Gene

KWMTBOMO03309

Pre Gene Modal

BGIBMGA006417

Annotation

PREDICTED:_tyrosine-protein_kinase_Fps85D_isoform_X4_[Bombyx_mori]

Location

Bomo_Chr6(-):4051720-4054200      View in EpiBrowser

Full name

Tyrosine-protein kinase       + More
Non-specific protein-tyrosine kinase      
Tyrosine-protein kinase Fer      

Location in the cell

Extracellular   Reliability : 1.16 Mitochondrial   Reliability : 1.542

CDS

ATGGGTTTTGTCTACCCAATATTTCTTCTAGGAGGTTCTCTTCTCACATACCTCCGTACGAGGGCAGCTGCGCTTAGTTCTCGCACGCTGATGGCGATGTGCCGGGACGCGGCGGGGGGCATGCGGTACCTCGAGTCCAAGAACTGCATTCACCGCGACCTCGCCGCCAGAAACTGCCTCGTCGGAGACGACAACATTGTGAAAATATCAGACTTTGGCATGTCTAGGGAAGAAGAGGAGTACATAGTTTCCGGAGGAATGAAACAAATACCTATCAAATGGACGGCACCTGAGGCATTGAATTTCGGAAAATACACTTCGCTATGTGATGTATGGAGTTACGGAGTATTGATGTGGGAAATATTTGCAAAGGGAGACACGCCATACGCGGGAATGAGCAATTCAAGGGCTAGAGAAAAAATCGATACCGGATATCGTATGCCAGCACCGGAAGGATGTCCCGAAGACGTGTACGCACTTATGCTGAGGTGCTGGGAGTATGAGCCTGATAAGCGGCCGCATTTCCACCAGATATACACTATCATAGACAGTATATACAATAGATAA

Protein

MGFVYPIFLLGGSLLTYLRTRAAALSSRTLMAMCRDAAGGMRYLESKNCIHRDLAARNCLVGDDNIVKISDFGMSREEEEYIVSGGMKQIPIKWTAPEALNFGKYTSLCDVWSYGVLMWEIFAKGDTPYAGMSNSRAREKIDTGYRMPAPEGCPEDVYALMLRCWEYEPDKRPHFHQIYTIIDSIYNR

Description

Tyrosine-protein kinase which is required during embryogenesis for formation of the actin cable in leading edge cells of the dorsal epidermis and for the timely progression of dorsal closure. May play a role in regulation of adherens junctions and cell adhesion through phosphorylation of the beta-catenin arm.

Catalytic Activity

ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]

Similarity

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.
Belongs to the protein kinase superfamily. Tyr protein kinase family.

Keywords

Alternative splicing   ATP-binding   Cell junction   Coiled coil   Complete proteome   Developmental protein   Kinase   Membrane   Nucleotide-binding   Phosphoprotein   Reference proteome   SH2 domain   Transferase   Tyrosine-protein kinase  

Feature

chain  Tyrosine-protein kinase Fer
splice variant  In isoform D.

Uniprot

H9JA72   S4PXN7   A0A2W1BPQ8   A0A212FNB9   A0A194Q1C3   A0A1B6C6R0   + More
A0A1B6DQU3   A0A224XJB3   A0A182FZQ9   A0A1Q3FTM0   A0A023F4U3   A0A067RJR2   A0A2C9H8G3   A0A2C9GPE0   Q16G61   A0A2J7REC4   A0A1S4G2G3   A0A182T306   A0A2J7RED2   U5EPN0   A0A2J7REC3   A0A0C9Q248   W5JHH5   K7IYX7   A0A2J7RED1   A0A2C9H8G5   A0A2C9GPD8   A0A0C9RM74   A0A2R7X0G0   A0A2H8TTT4   A0A146L1B7   A0A154PAX4   A0A2A3EFE6   A0A087ZYS3   A0A1B6JS20   A0A084VTM9   A0A1B6F723   A0A0M8ZVV5   E9JD88   A0A182KXS3   A0A1W4X589   A0A1B6FKQ6   A0A0J7KUC9   Q7QAK4   A0A182MRX8   A0A2S2P0W6   A0A182VGQ8   A0A1L8DLX7   A0A182VWY2   A0A1W4X422   A0A182R136   W8ATK3   A0A0Q9X355   A0A158NSJ9   A0A0A9VXQ2   A0A195FTY7   F5HLC9   A0A0R3NKN3   E2A492   A0A3B0K594   A0A026VZI7   A0A151J429   W8BFW6   A0A0A9W0J5   A0A3L8DZ09   A0A1W4VQ84   A0A0Q9WTA4   A0A182J4H5   A0A0A9W516   A0A3Q0J188   A0A0R1E298   A0A0R3NEX2   A0A151HYE7   A0A0Q9WMK3   A0A1Y1KFP9   A0A1W4W1H0   A0A0Q9X890   E0VKB1   A0A1W4W2B3   A0A0R1E1X2   A0A0R1E1T7   A0A0K8WL72   A0A0Q9WR25   A0A1Y1KL15   A0A1B0C3F8   P18106-2   A0A1A9WPB9   B4NAI9   B4GP50   B3M068   Q29BL5   A0A1A9VG14   A0A0P8XXZ8   P18106-3   A0A1A9YSS8   A0A1B6KG66   A0A1A9ZYX9   A0A1I8MX55   T1P8M7   A0A1B0FEI7  

