Gene

KWMTBOMO03295

Annotation

reverse_transcriptase_[Bombyx_mori]

Location

Bomo_Chr6(+):3519416-3523091      View in EpiBrowser

Full name

RNA-directed DNA polymerase from mobile element jockey       + More
Probable RNA-directed DNA polymerase from transposon BS      

Alternative Name

Reverse transcriptase

Location in the cell

Nuclear   Reliability : 2.481

CDS

ATGGTTAGGAATGACAGACTCACCGCCTCCAAAGGCGGGACTGCCATTTACTATAGGCGGGCCCTGCACGTTGTCCCTCTCGATACTCCCTCGCTCTCACATATCGAGGCGTCAGTGTGCCGTATCTCGCTGACGGGACACCAGCCGATCGTCATCGCATCCGTTTATCTCCCCCCGGACAAGCCCCTTCTGAGCAGTGACATCGAGTCACTGTTCGGCATGGGAGACTCTGTCATCCTGGCAGGCGATTTAAATTGCCACCACACTAGGTGGAACTGCCATCGTACAAACGTTAACGGTAGGCGTCTCGACGCGTTTATAGACGACCTCACCTTTGAAATAGTCGGTCCCCCAACTCCAACATGTTATCCGTATAACATCGCGCTCCGTCCGAGCACTATAGACCTGGCATTGCTTAGGAACGTAACTCTGCGCTTGCGTTCCATCGAAGCAATGCCAGAGCTCGACTCAGACCACCGACCTGTCGTTATGCAGCTCGGTCGCCCTCACAACCCAGTCACTGTTACGAGGACCATGGTGGATTGGAATAAGCTGGGCACGTGCCTAGCCGACGCCGCTCCGCCAATCCTCCCTTACGGCCCGGATTCGAATCCATCCCCAGAGGACACCGTCGAATCCATAAACATCATTACCGATCACATCTCTTCCGCGATCATTAGATCTTCTAAAGAAGTCGATGTGGAGGACAGCTTCCACCGCATCAGACTGTCCCCCGATCTTAGGAATCTCTTAAGAGTTAGGAACGCGGCAATCCGGGCCTACGATCGTCTTCCCACGCATTCAAACCGGATTCAGATGCGTCGTCTACAACGCGAAGTCCACTCCCGCTTAAGCGACGCGCGTAACGATAATTGGCATAGTTATTTAGAACAACTCGCGCCCTCCCACCAAGCATACTGGCGACTAGCTAGGACTCTCAAATCCGAAACTACCGCTACTATGCCTCCCCTCTTACGCCCTTCAGGCCAACCACCGGCATTCGATGACGATGACAAGGCTGAGCTGCTGGCCGATGCACTGCAAGAGCAGTGCACCACCAGCACTCAACACGCGGACCCCGAACACACCGAGTTAGTCGACAGGGAGGTCGAGCGCAGAGCTTCCCTGCCGCCCTCGGACGCGTTACCCCCCATTACCACGGACGAAGTTAGAGACGCGATCCACAACCTCCAACCTAGGAAGGCACCAGGCTCCGACGGCATCCACAACCGCGCGCTAAAATTTTTGCCAGTCCAACTGATAGCAATGTTGGCTACAATTTTAAATGCCGCTATGACGCACTGCATCTTTCCCGCGGTGTGGAAAGAAGCGGACGTTATCGGTATACATAAGCCGGGCAAACCGAGAAACGAAACTTCTAGTTACCGTCCGATTAGTCTCCTCTCGACGATAGGAAAAATTTACGAACGTCTCCTTAGGAAACGCCTCTGGGATTTTGTTACCGCGAACAAAATTCTCATAGACGAACAGTTCGGATTCCGCTCAAAACACTCGTGCGTACAACAAGTGCACCGCCTCACGGAGCACATTCTGATAGGACTAAATAGGCGTAAACAAATCCCGACCGGCGCCCTCTTCTTCGACATCGCGAAGGCGTTCGACAAAGTCTGGCACAACGGTTTAATTTATAAACTGTACAACATGGGAGTGCCAGACAGACTCGTGCTCATCATACGAGACTTCTTGTCGAACCGTTCGTTTCGATATCGAGTAGAGGGAACTCGTTCTCGTCCCCGTCAACTGACCGCCGGAGTCCCGCAAGGCTCCGCGCTCTCCCCGTTATTATTTAGTTTGTATATCAATGATATACCCCGGTCTCCGGAGACCCATCTAGCGCTCTTCGCCGACGACACGGCTATCTACTACTCGTGTAGGAAGATGTCGCTGCTTCATCGGCGACTCCAGATCGCAGTAGCCACCATGGGACAGTGGTTCCGGAAGTGGCGAATAGACATCAACCCCACGAAAAGCGCAGCGGTGCTCTTCAAAAGGGGTCGCCCTCCGAACATCACTTCGAGCATCCCACTCCGTAGTAGGCGCGCAAACACCTCCGCCGTTAGTCCCATCACTCTCTTTGGCCAGCCCATACCGTGGGTCTCGAAGGTCAAATATCTAGGCGTCACCCTCGACAGAGGGATGACATTCCGTCCCCATATAAAAACGGTACGCGACCGCGCCGCGTTTATTCTAGGACGACTCTATCCAATGCTTTGTAGTCGAAGCAAACTGTCCCTCCGTAATAAGGTAACTCTCTACAAAACTTGTATACGCCCCGTCATGACGTATGCAAGCGTAGTGTTCGCTCACGCAGCCCGCACCAACTTGAAATCCCTTCAGGTTATTCAATCACGATTCTGCAGGATAGCCGTCGGAGCGCCTTGGTTCCTTAGGAATGTGGATCTCCACGACGACCTGGAGCTCGACTCTTTTAGTAAGTATCTACAGTCGGCATCGCTGCGCCATTTTGAGAAGGCGGCACGACATGAGAACCCTCTCATCGTAGCCGCTGGAAATTACATACCCGACCCAGTAGACCGAATGATGCAAAAGAAAACTAATTGA

