Gene

KWMTBOMO03175

Pre Gene Modal

BGIBMGA013463

Annotation

PREDICTED:_MOB_kinase_activator-like_1_[Papilio_polytes]

Location

Bomo_Chr6(-):814527-819142      View in EpiBrowser

Full name

MOB kinase activator-like 1      

Alternative Name

Mob as tumor suppressor protein 1
Mps one binder kinase activator-like 1

Location in the cell

Cytoplasmic   Reliability : 2.001

CDS

ATGAGCTTCCTATTTGGTAGTCGCTCAAACAAAACTTTCAAACCAAAGAAGAATATTCCTGAGGGCACCCATCAGTACGATTTGATGAGGCACGCAGCAGCCACACTTGGTTCCGGGAACTTGCGCCTCGCTGTTATGTTACCCGAAGGGGAGGACCTCAATGAGTGGGTTGCCGTGAACACTGTGGATTTCTTCAATCAGATCAACATGTTATATGGGACCATAACAGAATTCTGCACAGAGGAGTCATGTGCTGTCATGTCTGCCGGACCAAAATATGAATACCATTGGGCTGACGGACACACAGTGAAGAAACCTATCAAGTGTTCGGCCCCAAAGTATATAGATTATTTGATGACGTGGGCACAGGATCAGCTTGATGACGAAACCCTGTTCCCTTCGAAAATTGGTGTGCCATTCCCGAAGAGTTTCCTACTGATGGCAAAAACTATATTGAAGCGTTTGTTCCGCGTGTACGCGCACATCTACCACCAGCACTTCCCGGAGGTGGTGCAGCTGGGGGAAGAGGCTCACCTCAATACGTCATTCAAACATTTTATATTCTTTGTACAGGAGTTTAATCTGATCGAGCGCAAAGAGTTAGCGCCCTTACAGGAGCTCATCGACAAACTGACAGCGAAGGACGCGCGATGA

Protein

MSFLFGSRSNKTFKPKKNIPEGTHQYDLMRHAAATLGSGNLRLAVMLPEGEDLNEWVAVNTVDFFNQINMLYGTITEFCTEESCAVMSAGPKYEYHWADGHTVKKPIKCSAPKYIDYLMTWAQDQLDDETLFPSKIGVPFPKSFLLMAKTILKRLFRVYAHIYHQHFPEVVQLGEEAHLNTSFKHFIFFVQEFNLIERKELAPLQELIDKLTAKDAR

Description

Coactivator of Warts (Wts) kinase in the Hippo/SWH (Sav/Wts/Hpo)signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki)oncoprotein. The Hippo/SWH signaling pathway inhibits the activity of the transcriptional complex formed by Scalloped (sd) and Yki and the target genes of this pathway include cyclin-E (cycE), diap1 and bantam. Mats is essential for early development and is required for proper chromosomal segregation in developing embryos.

Subunit

Interacts with and activates trc and wts.

Similarity

Belongs to the MOB1/phocein family.

Keywords

Apoptosis   Cell membrane   Chromosome partition   Complete proteome   Cytoplasm   Cytoskeleton   Developmental protein   Membrane   Metal-binding   Nucleus   Phosphoprotein   Reference proteome   Zinc  

Feature

chain  MOB kinase activator-like 1

Uniprot

H9JVA0   A0A212ELZ8   A0A2A4J2U2   A0A3S2NFW3   A0A2H1VAB1   A0A1E1WLE1   + More
A0A2A3E2E4   V9ILH2   A0A088ABP9   A0A158NT28   A0A310SFS1   A0A2W1BHZ1   E2C8F5   A0A1B6DB19   A0A0T6ATU7   A0A1B6LYH4   A0A1B6JXF1   A0A1B6F1B5   A0A0L7QQS7   A0A1Y1L947   A0A1W4WW80   T1IPE9   A0A1S4ELC1   X5J6H4   D6X544   A0A2R7WNU9   J3JY93   A0A154PFT6   A0A195BHG8   A0A2J7QI29   K7J160   A0A0A9VRJ9   A0A0A9VT23   E9IBE6   A0A3L8D714   A6YPT6   A0A069DQP2   A0A232FI84   B4NH61   B4K5C9   A0A1B0CDJ9   A0A1S3JE19   A0A0L0CJJ7   B4G4N9   B4JTX7   A0A151XBS8   A0A3B0KVZ4   B5DYN3   B4LXU3   A0A2T7PZP6   A0A1L8DKX1   B3M227   A0A1D2MM14   A0A1I8MFM9   A0A2P6L9A8   A0A1A9XMA6   A0A1B0BWG5   W8BMG8   A0A0K8U5Q1   A0A034WQX3   A0A1W4W2L5   E9GD71   A0A0P5NX87   A0A1A9V8R9   A0A1B0A7V2   A0A1A9WNM0   D3TRA2   A0A1I8PJ80   A0A2R5LNB3   V4AN84   A0A067R962   A0A2P2I9U2   A0A131Y244   A0A0B6YXY1   A0A195F0K0   A0A087TGV5   A0A3S3P803   B4R014   B4PLP8   B4HE84   A0A0B4KGK3   Q95RA8   F4WG46   B3P7J0   A0A0P4WG65   C1BQJ6   A0A0K8RHM4   G3MSP7   A0A224Z0X5   A0A131YX18   L7M4F8   A0A131XKK8   A7SEP4   T1GFB1   A0A0K8TT26   A0A293MGX9   D3PFP5   A0A0L8HMV0   A0A336M2E2   A0A3S1BPR3  

