Gene

KWMTBOMO03211

Pre Gene Modal

BGIBMGA013579

Annotation

PREDICTED:_carbonic_anhydrase_1-like_[Bombyx_mori]

Location

Bomo_Chr6(+):1728154-1730879      View in EpiBrowser

Full name

Carbonic anhydrase 9      

Alternative Name

Carbonate dehydratase IX
Carbonic anhydrase IX
Membrane antigen MN homolog

Location in the cell

Cytoplasmic   Reliability : 1.133 Nuclear   Reliability : 1.233

CDS

ATGCATTTCCACTGGATTTCCGAACACTCTTTAAACGGAATTAAGTTCCCAATGGAAATACATTTCGTTCATGTTCAATCGGACCTCTCTGTCGACGAGGCTCTAATGAAGAGAGACGGCTTAGCTATCATAGCTGTGTTTTGTGAAGTACAAGCAGATTTAGACGACTACGAAAACACTCCTGTCGATGAAATAATTGAGCACCTTCCGAACCTGACGAGTACCGGAGACAGAATGAGTGGCATACTACTGGATATAAGTAAACTCCTAAGTCCTAAAAACAACAATTATTTCACGTACGCTGGATCTTTAACTTCGCCGGAGTGCAATGAGGTTGTTATTTGGATCATCTATCAATATCCTATACGCATATCGGATACGCAGCAAAAAGAATAA

Protein

MHFHWISEHSLNGIKFPMEIHFVHVQSDLSVDEALMKRDGLAIIAVFCEVQADLDDYENTPVDEIIEHLPNLTSTGDRMSGILLDISKLLSPKNNNYFTYAGSLTSPECNEVVIWIIYQYPIRISDTQQKE

Description

Reversible hydration of carbon dioxide. Participates in pH regulation (By similarity).

Catalytic Activity

H(+) + hydrogencarbonate = CO2 + H2O

Cofactor

Zn(2+)

Subunit

Forms oligomers linked by disulfide bonds.

Similarity

Belongs to the alpha-carbonic anhydrase family.

Keywords

Alternative splicing   Cell membrane   Cell projection   Complete proteome   Disulfide bond   Glycoprotein   Lyase   Membrane   Metal-binding   Phosphoprotein   Reference proteome   Signal   Transmembrane   Transmembrane helix   Zinc  

Feature

chain  Carbonic anhydrase 9
splice variant  In isoform 2.

Uniprot

H9JVL6   A0A212F2G6   A0A2W1BSS8   A0A2A4ISD7   A0A194Q7X0   A0A0N1IHJ4   + More
A0A0L7L7H9   A0A2W1C1Z7   A0A2A4IRL2   A0A2H1V6M7   A0A212F719   G3TMC4   V4AH85   A0A0R3PNH9   V3ZXK9   A0A1I8CXN0   H9JVL5   A0A0L8I5X5   A0A0K0DQ44   A0A016TA97   Q3TLN7   A0A016U4Q3   A0A2P8YTE9   Q9XZG6   A0A1W4WVW2   A0A183TZ78   A0A0B2UVH4   M1EKM3   A0A2Y9DD68   A0A1U7R4S6   A0A140JWS1   A0A151N5U6   A0A1L8FCD4   T1JMA7   A0A1B0GN58   V9KKB5   E5SQL9   A0A3P4LVU6   A0A1L8F4P1   A0A016U4B9   M7BKI1   T1ISC0   F7IMS5   A0A2K6TFQ4   A0A0V1BC16   F7I0J5   A0A2K6G200   A0A0V0SHU4   A0A0V1BCN8   A0A1A8E027   A0A2R8NBR1   A0A1I8B3L8   A0A2P8XJ35   A0A091HTU2   A0A3B1JDI7   A0A2K6G203   A0A2K6FDD4   F7FL00   G1LSI9   A0A016TAD1   G3S576   Q3UUZ9   Q8VHB5   A0A3M0KBQ2   A0A3Q0D3V9   A0A3B4FV88   A0A087ZQS3   B3M1T1   A0A2Y9J8S9   A0A2K6RHV1   A0A1U7R3S6   A0A2I3G6J0   A0A3B1J929   A0A1A8PNH9   A0A2Y9E302   A0A2P2HXR5   A0A1B6GUM7   M3Y1M1   A2IBE1   A0A2U3VD21   A0A0A9X516   A0A1U7U5Z9   A0A2Y9JCI1   A0A146KNY1   A0A1D2NK15   A0A2U3YVE9   I3JGP7   A0A2R9C852   A0A2I3T6U9   A0A2J8T0E9   A0A2K6LTN4   A0A1A8RH30   L5KEW3   A0A1U7RKV7   G3SEJ4   G1SYS8   A0A3Q0GC63   A0A091GQF2  

