Gene

KWMTBOMO03177  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA013462

Annotation

PREDICTED:_programmed_cell_death_6-interacting_protein_[Papilio_xuthus]

Location

Bomo_Chr6(-):826644-847202      View in EpiBrowser

Full name

Histone H4      

Location in the cell

Cytoplasmic   Reliability : 2.533

CDS

ATGGCTGAATTGTTGTTTGTGCCGTTTAAAAAGTCTTCGGACGTTGATATTGTTAAACCTTTGAAGAATTTAATACAATCTACTTACAACAGTGCCGAGAACACAGAAGATTATACCGATGCCTTAAATGAACTGAGCCGGTTGCGTACCAACGCAGTTTGGAAAGTCTTCGAGAAAACCTCTCTTGACACTATTTACAGTTACTATGATCAACTGGTGGCCCTTGAGAGCAAGATTCCTCCTCAAGAAGTTCAAATTCCATTCAAATGGAAGGATGCATTTGACAAGGGTTCTATCTTTGGAGGCAGGATGAGTCTCACAATCAGTTCATTGGAATATGAAAGAATGTGCATCTTATTCAACATAGCAGCTATGCAGAGCATGATTGCAGCTCAGGAACCTCTCGACACTGAGGATTCACTCAAGCTAGCTGCCAAATATTTTCAGCAATCAGCTGGCATCTTTGTATACCTGAAGGCGAACATCATGATGGCAGTGCACCAGGAAACCACACCAGATTTGAACCCTGAAACGCTGGATGCATTGGCCAAACTAATGCTCGCACAGGCACAGGAGGTTATCGCCCATAAATGCATCAGAGATGAGATGAAGGAGAGCATGGTGGCAAAGGTGTGCGCGCAGTGCGAGGAGCTGTACGTGGACGCGCTGCGGGCCATGCTCAAGGAGAACCCCAAGTCGCTCTGGGAAAAGGACTGGGTACCAAATGTTCAAGCGAAGCAGATGGCGTTCCGCGGCCTGGCGCAGTACTACCAGAGCCTGGTGTGCCGCGCCAACAAGGCCGTGGGCGAGGAGATCGCCAGACTACAATTCGCAGTAGATCAGCTGAAGGGTGCCCAGTCGCGGCTGTCGCCCAGCTACCTGCAGGAGCAGGCGTCGAAGGCAGCGCGCAACCTTCAAGAGGCGATGAAGGACAACGACTTCATCTACCACGAGCGCATCCCGGACCTCAAGCAGCTGGAGCTCATCTCCAAGGCGGCCATCGCTAAACCTTTGCCTCCACAAGAGAAGTGGGGCTCGGGGGGGAAAGATCTGTTCGCTGGGCTGGTCCCGCTGGCGGTGCACCACGCGGCGGCGGCCAGCAGCGCGCGCCGCGCCGAGCTGGTCTCCGCCGAGGTCGCCAAGCTGCGGGACGCCACGCAGCTGCTCAACAGCATCCTGGCGTCGCTGAACCTGCCGGCGTGCATCGAGTCGTGCGACGAGGAGGGCTCGCTGCCGGAGTCCATCCGCAGCAAGGCGCGCGCCGTGCGGGACGCGGGCGGCCTGCAAGAGCTGCAGCGCCTCATGGCCGAGCTGCCGGACCTGCTGCAGAGGAACAAGGACATCCTCGACGAGGCGGAGCGCATGCTGCGGGAGGAGGCGGAGGCGGACGCGGCGCTGCGGCAACAGTTCGGGGCCCGCTGGACGCGCACGCCCTCCGCCGCGCTCACCGAGGCCTTCCGCGCCAACGCGGACAAGTACCGGCAGATCATCGACAACGCCGTGCGCGCCGACAACATCGTGCAGCAGAAGTACCAGCAGCACAAGGACAACATAGCGCTGCTGAGCGGCAGCGAGGGCGACATCACGGCGGGGGTGCCCTCCGCGCCCGCCGCCGGGCCCGCCGACACGCGCGCACTCTCCACGCTGCGAGGTCTCATGGAGGAGGTGGAGAGGCTGAAGGCGGAGCGGGACAGCATCGAGTGCTCGCTGAAGGACGCGAGCGTGGACCTGCGGGAGCAGTTCCTGGCGGCGCTGAGCGCGGACGGCGCCATCGACGAGCCCGCGCTGTCCGCCGCCGCGCTGGGCCGCGCGCTGGGCCCGCTGCAGGCGCAGCTCGCCGCCTCGCTCGCCGCGCAGGACGACCTCGTGGCGCGCATACAGAAAGCCCACGGCAGCCTGGAGTCTGGCGGGGGGGGCGCGGGCGGGAGGGACGCGGTGCTGGGCCGCCTGGCCGCTGCCTACGACGCCTTCCAGGACCTCACCGGCAACCTCAGGGAGGGGGTCAAGTTCTACAACGACCTCACGCAGCTGCTGGTCGCCTTCCAAAACAAAGTATCGGACTTCTGTTTCGCTCGTAAGACTGAGAAGGAGGAGCTCCTCAAGGACCTCACCCAGGAGGCCTCCCGCCCCGCGACCAGGCCCGCCCCGAGCCCGCCGCAACACCACACCGACGCCGTGGCCGAGGTAAACAGAGTATTCTAA

