Gene

KWMTBOMO03183  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA013454

Annotation

hypothetical_protein_KGM_13996_[Danaus_plexippus]

Location

Bomo_Chr6(+):936663-941181      View in EpiBrowser

Full name

WD40 repeat-containing protein SMU1      

Alternative Name

Smu-1 suppressor of mec-8 and unc-52 protein homolog

Location in the cell

Cytoplasmic   Reliability : 1.239 Mitochondrial   Reliability : 1.337 Nuclear   Reliability : 1.298

CDS

ATGTCCATTGAGATAGAATCAGCCGATGTTATCAGACTGATACAACAATACTTGAAGGAGTCAAATTTAACCAAAACATTGCAGACTTTGCAGGAGGAAACTGGAGTGACTCTAAATACAGTAGACAGCGTGGACGGTTTCTGCGCAGATATTAACAATGGCCACTGGGACACAGTACTTAAAGCTACTGCTTCACTCAAGCTTCCTGACAAAAAGTTGATGGAGTTATATGAGCAGGTTGTATTGGAGTTGATAGAACTGCGAGAATTGGGTGCTGCGAGATCCTTGCTACGTCAGACACATCCTTGTCTGTTGATGAAGCAGCATGAAACAGATCGGTATATGCATCTTGAAAACCTGTTAGCACGTTCATATTTCGATCCTCGTGAGGCATACGGCAGTGGAGGAGGCAAGGAGCGGCGCCGCGCTGCCATCGCAGCGTCCCTCGCCGGGGAGGTGTCCGTCGTACCGTCGTCCCGTCTGCTGGCACTACTGGGCCAGGCCCTCAAATGGCAACAGCACCAGGGTCTGCTCCCTCCCGGCACCACTATAGATTTGTTCCGTGGTAAAGCCGCAATAAGAGACCAAGAAGACGATCTCTGCCCCACCCAACTGTCCAAGATCATCAAATTCGGTCAGAAGTCCCACGTGGAGTGCGCGCGATTTTCTCCTGATGGACAATATTTAGTGACGGGCTCCGTAGATGGCGTCGTTGAAGTTTGGAACTTTACAACAGGAAAAATCCGTAAGGATTTGCGTTATCAGGCTCATGATGAGTACATGTGCATGGAAGAGGCGGTGCTGAGCCTGGCTTTTGCGAGGGATAGCGACACATTGGCTGCTGGGTCTAATGATGGAAAAATTAAGGTCTGGAAAGTGTCAACGGGTAAAGTGCAACGCAAACTGGACCGAGCTCACTCTAAGGGCGTGACCTGCCTGCAGTTCACCCGAGACAACACTCAGATCCTCTCGGCCTCCTTTGATCGGACCATAAGAATCCACGGCCTAAAATCTGGTAAAGTCTTGAAGGAGTTCCGAGGTCACACTTCGTTCGTGAACGAGGCGGTGTTCACGCTGGACGGGCACGCGGTGCTCAGCGGCTCGTCCGACGGGACCGTGAAGGTGTGGGCCGTCCGCTCGGGCGAGTGCACGGCCACGCTCAAGCCCCTCGGCAGCGGGGAGCCCCCGGTCAACACCCTACTCCTCACCCCGAAGAACCCGGACCATTTCGTGGTGTGCAACCGGACGAATACCGTGGCGATAATGAACATGCAAGGGCAAATCGTGAGGTCGTTCTCGAGCGGGAGGCGCGAGGAGGAGGGCGGCGCGCTGGTGTCGGCGGCGCTGAGTGCGCGCGGGAGGCTGGTGTACTGCGCCGGGGAGGACCTCGTGCTGTACGCCTTCTGCGCCAACACCGGCAAGCTGGAGAGGACCATTAATATTCACGAGAAGGCGGTGATCGGGCTGACGCATCACCCGCACCAGAATCTGCTGGCCACGTACAGCGAGGACGGCTTGCTTAAGCTGTGGAAACCATAA

