGGAAGCTCTCCCGATCATCAGGTGAGCGTGAGTGAGACAGAGCGTTCTCTAGTGGAACAGGAGTGGTTCCACGGTGTATTACCACGCGAGGAGGTGGTGAGGCTGTTGCGTAGTGACGGAGACTACCTAGTCCGTGAAACAACCAGGAACCACGCGAGGCAGCTAGTGTTATCCGTTTGCTGGGGACAGCATAAGCACTTCATTGTACAGACCACGCCAGAGGGTCACTATCGTTTCGAAGGAGCAGCGTTCCCGTCCGTGGCCGAGCTGATAGCGTGGCAGAGGGCTAGCGGCGTGCCCGTGACGGCGCGTTCGGGCGCGTTACTGCGGCGCGCGGTGCCCAGAGAGAACTGGGAACTCAACAACGATGATGTACAACTGCTCGATAAGATTGGAAGGGGTAATTTCGGTGACGTGTATAAAGCGCGTCTGAAGACGACAGGACAGGAGGTAGCCGTGAAGACGTGTAGGGTTGCGCTACCAGAGGAGCAGAAGCGGACGTTCCTACAGGAGGGACGGATCCTCAAGCAGTACCAGCACCCTAACATCGTCCGGCTTATTGGCATCGCCGTACAGAAGCAACCCATTATGATTGTCATGGAGCTCGTTTCAGGTACAAATTATTATAATTTCCAGAATAATATTATGATTTTTATTGCTTACTAG

Protein

MGYTTNGAGRAAHEALLARQDAELRLMEAMKRSLQAKMKSDREYALALSAAAAQGQKMDKCEELNGSVIAAAWRTMTEEWDNTSRLIKLNAEALESRALDRLTTLMTERRKARKMYQEDHTKISSQFTQLSEEVQRKQSEYQKCLESYKQMRAKFEENYLKCPTSRGGRKLDETRDKYGKACRRLHRAHNEYVLLLAEATECERALRTAAIPALLEQQRRQGEATATSWKGILLEVVQRSDYSTEKFREIQTKVETTVQNLRPQDEYKEFLEKYKSPPSTPVIFTFDESLVEDTSGKLQPNQLTVDNLTVEWLKEKLTELEATLQDNREKQTALQGPEIIGNGVCKNNNTGLTNGVNGIDRHSPPPIPVTTSEPIKLLELRVAERKCAKQAEMIRSALAELGCEEAPSGCPDLSAETVGVDSLDGSSPDHQVSVSETERSLVEQEWFHGVLPREEVVRLLRSDGDYLVRETTRNHARQLVLSVCWGQHKHFIVQTTPEGHYRFEGAAFPSVAELIAWQRASGVPVTARSGALLRRAVPRENWELNNDDVQLLDKIGRGNFGDVYKARLKTTGQEVAVKTCRVALPEEQKRTFLQEGRILKQYQHPNIVRLIGIAVQKQPIMIVMELVSGTNYYNFQNNIMIFIAY

Description

Tyrosine-protein kinase which is required during embryogenesis for formation of the actin cable in leading edge cells of the dorsal epidermis and for the timely progression of dorsal closure. May play a role in regulation of adherens junctions and cell adhesion through phosphorylation of the beta-catenin arm.

Catalytic Activity

ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]

Similarity

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.
Belongs to the protein kinase superfamily. Tyr protein kinase family.

Keywords

Alternative splicing   ATP-binding   Cell junction   Coiled coil   Complete proteome   Developmental protein   Kinase   Membrane   Nucleotide-binding   Phosphoprotein   Reference proteome   SH2 domain   Transferase   Tyrosine-protein kinase  

Feature

chain  Tyrosine-protein kinase Fer
splice variant  In isoform D.

