Gene

KWMTBOMO03173  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA013449

Annotation

H2A_histone_family_member_V_[Bombyx_mori]

Location

Bomo_Chr6(+):787233-789677      View in EpiBrowser

Full name

Histone H2A       + More
Histone H2A.V      

Alternative Name

H2A.F/Z

Location in the cell

Nuclear   Reliability : 4.302

CDS

ATGGGCGGTGGTAAAGCGGGTAAAGATTCTGGTAAAGCCAAGGCGAAAGCTGTCTCAAGATCAGCTAGAGCAGGACTTCAGTTTCCCGTTGGAAGAATTCATAGGCATCTTAAGAATAGGACAACAAGCCACGGGCGCGTAGGAGCTACGGCAGCAGTTTATTCTGCCGCTATTTTGGAATATCTTACAGCAGAGGTTTTGGAGTTGGCGGGAAATGCGTCTAAAGATTTAAAAGTGAAGCGTATTACTCCTCGGCACTTACAACTTGCTATTAGAGGAGATGAAGAATTGGACAGCCTCATAAAAGCAACTATCGCTGGCGGAGGCGTCATCCCACACATACACAAATCTCTCATTGGAAAGAAAGGCGGTCCTGGTGCACCCGTTTAA

Protein

MGGGKAGKDSGKAKAKAVSRSARAGLQFPVGRIHRHLKNRTTSHGRVGATAAVYSAAILEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIKATIAGGGVIPHIHKSLIGKKGGPGAPV

Description

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division (By similarity).

Subunit

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2AF/Z forms a heterodimer with H2B (By similarity).

Similarity

Belongs to the histone H2A family.

Keywords

Acetylation   Chromosome   Complete proteome   DNA-binding   Isopeptide bond   Nucleosome core   Nucleus   Reference proteome   Ubl conjugation  

Feature

chain  Histone H2A.V

Uniprot

A0A212EHH0   A0A2W1BA87   A0A2A4J327   A0A3S2LMR0   A0A2H1VKX0   S4PMY0   + More
A0A194Q2H5   H9JV86   Q1HPV7   A0A0N1PJY6   A0A226ETT1   A0A1L8DWD4   A0A182XBV7   T1DJ20   A0A1Q3EXA5   U5EY26   A0A182YHA2   A0A1J1J3V5   A0A0N8EQB5   A0A1B0CKZ4   A0A182MAP1   A0A182Q1X8   A0A182NCC9   A0A182VV72   B0WN56   A0A182JIT9   Q7QF50   A0A182RM67   A0A182IAM7   A0A023EE28   A0A1D6TJW7   A0A182GPV1   A0A0P6AL54   A0A164PX54   E9HDK1   Q171J5   A0A443R1Z2   A0A3S3PJ63   A0A0P6DAX8   A0A443SJE1   A0A2I4K5F2   R7UAU0   A0A0P6I5Q8   T1EMA3   A0A0P5EHR4   A0A0P5C2K0   A0A1P8SD63   A0A0N7ZQC9   A0A0P5CX83   T1KGY2   A0A0K8TNW2   A0A023GH79   G3MNR4   A0A224YZ06   A0A2R5LMH7   A0A131YWD3   A0A023FHJ9   L7M432   A0A023FWI5   A0A293N6F4   A0A131XKR3   A0A1E1WWZ1   A0A0K8RI49   B6VEZ2   A0A1S3JXT8   A0A0L8HP78   W4Z9R4   A0A1Y1M590   V5GRG8   A0A1W4WDP3   C3XZY0   P08991   H6T4K6   A0A249JKG5   J9Q5J0   A0A1V9XJ74   H2ZD31   K7J528   A0A0L7RJB8   A0A0M9A7N7   A0A026WZC4   G0YFD8   A0A0N7Z8R0   D2CFK6   A0A158P1E0   E2AGF1   A0A2B4RVM0   A7RQH8   E2BIJ4   A0A224XP52   A0A2R7VZC3   A0A423SG35   A0A023FBA4   R4FMP4   R4WR97   A0A2P2HYK5   D2DSH4   A0A069DMZ7   F6RLX1   A0A0A9YW58  