Pubmed

19121390    22118469    21347285    28756777    20798317    28004739    + More
18362917    19820115    22516182    20075255    25401762    26823975    21282665    30249741    18207082    26334808    28648823    17994087    26108605    15632085    27289101    25315136    24495485    25348373    21292972    20353571    23254933    24845553    17550304    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    12537569    15766530    15975907    17347649    18245354    19913529    21719571    22216098    28797301    26830274    25576852    28049606    17615350    26369729   

EMBL

BABH01037339    AGBW02013968    OWR42497.1    NWSH01003364    PCG66467.1    RSAL01000053    + More
RVE50045.1    ODYU01001478    SOQ37726.1    GDQN01003286    JAT87768.1    KZ288466    PBC25436.1    JR051585    AEY61522.1    ADTU01025480    KQ765605    OAD53876.1    KZ150187    PZC72446.1    GL453666    EFN75790.1    GEDC01028482    GEDC01014415    JAS08816.1    JAS22883.1    LJIG01022821    KRT78545.1    GEBQ01011229    JAT28748.1    GECU01003854    JAT03853.1    GECZ01029713    GECZ01028659    GECZ01025727    JAS40056.1    JAS41110.1    JAS44042.1    KQ414786    KOC60846.1    GEZM01066976    JAV67607.1    JH431260    HF969261    CCX34990.1    KQ971382    EEZ97199.1    KK855177    PTY21292.1    BT128217    AEE63178.1    KQ434896    KZC10719.1    KQ976488    KYM83611.1    NEVH01013964    PNF28229.1    GBHO01045217    GBHO01045215    GBRD01002085    GDHC01000451    JAF98386.1    JAF98388.1    JAG63736.1    JAQ18178.1    GBHO01045218    JAF98385.1    GL762111    EFZ22023.1    QOIP01000012    RLU16011.1    EF639097    ABR27982.1    GBGD01002868    JAC86021.1    NNAY01000180    OXU30240.1    CH964272    EDW84558.1    CH933806    EDW16155.2    AJWK01007944    JRES01000310    KNC32420.1    CH479179    EDW24555.1    CH916374    EDV91556.1    KQ982320    KYQ57814.1    OUUW01000013    SPP88138.1    CM000070    EDY68014.2    CH940650    EDW67902.1    PZQS01000001    PVD38870.1    GFDF01007023    JAV07061.1    CH902617    EDV43351.1    LJIJ01000890    ODM93915.1    MWRG01000847    PRD35168.1    JXJN01021768    GAMC01006588    JAB99967.1    GDHF01030396    JAI21918.1    GAKP01002357    JAC56595.1    GL732539    EFX82745.1    GDIQ01136452    LRGB01000944    JAL15274.1    KZS14646.1    CCAG010015572    EZ423954    ADD20230.1    GGLE01006853    MBY10979.1    KB201234    ESO98617.1    KK852854    KDR15007.1    IACF01005205    LAB70791.1    GEFM01002477    JAP73319.1    HACG01014364    CEK61229.1    KQ981897    KYN33682.1    KK115167    KFM64344.1    NCKU01003595    NCKU01003589    RWS07230.1    RWS07244.1    CM000364    EDX13920.1    CM000160    EDW97997.1    CH480815    EDW43181.1    AE014297    AGB96215.1    AHN57464.1    AY061520    AAF55993.2    AAL29068.1    GL888128    EGI66813.1    CH954182    EDV54151.1    GDRN01050809    JAI66442.1    BT076875    ACO11299.1    GADI01003789    JAA70019.1    JO844898    AEO36515.1    GFPF01008524    MAA19670.1    GEDV01004824    JAP83733.1    GACK01005833    JAA59201.1    GEFH01000547    JAP68034.1    DS469638    EDO37824.1    CAQQ02126288    GDAI01000312    JAI17291.1    GFWV01015425    MAA40154.1    BT120451    ADD24091.1    KQ417740    KOF90532.1    UFQT01000109    SSX20128.1    RQTK01000081    RUS88512.1   

