Gene

KWMTBOMO03265

Pre Gene Modal

BGIBMGA013608

Annotation

PREDICTED:_activin_receptor_type-2B-like_[Bombyx_mori]

Location

Bomo_Chr6(-):2604668-2616916      View in EpiBrowser

Full name

Serine/threonine-protein kinase receptor       + More
Receptor protein serine/threonine kinase      

Location in the cell

Extracellular   Reliability : 1.26

CDS

ATGAAGTTCCTACACATAATCTTGCTTGTGCTTGGTATGCATGCAATAACACTGGCGGCTCCACCATCACAAGAAAACCTCCCACCGAGGCCGAAAGAAGGCGGAGTAACCACCAGATACTGCGAATTCTACAATAGCTCCACTCCTAGCTGTAATCCAGCAACGAACTCTTCATGCGTACCTGAAACAATTATAGAGGAATGCCATCCATTCGAAGCGGAAAAAAGTGTACACTGCTTTGTGTTGTGGCAGTTTGATAACGAAATGTACACCGCATATCCTAAAGTCAAAGGATGTTTCGTCGATACAGTCTCGTGTAAAGACAGAGCATCCAACTGCACCCTCCACAATACGCTACTGCCACTTCTACACTGCTGTTGCGAAGGAGACATGTGCAACAAAAATCTTACGTTCCCCAATCCGAAATCATTTATGACACAAACAGATAATCCCAAAGAACACAGTACTGTCGCCTCCCCAATTCCCGCTGCAATGCCGGACGTCATTGCGTACACGCTGACACCGTTGTTCCTGCTATTCGCTGTGTTAGTCGGATGCTACCTGTTATACAGGAAACGTAAAGGCAGCTCTTTTGCTGAACTAGCCAGCGGCGAGAATTCTCTGTCCAGGCCTCCGTCGGCGGGCGGCGGTATGGAAAATGAATCCGGCGTGTTAGTCACTCAGGTGGCGCTCTGTGAAGTGAGAGCCCGCGGGAGATTTGGAGCGGTTTGGCGAGCGAGACTAGGACAAAAGGACGTGGCGGTTAAAGTGTTTCCCCTACAGGACAAGCAGTCGTGGTTAGCCGAGCAAGAGGTGTTCCGACTGCCCAGGATGGATCATCCCGACATTTTGCAGTACATCGGCGTTGATAAAACTGGCGATAATCTACAGGCAGAATATTGGCTCATCACAGCTTATCATGAGAAGGGCTCCCTATGCGACTACCTGAAAGCTAACACGCTAACTTGGGCTAAAGCGTGGCGTATAGCAGCTTGCGTGGCTCGGGGTCTGTCCCACCTGCACGAAGAAGGCGGTGGCAAACCCGCAATAGCGCACAGGGACTTTAAATCCAAAAACGTACTGTTGAAAGCGGATTTGAGCGCGTGCATCGCTGATTTCGGCCTAGCTCTGATATTCGTGCCGGCAAGAGGCTGTGGGGATGCTCACGGCCAGGTCGGAACAAGACGGTACATGGCTCCGGAGGTCCTGGACGGAGCTATCAACTTCACTAAAGACGCCTTCTTGAGGATTGACATGTACGCGTGCGCGCTGGTGCTATGGGAAATAGCTTCGAGATGCAGTGACGTAGGCGCAGACGATACGTCCCAGTACCGTTTGCCGTTGGAAGAAGAAGTCGGATCTCATCCGAGCCTCGAGGAGATGCAGGAAGCGGTCGTGCAAAGGAAACTCCGTCCGCACATACCGCAGCACTGGAGAGACCACCCGGGCATGTCAGTGCTGTGCGACACCATGGAGGAGTGCTGGGACCACGACGCGGAGGCGCGGCTGTCTGCGTCGTGCGTGCTGGAGCGCGTGGCCGCCCAGCGCGCCCCGTGCTCGGACAGTGCGCCGCTGCTCCTCCACCCCCCGCCCTGCTGA

