Gene

KWMTBOMO03303

Pre Gene Modal

BGIBMGA006423

Annotation

scolexin_precursor_[Bombyx_mori]

Location

Bomo_Chr6(-):3855404-3869421      View in EpiBrowser

Full name

Scolexin B       + More
Trypsin 3A1      

Location in the cell

Cytoplasmic   Reliability : 1.429 Extracellular   Reliability : 1.126

CDS

ATGTTCGCCAACAAACAGTCGGTTCTCGCGGTGATCGCGCTGGCGGCAAGTGCGTGCGCGCTACCTCAACCCGGCGCCAATGACATACCGGATTTAAAACAAAAATCTGCGCTGGTAACAACTGAAATTACAAAGACACAGTCTGATGTGAAAGCAGTACACGAAAGGTTTCCACATGCCGTTCTTTTCGGTGGTACCTGTGGAGGTTCCATTATTAGCCCGAAATGGATCCTCACTGCGGGACACTGCACACTGTTCACGAACGGTCATTACGTATTGGCCGGTACTAACAAATCAGACGACCAAAGCGGCATTATTCGCTACGTGAAACGAATGGTCATCCACCCGCTCTTCTCTGTTGGACCATACTGGCTTGACGTAGAAGATTTTAATCTTAAACAGGTAGCAGCTAGGTGGGACTTTTTACTGGTCGAATTGGAGGAGCCCTTACCCGTGGACGGCAAAACGATAAAAGTTGCAACACTCGATGATCAGCCAAATCTACCAATCGGAGTCGACGTCGGATATGCTGGCTACGGAACTGACGAGCATGGGGGCGTGATGCGTAAAGATATGCACGCCATGGAGCTATCAACGCAGTCCGACGAAGTATGTTCTAAATTAGAGCAATACAACTCTCTGGATATGATCTGCGCTAAAGGTCGCCCCCCACGGTTCGACTCTGCTTGCAATGGTGATAGTGGCAGCGGGCTCGTGGACGGCGAGGGGCGGCTGGTGGGGGTGGCGTCGTGGGTGGAAAATGACGCTTTTGAGTGCCGCAACGGAAACCTTGTCGTCTTCTCCAGGGTCTCCAGAGCGAGGGACTGGATCCGAGAGGTCACCGAGATTTAA

Protein

MFANKQSVLAVIALAASACALPQPGANDIPDLKQKSALVTTEITKTQSDVKAVHERFPHAVLFGGTCGGSIISPKWILTAGHCTLFTNGHYVLAGTNKSDDQSGIIRYVKRMVIHPLFSVGPYWLDVEDFNLKQVAARWDFLLVELEEPLPVDGKTIKVATLDDQPNLPIGVDVGYAGYGTDEHGGVMRKDMHAMELSTQSDEVCSKLEQYNSLDMICAKGRPPRFDSACNGDSGSGLVDGEGRLVGVASWVENDAFECRNGNLVVFSRVSRARDWIREVTEI

Description

Major function may be to aid in digestion of the blood meal.

Catalytic Activity

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Similarity

Belongs to the peptidase S1 family.

Keywords

Direct protein sequencing   Disulfide bond   Hydrolase   Protease   Serine protease   Signal   Alternative splicing   Complete proteome   Digestion   Reference proteome   Secreted   Zymogen  

Feature

chain  Scolexin B
propeptide  Activation peptide
splice variant  In isoform A.

Uniprot

Q1HPY5   O96991   A0A2W1BRL8   C1JE15   A0A0L7L8X2   A0A1E1W1P6   + More
O96990   A0A194Q319   A0A3G1T190   A0A212F307   S4PB00   A0A0N0PC69   A0A225VJS1   A0A0K8VJE5   A0A1B0FQA8   A0A0K8U381   D3TKK0   A0A1A9ZCT6   A0A034WPU6   A0A1A9XJL9   A0A1W4X1D3   B4KK94   Q16ID3   A0A1B0BCW7   A0A3B0JB03   A0A1A9WKF8   A0A182HBG3   B4I2Z7   B4Q9L4   A0A329SI46   A0A0A1XQQ7   P29786-2   E2BS71   Q8IQ10   P29786   A0A1B0DA37   A0A3G5BIL4   B3N333   A0A1I8NEJ2   A0A1W4V706   A0A182G5M7   A0A182UM13   V9F078   W2WWN2   W2Q3Q9   W2Z440   A0A081A1S3   W2N5V5   B4NXX8   Q0IF85   A0A1A9VW11   A0A182KQG4   A0A0W8C2U1   W2L088   Q7QIZ2   M3YX35   G9D4L8   W8C3D6   Q171L4   A0A0K8VH40   A0A225UX55   A0A1S4FH94   K3WIR9   A0A2Y9KEI8   A0A182G8J0   H3D9R1   Q4RZ78   A0A3B3ZBI4   A0A0L0CEM4   A0A315VEJ6   Q16ID4   H3H1Y5   B4KK93   D0V550   A0A182H3A3   A0A1A9XTE4   A0A329T0I7   A0A0M4EPN7   B3MP30   A0A225VKG3   Q29MC6   A0A1S4FZU0   A0A1V1FIS6   A0A182GUL7   C5IBF7   M3X005   A2TGR7   A0A212F633   M4VEY6   E5RVK3   A0A1B3TNV7   W8C5I2   A0A2C9GRR7   Q16KW4  

