SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO03175
Pre Gene Modal
BGIBMGA013463
Annotation
PREDICTED:_MOB_kinase_activator-like_1_[Papilio_polytes]
Full name
MOB kinase activator-like 1      
Alternative Name
Mob as tumor suppressor protein 1
Mps one binder kinase activator-like 1
Location in the cell
Cytoplasmic   Reliability : 2.001
 

Sequence

CDS
ATGAGCTTCCTATTTGGTAGTCGCTCAAACAAAACTTTCAAACCAAAGAAGAATATTCCTGAGGGCACCCATCAGTACGATTTGATGAGGCACGCAGCAGCCACACTTGGTTCCGGGAACTTGCGCCTCGCTGTTATGTTACCCGAAGGGGAGGACCTCAATGAGTGGGTTGCCGTGAACACTGTGGATTTCTTCAATCAGATCAACATGTTATATGGGACCATAACAGAATTCTGCACAGAGGAGTCATGTGCTGTCATGTCTGCCGGACCAAAATATGAATACCATTGGGCTGACGGACACACAGTGAAGAAACCTATCAAGTGTTCGGCCCCAAAGTATATAGATTATTTGATGACGTGGGCACAGGATCAGCTTGATGACGAAACCCTGTTCCCTTCGAAAATTGGTGTGCCATTCCCGAAGAGTTTCCTACTGATGGCAAAAACTATATTGAAGCGTTTGTTCCGCGTGTACGCGCACATCTACCACCAGCACTTCCCGGAGGTGGTGCAGCTGGGGGAAGAGGCTCACCTCAATACGTCATTCAAACATTTTATATTCTTTGTACAGGAGTTTAATCTGATCGAGCGCAAAGAGTTAGCGCCCTTACAGGAGCTCATCGACAAACTGACAGCGAAGGACGCGCGATGA
Protein
MSFLFGSRSNKTFKPKKNIPEGTHQYDLMRHAAATLGSGNLRLAVMLPEGEDLNEWVAVNTVDFFNQINMLYGTITEFCTEESCAVMSAGPKYEYHWADGHTVKKPIKCSAPKYIDYLMTWAQDQLDDETLFPSKIGVPFPKSFLLMAKTILKRLFRVYAHIYHQHFPEVVQLGEEAHLNTSFKHFIFFVQEFNLIERKELAPLQELIDKLTAKDAR