EC Number

4.2.1.1

Pubmed

19121390    22118469    28756777    26354079    26227816    23254933    + More
26829753    25730766    10349636    11042159    11076861    11217851    12466851    16141073    29403074    10222325    23236062    22293439    27762356    24402279    23624526    25243066    18809916    25329095    15057822    15632090    20010809    22398555    12040188    15489334    14604546    17994087    25362486    16831598    25401762    26823975    27289101    25186727    22722832    16136131    23258410    21993624   

EMBL

BABH01032447    AGBW02010745    OWR47922.1    KZ149911    PZC78132.1    NWSH01008790    + More
PCG62416.1    KQ459579    KPI99505.1    KQ460542    KPJ14143.1    JTDY01002414    KOB71457.1    PZC78133.1    PCG62415.1    ODYU01000955    SOQ36493.1    AGBW02009941    OWR49535.1    KB201498    ESO96282.1    UYYA01003961    VDM58193.1    ESO96283.1    KQ416468    KOF96872.1    JARK01001457    EYB99595.1    AK166403    BAE38755.1    JARK01001395    EYC09827.1    PYGN01000371    PSN47515.1    AF140537    AAD32675.1    UYWY01001209    VDM26386.1    JPKZ01003115    KHN73413.1    JP006735    AER95332.1    AB985738    BAU61548.1    AKHW03004004    KYO32204.1    CM004480    OCT69244.1    JH431506    AJVK01004379    JW865954    AFO98471.1    CYRY02002054    VCW66726.1    CM004481    OCT66537.1    EYC09826.1    KB521250    EMP37714.1    JH431429    JYDH01000063    KRY34645.1    GAMT01000477    JAB11384.1    JYDL01000008    KRX26235.1    KRY34648.1    HAEA01011057    SBQ39537.1    PYGN01001954    PSN32015.1    KL217847    KFO99718.1    AC121204    CH473962    EDL98746.1    ACTA01018962    ACTA01026962    EYB99596.1    CABD030000622    CABD030000623    BC120544    BC120546    AK136579    AK137719    CH466565    AAI20545.1    BAE23060.1    BAE23474.1    EDL02470.1    AY049077    AJ245857    AB086322    QRBI01000111    RMC10623.1    CH902617    EDV42191.2    ADFV01080394    ADFV01080395    ADFV01080396    ADFV01080397    ADFV01080398    ADFV01080399    ADFV01080400    HAEG01008708    SBR82567.1    IACF01000823    LAB66573.1    GECZ01003640    JAS66129.1    AEYP01022154    AEYP01022155    EF187254    ABM64773.1    GBHO01029697    GBHO01029696    JAG13907.1    JAG13908.1    GDHC01021234    JAP97394.1    LJIJ01000021    ODN05569.1    AERX01042727    AJFE02076650    AJFE02076651    AJFE02076652    AACZ04044244    AACZ04044245    NBAG03000330    PNI39838.1    NDHI03003533    PNJ26502.1    HAEI01008577    SBS05395.1    KB030846    ELK09033.1    AAGW02033514    KL509086    KFO85841.1   

Proteomes

UP000005204    UP000007151    UP000218220    UP000053268    UP000053240    UP000037510    + More
UP000007646    UP000030746    UP000050601    UP000267027    UP000095286    UP000053454    UP000035642    UP000024635    UP000245037    UP000192223    UP000050794    UP000267007    UP000031036    UP000248480    UP000189706    UP000050525    UP000186698    UP000092462    UP000031443    UP000008225    UP000233220    UP000054776    UP000233160    UP000054630    UP000095281    UP000054308    UP000018467    UP000002494    UP000008912    UP000001519    UP000000589    UP000269221    UP000261460    UP000005203    UP000007801    UP000248482    UP000233200    UP000001073    UP000000715    UP000245340    UP000189704    UP000094527    UP000245341    UP000005207    UP000240080    UP000002277    UP000233180    UP000010552    UP000189705    UP000001811   