Protein

MAELLFVPFKKSSDVDIVKPLKNLIQSTYNSAENTEDYTDALNELSRLRTNAVWKVFEKTSLDTIYSYYDQLVALESKIPPQEVQIPFKWKDAFDKGSIFGGRMSLTISSLEYERMCILFNIAAMQSMIAAQEPLDTEDSLKLAAKYFQQSAGIFVYLKANIMMAVHQETTPDLNPETLDALAKLMLAQAQEVIAHKCIRDEMKESMVAKVCAQCEELYVDALRAMLKENPKSLWEKDWVPNVQAKQMAFRGLAQYYQSLVCRANKAVGEEIARLQFAVDQLKGAQSRLSPSYLQEQASKAARNLQEAMKDNDFIYHERIPDLKQLELISKAAIAKPLPPQEKWGSGGKDLFAGLVPLAVHHAAAASSARRAELVSAEVAKLRDATQLLNSILASLNLPACIESCDEEGSLPESIRSKARAVRDAGGLQELQRLMAELPDLLQRNKDILDEAERMLREEAEADAALRQQFGARWTRTPSAALTEAFRANADKYRQIIDNAVRADNIVQQKYQQHKDNIALLSGSEGDITAGVPSAPAAGPADTRALSTLRGLMEEVERLKAERDSIECSLKDASVDLREQFLAALSADGAIDEPALSAAALGRALGPLQAQLAASLAAQDDLVARIQKAHGSLESGGGGAGGRDAVLGRLAAAYDAFQDLTGNLREGVKFYNDLTQLLVAFQNKVSDFCFARKTEKEELLKDLTQEASRPATRPAPSPPQHHTDAVAEVNRVF

Description

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Subunit

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

Similarity

Belongs to the histone H4 family.

