Gene

KWMTBOMO03261

Pre Gene Modal

BGIBMGA013603

Annotation

PREDICTED:_protein_SMG8_[Bombyx_mori]

Location

Bomo_Chr6(+):2560957-2574195      View in EpiBrowser

Full name

Protein SMG8      

Alternative Name

Protein smg-8 homolog

Location in the cell

Nuclear   Reliability : 1.324 PlasmaMembrane   Reliability : 1.476

CDS

ATGAAGGTTTTTAAATTAAATGATATACCAGAGTTTTCCAAAAGGGAGAGAATAGTAGTTGTCGGAATTATTGGCAAATCTCCTCACCGGTATCCAAACAAGACAACTCCACTACTTTCTGCAGTACAATCTCAAGAAATTGGCATCGAATGTCACTGGGATGAGCGCCGTGGTGTTCTGTTTCTCCATGCCCTCACGTATCTTGACACAAAACATCTTTCAGCCTTAGCTGCTGACTTGAATGAGAATTCCAAAAGCACAATTAAAGATGCAGATGCCTCAAATTGGCTTGTTGCATCGGGTGAACTAGCTATAGACTCATGCAAGATTATTGGATTGCTTTTTAATTTGTGTCATATTGTGGTGCTGTCATCACCCACCACTGTTTTTGATCTCGGATACCTACAATTATTTAAAGCTATCGATGCTTTTAGATTGGAAATAACAAACCGTACCTCAGTGGCCTTATCTGAAGCAGAGTTAGGTGGCACATGGATCTCGCATGGACGTTGTTGTTGCCCACGGCTACTGTTCCACATGCGTCGAGCTCCCGTACCTTTGAAACGTAATCCTGGAGCTTTAAAACGACTCGAACACTCCATTGAAGACCAACTTTATTCTATACTTAGAAAGTCTAGGATCATAACTAATGTTTGTGCAAAAGCCCTATTTGCAATACCGAAAAATGAAGAGTTTGTGTACATAAGCACTGATGAGGAAGTGTGTAACGCTCGCGACGTTAGCGTGCTGGTGAGCGGGCTGGTGCGCATGTGTGGCGGCGCGCAGCCCGACCGCCCCGCCGGGGAGAGGCCCGGCTTCGCGCAGTTCCTGCAGGGGCACATAGACTTGGCGTTCGCCGAAGGATTCGACGACAACGTCGGGAAATACGCGATGAGTACGTCATTCTTTGAGCTGCCGAGCGCAGAATCATGGCGTAAAGCAGCCGAGGTCCTGACGCCGCTGTACCTGGAGGATCCCGTGCAGGTGGACGAGGGCTCGGAGATCGGCCGCACTCTGTTCCTGATACTCGCCACTGACGTACGGTTCTCCCAGGCTCGATGCGCCAAGATATTACCAATAGCCCAGGCATCCTACACGGAGGGCATGCCGGCGCACTACTCCAGCCAGCACCACGCGCATAAGGTGAAGGTAGCCCTAGGAGTGCTGGAGACGATGGCCCGCGGTCCGCTGGCGGGCGGGGCTCGCGCGAGGCTGCAGGCCGCGTGTGACGTCACGTGGCGCTCCCGCAGTCTGTGCGAGGCGTTGTCCCTCACCGGACATCCGTGTATAGAACCCGAACACGACGGCGGCACGGAGCACTCGTCGGGCGTGCGCTACGTGTCGGCGTGCGCGTGCGGGCGCAGCAAGTGCTCGCGCGACGACCCGTACACGCCGCGCGCCGCCAACCTCGCCTTCTACTCGCTCGCGGCCGACCAGTGCGCGCACTGCCGCACGCTGCAGGCCGTCGCCTTCCCGGTCTTCCAGCCCTCCACGCCCACCTACAAAGCGGCATCAGTAAAAGGAGCACAAAGTCAAGAGGCCTACGAAAGTTCGACGGTCCGCGAGACGGAGGGGAACTCCGCGTCGGGGGGCGAGGGGGGAGAGGGGGACGAGTCGGGGGGCTGGTCCGCGCCGCACGCGCTGTCCCCGGGGTCGGGCGGGGACGACGACGAGGAGAACAAGTCCCCCGCAGCCGAGAACAGATACGTCGTGCCCGTTACTGGGGACTCTAATACTGATAAGATGATCCGCCGCCAGCCGTCGACGACGGAGTACCTGCCGGGCATGCTGCACACCGCCAGCCCGGCCGGCCTGCTGCCCGCCTACTGCTCCTGGAGCCTGGTGTGCGTGGGCGCCTCCTCTCTGTACTCGCACAGCATGGGCCTGCCGGACCACCTGCAGCCCGGCTTCCTGCCCCACACCAACTATCTGCTGCCCTGGGACTGCGCCGTCAGGATGGAACAAGTGAGCCTGTGGCGTATGGCCCAGGCGTCGTCTCGCGGCCGCGGTAAGCCGACCCCGCCGCATCACCTCACAGTCAAAATCTTCATCGGGTTTGAATATGAATGTCCTAGAGGACACAGGCTGATGATGTCGTCCCCCACGAGTGCGGTGAGCGGGGGCTCGTGCGGGCGCGAGGCGGGGGCGCGGCTGGCGGCCAGCGACATGCCGCTGTACGTGCCCTGTCTGTGCTCCGTGCCCCTCCCCGCGCAGCTCACCCGGCTGCACGTCGTCACGCCCAAGGCTCCTGTACACGTCACGCTGGACCCCAGGGTGCAGCCGGTGCCCGGCGGGCCGATCTTCGTCCCGCAGCCCGTGGGCTCGCCGGCCATCAAGCTGTCGGCGTCCGCCTACTGGATCCTCCGCCTCCCGTTCGTGTACTGCGACGAGCGTGGCGCGCTGCCCCGCCCCCGCACCGCGCCCTCCTCCCCGCTGTCGCAAGGCGTTATACTAGCCCCACTGTTCGGGCTCGCCGACTGA