Pubmed

22118469    28756777    23622113    26354079    19121390    24330624    + More
25244985    12364791    14747013    17210077    24945155    26483478    21292972    17510324    23254933    26369729    22216098    28797301    26830274    25576852    28049606    28503490    28004739    18563158    2438657    7796537    22253857    28848447    22833317    28327890    20075255    24508170    21818309    27129103    21347285    20798317    17615350    25474469    23691247    26334808    12481130    15114417    25401762   

EMBL

AGBW02014893    OWR40928.1    KZ150187    PZC72449.1    NWSH01003364    PCG66465.1    + More
RSAL01000053    RVE50043.1    ODYU01003128    SOQ41499.1    GAIX01003300    JAA89260.1    KQ459579    KPI99538.1    BABH01037341    DQ443295    AB273625    ABF51384.1    BAF79922.1    KQ459753    KPJ20158.1    LNIX01000002    OXA61012.1    GFDF01003327    JAV10757.1    GALA01000581    JAA94271.1    GFDL01015139    JAV19906.1    GANO01002230    JAB57641.1    CVRI01000070    CRL07117.1    GDIQ01004348    JAN90389.1    AJWK01016803    AXCM01001564    AXCN02002174    DS232007    EDS31487.1    AXCP01006511    AAAB01008846    EAA06529.3    APCN01001278    GAPW01006016    GAPW01006015    JAC07582.1    JXUM01001871    JXUM01001872    KQ560129    KXJ84295.1    GDIP01027824    JAM75891.1    LRGB01002536    KZS07229.1    GL732624    EFX70199.1    CH477452    EAT40679.1    NCKU01002797    NCKU01002580    RWS08769.1    RWS09284.1    NCKU01000257    RWS16280.1    GDIQ01081669    JAN13068.1    NCKV01001860    RWS27647.1    KR021369    AMJ39612.1    AMQN01009726    KB306072    ELU00382.1    GDIQ01026056    JAN68681.1    AMQM01005426    KB096945    ESO00381.1    GDIP01146262    JAJ77140.1    GDIP01180502    JAJ42900.1    KX454487    APY18893.1    GDIP01222905    JAJ00497.1    GDIP01180503    JAJ42899.1    CAEY01000073    GDAI01001526    JAI16077.1    GBBM01003065    JAC32353.1    JO843515    AEO35132.1    GFPF01008417    MAA19563.1    GGLE01006596    MBY10722.1    GEDV01006336    JAP82221.1    GBBK01004269    JAC20213.1    GACK01006427    JAA58607.1    GBBL01002290    JAC25030.1    GFWV01022493    MAA47220.1    GEFH01000487    JAP68094.1    GFAC01007897    JAT91291.1    GADI01003003    GEFM01002691    JAA70805.1    JAP73105.1    FJ380208    ACJ12611.1    KQ417740    KOF90535.1    AAGJ04105829    GEZM01040178    JAV80942.1    GALX01001702    JAB66764.1    GG666477    EEN66346.1    X05547    HQ242649    AEH58058.1    MF152784    ASY01577.1    JN091826    AFJ91768.1    MNPL01009853    OQR73491.1    AAZX01000333    AAZX01008322    KQ414580    KOC71067.1    KQ435729    KOX77603.1    KK107054    EZA61420.1    HQ678186    AEM36062.1    GDKW01002651    JAI53944.1    DQ463963    ABE77334.1    ADTU01006360    ADTU01006361    GL439310    EFN67484.1    LSMT01000301    PFX20843.1    DS469528    EDO46289.1    GL448516    EFN84489.1    GFTR01002161    JAW14265.1    KK854190    PTY12844.1    QCYY01003489    ROT63113.1    GBBI01000509    JAC18203.1    GAHY01000898    JAA76612.1    AK417192    BAN20407.1    IACF01000962    LAB66696.1    FJ774663    ACY66386.2    GBGD01003461    JAC85428.1    EAAA01001217    GBHO01007170    GBRD01014570    JAG36434.1    JAG51256.1   

Proteomes

UP000007151    UP000218220    UP000283053    UP000053268    UP000005204    UP000053240    + More
UP000198287    UP000076407    UP000076408    UP000183832    UP000092461    UP000075883    UP000075886    UP000075884    UP000075920    UP000002320    UP000075880    UP000007062    UP000075900    UP000075840    UP000069940    UP000249989    UP000076858    UP000000305    UP000008820    UP000285301    UP000288716    UP000014760    UP000015101    UP000015104    UP000085678    UP000053454    UP000007110    UP000192223    UP000001554    UP000192247    UP000007875    UP000002358    UP000053825    UP000053105    UP000053097    UP000005205    UP000000311    UP000225706    UP000001593    UP000008237    UP000283509    UP000008144   

