Gene

KWMTBOMO03166

Pre Gene Modal

BGIBMGA013465

Annotation

high-affinity_choline_transporter_[Trichoplusia_ni]

Location

Bomo_Chr6(-):683530-710322      View in EpiBrowser

Full name

High-affinity choline transporter 1      

Location in the cell

PlasmaMembrane   Reliability : 4.979

CDS

ATGATAAACATAGCCGGCGTGATCTCCATCATTCTGTTTTACGTGCTGATCCTGGCAGTCGGTATATGGGCTGGGAGGAAGAAGCCTCCGGGAAATGACTCCGAAGAGGAGGTAATGCTGGCGGGACGATCCATTGGGCTGTTCGTCGGCATCTTTACTATGACTGCGACCTGGGTTGGTGGCGGCTATATCAATGGGACAGCAGAAGCGATATACACGTCGGGGCTGGTGTGGTGTCAGGCGCCTTTTGGATATGCCCTGTCCCTGGTCTTTGGCGGTATATTCTTCGCGAATCCAATGCGTCGTCAAGGCTACATTACGATGCTGGACCCTTTACAAGATTCTTTTGGAAGTCGCATGGGAGGTCTGCTGTTCTTGCCAGCTCTCTGCGGTGAGGTCTTTTGGGCTGCTGGAATATTGGCTGCGCTTGGTGCAACCCTGGCCGTCATCATCGACATGGATCAACGCACTTCTGTGATCTTCAGCGCATGCGTGGCAGTCTTCTACACTTTGTTCGGAGGCCTATACTCCGTGGCCTACACAGACGTCATTCAGTTATTCTGCATATTCATCGGTCTATGGATGTGTATACCGTTCGCTTGGGCGAACCCTCACGTGAAGCCGCTGAGCTCCATGGAGGTGGACTGGATAGGGAAGGTGGATTCGGACTATTATTGGTTCTATATCGATTATGGTCTATTGCTGATCTTTGGAGGGATTCCTTGGCAGGTTTATTTCCAACGAGTGTTGAGCAGCAAGACAGCAGGCAGAGCGCAGGTGCTCTCCTATGTAGCTGCAATTGGCTGCATCTTCATGGCCATCCCACCAGTTCTCATCGGGGCTATAGCTAAGGGCACTGCCTGGAACGAGACGGATTATCACGGAGACCTCACACCGGATGGAGAGCTCACCTCGGCGCAGACCTCAATGATTCTGCCACTGGTACTCCAACATCTCACACCGGAGTTTGTCTCATTCTTTGGGCTTGGAGCTGTCTCGGCTGCTGTCATGTCCTCGGCCGACTCGAGCGTGCTTAGTGCGTCTTCTATGTTTGCCAGGAATGTGTACAAGCTGATCTTCAGACAGAACGCTTCAGAGATGGAGATAATCTGGGTGATGCGGGTGTCTATACTTATCGTCGGGTTCCTGGCTACCGTCATGGCCCTCACCATACCTTCAATCTACGGATTATGGTCAATGTGCTCAGATCTGGTGTACGTGATTCTCTTCCCGCAACTCCTGATGGTGGTACACTTCAAGAAGTATTGCAACACCTATGGCTCTCTGGCTGCATACATCGTGGCTCTCTTAGTTAGGATGTCTGGAGGGGAGAAGATGTTAGGACTGCCGCCGCTGATCCACTATCCTATGTGGGACCCAAAAGAAGAAGTCCAGCTGTTTCCATTCCGAACCATGGCGATGGTTCTCTCACTCTTCACACTAGCCTTCATTTCATGGCTCTCCGTATTTCTCTTTAACTCCGGATACCTGAGCCCCGAGTCGGACTACTTCAACTGCGTCGTCAACATCCCGGAGGATATCCGTCGCGTGGACGAGCCATCCGAAGCTGGAGAGCAGATGTCCGTGCTGGGAGGAGTCCCGGGTCGACTCTACGGAGCTGCCTCCACTTTGGTCGGCCCCGATGAGAAGTCCGGAAGAATCAACCCGGCCCTGGAACCGGATGACGATGACCTGGATGACCCCAATGACGGGCCGACGCCGCTCTTTGGCTCCAGTAGCGCCCCGCCCCCAGTGCAACCCTACGGCAAGCAGACCGCCTTTTAA