Protein

MVRNDRLTASKGGTAIYYRRALHVVPLDTPSLSHIEASVCRISLTGHQPIVIASVYLPPDKPLLSSDIESLFGMGDSVILAGDLNCHHTRWNCHRTNVNGRRLDAFIDDLTFEIVGPPTPTCYPYNIALRPSTIDLALLRNVTLRLRSIEAMPELDSDHRPVVMQLGRPHNPVTVTRTMVDWNKLGTCLADAAPPILPYGPDSNPSPEDTVESINIITDHISSAIIRSSKEVDVEDSFHRIRLSPDLRNLLRVRNAAIRAYDRLPTHSNRIQMRRLQREVHSRLSDARNDNWHSYLEQLAPSHQAYWRLARTLKSETTATMPPLLRPSGQPPAFDDDDKAELLADALQEQCTTSTQHADPEHTELVDREVERRASLPPSDALPPITTDEVRDAIHNLQPRKAPGSDGIHNRALKFLPVQLIAMLATILNAAMTHCIFPAVWKEADVIGIHKPGKPRNETSSYRPISLLSTIGKIYERLLRKRLWDFVTANKILIDEQFGFRSKHSCVQQVHRLTEHILIGLNRRKQIPTGALFFDIAKAFDKVWHNGLIYKLYNMGVPDRLVLIIRDFLSNRSFRYRVEGTRSRPRQLTAGVPQGSALSPLLFSLYINDIPRSPETHLALFADDTAIYYSCRKMSLLHRRLQIAVATMGQWFRKWRIDINPTKSAAVLFKRGRPPNITSSIPLRSRRANTSAVSPITLFGQPIPWVSKVKYLGVTLDRGMTFRPHIKTVRDRAAFILGRLYPMLCSRSKLSLRNKVTLYKTCIRPVMTYASVVFAHAARTNLKSLQVIQSRFCRIAVGAPWFLRNVDLHDDLELDSFSKYLQSASLRHFEKAARHENPLIVAAGNYIPDPVDRMMQKKTN

Catalytic Activity

a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)

Cofactor

Mg(2+)
Mn(2+)

Miscellaneous

Prefers poly(rC) and poly(rA) as template and activated DNA is not effective.

Keywords

Nucleotidyltransferase   RNA-directed DNA polymerase   Transferase   Transposable element  