Uniprot

H9JV99   A0A2H1VQU3   A0A212ELZ9   A0A2J7PWQ8   A0A2J7PWR4   A0A437BHX4   + More
A0A067RRI5   A0A1Y1LGS8   D6WD78   A0A154PAW4   A0A0L7RGL7   J3JTI1   A0A026WAB2   V5G0L5   A0A1B6HFU3   A0A151J4B4   E2BRJ3   A0A1I9WLI5   T1HX75   A0A0P4VM27   A0A088ANI4   A0A1B0GP78   V9IJ51   A0A1B6KHR9   A0A195FSG0   A0A069DX83   A0A1B6MPS5   A0A195BL44   A0A411G6S2   A0A1B6KH93   A0A0V0G4D7   A0A1L8DJF9   A0A023F397   A0A158NSG5   F4WFM8   A0A1B6EQG9   A0A0M8ZPZ9   A0A224XJK6   A0A1B6MA61   A0A1B6KGS5   A0A1B6MMN7   A5XB12   A0A0P4W5P3   T1JEE2   B4KAS5   A0A1W4VL42   A0A0M4F2Q1   A0A0A1X512   A0A3B0KAX2   B4JU60   T1PEF6   W8BYV1   A0A1B6MV22   B4M616   B4IGV4   B3LX31   B4QY34   A0A1I8P1A3   B4NAS1   B4PRA8   A0A1A9WC01   Q9VB05   A0A3B0K3Z2   Q29BG1   A0A1B0FP40   A0A1A9Z7A3   E0V9Q3   A0A034W514   B3P5Y2   A0A182HDP2   A0A444THJ6   A0A0K8V4B1   A0A023EVA8   A0A0P6ATJ7   A0A0P5APV9   A0A0N8A152   A0A0P5KN73   A0A0P6JF15   A0A0P6E396   A0A0L0BNC6   A0A2P2HW37   Q16QI6   A0A0P5TZM9   A0A0P4ZR37   A0A1A9ULX9   A0A2A3ECD3   A0A336M9W6   A0A1Q3FE56   A0A0A9XXL8   A0A146L7V4   A0A0P5PIU4   A0A0J7K5H8   T1E1D8   B4GNW9   E9G102   A0A084VZ78   A0A2R5LI09   A0A293MWL8   A0A2S2QYR3   A0A023GNS2  

Pubmed

19121390    22118469    24845553    28004739    18362917    19820115    + More
22516182    23537049    24508170    30249741    20798317    27538518    27129103    26334808    25474469    21347285    21719571    17383199    17994087    25830018    25315136    24495485    17550304    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    15632085    20566863    25348373    26483478    24945155    26108605    17510324    25401762    26823975    24330624    21292972    24438588   

