Gene

KWMTBOMO03250

Pre Gene Modal

BGIBMGA013613

Annotation

putative_F-box_only_protein_9_[Danaus_plexippus]

Location

Bomo_Chr6(-):2449168-2456376      View in EpiBrowser

Full name

F-box only protein 9      

Location in the cell

Nuclear   Reliability : 2.807

CDS

ATGGCATCAGGACATGGTGAGACTAGCAGCGAGTGTGAAGGCGAGGAGCAAGAAGACTCTTCTTCGTCTCATTCTAATAATGTGCTTGAAGCTTGCAATACTCTTGACAATTTGAGTTTACAAGACAATGCGCAAAATACAAATCACGGTGAAGATGAGCTTTCAGTCTTCCGGCAGCAGTGGCAGAGAGAACTCGAATCAACACCGACAACACAGAAAGGATCAAAGCTTGAAGAATCATTTGCAGAACCACTCACTGATGAGGATAAGGCTAAGCAACTGTTCCTCCGTGGCGTTGAATTCGAGCGCGGGGGGAAGTTGTATGAAGCTATACAACATTACAAGCGAGCCATACAGATCGTACCGGACGTCGAGACGCGGCTGTACGAGGGAAGCGAGCTCAGGGGAGATACGCCGGAAGATTCAGAGGTGGAGGAAGAGGTTTGCGCGGACAAGGCTCCTCCCTCCGAGGATGAGGACGAGGAGGTCGTGGAGGGGGAGGAACTGCTTGCGAGGCTGCAACGAATTCTAGCTAGGAGGGGCTTGCTGTGTGAACCGAAACTACCCACGGTGTCGGCGCACATATCGTGGCTCCCGTACGAGGTGTTGCTGGTGGTGCTGCGCTGGGTGGTGAGCTCGGAGCTGGACGCGGGCGCGCTGGAGGCGGCGGCCGGCGTGTGCCGCGGCTGGTACGTGGCCGCCCGGGAGCCCGACCTCTGGCGCTCCATCTGCGTCAGAACATGGGGCATAGAGTGCGGCACCCCCCGCGCTAACGGCTGGTCGAGCTGGCGCGACATGTACATCGCGCGTCCCCGGCTGCGACTCAACGGCTGCTACATCAGCAAGACCACGTACCTGCGCCACGGGGAGAACTCCTTCCAGGACCAGTTCTACAGGCCGTGGTATCTTATTTACTACTACAGGTACCTCAGGTGA

Protein

MASGHGETSSECEGEEQEDSSSSHSNNVLEACNTLDNLSLQDNAQNTNHGEDELSVFRQQWQRELESTPTTQKGSKLEESFAEPLTDEDKAKQLFLRGVEFERGGKLYEAIQHYKRAIQIVPDVETRLYEGSELRGDTPEDSEVEEEVCADKAPPSEDEDEEVVEGEELLARLQRILARRGLLCEPKLPTVSAHISWLPYEVLLVVLRWVVSSELDAGALEAAAGVCRGWYVAAREPDLWRSICVRTWGIECGTPRANGWSSWRDMYIARPRLRLNGCYISKTTYLRHGENSFQDQFYRPWYLIYYYRYLR

Description

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1 (By similarity).

Subunit

Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO9) composed of CUL1, SKP1, RBX1 and FBXO9. Interacts with TTI1 and TELO2; when TTI1 and TELO2 are phosphorylated by CK2 (By similarity).

Keywords

Complete proteome   Cytoplasm   Phosphoprotein   Reference proteome   TPR repeat   Ubl conjugation pathway  