Protein

MKVFKLNDIPEFSKRERIVVVGIIGKSPHRYPNKTTPLLSAVQSQEIGIECHWDERRGVLFLHALTYLDTKHLSALAADLNENSKSTIKDADASNWLVASGELAIDSCKIIGLLFNLCHIVVLSSPTTVFDLGYLQLFKAIDAFRLEITNRTSVALSEAELGGTWISHGRCCCPRLLFHMRRAPVPLKRNPGALKRLEHSIEDQLYSILRKSRIITNVCAKALFAIPKNEEFVYISTDEEVCNARDVSVLVSGLVRMCGGAQPDRPAGERPGFAQFLQGHIDLAFAEGFDDNVGKYAMSTSFFELPSAESWRKAAEVLTPLYLEDPVQVDEGSEIGRTLFLILATDVRFSQARCAKILPIAQASYTEGMPAHYSSQHHAHKVKVALGVLETMARGPLAGGARARLQAACDVTWRSRSLCEALSLTGHPCIEPEHDGGTEHSSGVRYVSACACGRSKCSRDDPYTPRAANLAFYSLAADQCAHCRTLQAVAFPVFQPSTPTYKAASVKGAQSQEAYESSTVRETEGNSASGGEGGEGDESGGWSAPHALSPGSGGDDDEENKSPAAENRYVVPVTGDSNTDKMIRRQPSTTEYLPGMLHTASPAGLLPAYCSWSLVCVGASSLYSHSMGLPDHLQPGFLPHTNYLLPWDCAVRMEQVSLWRMAQASSRGRGKPTPPHHLTVKIFIGFEYECPRGHRLMMSSPTSAVSGGSCGREAGARLAASDMPLYVPCLCSVPLPAQLTRLHVVTPKAPVHVTLDPRVQPVPGGPIFVPQPVGSPAIKLSASAYWILRLPFVYCDERGALPRPRTAPSSPLSQGVILAPLFGLAD

Description

Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Probable component of kinase complex containing SMG1 and recruited to stalled ribosomes (By similarity).

Similarity

Belongs to the SMG8 family.

Keywords

Complete proteome   Nonsense-mediated mRNA decay   Reference proteome  

Feature

chain  Protein SMG8

Uniprot

A0A0N1IDX7   A0A194Q2A1   A0A2H1WU70   A0A212EMA1   E9I9E8   A0A151X4Z1   + More
A0A0N0U4X6   K7IM59   E2C2F5   A0A232FCJ7   E2AYJ9   A0A1W4W9L7   A0A087ZNV5   A0A0C9QZU7   A0A195C6Y4   A0A2A3END4   A0A195FUN0   A0A026W6E2   A0A195DCR3   A0A2J7RA93   D6WLV3   A0A2S2PTR6   E0VLC2   A0A1Y1N4Z3   A0A0J7L2B1   A0A154NXU2   A0A310SNP8   N6UDI8   A0A195BBG7   U4UXZ9   A0A0P5CXL4   A0A2P8ZMG1   A0A0P5WWA2   A0A0P5X300   A0A158NAF5   A0A0N8ATD3   A0A0N8C2P8   A0A0P5H4Q0   A0A0P5YDR7   A0A0P5ZJL4   A0A0T6B2H2   B0W730   A0A182G2A5   Q17G65   E9G817   A0A0N8EK61   T1JDF4   A0A0P4YWM1   A0A0C9RFH3   A0A1I8PLZ8   A0A1A9UMJ9   A0A1I8N716   A0A0P5V3P1   A0A1B0FLQ3   A0A336LT62   A0A0L0C1U7   A0A0N8E839   C3XZ69   A0A0P6CIN9   R7VIE9   A0A1J1IMR3   A0A023F091   A0A0P4Z8J4   A0A0P5QLV7   A0A0N8CLP6   A0A093TCS1   H3ACG2   A0A1A8MTX0   A0A1A8NUJ9   A0A0Q3MF02   A0A1A7ZLS3   A0A1A8J720   A0A1A7Y2X7   A0A3B4FNS8   A0A1A7XGG0   A0A1A8JV23   A0A1A8D556   A0A1A8DD97   A0A1A8EVS1   A0A2I0LYQ4   A0A091M640   A0A3Q0H5P8   A0A091TP51   A0A3P8Q4I7   A0A3P9BTX5   A0A2I4CNZ2   A0A099ZE28   A0A093HMD8   R0K5X3   I3KL83   A0A287AXJ0   A0A091EKN1  