EC Number

3.4.21.-
3.4.21.4

Pubmed

19121390    10210202    28756777    19442669    26227816    26354079    + More
22118469    23622113    20353571    25348373    17994087    17510324    26483478    22936249    25830018    9087545    20798317    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    30400621    25315136    17550304    20966253    12364791    14747013    17210077    21967427    24495485    15496914    25463417    26108605    29703783    16946064    20017753    15632085    28410430    19204376    17975172    23190728    27553646   

EMBL

BABH01008993    DQ443267    ABF51356.1    AF087005    AAD14592.1    KZ149939    + More
PZC76961.1    FJ561484    ACO55200.1    JTDY01002173    KOB71952.1    GDQN01010192    JAT80862.1    AF087004    AAD14591.1    KQ459579    KPI99399.1    MG846904    AXY94756.1    AGBW02010641    OWR48128.1    GAIX01004796    JAA87764.1    KQ460650    KPJ13067.1    NBNE01004358    OWZ05585.1    GDHF01013298    JAI39016.1    CCAG010020679    GDHF01031554    JAI20760.1    EZ421932    EZ423329    ADD18228.1    ADD19605.1    GAKP01003189    JAC55763.1    CH933807    EDW12625.1    CH478086    EAT34033.1    JXJN01012155    OUUW01000004    SPP79185.1    JXUM01032511    KQ560958    KXJ80213.1    CH480820    EDW54142.1    CM000361    CM002910    EDX03625.1    KMY87907.1    MJFZ01000145    RAW36231.1    GBXI01001399    JAD12893.1    AF487426    AF508783    X64362    CH477469    GL450151    EFN81463.1    AE014134    BT023549    AAN10373.1    AAY84949.1    AJVK01028773    MK075220    AYV99623.1    CH954177    EDV57632.1    JXUM01043731    KQ561373    KXJ78808.1    ANIZ01001910    ETI44158.1    ANIX01002191    ETP14009.1    KI669591    ETN07813.1    ANIY01002292    ETP42058.1    ANJA01002024    ETO72834.1    KI686868    KI673545    KI693489    ETK84194.1    ETL37631.1    ETM44072.1    CM000157    EDW87549.1    CH477389    EAT42001.1    LNFO01005340    KUF78372.1    KI680266    ETL90777.1    AAAB01008807    EAA04161.3    AEYP01008298    JF777271    AEU11616.1    GAMC01002772    JAC03784.1    CH477451    EAT40684.1    GDHF01014131    JAI38183.1    NBNE01010492    OWY97407.1    GL376564    JXUM01047815    KQ561534    KXJ78237.1    CAAE01014957    CAG06304.1    JRES01000608    KNC29914.1    NHOQ01001935    PWA20604.1    EAT34032.1    DS566107    EDW12624.1    GU018015    ACY24348.1    JXUM01107033    KQ565105    KXJ71330.1    MJFZ01000031    RAW41402.1    CP012523    ALC38837.1    CH902620    EDV31196.1    OWZ05584.1    CH379060    EAL33768.1    FX985298    BAX07311.1    JXUM01089555    KQ563779    KXJ73325.1    FJ839347    ACR61328.1    AANG04003369    EF199627    ABM88498.1    AGBW02010081    OWR49201.1    CP003537    AGH96601.1    AB604648    BAJ46146.1    KU925715    AOG75340.1    GAMC01001732    JAC04824.1    APCN01000169    CH477936    EAT34942.1   