Feature

chain  F-box only protein 9

Uniprot

H9JVQ0   A0A1E1WG50   A0A0N1I7R6   A0A194Q1Q0   A0A212ELZ5   A0A2A4J9Z6   + More
A0A2H1W276   A0A0C9RF42   A0A0C9R7W0   A0A1B6DUW8   A0A1B6G5H9   A0A232EW16   A0A067QSD7   A0A026VYZ4   A0A088ATP1   A0A3L8DPL9   A0A0M9ACY8   A0A0J7L8Q6   E2BX07   K7IN34   A0A151IFE6   A0A158NH73   A0A0L7QLQ0   A0A154PBI9   E9ILF0   E2AME0   A0A151XD48   A0A310SJZ1   A0A195DXP2   A0A0A9XGR1   V5IA03   F4WZM2   D6X4P0   A0A195FFU6   T1I2X2   A0A2A3E7S1   B0X0N5   A0A0T6B1I3   A0A1W4XQS4   A0A1Q3FI59   A0A171A7K1   A0A1B0CQ84   U5EZS5   U4UJ00   A0A1L8DB49   A0A182N7H8   A0A182TXN1   A0A1L8DD09   A0A182YJG9   A0A182WI53   A0A182JVW9   A0A182M1F4   A0A182PEW6   A0A182SBC1   W5JBU0   Q7QIC8   Q0IFG5   A0A182X254   A0A182R9C0   A0A182USR3   A0A182I6B5   A0A182L425   A0A2M3Z4G5   E0VE31   A0A2M3Z4I3   A0A084WMZ4   A0A182QHS3   A0A1B0DQF6   A0A2M4BU22   E9G8G9   A0A182FFH8   T1DTP2   A0A0K8TRB3   B5X2L4   A0A023ESI2   Q5U2X1   A0A023ETM9   A0A1W4ZX87   A0A1W4ZWH1   A0A0P7U757   A0A2M3ZGT8   A0A0P4VNI0   A0A023ETM6   A0A182H5B6   A0A336M4K0   A0A250YI34  

Pubmed

19121390    26354079    22118469    28648823    24845553    24508170    + More
30249741    20798317    20075255    21347285    21282665    25401762    26823975    21719571    18362917    19820115    23537049    25244985    20920257    23761445    12364791    14747013    17210077    17510324    20966253    20566863    24438588    21292972    26369729    20433749    24945155    15489334    22673903    27129103    26483478    28087693   

EMBL

BABH01032321    GDQN01005074    JAT85980.1    KQ460542    KPJ14108.1    KQ459579    + More
KPI99476.1    AGBW02013960    OWR42512.1    NWSH01002255    PCG68791.1    ODYU01005868    SOQ47190.1    GBYB01005606    JAG75373.1    GBYB01002851    JAG72618.1    GEDC01007825    JAS29473.1    GECZ01012080    JAS57689.1    NNAY01001934    OXU22511.1    KK853353    KDR08236.1    KK107681    EZA48079.1    QOIP01000006    RLU21839.1    KQ435698    KOX80713.1    LBMM01000270    KMR02240.1    GL451202    EFN79726.1    KQ977793    KYM99673.1    ADTU01015190    KQ414915    KOC59484.1    KQ434851    KZC08618.1    GL764074    EFZ18613.1    GL440813    EFN65364.1    KQ982294    KYQ58188.1    KQ765373    OAD53955.1    KQ980107    KYN17670.1    GBHO01027334    GDHC01005441    JAG16270.1    JAQ13188.1    GALX01002035    JAB66431.1    GL888480    EGI60297.1    KQ971380    EEZ97671.2    KQ981625    KYN39097.1    ACPB03014809    KZ288357    PBC27101.1    DS232242    EDS38277.1    LJIG01016240    KRT81194.1    GFDL01007826    JAV27219.1    GEMB01001406    JAS01750.1    AJWK01023229    AJWK01023230    GANO01000241    JAB59630.1    KB632375    ERL94039.1    GFDF01010391    JAV03693.1    GFDF01009874    JAV04210.1    AXCM01015948    ADMH02001849    ETN60888.1    AAAB01008807    EAA04165.3    CH477317    EAT43750.1    APCN01003602    GGFM01002659    MBW23410.1    DS235088    EEB11637.1    GGFM01002681    MBW23432.1    ATLV01024541    KE525352    KFB51588.1    AXCN02000573    AJVK01019082    AJVK01019083    GGFJ01007439    MBW56580.1    GL732535    EFX84272.1    GAMD01000834    JAB00757.1    GDAI01000932    JAI16671.1    BT045283    ACI33545.1    GAPW01001368    JAC12230.1    BC085831    GAPW01001367    JAC12231.1    JARO02003579    KPP70214.1    GGFM01007025    MBW27776.1    GDKW01002543    JAI54052.1    GAPW01000898    JAC12700.1    JXUM01111220    KQ565482    KXJ70920.1    UFQT01000550    SSX25185.1    GFFW01001527    JAV43261.1   