Feature

chain  RNA-directed DNA polymerase from mobile element jockey

Uniprot

Q93137   Q9XXW0   Q9BPQ0   A0A0N1PFV1   O96546   A0A1Y1NA23   + More
A0A139W8G9   A0A139WA11   V5GNJ2   V5GNF3   A0A023EYS8   A0A023EZE6   A0A2S2PPK8   X1WLB2   Q07995   A0A224XF24   A0A2S2Q383   A0A3N5Z7I3   J9LC21   D7EM17   A0A2S2QEE0   J9M522   A0A2M4BD66   A0A224X6Q4   A0A2M4BDA5   A0A2M4BD62   X1WNI2   A0A2S2NGV8   A0A2M4CV42   J9KKL3   A0A2J7R7D0   A0A2J7QR37   A0A2M4BEF4   A0A087UGF5   A0A2M4CV52   A0A2M4BEZ9   A0A2J7PU96   X1WZH0   A0A2M4BD67   A0A2J7PBY3   A0A2J7QY69   A0A2M4BDV6   A0A224XB44   A0A2S2N814   K7IN67   A0A2J7PDM0   J9LFC9   A0A1Y1LKN6   A0A069DZL8   A0A224X6S1   X1WQI9   A0A224X6T4   A0A2H8TF37   A0A2J7Q6J2   A0A0A9YJ00   A0A0A9YU04   A0A2S2R9D4   A0A224XI99   A0A2J7PVX3   A0A2J7PQB5   A0A224X6U5   P21329   A0A224X6R6   A0A224X746   A0A0L0CBP5   A0A2S2P698   J9JS95   A0A1Y1KFR3   A0A087UCW3   D7GYA5   P21328   A0A224XJI0   A0A2A4IUM2   A0A0A9YSX4   A0A2S2NH02   A0A1B6EGD8   Q95SX7   A0A069DX78   A0A2J7QB68   A0A2S2PJG2   A0A2S2NPG3   Q8T9X4   A0A352X8G4   Q8I7P8   A0A224XHW8   A0A2J7RE85   A0A2J7PP17   A0A0V0G5B6   A0A2A4K918   A0A0J7MYU2   A0A2S2N6Q7   A0A2S2NPJ7   A0A2S2P6C4  

EC Number

2.7.7.49

Pubmed

10333566    26354079    10380107    28004739    18362917    19820115    + More
25474469    8387152    30086797    20075255    26334808    25401762    1701254    26108605    2463954    3040362    1714378    7753626    12537569    30148503   

EMBL

U07847    AAA17752.1    AB018558    BAA76304.1    AB055391    BAB21761.1    + More
KQ459265    KPJ02064.1    AF081103    AAC72921.1    GEZM01008457    JAV94772.1    KQ973342    KXZ75569.1    KQ971729    KYB24751.1    GALX01005299    JAB63167.1    GALX01005359    JAB63107.1    GBBI01004395    JAC14317.1    GBBI01004571    JAC14141.1    GGMR01018716    MBY31335.1    ABLF02042518    ABLF02057746    S59870    AAB26437.2    GFTR01008038    JAW08388.1    GGMS01002992    MBY72195.1    RPOV01000134    RPJ78669.1    ABLF02036316    ABLF02036319    ABLF02048663    ABLF02066977    KQ973412    EFA12510.2    GGMS01006359    MBY75562.1    ABLF02024246    GGFJ01001844    MBW50985.1    GFTR01008279    JAW08147.1    GGFJ01001842    MBW50983.1    GGFJ01001843    MBW50984.1    ABLF02008153    ABLF02008462    ABLF02008464    GGMR01003407    MBY16026.1    GGFL01005012    MBW69190.1    ABLF02029306    ABLF02029314    ABLF02060138    NEVH01006736    PNF36716.1    NEVH01011985    PNF31054.1    GGFJ01002256    MBW51397.1    KK119692    KFM76444.1    GGFL01004957    MBW69135.1    GGFJ01002257    MBW51398.1    NEVH01021205    PNF19912.1    ABLF02034467    GGFJ01001858    MBW50999.1    NEVH01027074    PNF13841.1    NEVH01009134    PNF33528.1    GGFJ01001857    MBW50998.1    GFTR01008262    JAW08164.1    GGMR01000676    MBY13295.1    NEVH01026386    PNF14434.1    ABLF02023911    GEZM01053022    JAV74219.1    GBGD01000415    JAC88474.1    GFTR01008271    JAW08155.1    ABLF02022418    GFTR01008261    JAW08165.1    GFXV01000908    MBW12713.1    NEVH01017470    PNF24199.1    GBHO01010547    GBHO01010546    JAG33057.1    JAG33058.1    GBHO01021814    GBHO01010549    JAG21790.1    JAG33055.1    GGMS01017365    MBY86568.1    GFTR01008256    JAW08170.1    NEVH01020940    PNF20481.1    NEVH01022639    PNF18527.1    GFTR01008251    JAW08175.1    M38437    GFTR01008269    JAW08157.1    GFTR01008151    JAW08275.1    JRES01000644    KNC29657.1    GGMR01012305    MBY24924.1    ABLF02028535    ABLF02028545    GEZM01084969    JAV60363.1    KK119261    KFM75202.1    KQ973363    EFA13335.2    M22874    M38643    GFTR01008257    JAW08169.1    NWSH01007753    PCG62823.1    GBHO01008295    JAG35309.1    GGMR01003864    MBY16483.1    GEDC01000337    JAS36961.1    AY060438    AAL25477.1    GBGD01000389    JAC88500.1    NEVH01016302    PNF25823.1    GGMR01016905    MBY29524.1    GGMR01006408    MBY19027.1    AF456125    AAL57609.1    DNOY01000259    HBE18313.1    AY180919    AAN87272.1    GFTR01008254    JAW08172.1    NEVH01005277    PNF39135.1    NEVH01023280    PNF18085.1    GECL01003538    JAP02586.1    NWSH01000032    PCG80496.1    LBMM01013518    KMQ85605.1    GGMR01000226    MBY12845.1    GGMR01006491    MBY19110.1    GGMR01012283    MBY24902.1   