PRIDE

H9JVL6    H9JVL5    Q8VHB5    I3JGP7   

Pfam

PF00194   Carb_anhydrase

Interpro

IPR036398   CA_dom_sf        + More
IPR018428   Carbonic_anhydrase_CA6       
IPR023561   Carbonic_anhydrase_a-class       
IPR001148   CA_dom       
IPR018338   Carbonic_anhydrase_a-class_CS       
IPR018343   Carbonic_anhydrase_CA4       
IPR018429   CA9       
IPR018431   Carbonic_anhydrase_CA14       
IPR041874   CA4/CA15       
IPR018442   Carbonic_anhydrase_CA1       

SUPFAM

SSF51069   SSF51069       

Gene 3D

3.10.200.10    

CDD

cd03117  alpha_CA_IV_XV_like

ProteinModelPortal

H9JVL6   A0A212F2G6   A0A2W1BSS8   A0A2A4ISD7   A0A194Q7X0   A0A0N1IHJ4   + More
A0A0L7L7H9   A0A2W1C1Z7   A0A2A4IRL2   A0A2H1V6M7   A0A212F719   G3TMC4   V4AH85   A0A0R3PNH9   V3ZXK9   A0A1I8CXN0   H9JVL5   A0A0L8I5X5   A0A0K0DQ44   A0A016TA97   Q3TLN7   A0A016U4Q3   A0A2P8YTE9   Q9XZG6   A0A1W4WVW2   A0A183TZ78   A0A0B2UVH4   M1EKM3   A0A2Y9DD68   A0A1U7R4S6   A0A140JWS1   A0A151N5U6   A0A1L8FCD4   T1JMA7   A0A1B0GN58   V9KKB5   E5SQL9   A0A3P4LVU6   A0A1L8F4P1   A0A016U4B9   M7BKI1   T1ISC0   F7IMS5   A0A2K6TFQ4   A0A0V1BC16   F7I0J5   A0A2K6G200   A0A0V0SHU4   A0A0V1BCN8   A0A1A8E027   A0A2R8NBR1   A0A1I8B3L8   A0A2P8XJ35   A0A091HTU2   A0A3B1JDI7   A0A2K6G203   A0A2K6FDD4   F7FL00   G1LSI9   A0A016TAD1   G3S576   Q3UUZ9   Q8VHB5   A0A3M0KBQ2   A0A3Q0D3V9   A0A3B4FV88   A0A087ZQS3   B3M1T1   A0A2Y9J8S9   A0A2K6RHV1   A0A1U7R3S6   A0A2I3G6J0   A0A3B1J929   A0A1A8PNH9   A0A2Y9E302   A0A2P2HXR5   A0A1B6GUM7   M3Y1M1   A2IBE1   A0A2U3VD21   A0A0A9X516   A0A1U7U5Z9   A0A2Y9JCI1   A0A146KNY1   A0A1D2NK15   A0A2U3YVE9   I3JGP7   A0A2R9C852   A0A2I3T6U9   A0A2J8T0E9   A0A2K6LTN4   A0A1A8RH30   L5KEW3   A0A1U7RKV7   G3SEJ4   G1SYS8   A0A3Q0GC63   A0A091GQF2  

PDB

5DVX     E-value=6.45804e-19,     Score=224

KEGG

101745468    K01672 carbonic anhydrase [EC:4.2.1.1] | (RefSeq) carbonic anhydrase 1-like

PATHWAY

00910    Nitrogen metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0004089   GO:0008270   GO:0001580   GO:0005615   GO:0006730   GO:0016021   GO:0031225   GO:0005886   GO:0046872   GO:0046903   GO:0002009   GO:0001666   GO:0033574   GO:0016323   GO:0042493   GO:0031528   GO:0015670   GO:0042539   GO:0007155   GO:0005515   GO:0045211   GO:0006281   GO:0048384  

PANTHER

PTHR18952:SF110   PTHR18952   PTHR18952:SF95   PTHR18952:SF18   PTHR18952:SF84   PTHR18952:SF82  

Subcellular location

Cell membrane  
Cell projection  
Microvillus membrane  

Length:

131

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.09557

Exp number, first 60 AAs:

0.00023

Total prob of N-in:

0.11787

outside

1  -  131

 

 

Pi

209.009276

Theta

149.432322

Tajima's D

1.044498

CLR

0

CSRT

0.674116294185291

Interpretation

Uncertain