Uniprot

A0A1W4X589   A0A139WAL6   A0A139WAJ6   A0A2J7REC4   A0A212FNB9   A0A139WAM2   + More
A0A1W4X422   A0A1Y1KG60   A0A1Y1KFP9   U5EPN0   E2C012   A0A1L8DLX7   A0A0Q9X890   A0A026VZI7   A0A034V6J5   A0A2C9H8G3   W8ATK3   A0A2C9GPE0   A0A0Q9WMK3   A0A0K8UB42   K7IYX7   A0A182FZQ9   A0A1Q3FTM0   A0A0Q9X355   A0A0R1E298   P18106-1   A0A1W4VQ84   A0A3B0K594   A0A0R3NKN3   A0A0P9APC1   A0A0P8XY13   A0A087ZYS3   A0A151WIH7   A0A1B6F723   A0A0L7RDA6   A0A023F4U3   A0A1I8Q228   F5HLC9   A0A0A9VXQ2   A0A0A9W0J5   E0VKB1   A0A087UB48   A0A224XJB3   T1J3P8   A0A146KSL8   A0A1J1J7X7   A0A1B6CBF0   A0A146KYY4   A0A0P4Z062   A0A0P5FXE6   A0A0P5STU2   A0A0J7KUC9   A0A0M5J2E4   A0A0Q9WXK2   A0A0R1E1X2   A0A0B4KGK6   A0A0Q9WR25   A0A0R1E1T7   A0A0Q9WTA4   A0A0B4KFK7   B4K4Y8   B4HKF0   A0A1W4W2B3   B4PUM4   P18106   A0A1B6FKQ6   B3P1Q9  

EC Number

2.7.10.2

Pubmed

18362917    19820115    22118469    28004739    20798317    17994087    + More
24508170    25348373    24495485    20075255    17550304    1898762    9038371    10731132    12537572    9731193    16831834    15632085    25474469    12364791    25401762    20566863    26823975    12537568    12537573    12537574    16110336    17569856    17569867   

EMBL

KQ971382    KYB24939.1    KYB24938.1    NEVH01005277    PNF39177.1    AGBW02006689    + More
OWR55199.1    KYB24940.1    GEZM01084983    JAV60344.1    GEZM01084984    JAV60343.1    GANO01004628    JAB55243.1    GL451712    EFN78708.1    GFDF01006625    JAV07459.1    CH933806    KRG00743.1    KK107652    EZA48284.1    GAKP01020013    GAKP01020011    JAC38941.1    GAMC01014380    JAB92175.1    APCN01003223    APCN01003224    APCN01003225    APCN01003226    APCN01003227    APCN01003228    APCN01003229    CH940650    KRF82737.1    GDHF01028521    JAI23793.1    GFDL01004084    JAV30961.1    CH964232    KRF99341.1    CM000160    KRK03253.1    X52844    U50450    AE014297    BT003462    AJ002916    OUUW01000005    SPP81169.1    CM000070    KRS99698.1    CH902617    KPU79527.1    KPU79526.1    KQ983089    KYQ47663.1    GECZ01023737    JAS46032.1    KQ414613    KOC68952.1    GBBI01002679    JAC16033.1    AAAB01008888    EGK97090.1    GBHO01043648    GBRD01006599    JAF99955.1    JAG59222.1    GBHO01043646    GBRD01006598    JAF99957.1    JAG59223.1    DS235241    EEB13817.1    KK119063    KFM74587.1    GFTR01007876    JAW08550.1    JH431830    GDHC01020422    JAP98206.1    CVRI01000074    CRL07876.1    GEDC01026629    JAS10669.1    GDHC01018293    JAQ00336.1    GDIP01219564    JAJ03838.1    GDIQ01250321    JAK01404.1    GDIP01140633    JAL63081.1    LBMM01003172    KMQ93859.1    CP012526    ALC47136.1    KRG00742.1    KRK03256.1    AGB95793.1    KRF82736.1    KRK03254.1    KRF99340.1    AGB95794.1    EDW13959.2    CH480815    EDW42900.1    EDW96641.1    GECZ01019008    JAS50761.1    CH954181    EDV49797.1   

Proteomes

UP000192223    UP000007266    UP000235965    UP000007151    UP000008237    UP000009192    + More
UP000053097    UP000076407    UP000075840    UP000008792    UP000002358    UP000069272    UP000007798    UP000002282    UP000000803    UP000192221    UP000268350    UP000001819    UP000007801    UP000005203    UP000075809    UP000053825    UP000095300    UP000007062    UP000009046    UP000054359    UP000183832    UP000036403    UP000092553    UP000001292    UP000008711   