EC Number

2.7.10.2

Pubmed

19121390    23622113    28756777    22118469    26354079    25474469    + More
24845553    17510324    20920257    23761445    20075255    26823975    24438588    21282665    20966253    12364791    24495485    17994087    21347285    25401762    15632085    20798317    24508170    30249741    17550304    28004739    20566863    1898762    9038371    10731132    12537572    9731193    16831834    23185243    25315136   

EMBL

BABH01009005    GAIX01004718    JAA87842.1    KZ149939    PZC76968.1    AGBW02006689    + More
OWR55199.1    KQ459579    KPI99382.1    GEDC01028363    JAS08935.1    GEDC01009251    JAS28047.1    GFTR01007876    JAW08550.1    GFDL01004084    JAV30961.1    GBBI01002679    JAC16033.1    KK852427    KDR24086.1    APCN01003223    APCN01003224    APCN01003225    APCN01003226    APCN01003227    APCN01003228    APCN01003229    CH478325    EAT33226.1    NEVH01005277    PNF39177.1    PNF39178.1    GANO01004628    JAB55243.1    PNF39179.1    GBYB01008083    JAG77850.1    ADMH02001180    ETN63822.1    PNF39180.1    GBYB01008081    JAG77848.1    KK856104    PTY24890.1    GFXV01005555    MBW17360.1    GDHC01016870    JAQ01759.1    KQ434864    KZC09059.1    KZ288269    PBC29929.1    GECU01005672    JAT02035.1    ATLV01016367    ATLV01016368    KE525079    KFB41323.1    GECZ01023737    JAS46032.1    KQ435824    KOX72190.1    GL771866    EFZ09151.1    GECZ01019008    JAS50761.1    LBMM01003172    KMQ93859.1    AAAB01008888    EAA08820.5    AXCM01005796    AXCM01005797    GGMR01010522    MBY23141.1    GFDF01006625    JAV07459.1    AXCN02001598    GAMC01014380    JAB92175.1    CH964232    KRF99341.1    ADTU01024980    GBHO01043648    GBRD01006599    JAF99955.1    JAG59222.1    KQ981261    KYN44085.1    EGK97090.1    CM000070    KRS99698.1    GL436596    EFN71763.1    OUUW01000005    SPP81169.1    KK107652    EZA48284.1    KQ980211    KYN17189.1    GAMC01014381    GAMC01014379    JAB92176.1    GBHO01043646    GBRD01006598    JAF99957.1    JAG59223.1    QOIP01000003    RLU25179.1    KRF99340.1    GBHO01043649    JAF99954.1    CM000160    KRK03253.1    KRS99699.1    KQ976720    KYM76717.1    CH940650    KRF82737.1    GEZM01084984    JAV60343.1    CH933806    KRG00743.1    DS235241    EEB13817.1    KRK03256.1    KRK03254.1    GDHF01000689    JAI51625.1    KRF82736.1    GEZM01084982    JAV60345.1    JXJN01024937    X52844    U50450    AE014297    BT003462    AJ002916    EDW80803.1    CH479186    EDW38933.1    CH902617    EDV42025.2    EAL26982.2    KPU79528.1    GEBQ01029568    JAT10409.1    KA645012    AFP59641.1    CCAG010001988   

Proteomes

UP000005204    UP000007151    UP000053268    UP000069272    UP000027135    UP000076407    + More
UP000075840    UP000008820    UP000235965    UP000075901    UP000000673    UP000002358    UP000076502    UP000242457    UP000005203    UP000030765    UP000053105    UP000075882    UP000192223    UP000036403    UP000007062    UP000075883    UP000075903    UP000075920    UP000075886    UP000007798    UP000005205    UP000078541    UP000001819    UP000000311    UP000268350    UP000053097    UP000078492    UP000279307    UP000192221    UP000075880    UP000079169    UP000002282    UP000078540    UP000008792    UP000009192    UP000009046    UP000092460    UP000000803    UP000091820    UP000008744    UP000007801    UP000078200    UP000092443    UP000092445    UP000095301    UP000092444   