Pubmed

26354079    22118469    21282665    20075255    20798317    28648823    + More
24508170    30249741    18362917    19820115    20566863    28004739    23537049    29403074    21347285    26483478    17510324    21292972    25315136    26108605    18563158    23254933    25474469    9215903    23371554    25186727   

EMBL

KQ460650    KPJ13129.1    KQ459579    KPI99463.1    ODYU01011087    SOQ56603.1    + More
AGBW02013858    OWR42615.1    GL761800    EFZ22785.1    KQ982544    KYQ55349.1    KQ435798    KOX73371.1    GL452124    EFN77905.1    NNAY01000419    OXU28536.1    GL443918    EFN61487.1    GBYB01000141    JAG69908.1    KQ978220    KYM96395.1    KZ288204    PBC33275.1    KQ981264    KYN43997.1    KK107374    QOIP01000010    EZA51583.1    RLU18184.1    KQ980989    KYN10700.1    NEVH01006576    PNF37753.1    KQ971343    EFA03396.2    GGMR01019617    MBY32236.1    DS235271    EEB14178.1    GEZM01013527    JAV92508.1    LBMM01001138    KMQ96836.1    KQ434781    KZC04496.1    KQ762329    OAD55967.1    APGK01032722    KB740848    ENN78691.1    KQ976528    KYM81878.1    KB632411    ERL95246.1    GDIP01164021    JAJ59381.1    PYGN01000016    PSN57691.1    GDIP01140632    GDIP01080681    GDIQ01030341    LRGB01000243    JAM23034.1    JAN64396.1    KZS20174.1    GDIP01078187    JAM25528.1    ADTU01001471    ADTU01001472    GDIQ01244795    JAK06930.1    GDIQ01120675    JAL31051.1    GDIQ01231442    JAK20283.1    GDIP01059240    JAM44475.1    GDIP01046280    JAM57435.1    LJIG01016131    KRT81522.1    DS231851    JXUM01138823    KQ568798    KXJ68880.1    CH477265    GL732534    EFX84763.1    GDIQ01018780    JAN75957.1    JH432105    GDIP01221972    JAJ01430.1    GBYB01011867    JAG81634.1    GDIP01105230    JAL98484.1    CCAG010020502    UFQT01000177    SSX21184.1    JRES01001119    KNC25374.1    GDIQ01052556    JAN42181.1    GG666475    EEN66633.1    GDIP01007916    JAM95799.1    AMQN01004377    KB293367    ELU16071.1    CVRI01000054    CRL00836.1    GBBI01003797    JAC14915.1    GDIP01216264    JAJ07138.1    GDIQ01112430    JAL39296.1    GDIP01119479    JAL84235.1    KL433323    KFW92204.1    AFYH01004161    HAEF01018867    HAEG01004270    SBR60026.1    HAEH01003992    HAEI01017105    SBR72745.1    LMAW01002498    KQK80936.1    HADY01004776    HAEJ01006173    SBP43261.1    HAED01019009    SBR05454.1    HADX01002103    SBP24335.1    HADW01015514    SBP16914.1    HAEE01003970    SBR23990.1    HADZ01022374    SBP86315.1    HAEA01002796    SBQ31276.1    HAEB01003417    HAEC01014014    SBQ49944.1    AKCR02000061    PKK22552.1    KK520115    KFP66094.1    KK461507    KFQ79401.1    KL892615    KGL79982.1    KL206227    KFV80172.1    KB742712    EOB05162.1    AERX01026576    KK718508    KFO57172.1   