Protein

MKFLHIILLVLGMHAITLAAPPSQENLPPRPKEGGVTTRYCEFYNSSTPSCNPATNSSCVPETIIEECHPFEAEKSVHCFVLWQFDNEMYTAYPKVKGCFVDTVSCKDRASNCTLHNTLLPLLHCCCEGDMCNKNLTFPNPKSFMTQTDNPKEHSTVASPIPAAMPDVIAYTLTPLFLLFAVLVGCYLLYRKRKGSSFAELASGENSLSRPPSAGGGMENESGVLVTQVALCEVRARGRFGAVWRARLGQKDVAVKVFPLQDKQSWLAEQEVFRLPRMDHPDILQYIGVDKTGDNLQAEYWLITAYHEKGSLCDYLKANTLTWAKAWRIAACVARGLSHLHEEGGGKPAIAHRDFKSKNVLLKADLSACIADFGLALIFVPARGCGDAHGQVGTRRYMAPEVLDGAINFTKDAFLRIDMYACALVLWEIASRCSDVGADDTSQYRLPLEEEVGSHPSLEEMQEAVVQRKLRPHIPQHWRDHPGMSVLCDTMEECWDHDAEARLSASCVLERVAAQRAPCSDSAPLLLHPPPC

Catalytic Activity

[receptor-protein]-L-serine + ATP = [receptor-protein]-O-phospho-L-serine + ADP + H(+)
[receptor-protein]-L-threonine + ATP = [receptor-protein]-O-phospho-L-threonine + ADP + H(+)

Similarity

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

Feature

chain  Serine/threonine-protein kinase receptor

Uniprot

H9JVP5   A0A2A4JKH1   A0A2H1VND3   A0A2W1BGW3   A0A212EM83   A0A0N0PCA0   + More
A0A194Q296   A0A0L7KQP8   A0A232F241   K7J138   A0A088ANA1   A0A067RJQ7   A0A2A3EBL9   A0A1B6FDB3   A0A151WES3   E2BIN9   F4WR66   A0A195BBP4   A0A151IQG0   A0A0L7RG85   A0A1B6CZD7   A0A3L8DEJ0   A0A1Y1ME07   A0A026WSB3   A0A1W4W8K5   A0A151J326   D6X465   A0A1B6M5B9   T1HXB4   A0A023F3N5   U4UJ22   A0A0N8CKI7   A0A0P6JKQ6   A0A158NUB9   A0A195FKB9   A0A0A9YX77   A0A154PCP5   A0A2H8TI06   A0A2L2YPG4   A0A3Q0IY43   A0A385XRK0   A0A087T9S8   U5EVS8   J9JVN2   A0A1Q3F5D7   A0A023ET35   A0A182N1J7   A0A1Z5KX47   T1IHR6   A0A182FIE5   W5JT00   A0A293M8C5   A0A2M4AC59   A0A2M4BJJ1   A0A182XXR6   A0A2M4BKG1   A0A1L8DJS6   A0A182I9J1   A0A182QZB7   A0A1L8DK39   A0A2R7WNY7   Q0IEL3   A0A084VIW5   A0A1S4FGD1   A0A1S4FMY1   Q172G8   A0A182K107   A0A336MK22   A0A336LB80   A0A182XEL0   B4PSR2   A0A182V0B1   Q7QE97   B4NK20   A0A182LIN0   B3P3L7   A0A0B4KG59   Q24468   Q24229   A0A182RH81   A0A182M3H7   A0A0P4W8U5   B4HEL0   B4QZT3   B4G5Q5   Q299T8   A0A182IST1   C5WLU3   A0A3B0JD99   A0A182W474   A0A1W4V5R5   A0A147BTK8   A0A1I8MWT9   B4JXY6   B3LW28   B4K9K1   A0A2S2Q7T7   A0A0K8VH74   A0A034VX52   B4LVW1  

EC Number

2.7.11.30

Pubmed

19121390    28756777    22118469    26354079    26227816    28648823    + More
20075255    24845553    20798317    21719571    30249741    28004739    24508170    18362917    19820115    25474469    23537049    21347285    25401762    26823975    26561354    24945155    28528879    20920257    23761445    25244985    17510324    24438588    17994087    17550304    12364791    14747013    17210077    20966253    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    7697719    26109357    26109356    8415726    15632085    29652888    25315136    25348373   