Proteomes

UP000053268    UP000007266    UP000007819    UP000235965    UP000054359    UP000002358    + More
UP000037069    UP000218220    UP000036403   

PRIDE

Q93137    Q9XXW0    Q9BPQ0    P21329    P21328    Q95SX7    + More
Q8T9X4    Q8I7P8   

Pfam

PF00078   RVT_1        + More
PF14529   Exo_endo_phos_2
PF07530   PRE_C2HC
PF03372   Exo_endo_phos
PF07727   RVT_2

Interpro

IPR036691   Endo/exonu/phosph_ase_sf        + More
IPR005135   Endo/exonuclease/phosphatase       
IPR000477   RT_dom       
IPR006579   Pre_C2HC_dom       
IPR013103   RVT_2       

SUPFAM

SSF56219   SSF56219       

Gene 3D

3.60.10.10    

ProteinModelPortal

Q93137   Q9XXW0   Q9BPQ0   A0A0N1PFV1   O96546   A0A1Y1NA23   + More
A0A139W8G9   A0A139WA11   V5GNJ2   V5GNF3   A0A023EYS8   A0A023EZE6   A0A2S2PPK8   X1WLB2   Q07995   A0A224XF24   A0A2S2Q383   A0A3N5Z7I3   J9LC21   D7EM17   A0A2S2QEE0   J9M522   A0A2M4BD66   A0A224X6Q4   A0A2M4BDA5   A0A2M4BD62   X1WNI2   A0A2S2NGV8   A0A2M4CV42   J9KKL3   A0A2J7R7D0   A0A2J7QR37   A0A2M4BEF4   A0A087UGF5   A0A2M4CV52   A0A2M4BEZ9   A0A2J7PU96   X1WZH0   A0A2M4BD67   A0A2J7PBY3   A0A2J7QY69   A0A2M4BDV6   A0A224XB44   A0A2S2N814   K7IN67   A0A2J7PDM0   J9LFC9   A0A1Y1LKN6   A0A069DZL8   A0A224X6S1   X1WQI9   A0A224X6T4   A0A2H8TF37   A0A2J7Q6J2   A0A0A9YJ00   A0A0A9YU04   A0A2S2R9D4   A0A224XI99   A0A2J7PVX3   A0A2J7PQB5   A0A224X6U5   P21329   A0A224X6R6   A0A224X746   A0A0L0CBP5   A0A2S2P698   J9JS95   A0A1Y1KFR3   A0A087UCW3   D7GYA5   P21328   A0A224XJI0   A0A2A4IUM2   A0A0A9YSX4   A0A2S2NH02   A0A1B6EGD8   Q95SX7   A0A069DX78   A0A2J7QB68   A0A2S2PJG2   A0A2S2NPG3   Q8T9X4   A0A352X8G4   Q8I7P8   A0A224XHW8   A0A2J7RE85   A0A2J7PP17   A0A0V0G5B6   A0A2A4K918   A0A0J7MYU2   A0A2S2N6Q7   A0A2S2NPJ7   A0A2S2P6C4  

PDB

6AR3     E-value=0.000733511,     Score=105

KEGG

105842121    no KO assigned | (RefSeq) uncharacterized LOC105842121

GO

GO:0003964   GO:0004519   GO:0006313  

Length:

860

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.90814

Exp number, first 60 AAs:

0.00735

Total prob of N-in:

0.01290

outside

1  -  860

 

 

Pi

1.165647

Theta

1.884856

Tajima's D

0

CLR

7.848316

CSRT

0.410029498525074

Interpretation

Uncertain