Protein

MSIEIESADVIRLIQQYLKESNLTKTLQTLQEETGVTLNTVDSVDGFCADINNGHWDTVLKATASLKLPDKKLMELYEQVVLELIELRELGAARSLLRQTHPCLLMKQHETDRYMHLENLLARSYFDPREAYGSGGGKERRRAAIAASLAGEVSVVPSSRLLALLGQALKWQQHQGLLPPGTTIDLFRGKAAIRDQEDDLCPTQLSKIIKFGQKSHVECARFSPDGQYLVTGSVDGVVEVWNFTTGKIRKDLRYQAHDEYMCMEEAVLSLAFARDSDTLAAGSNDGKIKVWKVSTGKVQRKLDRAHSKGVTCLQFTRDNTQILSASFDRTIRIHGLKSGKVLKEFRGHTSFVNEAVFTLDGHAVLSGSSDGTVKVWAVRSGECTATLKPLGSGEPPVNTLLLTPKNPDHFVVCNRTNTVAIMNMQGQIVRSFSSGRREEEGGALVSAALSARGRLVYCAGEDLVLYAFCANTGKLERTINIHEKAVIGLTHHPHQNLLATYSEDGLLKLWKP

Description

Involved in pre-mRNA splicing as a component of the spliceosome (By similarity). Regulates alternative splicing of the HSPG2 pre-mRNA (By similarity). Required for normal accumulation of IK (By similarity). Required for normal mitotic spindle assembly and normal progress through mitosis (By similarity).

Subunit

Component of the spliceosome B complex. Interacts with IK.

Similarity

Belongs to the WD repeat SMU1 family.

Keywords

Complete proteome   Cytoplasm   mRNA processing   mRNA splicing   Nucleus   Reference proteome   Repeat   Spliceosome   WD repeat  

Feature

chain  WD40 repeat-containing protein SMU1

Uniprot

H9JV91   A0A2W1BBT8   A0A2A4J3B4   A0A212ELZ0   A0A194Q841   D6W9U1   + More
A0A182H527   A0A087ZNB0   Q16RP1   A0A195DCZ9   B4K8N7   K7J7Q8   F4WVS3   A0A151I0Z8   A0A151JTA6   A0A158NMQ6   A0A1Q3F9E2   E9J2F0   A0A067QQP2   E2ALM2   B4LYJ3   B0W123   E2BSA9   A0A0J7L1Y6   B4JTM1   A0A1B6ETQ3   A0A1W4UN07   A0A151X1J7   W8BX47   B4PMQ0   B4IME6   B3P389   Q9VE18   A0A3B0JQH8   Q298E2   B4G3N5   A0A1I8P4N2   A0A1B6IIU5   A0A1A9XI92   A0A1B0AYC7   A0A0C9QYQ5   B4NG11   A0A0A1XQ93   A0A0K8VSX6   A0A026WMG5   A0A0A9X6C7   A0A1B0FB26   A0A1A9V3F1   A0A1A9Z8A6   A0A1A9W7Z3   A0A232F0X1   A0A154PDV7   B3MSS4   A0A1I8MVW9   A0A182Q740   A0A1W4WP77   A0A182N5F0   A0A182FA53   W5JLX7   A0A182MS23   A0A182VRA5   A0A2M4AVP5   A0A182SDM1   A0A182TQJ6   A0A182RPM3   A0A2A3E7E7   A0A182Y575   A0A182L943   A0A182V398   A0A182X9V2   Q7PUS7   A0A182HKT4   A0A0M4EW23   A0A182P2F3   A0A1Y1KW99   A0A182K9Z3   A0A182JLN2   A0A084W584   A0A151IBQ0   J3JTL2   A0A336LJ14   A0A0K8UZE1   A0A0L0CKH4   A0A0P4VR61   T1IDJ2   A0A023F5N8   A0A069DU97   T1JMW6   A0A1B0D7E2   A0A224XLW0   A0A087UIC2   A0A3Q2Z3K9   A0A3L8SCG3   A0A2I4D012   A0A218UJB0   A0A3M0LTV2   Q5ZME8   A0A151NER3   A0A0Q3M8Z4   A0A0P6K7N1  

Pubmed

19121390    28756777    22118469    26354079    18362917    19820115    + More
26483478    17510324    17994087    20075255    21719571    21347285    21282665    24845553    20798317    24495485    17550304    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    15632085    25830018    24508170    30249741    25401762    26823975    28648823    25315136    20920257    23761445    25244985    20966253    12364791    14747013    17210077    28004739    24438588    22516182    26108605    27129103    25474469    26334808    30282656    15642098    22293439   