EMBL

BABH01032296    BABH01032297    NWSH01001169    PCG72276.1    ODYU01003477    SOQ42323.1    + More
KZ150071    PZC74058.1    AGBW02013858    OWR42610.1    KQ460650    KPJ13124.1    KQ459579    KPI99458.1    JTDY01007140    KOB65435.1    NNAY01001172    OXU24886.1    KK852470    KDR23233.1    KZ288292    PBC29173.1    GECZ01021577    JAS48192.1    KQ983238    KYQ46368.1    GL448520    EFN84433.1    GL888284    EGI63293.1    KQ976532    KYM81630.1    KQ976780    KYN08388.1    KQ414596    KOC69977.1    GEDC01018507    JAS18791.1    QOIP01000009    RLU18741.1    GEZM01036296    JAV82820.1    KK107119    EZA58551.1    KQ980298    KYN16824.1    KQ971410    EEZ97734.1    GEBQ01008879    JAT31098.1    ACPB03011000    GBBI01002717    JAC15995.1    KB632345    ERL93082.1    GDIP01122751    LRGB01000007    JAL80963.1    KZS21938.1    GDIQ01016002    JAN78735.1    ADTU01026290    ADTU01026291    KQ981512    KYN40848.1    GBHO01009459    GDHC01020140    GDHC01004116    JAG34145.1    JAP98488.1    JAQ14513.1    KQ434864    KZC08970.1    GFXV01001874    MBW13679.1    IAAA01042312    LAA09984.1    MG545146    AYC12380.1    KK114189    KFM61867.1    GANO01003274    JAB56597.1    ABLF02033113    GFDL01012306    JAV22739.1    GAPW01001150    JAC12448.1    GFJQ02007432    JAV99537.1    JH429991    ADMH02000457    ETN66398.1    GFWV01010476    MAA35205.1    GGFK01005046    MBW38367.1    GGFJ01004061    MBW53202.1    GGFJ01004137    MBW53278.1    GFDF01007371    JAV06713.1    APCN01000984    AXCN02002441    GFDF01007370    JAV06714.1    KK855179    PTY21304.1    CH477600    EAT38449.1    ATLV01013412    KE524855    KFB37909.1    CH477437    EAT40929.1    UFQT01000674    SSX26408.1    UFQS01002415    UFQT01002415    SSX13983.1    SSX33402.1    CM000160    EDW97558.2    AAAB01008847    EAA06869.4    CH964272    EDW85062.1    CH954181    EDV48905.1    AE014297    AGB95956.1    L38495    AAC41566.1    AAF55079.1    L22176    AAA03579.1    AXCM01000900    GDRN01077355    GDRN01077354    JAI62754.1    CH480815    EDW42167.1    CM000364    EDX12931.1    CH479179    EDW24921.1    CM000070    EAL27613.2    BT088908    ACT09405.1    OUUW01000005    SPP80354.1    GEGO01001316    JAR94088.1    CH916377    EDV90548.1    CH902617    EDV41561.1    CH933806    EDW16661.2    GGMS01004417    MBY73620.1    GDHF01020987    GDHF01014404    JAI31327.1    JAI37910.1    GAKP01012839    JAC46113.1    CH940650    EDW67566.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000053240    UP000053268    UP000037510    + More
UP000215335    UP000002358    UP000005203    UP000027135    UP000242457    UP000075809    UP000008237    UP000007755    UP000078540    UP000078542    UP000053825    UP000279307    UP000053097    UP000192223    UP000078492    UP000007266    UP000015103    UP000030742    UP000076858    UP000005205    UP000078541    UP000076502    UP000079169    UP000054359    UP000007819    UP000075884    UP000069272    UP000000673    UP000076408    UP000075840    UP000075886    UP000008820    UP000030765    UP000075881    UP000076407    UP000002282    UP000075903    UP000007062    UP000007798    UP000075882    UP000008711    UP000000803    UP000075900    UP000075883    UP000001292    UP000000304    UP000008744    UP000001819    UP000075880    UP000268350    UP000075920    UP000192221    UP000095301    UP000001070    UP000007801    UP000009192    UP000008792   