EMBL

BABH01037335    BABH01037336    BABH01037337    BABH01037338    BABH01037339    ODYU01003886    + More
SOQ43205.1    AGBW02013968    OWR42499.1    NEVH01020869    PNF20765.1    PNF20766.1    RSAL01000053    RVE50047.1    KK852470    KDR23230.1    GEZM01057943    GEZM01057942    JAV72081.1    KQ971312    EEZ98352.1    KQ434864    KZC08983.1    KQ414596    KOC69968.1    APGK01047880    APGK01047881    APGK01047882    BT126538    KB741092    KB632050    AEE61502.1    ENN73916.1    ERL88308.1    KK107295    QOIP01000003    EZA52990.1    RLU24287.1    GALX01004921    JAB63545.1    GECU01034184    JAS73522.1    KQ980159    KYN17416.1    GL449965    EFN81685.1    KU932369    APA34005.1    ACPB03011000    GDKW01000447    JAI56148.1    AJVK01014999    JR047269    AEY60369.1    GEBQ01028960    JAT11017.1    KQ981276    KYN43525.1    GBGD01000468    JAC88421.1    GEBQ01002098    JAT37879.1    KQ976444    KYM86247.1    MH365754    QBB01563.1    GEBQ01029161    JAT10816.1    GECL01003584    JAP02540.1    GFDF01007523    JAV06561.1    GBBI01003046    JAC15666.1    ADTU01024896    ADTU01024897    GL888120    EGI67005.1    GECZ01029570    JAS40199.1    KQ436008    KOX67616.1    GFTR01008113    JAW08313.1    GEBQ01007152    GEBQ01001159    JAT32825.1    JAT38818.1    GEBQ01029310    JAT10667.1    GEBQ01002771    JAT37206.1    DQ787160    ABG82044.1    GDRN01070718    JAI63819.1    JH432116    CH933806    EDW16812.1    CP012526    ALC45750.1    GBXI01007883    JAD06409.1    OUUW01000005    SPP80718.1    CH916374    EDV91030.1    KA647074    AFP61703.1    GAMC01002068    JAC04488.1    GEBQ01000214    JAT39763.1    CH940652    EDW59092.1    CH480837    EDW49072.1    CH902617    EDV43870.1    CM000364    EDX14682.1    CH964232    EDW80885.1    CM000160    EDW98472.1    AE014297    AY069534    AAF56740.1    AAL39679.1    SPP80719.1    CM000070    EAL27037.1    CCAG010023115    DS234995    EEB10088.1    GAKP01009550    JAC49402.1    CH954182    EDV53382.1    JXUM01130051    JXUM01130052    JXUM01130053    JXUM01130054    JXUM01130055    JXUM01130056    KQ567530    KXJ69388.1    SAUD01002650    RXG69456.1    GDHF01018889    JAI33425.1    GAPW01000213    JAC13385.1    GDIP01026445    JAM77270.1    GDIP01196175    JAJ27227.1    GDIP01192721    GDIP01090984    JAJ30681.1    GDIQ01189146    JAK62579.1    GDIQ01008511    JAN86226.1    GDIQ01190400    GDIQ01189147    GDIQ01068754    JAN25983.1    JRES01001623    KNC21423.1    IACF01000188    LAB65991.1    CH477747    EAT36654.1    GDIP01120278    JAL83436.1    GDIP01209968    JAJ13434.1    KZ288292    PBC29144.1    UFQT01000550    SSX25167.1    GFDL01009218    JAV25827.1    GBHO01019488    GBHO01010930    GBRD01012240    GBRD01012238    JAG24116.1    JAG32674.1    JAG53584.1    GDHC01014954    JAQ03675.1    GDIQ01149374    JAL02352.1    LBMM01013273    KMQ85728.1    GALA01001769    JAA93083.1    CH479186    EDW38852.1    GL732529    EFX86720.1    ATLV01018617    KE525239    KFB43272.1    GGLE01005025    MBY09151.1    GFWV01019613    MAA44341.1    GGMS01013059    MBY82262.1    GBBM01000540    JAC34878.1   

Proteomes

UP000005204    UP000007151    UP000235965    UP000283053    UP000027135    UP000007266    + More
UP000076502    UP000053825    UP000019118    UP000030742    UP000053097    UP000279307    UP000078492    UP000008237    UP000015103    UP000005203    UP000092462    UP000078541    UP000078540    UP000005205    UP000007755    UP000053105    UP000009192    UP000192221    UP000092553    UP000268350    UP000001070    UP000095301    UP000008792    UP000001292    UP000007801    UP000000304    UP000095300    UP000007798    UP000002282    UP000091820    UP000000803    UP000001819    UP000092444    UP000092445    UP000009046    UP000008711    UP000069940    UP000249989    UP000288706    UP000037069    UP000008820    UP000078200    UP000242457    UP000036403    UP000008744    UP000000305    UP000030765   

PRIDE

H9JV99    Q9VB05   

Pfam

PF03097   BRO1        + More
PF13949   ALIX_LYPXL_bnd
PF15511   CENP-T_C
PF00271   Helicase_C
PF04408   HA2
PF00575   S1
PF07717   OB_NTP_bind

Interpro

IPR004328   BRO1_dom        + More
IPR038499   BRO1_sf       
IPR025304   ALIX_V_dom       
IPR019809   Histone_H4_CS       
IPR001951   Histone_H4       
IPR004823   TAF_TATA-bd       
IPR035425   CENP-T/H4_C       
IPR009072   Histone-fold       
IPR022967   S1_dom       
IPR007502   Helicase-assoc_dom       
IPR003029   S1_domain       
IPR027417   P-loop_NTPase       
IPR002464   DNA/RNA_helicase_DEAH_CS       
IPR001650   Helicase_C       
IPR014001   Helicase_ATP-bd       
IPR011709   DUF1605       
IPR012340   NA-bd_OB-fold       