Proteomes

UP000005204    UP000053240    UP000053268    UP000007151    UP000218220    UP000215335    + More
UP000027135    UP000053097    UP000005203    UP000279307    UP000053105    UP000036403    UP000008237    UP000002358    UP000078542    UP000005205    UP000053825    UP000076502    UP000000311    UP000075809    UP000078492    UP000007755    UP000007266    UP000078541    UP000015103    UP000242457    UP000002320    UP000192223    UP000092461    UP000030742    UP000075884    UP000075902    UP000076408    UP000075920    UP000075881    UP000075883    UP000075885    UP000075901    UP000000673    UP000007062    UP000008820    UP000076407    UP000075900    UP000075903    UP000075840    UP000075882    UP000009046    UP000030765    UP000075886    UP000092462    UP000000305    UP000069272    UP000087266    UP000002494    UP000192224    UP000034805    UP000069940    UP000249989   

PRIDE

H9JVQ0    Q5U2X1   

Pfam

PF12937   F-box-like        + More
PF00646   F-box

Interpro

IPR019734   TPR_repeat        + More
IPR001810   F-box_dom       
IPR011990   TPR-like_helical_dom_sf       
IPR013026   TPR-contain_dom       
IPR036047   F-box-like_dom_sf       
IPR036181   MIT_dom_sf       

SUPFAM

SSF81383   SSF81383        + More
SSF48452   SSF48452       
SSF116846   SSF116846       

Gene 3D

1.25.40.10    

ProteinModelPortal

H9JVQ0   A0A1E1WG50   A0A0N1I7R6   A0A194Q1Q0   A0A212ELZ5   A0A2A4J9Z6   + More
A0A2H1W276   A0A0C9RF42   A0A0C9R7W0   A0A1B6DUW8   A0A1B6G5H9   A0A232EW16   A0A067QSD7   A0A026VYZ4   A0A088ATP1   A0A3L8DPL9   A0A0M9ACY8   A0A0J7L8Q6   E2BX07   K7IN34   A0A151IFE6   A0A158NH73   A0A0L7QLQ0   A0A154PBI9   E9ILF0   E2AME0   A0A151XD48   A0A310SJZ1   A0A195DXP2   A0A0A9XGR1   V5IA03   F4WZM2   D6X4P0   A0A195FFU6   T1I2X2   A0A2A3E7S1   B0X0N5   A0A0T6B1I3   A0A1W4XQS4   A0A1Q3FI59   A0A171A7K1   A0A1B0CQ84   U5EZS5   U4UJ00   A0A1L8DB49   A0A182N7H8   A0A182TXN1   A0A1L8DD09   A0A182YJG9   A0A182WI53   A0A182JVW9   A0A182M1F4   A0A182PEW6   A0A182SBC1   W5JBU0   Q7QIC8   Q0IFG5   A0A182X254   A0A182R9C0   A0A182USR3   A0A182I6B5   A0A182L425   A0A2M3Z4G5   E0VE31   A0A2M3Z4I3   A0A084WMZ4   A0A182QHS3   A0A1B0DQF6   A0A2M4BU22   E9G8G9   A0A182FFH8   T1DTP2   A0A0K8TRB3   B5X2L4   A0A023ESI2   Q5U2X1   A0A023ETM9   A0A1W4ZX87   A0A1W4ZWH1   A0A0P7U757   A0A2M3ZGT8   A0A0P4VNI0   A0A023ETM6   A0A182H5B6   A0A336M4K0   A0A250YI34  

KEGG

101737813    K10295 F-box protein 9 | (RefSeq) F-box only protein 9

GO

GO:0005737   GO:0031146   GO:0019005   GO:0032006   GO:0045444   GO:0045087   GO:0016567   GO:0005515   GO:0000166   GO:0016301   GO:0004143   GO:0007205   GO:0003678   GO:0005634   GO:0006270   GO:0042555   GO:0048384  

Subcellular location

Cytoplasm  

Length:

311

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.04184

Exp number, first 60 AAs:

0

Total prob of N-in:

0.02683

outside

1  -  311

 

 

Pi

213.407513

Theta

152.14746

Tajima's D

0.7774

CLR

0.179774

CSRT

0.5965201739913

Interpretation

Uncertain