Proteomes

UP000053240    UP000053268    UP000007151    UP000075809    UP000053105    UP000002358    + More
UP000008237    UP000215335    UP000000311    UP000192223    UP000005203    UP000078542    UP000242457    UP000078541    UP000053097    UP000279307    UP000078492    UP000235965    UP000007266    UP000009046    UP000036403    UP000076502    UP000019118    UP000078540    UP000030742    UP000245037    UP000076858    UP000005205    UP000002320    UP000069940    UP000249989    UP000008820    UP000000305    UP000095300    UP000078200    UP000095301    UP000092444    UP000037069    UP000001554    UP000014760    UP000183832    UP000008672    UP000051836    UP000261460    UP000053872    UP000189705    UP000265100    UP000265160    UP000192220    UP000053641    UP000053584    UP000005207    UP000008227    UP000052976   

PRIDE

B0W730    Q17G65   

Pfam

PF10220   Smg8_Smg9        + More
PF05839   Apc13p
PF01504   PIP5K
PF01363   FYVE
PF00118   Cpn60_TCP1

Interpro

IPR028802   SMG8        + More
IPR019354   Smg8/Smg9       
IPR036116   FN3_sf       
IPR002423   Cpn60/TCP-1       
IPR027484   PInositol-4-P-5-kinase_N       
IPR017455   Znf_FYVE-rel       
IPR013083   Znf_RING/FYVE/PHD       
IPR008401   Apc13p       
IPR002498   PInositol-4-P-5-kinase_core       
IPR011011   Znf_FYVE_PHD       
IPR000306   Znf_FYVE       
IPR000591   DEP_dom       
IPR027409   GroEL-like_apical_dom_sf       

SUPFAM

SSF49265   SSF49265        + More
SSF52029   SSF52029       
SSF57903   SSF57903       

Gene 3D

3.30.40.10     3.30.800.10     3.50.7.10    

ProteinModelPortal

A0A0N1IDX7   A0A194Q2A1   A0A2H1WU70   A0A212EMA1   E9I9E8   A0A151X4Z1   + More
A0A0N0U4X6   K7IM59   E2C2F5   A0A232FCJ7   E2AYJ9   A0A1W4W9L7   A0A087ZNV5   A0A0C9QZU7   A0A195C6Y4   A0A2A3END4   A0A195FUN0   A0A026W6E2   A0A195DCR3   A0A2J7RA93   D6WLV3   A0A2S2PTR6   E0VLC2   A0A1Y1N4Z3   A0A0J7L2B1   A0A154NXU2   A0A310SNP8   N6UDI8   A0A195BBG7   U4UXZ9   A0A0P5CXL4   A0A2P8ZMG1   A0A0P5WWA2   A0A0P5X300   A0A158NAF5   A0A0N8ATD3   A0A0N8C2P8   A0A0P5H4Q0   A0A0P5YDR7   A0A0P5ZJL4   A0A0T6B2H2   B0W730   A0A182G2A5   Q17G65   E9G817   A0A0N8EK61   T1JDF4   A0A0P4YWM1   A0A0C9RFH3   A0A1I8PLZ8   A0A1A9UMJ9   A0A1I8N716   A0A0P5V3P1   A0A1B0FLQ3   A0A336LT62   A0A0L0C1U7   A0A0N8E839   C3XZ69   A0A0P6CIN9   R7VIE9   A0A1J1IMR3   A0A023F091   A0A0P4Z8J4   A0A0P5QLV7   A0A0N8CLP6   A0A093TCS1   H3ACG2   A0A1A8MTX0   A0A1A8NUJ9   A0A0Q3MF02   A0A1A7ZLS3   A0A1A8J720   A0A1A7Y2X7   A0A3B4FNS8   A0A1A7XGG0   A0A1A8JV23   A0A1A8D556   A0A1A8DD97   A0A1A8EVS1   A0A2I0LYQ4   A0A091M640   A0A3Q0H5P8   A0A091TP51   A0A3P8Q4I7   A0A3P9BTX5   A0A2I4CNZ2   A0A099ZE28   A0A093HMD8   R0K5X3   I3KL83   A0A287AXJ0   A0A091EKN1  

PDB

5NKM     E-value=2.79309e-07,     Score=134

KEGG

101742295    K18734 protein SMG8 | (RefSeq) protein SMG8

GO

GO:0000184   GO:0016021   GO:0016307   GO:0046872   GO:0005680   GO:0035556   GO:0005524   GO:0016559   GO:0015031   GO:0006886   GO:0016192   GO:0030117   GO:0005634   GO:0006270   GO:0042555   GO:0048384  

PANTHER

PTHR13091  

Length:

826

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

2.1366

Exp number, first 60 AAs:

7e-05

Total prob of N-in:

0.09402

outside

1  -  826

 

 

Pi

191.870549

Theta

186.84699

Tajima's D

0.222287

CLR

0.183748

CSRT

0.432328383580821

Interpretation

Uncertain