PRIDE

P18106   

Pfam

PF00017   SH2        + More
PF07714   Pkinase_Tyr
PF00611   FCH
PF07528   DZF

Interpro

IPR001245   Ser-Thr/Tyr_kinase_cat_dom        + More
IPR011009   Kinase-like_dom_sf       
IPR035849   Fes/Fps/Fer_SH2       
IPR017441   Protein_kinase_ATP_BS       
IPR008266   Tyr_kinase_AS       
IPR016250   Tyr-prot_kinase_Fes/Fps       
IPR027267   AH/BAR_dom_sf       
IPR020635   Tyr_kinase_cat_dom       
IPR001060   FCH_dom       
IPR036860   SH2_dom_sf       
IPR000980   SH2       
IPR031160   F_BAR       
IPR000719   Prot_kinase_dom       
IPR003604   Matrin/U1-like-C_Znf_C2H2       
IPR013087   Znf_C2H2_type       
IPR006561   DZF_dom       
IPR036236   Znf_C2H2_sf       
IPR028539   Fer       

SUPFAM

SSF56112   SSF56112        + More
SSF103657   SSF103657       
SSF55550   SSF55550       
SSF57667   SSF57667       

Gene 3D

1.20.1270.60     3.30.505.10    

CDD

cd10361  SH2_Fps_family

ProteinModelPortal

A0A1W4X589   A0A139WAL6   A0A139WAJ6   A0A2J7REC4   A0A212FNB9   A0A139WAM2   + More
A0A1W4X422   A0A1Y1KG60   A0A1Y1KFP9   U5EPN0   E2C012   A0A1L8DLX7   A0A0Q9X890   A0A026VZI7   A0A034V6J5   A0A2C9H8G3   W8ATK3   A0A2C9GPE0   A0A0Q9WMK3   A0A0K8UB42   K7IYX7   A0A182FZQ9   A0A1Q3FTM0   A0A0Q9X355   A0A0R1E298   P18106-1   A0A1W4VQ84   A0A3B0K594   A0A0R3NKN3   A0A0P9APC1   A0A0P8XY13   A0A087ZYS3   A0A151WIH7   A0A1B6F723   A0A0L7RDA6   A0A023F4U3   A0A1I8Q228   F5HLC9   A0A0A9VXQ2   A0A0A9W0J5   E0VKB1   A0A087UB48   A0A224XJB3   T1J3P8   A0A146KSL8   A0A1J1J7X7   A0A1B6CBF0   A0A146KYY4   A0A0P4Z062   A0A0P5FXE6   A0A0P5STU2   A0A0J7KUC9   A0A0M5J2E4   A0A0Q9WXK2   A0A0R1E1X2   A0A0B4KGK6   A0A0Q9WR25   A0A0R1E1T7   A0A0Q9WTA4   A0A0B4KFK7   B4K4Y8   B4HKF0   A0A1W4W2B3   B4PUM4   P18106   A0A1B6FKQ6   B3P1Q9  

PDB

4E93     E-value=2.02351e-51,     Score=514

KEGG

101737738    K08889 tyrosine-protein kinase Fer [EC:2.7.10.2] | (RefSeq) tyrosine-protein kinase Fps85D

GO

GO:0004715   GO:0005524   GO:0008270   GO:0003676   GO:0004713   GO:0046664   GO:0006468   GO:0051017   GO:0019898   GO:0007411   GO:0007394   GO:0007391   GO:0005912   GO:0005886   GO:0005543   GO:0016301   GO:0004672   GO:0006432   GO:0000287   GO:0003723   GO:0006270   GO:0042555   GO:0048384  

PANTHER

PTHR24418:SF227  

Subcellular location

Membrane   At stages 11-12 of embryogenesis, localizes to adherens junctions in epidermal cells. At stages 13-14, is no longer detected in the epidermal cell junctions which border with the amnioserosa.   With evidence from 6 publications.
Cell junction   At stages 11-12 of embryogenesis, localizes to adherens junctions in epidermal cells. At stages 13-14, is no longer detected in the epidermal cell junctions which border with the amnioserosa.   With evidence from 6 publications.
Adherens junction   At stages 11-12 of embryogenesis, localizes to adherens junctions in epidermal cells. At stages 13-14, is no longer detected in the epidermal cell junctions which border with the amnioserosa.   With evidence from 6 publications.

Length:

645

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.20314

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00104

outside

1  -  645

 

 

Pi

172.741033

Theta

172.21988

Tajima's D

0.058667

CLR

0.572148

CSRT

0.385280735963202

Interpretation

Uncertain