SUPFAM

SSF47113   SSF47113        + More
SSF50249   SSF50249       
SSF52540   SSF52540       

Gene 3D

1.25.40.280     1.10.20.10    

CDD

cd00076  H4
cd00079  HELICc

ProteinModelPortal

H9JV99   A0A2H1VQU3   A0A212ELZ9   A0A2J7PWQ8   A0A2J7PWR4   A0A437BHX4   + More
A0A067RRI5   A0A1Y1LGS8   D6WD78   A0A154PAW4   A0A0L7RGL7   J3JTI1   A0A026WAB2   V5G0L5   A0A1B6HFU3   A0A151J4B4   E2BRJ3   A0A1I9WLI5   T1HX75   A0A0P4VM27   A0A088ANI4   A0A1B0GP78   V9IJ51   A0A1B6KHR9   A0A195FSG0   A0A069DX83   A0A1B6MPS5   A0A195BL44   A0A411G6S2   A0A1B6KH93   A0A0V0G4D7   A0A1L8DJF9   A0A023F397   A0A158NSG5   F4WFM8   A0A1B6EQG9   A0A0M8ZPZ9   A0A224XJK6   A0A1B6MA61   A0A1B6KGS5   A0A1B6MMN7   A5XB12   A0A0P4W5P3   T1JEE2   B4KAS5   A0A1W4VL42   A0A0M4F2Q1   A0A0A1X512   A0A3B0KAX2   B4JU60   T1PEF6   W8BYV1   A0A1B6MV22   B4M616   B4IGV4   B3LX31   B4QY34   A0A1I8P1A3   B4NAS1   B4PRA8   A0A1A9WC01   Q9VB05   A0A3B0K3Z2   Q29BG1   A0A1B0FP40   A0A1A9Z7A3   E0V9Q3   A0A034W514   B3P5Y2   A0A182HDP2   A0A444THJ6   A0A0K8V4B1   A0A023EVA8   A0A0P6ATJ7   A0A0P5APV9   A0A0N8A152   A0A0P5KN73   A0A0P6JF15   A0A0P6E396   A0A0L0BNC6   A0A2P2HW37   Q16QI6   A0A0P5TZM9   A0A0P4ZR37   A0A1A9ULX9   A0A2A3ECD3   A0A336M9W6   A0A1Q3FE56   A0A0A9XXL8   A0A146L7V4   A0A0P5PIU4   A0A0J7K5H8   T1E1D8   B4GNW9   E9G102   A0A084VZ78   A0A2R5LI09   A0A293MWL8   A0A2S2QYR3   A0A023GNS2  

PDB

2OEV     E-value=7.56021e-119,     Score=1096

KEGG

101742207    K12200 programmed cell death 6-interacting protein | (RefSeq) programmed cell death 6-interacting pr

PATHWAY

04144    Endocytosis - Bombyx mori (domestic silkworm)

GO

GO:0003677   GO:0000786   GO:0005634   GO:0046982   GO:0006352   GO:0048133   GO:0005813   GO:0030041   GO:0000281   GO:0070938   GO:0048132   GO:0045171   GO:0046330   GO:1990182   GO:0030496   GO:0043162   GO:0005768   GO:0003676   GO:0005524   GO:0004386   GO:0016021   GO:0005515   GO:0003723   GO:0008270   GO:0005615   GO:0045211   GO:0006281   GO:0048384  

Subcellular location

Chromosome  
Nucleus  

Length:

733

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00109

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00006

outside

1  -  733

 

 

Pi

320.577449

Theta

183.941128

Tajima's D

2.419688

CLR

0.431736

CSRT

0.935653217339133

Interpretation

Uncertain