Summary

Description
Coactivator of Warts (Wts) kinase in the Hippo/SWH (Sav/Wts/Hpo)signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki)oncoprotein. The Hippo/SWH signaling pathway inhibits the activity of the transcriptional complex formed by Scalloped (sd) and Yki and the target genes of this pathway include cyclin-E (cycE), diap1 and bantam. Mats is essential for early development and is required for proper chromosomal segregation in developing embryos.
Subunit
Interacts with and activates trc and wts.
Similarity
Belongs to the MOB1/phocein family.
Keywords
Apoptosis   Cell membrane   Chromosome partition   Complete proteome   Cytoplasm   Cytoskeleton   Developmental protein   Membrane   Metal-binding   Nucleus   Phosphoprotein   Reference proteome   Zinc  
Feature
chain  MOB kinase activator-like 1
EMBL
BABH01037339    AGBW02013968    OWR42497.1    NWSH01003364    PCG66467.1    RSAL01000053    + More
RVE50045.1    ODYU01001478    SOQ37726.1    GDQN01003286    JAT87768.1    KZ288466    PBC25436.1    JR051585    AEY61522.1    ADTU01025480    KQ765605    OAD53876.1    KZ150187    PZC72446.1    GL453666    EFN75790.1    GEDC01028482    GEDC01014415    JAS08816.1    JAS22883.1    LJIG01022821    KRT78545.1    GEBQ01011229    JAT28748.1    GECU01003854    JAT03853.1    GECZ01029713    GECZ01028659    GECZ01025727    JAS40056.1    JAS41110.1    JAS44042.1    KQ414786    KOC60846.1    GEZM01066976    JAV67607.1    JH431260    HF969261    CCX34990.1    KQ971382    EEZ97199.1    KK855177    PTY21292.1    BT128217    AEE63178.1    KQ434896    KZC10719.1    KQ976488    KYM83611.1    NEVH01013964    PNF28229.1    GBHO01045217    GBHO01045215    GBRD01002085    GDHC01000451    JAF98386.1    JAF98388.1    JAG63736.1    JAQ18178.1    GBHO01045218    JAF98385.1    GL762111    EFZ22023.1    QOIP01000012    RLU16011.1    EF639097    ABR27982.1    GBGD01002868    JAC86021.1    NNAY01000180    OXU30240.1    CH964272    EDW84558.1    CH933806    EDW16155.2    AJWK01007944    JRES01000310    KNC32420.1    CH479179    EDW24555.1    CH916374    EDV91556.1    KQ982320    KYQ57814.1    OUUW01000013    SPP88138.1    CM000070    EDY68014.2    CH940650    EDW67902.1    PZQS01000001    PVD38870.1    GFDF01007023    JAV07061.1    CH902617    EDV43351.1    LJIJ01000890    ODM93915.1    MWRG01000847    PRD35168.1    JXJN01021768    GAMC01006588    JAB99967.1    GDHF01030396    JAI21918.1    GAKP01002357    JAC56595.1    GL732539    EFX82745.1    GDIQ01136452    LRGB01000944    JAL15274.1    KZS14646.1    CCAG010015572    EZ423954    ADD20230.1    GGLE01006853    MBY10979.1    KB201234    ESO98617.1    KK852854    KDR15007.1    IACF01005205    LAB70791.1    GEFM01002477    JAP73319.1    HACG01014364    CEK61229.1    KQ981897    KYN33682.1    KK115167    KFM64344.1    NCKU01003595    NCKU01003589    RWS07230.1    RWS07244.1    CM000364    EDX13920.1    CM000160    EDW97997.1    CH480815    EDW43181.1    AE014297    AGB96215.1    AHN57464.1    AY061520    AAF55993.2    AAL29068.1    GL888128    EGI66813.1    CH954182    EDV54151.1    GDRN01050809    JAI66442.1    BT076875    ACO11299.1    GADI01003789    JAA70019.1    JO844898    AEO36515.1    GFPF01008524    MAA19670.1    GEDV01004824    JAP83733.1    GACK01005833    JAA59201.1    GEFH01000547    JAP68034.1    DS469638    EDO37824.1    CAQQ02126288    GDAI01000312    JAI17291.1    GFWV01015425    MAA40154.1    BT120451    ADD24091.1    KQ417740    KOF90532.1    UFQT01000109    SSX20128.1    RQTK01000081    RUS88512.1   
Pfam
PF03637   Mob1_phocein
Interpro
IPR036703   MOB_kinase_act_sf        + More
IPR005301   MOB_kinase_act_fam       
SUPFAM
SSF101152   SSF101152       
Gene 3D
PDB
5B5V     E-value=2.4501e-113,     Score=1042

Ontologies

Topology

Subcellular location
Cytoplasm  
Cytoskeleton  
Microtubule organizing center  
Centrosome  
Nucleus  
Cytosol  
Cell membrane  
Length:
217
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.00514
Exp number, first 60 AAs:
0.00029
Total prob of N-in:
0.02513
outside
1  -  217
 
 

Population Genetic Test Statistics

Pi
62.288061
Theta
145.585075
Tajima's D
-0.453204
CLR
2.064247
CSRT
0.250287485625719
Interpretation
Uncertain

Multiple alignment of Orthologues

 
 

Gene Tree

 
 
Copyright@ 2018-2023    Any Comments and suggestions mail to:zhuzl@cqu.edu.cn   渝ICP备19006517号

渝公网安备 50010602502065号