Proteomes

UP000005204    UP000037510    UP000053268    UP000007151    UP000053240    UP000198211    + More
UP000092444    UP000092445    UP000092443    UP000192223    UP000009192    UP000008820    UP000092460    UP000268350    UP000091820    UP000069940    UP000249989    UP000001292    UP000000304    UP000251314    UP000008237    UP000000803    UP000092462    UP000008711    UP000095301    UP000192221    UP000075903    UP000018721    UP000018958    UP000018817    UP000018948    UP000028582    UP000053236    UP000053864    UP000054532    UP000002282    UP000078200    UP000075882    UP000052943    UP000054423    UP000007062    UP000000715    UP000248482    UP000007303    UP000261520    UP000037069    UP000005238    UP000092553    UP000007801    UP000001819    UP000011712    UP000075840   

PRIDE

Q1HPY5    P29786    Q8IQ10    A2TGR7    E5RVK3   

Pfam

PF00089   Trypsin        + More
PF00051   Kringle

Interpro

IPR001314   Peptidase_S1A        + More
IPR009003   Peptidase_S1_PA       
IPR018114   TRYPSIN_HIS       
IPR001254   Trypsin_dom       
IPR033116   TRYPSIN_SER       
IPR038178   Kringle_sf       
IPR000001   Kringle       
IPR013806   Kringle-like       
IPR018056   Kringle_CS       
IPR013032   EGF-like_CS       
IPR000742   EGF-like_dom       

SUPFAM

SSF50494   SSF50494        + More
SSF57440   SSF57440       

Gene 3D

2.40.20.10    

CDD

cd00190  Tryp_SPc
cd00108  KR

ProteinModelPortal

Q1HPY5   O96991   A0A2W1BRL8   C1JE15   A0A0L7L8X2   A0A1E1W1P6   + More
O96990   A0A194Q319   A0A3G1T190   A0A212F307   S4PB00   A0A0N0PC69   A0A225VJS1   A0A0K8VJE5   A0A1B0FQA8   A0A0K8U381   D3TKK0   A0A1A9ZCT6   A0A034WPU6   A0A1A9XJL9   A0A1W4X1D3   B4KK94   Q16ID3   A0A1B0BCW7   A0A3B0JB03   A0A1A9WKF8   A0A182HBG3   B4I2Z7   B4Q9L4   A0A329SI46   A0A0A1XQQ7   P29786-2   E2BS71   Q8IQ10   P29786   A0A1B0DA37   A0A3G5BIL4   B3N333   A0A1I8NEJ2   A0A1W4V706   A0A182G5M7   A0A182UM13   V9F078   W2WWN2   W2Q3Q9   W2Z440   A0A081A1S3   W2N5V5   B4NXX8   Q0IF85   A0A1A9VW11   A0A182KQG4   A0A0W8C2U1   W2L088   Q7QIZ2   M3YX35   G9D4L8   W8C3D6   Q171L4   A0A0K8VH40   A0A225UX55   A0A1S4FH94   K3WIR9   A0A2Y9KEI8   A0A182G8J0   H3D9R1   Q4RZ78   A0A3B3ZBI4   A0A0L0CEM4   A0A315VEJ6   Q16ID4   H3H1Y5   B4KK93   D0V550   A0A182H3A3   A0A1A9XTE4   A0A329T0I7   A0A0M4EPN7   B3MP30   A0A225VKG3   Q29MC6   A0A1S4FZU0   A0A1V1FIS6   A0A182GUL7   C5IBF7   M3X005   A2TGR7   A0A212F633   M4VEY6   E5RVK3   A0A1B3TNV7   W8C5I2   A0A2C9GRR7   Q16KW4  

PDB

3SO3     E-value=2.35355e-11,     Score=164

KEGG

100101171    no KO assigned | (RefSeq) scolexin

GO

GO:0004252   GO:0005615   GO:0007586   GO:0006508   GO:0005576   GO:0016021   GO:0008236   GO:0005524   GO:0005737   GO:0006432   GO:0000287   GO:0003723   GO:0006270   GO:0042555   GO:0048384  

Subcellular location

  
Secreted  

SignalP

Position:   1 - 20,         Likelihood:  0.967408

 

 

Length:

283

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

4.87521

Exp number, first 60 AAs:

4.29629

Total prob of N-in:

0.24508

outside

1  -  283

 

 

Pi

197.017135

Theta

169.170455

Tajima's D

-0.900366

CLR

1.199575

CSRT

0.156442177891105

Interpretation

Uncertain