EMBL

BABH01037322    KZ150187    PZC72438.1    NWSH01003270    PCG66637.1    AGBW02013968    + More
OWR42505.1    KQ459579    KPI99570.1    KQ971312    EEZ98547.1    JXUM01110781    KQ565443    KXJ70965.1    CH477701    EAT37071.1    KQ981010    KYN10314.1    CH933806    EDW15456.1    AAZX01008216    GL888394    EGI61693.1    KQ976593    KYM79652.1    KQ981936    KYN32766.1    ADTU01020670    GFDL01010850    JAV24195.1    GL767845    EFZ13011.1    KK853521    KDR07011.1    GL440609    EFN65631.1    CH940650    EDW68013.1    DS231819    EDS42840.1    GL450157    EFN81422.1    LBMM01001227    KMQ96691.1    CH916374    EDV91450.1    GECZ01028462    GECZ01017041    GECZ01015695    GECZ01011057    JAS41307.1    JAS52728.1    JAS54074.1    JAS58712.1    KQ982588    KYQ54124.1    GAMC01002723    JAC03833.1    CM000160    EDW95970.1    CH480980    EDW45842.1    CH954181    EDV48541.1    AE014297    AY051929    AAF55614.2    AAK93353.1    AFH06507.1    AFH06508.1    OUUW01000007    SPP82632.1    CM000070    EAL28013.1    CH479179    EDW24356.1    GECU01020875    JAS86831.1    JXJN01005669    GBYB01005782    JAG75549.1    CH964251    EDW83228.1    GBXI01001165    JAD13127.1    GDHF01023930    GDHF01010318    JAI28384.1    JAI41996.1    KK107152    QOIP01000007    EZA57220.1    RLU20029.1    GBHO01028065    GBRD01014101    GDHC01005703    JAG15539.1    JAG51725.1    JAQ12926.1    CCAG010023704    NNAY01001331    OXU24331.1    KQ434885    KZC10032.1    CH902623    EDV30314.1    AXCN02001174    ADMH02000756    ETN65146.1    AXCM01011496    GGFK01011548    MBW44869.1    KZ288357    PBC27146.1    AAAB01008987    EAA01078.4    APCN01000867    CP012526    ALC47655.1    GEZM01075820    JAV63945.1    ATLV01020524    KE525302    KFB45378.1    KQ978078    KYM97174.1    BT126569    AEE61533.1    UFQS01000017    UFQT01000017    SSW97480.1    SSX17866.1    GDHF01020285    JAI32029.1    JRES01000280    KNC32732.1    GDKW01001079    JAI55516.1    ACPB03002186    GBBI01002230    JAC16482.1    GBGD01001191    JAC87698.1    JH431646    AJVK01026893    AJVK01026894    AJVK01026895    GFTR01006844    JAW09582.1    KK119940    KFM77111.1    QUSF01000029    RLW00042.1    MUZQ01000284    OWK53510.1    QRBI01000092    RMC22437.1    AJ719436    AKHW03003207    KYO35025.1    LMAW01002607    KQK79173.1    GEBF01001117    JAO02516.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000053268    UP000007266    UP000069940    + More
UP000249989    UP000005203    UP000008820    UP000078492    UP000009192    UP000002358    UP000007755    UP000078540    UP000078541    UP000005205    UP000027135    UP000000311    UP000008792    UP000002320    UP000008237    UP000036403    UP000001070    UP000192221    UP000075809    UP000002282    UP000001292    UP000008711    UP000000803    UP000268350    UP000001819    UP000008744    UP000095300    UP000092443    UP000092460    UP000007798    UP000053097    UP000279307    UP000092444    UP000078200    UP000092445    UP000091820    UP000215335    UP000076502    UP000007801    UP000095301    UP000075886    UP000192223    UP000075884    UP000069272    UP000000673    UP000075883    UP000075920    UP000075901    UP000075902    UP000075900    UP000242457    UP000076408    UP000075882    UP000075903    UP000076407    UP000007062    UP000075840    UP000092553    UP000075885    UP000075881    UP000075880    UP000030765    UP000078542    UP000037069    UP000015103    UP000092462    UP000054359    UP000264820    UP000276834    UP000192220    UP000197619    UP000269221    UP000000539    UP000050525    UP000051836   

PRIDE

H9JV91    Q9VE18    Q5ZME8   

Pfam

PF00400   WD40        + More
PF12894   ANAPC4_WD40
PF00503   G-alpha
PF02036   SCP2