PRIDE

H9JVP5    Q24468    Q24229    C5WLU3   

Pfam

PF00069   Pkinase        + More
PF01064   Activin_recp
PF07714   Pkinase_Tyr

Interpro

IPR000719   Prot_kinase_dom        + More
IPR011009   Kinase-like_dom_sf       
IPR000333   TGFB_receptor       
IPR017194   Transform_growth_fac-b_typ-2       
IPR008271   Ser/Thr_kinase_AS       
IPR000472   Activin_recp       
IPR001245   Ser-Thr/Tyr_kinase_cat_dom       
IPR007110   Ig-like_dom       

SUPFAM

SSF56112   SSF56112       

ProteinModelPortal

H9JVP5   A0A2A4JKH1   A0A2H1VND3   A0A2W1BGW3   A0A212EM83   A0A0N0PCA0   + More
A0A194Q296   A0A0L7KQP8   A0A232F241   K7J138   A0A088ANA1   A0A067RJQ7   A0A2A3EBL9   A0A1B6FDB3   A0A151WES3   E2BIN9   F4WR66   A0A195BBP4   A0A151IQG0   A0A0L7RG85   A0A1B6CZD7   A0A3L8DEJ0   A0A1Y1ME07   A0A026WSB3   A0A1W4W8K5   A0A151J326   D6X465   A0A1B6M5B9   T1HXB4   A0A023F3N5   U4UJ22   A0A0N8CKI7   A0A0P6JKQ6   A0A158NUB9   A0A195FKB9   A0A0A9YX77   A0A154PCP5   A0A2H8TI06   A0A2L2YPG4   A0A3Q0IY43   A0A385XRK0   A0A087T9S8   U5EVS8   J9JVN2   A0A1Q3F5D7   A0A023ET35   A0A182N1J7   A0A1Z5KX47   T1IHR6   A0A182FIE5   W5JT00   A0A293M8C5   A0A2M4AC59   A0A2M4BJJ1   A0A182XXR6   A0A2M4BKG1   A0A1L8DJS6   A0A182I9J1   A0A182QZB7   A0A1L8DK39   A0A2R7WNY7   Q0IEL3   A0A084VIW5   A0A1S4FGD1   A0A1S4FMY1   Q172G8   A0A182K107   A0A336MK22   A0A336LB80   A0A182XEL0   B4PSR2   A0A182V0B1   Q7QE97   B4NK20   A0A182LIN0   B3P3L7   A0A0B4KG59   Q24468   Q24229   A0A182RH81   A0A182M3H7   A0A0P4W8U5   B4HEL0   B4QZT3   B4G5Q5   Q299T8   A0A182IST1   C5WLU3   A0A3B0JD99   A0A182W474   A0A1W4V5R5   A0A147BTK8   A0A1I8MWT9   B4JXY6   B3LW28   B4K9K1   A0A2S2Q7T7   A0A0K8VH74   A0A034VX52   B4LVW1  

PDB

2QLU     E-value=1.03489e-107,     Score=998

KEGG

101741860    K13596 activin receptor type-2B [EC:2.7.11.30] | (RefSeq) activin receptor type-2B-like

PATHWAY

04350    TGF-beta signaling pathway - Bombyx mori (domestic silkworm)

GO

GO:0005524   GO:0043235   GO:0004675   GO:0046872   GO:0007179   GO:0016021   GO:0004674   GO:0046332   GO:0019838   GO:0005887   GO:0007389   GO:0005026   GO:0048179   GO:0032924   GO:0048185   GO:0034713   GO:0005024   GO:0007476   GO:0030718   GO:0007411   GO:0042078   GO:0030509   GO:0007391   GO:0007428   GO:0008258   GO:0009953   GO:0070724   GO:0007443   GO:0036122   GO:0017002   GO:0005886   GO:0001745   GO:0045705   GO:0006468   GO:0048666   GO:0007424   GO:0004672   GO:0048813   GO:0004702   GO:0007178   GO:0016020   GO:0005634   GO:0006270   GO:0042555   GO:0048384   GO:0038023  

PANTHER

PTHR23255  

Subcellular location

Membrane  

SignalP

Position:   1 - 19,         Likelihood:  0.999678

 

 

Length:

532

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

31.61468

Exp number, first 60 AAs:

2.76829

Total prob of N-in:

0.16069

outside

1  -  167

TMhelix

168  -  190

inside

191  -  532

 

 

Pi

207.464052

Theta

187.735971

Tajima's D

0.338648

CLR

181.138187

CSRT

0.455027248637568

Interpretation

Uncertain