PRIDE

H9JV86    Q1HPV7    B0WN56    E9HDK1    G3MNR4    B6VEZ2    + More
C3XZY0    P08991    G0YFD8    D2CFK6    A7RQH8    E2BIJ4    D2DSH4    F6RLX1   

Pfam

PF00125   Histone        + More
PF16211   Histone_H2A_C
PF09289   FOLN
PF10591   SPARC_Ca_bdg

Interpro

IPR002119   Histone_H2A        + More
IPR032458   Histone_H2A_CS       
IPR009072   Histone-fold       
IPR007125   Histone_H2A/H2B/H3       
IPR032454   Histone_H2A_C       
IPR019577   SPARC/Testican_Ca-bd-dom       
IPR001999   Osteonectin_CS       
IPR015369   Follistatin/Osteonectin_EGF       
IPR011992   EF-hand-dom_pair       
IPR018247   EF_Hand_1_Ca_BS       

SUPFAM

SSF47113   SSF47113        + More
SSF47473   SSF47473       

Gene 3D

1.10.20.10    

CDD

cd00074  H2A

ProteinModelPortal

A0A212EHH0   A0A2W1BA87   A0A2A4J327   A0A3S2LMR0   A0A2H1VKX0   S4PMY0   + More
A0A194Q2H5   H9JV86   Q1HPV7   A0A0N1PJY6   A0A226ETT1   A0A1L8DWD4   A0A182XBV7   T1DJ20   A0A1Q3EXA5   U5EY26   A0A182YHA2   A0A1J1J3V5   A0A0N8EQB5   A0A1B0CKZ4   A0A182MAP1   A0A182Q1X8   A0A182NCC9   A0A182VV72   B0WN56   A0A182JIT9   Q7QF50   A0A182RM67   A0A182IAM7   A0A023EE28   A0A1D6TJW7   A0A182GPV1   A0A0P6AL54   A0A164PX54   E9HDK1   Q171J5   A0A443R1Z2   A0A3S3PJ63   A0A0P6DAX8   A0A443SJE1   A0A2I4K5F2   R7UAU0   A0A0P6I5Q8   T1EMA3   A0A0P5EHR4   A0A0P5C2K0   A0A1P8SD63   A0A0N7ZQC9   A0A0P5CX83   T1KGY2   A0A0K8TNW2   A0A023GH79   G3MNR4   A0A224YZ06   A0A2R5LMH7   A0A131YWD3   A0A023FHJ9   L7M432   A0A023FWI5   A0A293N6F4   A0A131XKR3   A0A1E1WWZ1   A0A0K8RI49   B6VEZ2   A0A1S3JXT8   A0A0L8HP78   W4Z9R4   A0A1Y1M590   V5GRG8   A0A1W4WDP3   C3XZY0   P08991   H6T4K6   A0A249JKG5   J9Q5J0   A0A1V9XJ74   H2ZD31   K7J528   A0A0L7RJB8   A0A0M9A7N7   A0A026WZC4   G0YFD8   A0A0N7Z8R0   D2CFK6   A0A158P1E0   E2AGF1   A0A2B4RVM0   A7RQH8   E2BIJ4   A0A224XP52   A0A2R7VZC3   A0A423SG35   A0A023FBA4   R4FMP4   R4WR97   A0A2P2HYK5   D2DSH4   A0A069DMZ7   F6RLX1   A0A0A9YW58  

PDB

4CAY     E-value=1.23423e-43,     Score=437

KEGG

733117    K11251 histone H2A | (RefSeq) his2Av, h2a.z; H2A histone family member V

GO

GO:0003677   GO:0000786   GO:0005634   GO:0046982   GO:0005615   GO:0062023   GO:0005509   GO:0005518   GO:0006325   GO:0000790   GO:0016021   GO:0005515   GO:0045211   GO:0006281   GO:0048384  

Subcellular location

Chromosome  
Nucleus  

Length:

129

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

1.24528

Exp number, first 60 AAs:

0.86387

Total prob of N-in:

0.17729

outside

1  -  129

 

 

Pi

34.968833

Theta

45.746255

Tajima's D

-0.751254

CLR

0.40756

CSRT

0.183890805459727

Interpretation

Possibly Positive selection