Proteomes

UP000005204    UP000007151    UP000218220    UP000283053    UP000242457    UP000005203    + More
UP000005205    UP000008237    UP000053825    UP000192223    UP000079169    UP000007266    UP000076502    UP000078540    UP000235965    UP000002358    UP000279307    UP000215335    UP000007798    UP000009192    UP000092461    UP000085678    UP000037069    UP000008744    UP000001070    UP000075809    UP000268350    UP000001819    UP000008792    UP000245119    UP000007801    UP000094527    UP000095301    UP000092443    UP000092460    UP000192221    UP000000305    UP000076858    UP000078200    UP000092445    UP000091820    UP000092444    UP000095300    UP000030746    UP000027135    UP000078541    UP000054359    UP000285301    UP000000304    UP000002282    UP000001292    UP000000803    UP000007755    UP000008711    UP000001593    UP000015102    UP000053454    UP000271974   

PRIDE

H9JVA0    Q95RA8   

Pfam

PF03637   Mob1_phocein

Interpro

IPR036703   MOB_kinase_act_sf        + More
IPR005301   MOB_kinase_act_fam       

SUPFAM

SSF101152   SSF101152       

Gene 3D

1.20.140.30    

ProteinModelPortal

H9JVA0   A0A212ELZ8   A0A2A4J2U2   A0A3S2NFW3   A0A2H1VAB1   A0A1E1WLE1   + More
A0A2A3E2E4   V9ILH2   A0A088ABP9   A0A158NT28   A0A310SFS1   A0A2W1BHZ1   E2C8F5   A0A1B6DB19   A0A0T6ATU7   A0A1B6LYH4   A0A1B6JXF1   A0A1B6F1B5   A0A0L7QQS7   A0A1Y1L947   A0A1W4WW80   T1IPE9   A0A1S4ELC1   X5J6H4   D6X544   A0A2R7WNU9   J3JY93   A0A154PFT6   A0A195BHG8   A0A2J7QI29   K7J160   A0A0A9VRJ9   A0A0A9VT23   E9IBE6   A0A3L8D714   A6YPT6   A0A069DQP2   A0A232FI84   B4NH61   B4K5C9   A0A1B0CDJ9   A0A1S3JE19   A0A0L0CJJ7   B4G4N9   B4JTX7   A0A151XBS8   A0A3B0KVZ4   B5DYN3   B4LXU3   A0A2T7PZP6   A0A1L8DKX1   B3M227   A0A1D2MM14   A0A1I8MFM9   A0A2P6L9A8   A0A1A9XMA6   A0A1B0BWG5   W8BMG8   A0A0K8U5Q1   A0A034WQX3   A0A1W4W2L5   E9GD71   A0A0P5NX87   A0A1A9V8R9   A0A1B0A7V2   A0A1A9WNM0   D3TRA2   A0A1I8PJ80   A0A2R5LNB3   V4AN84   A0A067R962   A0A2P2I9U2   A0A131Y244   A0A0B6YXY1   A0A195F0K0   A0A087TGV5   A0A3S3P803   B4R014   B4PLP8   B4HE84   A0A0B4KGK3   Q95RA8   F4WG46   B3P7J0   A0A0P4WG65   C1BQJ6   A0A0K8RHM4   G3MSP7   A0A224Z0X5   A0A131YX18   L7M4F8   A0A131XKK8   A7SEP4   T1GFB1   A0A0K8TT26   A0A293MGX9   D3PFP5   A0A0L8HMV0   A0A336M2E2   A0A3S1BPR3  

PDB

5B5V     E-value=2.4501e-113,     Score=1042

KEGG

101739784    K06685 MOB kinase activator 1 | (RefSeq) MATS1, MATS2, MATS3; MOB kinase activator-like 1

GO

GO:0016301   GO:0007059   GO:0005829   GO:0005886   GO:0006915   GO:0007275   GO:0019901   GO:0030295   GO:0005813   GO:0008283   GO:0005634   GO:0030707   GO:0035329   GO:0016021   GO:0007165   GO:0046872  

PANTHER

PTHR22599  

Subcellular location

Cytoplasm  
Cytoskeleton  
Microtubule organizing center  
Centrosome  
Nucleus  
Cytosol  
Cell membrane  

Length:

217

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00514

Exp number, first 60 AAs:

0.00029

Total prob of N-in:

0.02513

outside

1  -  217

 

 

Pi

62.288061

Theta

145.585075

Tajima's D

-0.453204

CLR

2.064247

CSRT

0.250287485625719

Interpretation

Uncertain