Interpro

IPR036322   WD40_repeat_dom_sf        + More
IPR019775   WD40_repeat_CS       
IPR020472   G-protein_beta_WD-40_rep       
IPR006595   CTLH_C       
IPR001680   WD40_repeat       
IPR024977   Apc4_WD40_dom       
IPR017986   WD40_repeat_dom       
IPR006594   LisH       
IPR015943   WD40/YVTN_repeat-like_dom_sf       
IPR001408   Gprotein_alpha_I       
IPR001019   Gprotein_alpha_su       
IPR027417   P-loop_NTPase       
IPR011025   GproteinA_insert       
IPR036527   SCP2_sterol-bd_dom_sf       
IPR003033   SCP2_sterol-bd_dom       

SUPFAM

SSF50978   SSF50978        + More
SSF52540   SSF52540       
SSF47895   SSF47895       
SSF55718   SSF55718       

Gene 3D

2.130.10.10     1.10.400.10     3.30.1050.10    

CDD

cd00066  G-alpha

ProteinModelPortal

H9JV91   A0A2W1BBT8   A0A2A4J3B4   A0A212ELZ0   A0A194Q841   D6W9U1   + More
A0A182H527   A0A087ZNB0   Q16RP1   A0A195DCZ9   B4K8N7   K7J7Q8   F4WVS3   A0A151I0Z8   A0A151JTA6   A0A158NMQ6   A0A1Q3F9E2   E9J2F0   A0A067QQP2   E2ALM2   B4LYJ3   B0W123   E2BSA9   A0A0J7L1Y6   B4JTM1   A0A1B6ETQ3   A0A1W4UN07   A0A151X1J7   W8BX47   B4PMQ0   B4IME6   B3P389   Q9VE18   A0A3B0JQH8   Q298E2   B4G3N5   A0A1I8P4N2   A0A1B6IIU5   A0A1A9XI92   A0A1B0AYC7   A0A0C9QYQ5   B4NG11   A0A0A1XQ93   A0A0K8VSX6   A0A026WMG5   A0A0A9X6C7   A0A1B0FB26   A0A1A9V3F1   A0A1A9Z8A6   A0A1A9W7Z3   A0A232F0X1   A0A154PDV7   B3MSS4   A0A1I8MVW9   A0A182Q740   A0A1W4WP77   A0A182N5F0   A0A182FA53   W5JLX7   A0A182MS23   A0A182VRA5   A0A2M4AVP5   A0A182SDM1   A0A182TQJ6   A0A182RPM3   A0A2A3E7E7   A0A182Y575   A0A182L943   A0A182V398   A0A182X9V2   Q7PUS7   A0A182HKT4   A0A0M4EW23   A0A182P2F3   A0A1Y1KW99   A0A182K9Z3   A0A182JLN2   A0A084W584   A0A151IBQ0   J3JTL2   A0A336LJ14   A0A0K8UZE1   A0A0L0CKH4   A0A0P4VR61   T1IDJ2   A0A023F5N8   A0A069DU97   T1JMW6   A0A1B0D7E2   A0A224XLW0   A0A087UIC2   A0A3Q2Z3K9   A0A3L8SCG3   A0A2I4D012   A0A218UJB0   A0A3M0LTV2   Q5ZME8   A0A151NER3   A0A0Q3M8Z4   A0A0P6K7N1  

PDB

6AHD     E-value=0,     Score=2006

KEGG

101738800    K13111 WD40 repeat-containing protein SMU1 | (RefSeq) WD40 repeat-containing protein SMU1

GO

GO:0008380   GO:0005634   GO:0005737   GO:0072553   GO:0007528   GO:0007274   GO:0071011   GO:0000398   GO:0071013   GO:0007188   GO:0005525   GO:0003924   GO:0031683   GO:0046872   GO:0071005   GO:0016607   GO:0000381   GO:0005515   GO:0004672   GO:0006468   GO:0046982   GO:0005615   GO:0016021   GO:0045211   GO:0006281   GO:0048384  

Subcellular location

Cytoplasm   Colocalizes with SRSF1 in nuclear speckles.   With evidence from 3 publications.
Nucleus   Colocalizes with SRSF1 in nuclear speckles.   With evidence from 3 publications.
Nucleus speckle   Colocalizes with SRSF1 in nuclear speckles.   With evidence from 3 publications.

Length:

512

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01085

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00154

outside

1  -  512

 

 

Pi

183.486696

Theta

148.089249

Tajima's D

0.473612

CLR

0.098587

CSRT

0.503424828758562

Interpretation

Uncertain