PRIDE

H9JA72    P18106   

Pfam

PF07714   Pkinase_Tyr        + More
PF00017   SH2
PF00611   FCH
PF04127   DFP

Interpro

IPR000980   SH2        + More
IPR000719   Prot_kinase_dom       
IPR020635   Tyr_kinase_cat_dom       
IPR016250   Tyr-prot_kinase_Fes/Fps       
IPR027267   AH/BAR_dom_sf       
IPR036860   SH2_dom_sf       
IPR008266   Tyr_kinase_AS       
IPR017441   Protein_kinase_ATP_BS       
IPR011009   Kinase-like_dom_sf       
IPR035849   Fes/Fps/Fer_SH2       
IPR001245   Ser-Thr/Tyr_kinase_cat_dom       
IPR031160   F_BAR       
IPR001060   FCH_dom       
IPR035929   CoaB-like_sf       
IPR007085   DNA/pantothenate-metab_flavo_C       

SUPFAM

SSF55550   SSF55550        + More
SSF103657   SSF103657       
SSF56112   SSF56112       
SSF102645   SSF102645       

Gene 3D

1.20.1270.60     3.30.505.10     3.40.50.10300    

CDD

cd10361  SH2_Fps_family

ProteinModelPortal

H9JA72   S4PXN7   A0A2W1BPQ8   A0A212FNB9   A0A194Q1C3   A0A1B6C6R0   + More
A0A1B6DQU3   A0A224XJB3   A0A182FZQ9   A0A1Q3FTM0   A0A023F4U3   A0A067RJR2   A0A2C9H8G3   A0A2C9GPE0   Q16G61   A0A2J7REC4   A0A1S4G2G3   A0A182T306   A0A2J7RED2   U5EPN0   A0A2J7REC3   A0A0C9Q248   W5JHH5   K7IYX7   A0A2J7RED1   A0A2C9H8G5   A0A2C9GPD8   A0A0C9RM74   A0A2R7X0G0   A0A2H8TTT4   A0A146L1B7   A0A154PAX4   A0A2A3EFE6   A0A087ZYS3   A0A1B6JS20   A0A084VTM9   A0A1B6F723   A0A0M8ZVV5   E9JD88   A0A182KXS3   A0A1W4X589   A0A1B6FKQ6   A0A0J7KUC9   Q7QAK4   A0A182MRX8   A0A2S2P0W6   A0A182VGQ8   A0A1L8DLX7   A0A182VWY2   A0A1W4X422   A0A182R136   W8ATK3   A0A0Q9X355   A0A158NSJ9   A0A0A9VXQ2   A0A195FTY7   F5HLC9   A0A0R3NKN3   E2A492   A0A3B0K594   A0A026VZI7   A0A151J429   W8BFW6   A0A0A9W0J5   A0A3L8DZ09   A0A1W4VQ84   A0A0Q9WTA4   A0A182J4H5   A0A0A9W516   A0A3Q0J188   A0A0R1E298   A0A0R3NEX2   A0A151HYE7   A0A0Q9WMK3   A0A1Y1KFP9   A0A1W4W1H0   A0A0Q9X890   E0VKB1   A0A1W4W2B3   A0A0R1E1X2   A0A0R1E1T7   A0A0K8WL72   A0A0Q9WR25   A0A1Y1KL15   A0A1B0C3F8   P18106-2   A0A1A9WPB9   B4NAI9   B4GP50   B3M068   Q29BL5   A0A1A9VG14   A0A0P8XXZ8   P18106-3   A0A1A9YSS8   A0A1B6KG66   A0A1A9ZYX9   A0A1I8MX55   T1P8M7   A0A1B0FEI7  

PDB

4E93     E-value=1.03601e-57,     Score=561

KEGG

101737738    K08889 tyrosine-protein kinase Fer [EC:2.7.10.2] | (RefSeq) tyrosine-protein kinase Fps85D

GO

GO:0004715   GO:0005524   GO:0004713   GO:0031234   GO:0042127   GO:0016301   GO:0005886   GO:0005543   GO:0007411   GO:0007394   GO:0007391   GO:0005912   GO:0046664   GO:0006468   GO:0051017   GO:0019898   GO:0004672   GO:0006432   GO:0000287   GO:0003723   GO:0006270   GO:0042555   GO:0048384  

Subcellular location

Membrane   At stages 11-12 of embryogenesis, localizes to adherens junctions in epidermal cells. At stages 13-14, is no longer detected in the epidermal cell junctions which border with the amnioserosa.   With evidence from 6 publications.
Cell junction   At stages 11-12 of embryogenesis, localizes to adherens junctions in epidermal cells. At stages 13-14, is no longer detected in the epidermal cell junctions which border with the amnioserosa.   With evidence from 6 publications.
Adherens junction   At stages 11-12 of embryogenesis, localizes to adherens junctions in epidermal cells. At stages 13-14, is no longer detected in the epidermal cell junctions which border with the amnioserosa.   With evidence from 6 publications.

Length:

188

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

2.09815

Exp number, first 60 AAs:

2.07882

Total prob of N-in:

0.05099

outside

1  -  188

 

 

Pi

154.661382

Theta

126.70708

Tajima's D

0.111746

CLR

1.024815

CSRT

0.395830208489576

Interpretation

Uncertain