Protein

MINIAGVISIILFYVLILAVGIWAGRKKPPGNDSEEEVMLAGRSIGLFVGIFTMTATWVGGGYINGTAEAIYTSGLVWCQAPFGYALSLVFGGIFFANPMRRQGYITMLDPLQDSFGSRMGGLLFLPALCGEVFWAAGILAALGATLAVIIDMDQRTSVIFSACVAVFYTLFGGLYSVAYTDVIQLFCIFIGLWMCIPFAWANPHVKPLSSMEVDWIGKVDSDYYWFYIDYGLLLIFGGIPWQVYFQRVLSSKTAGRAQVLSYVAAIGCIFMAIPPVLIGAIAKGTAWNETDYHGDLTPDGELTSAQTSMILPLVLQHLTPEFVSFFGLGAVSAAVMSSADSSVLSASSMFARNVYKLIFRQNASEMEIIWVMRVSILIVGFLATVMALTIPSIYGLWSMCSDLVYVILFPQLLMVVHFKKYCNTYGSLAAYIVALLVRMSGGEKMLGLPPLIHYPMWDPKEEVQLFPFRTMAMVLSLFTLAFISWLSVFLFNSGYLSPESDYFNCVVNIPEDIRRVDEPSEAGEQMSVLGGVPGRLYGAASTLVGPDEKSGRINPALEPDDDDLDDPNDGPTPLFGSSSAPPPVQPYGKQTAF

Description

Imports choline from the extracellular space to the neuron with high affinity. Rate-limiting step in acetylcholine synthesis. Sodium ion and chloride ion dependent (By similarity).

Similarity

Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.

Keywords

Complete proteome   Glycoprotein   Ion transport   Membrane   Neurotransmitter biosynthesis   Reference proteome   Sodium   Sodium transport   Symport   Transmembrane   Transmembrane helix   Transport  

Feature

chain  High-affinity choline transporter 1

Uniprot

A0A212FCP7   A0A2A4JEV3   A0A2W1BT95   Q693W0   A0A194Q2I4   A0A0N0PEZ3   + More
A0A0G3VIB0   A0A0L7LMF2   W8C9U8   A0A0K8UFU7   B4NI91   B4KC51   A0A182UTY4   A0A182IUT4   A0A182Y786   A0A182LFE7   A0A182XIB9   Q7QBY8   A0A182HTA4   A0A182PA39   A0A182W2X7   A0A182Q9L8   A0A0M4EGX8   A0A1A9XDK5   A0A1B0BTV7   A0A0L0CQ40   A0A1A9VS46   B4JS82   A0A1A9ZGD7   Q299V8   A0A336MDH6   B4MBB9   B3P3C1   B4QTZ8   B4PM04   Q9VE46   A0A1W4UB27   A0A182LS72   B3M1V6   A0A1I8MHF5   A0A1J1IZV3   A0A1B0CEQ2   A0A3B0JDD0   A0A1I8PBJ6   A0A182N4P0   A0A182GZL3   E0W160   A0A195BEB5   A0A151IFN6   F4WAY2   A0A158NRC3   A0A2J7Q7E1   A0A151XF84   B0W360   A0A151JBP3   A0A1B6KPI3   A0A1B6KJK3   A0A195FJW5   E9IS26   A0A3L8DJT7   A0A026WFH4   A0A084W1K7   A0A0L7RJP5   K7J532   A0A067R0S6   V9ICA4   A0A2A3EFI4   A0A1B6E374   A0A087ZWP8   A0A310STY2   B4I262   A0A0M9A7S1   A0A0C9QJM2   A0A154P4I0   A0A232EQX6   A0A0A9ZFC7   A0A1W4WRS7   A0A182F6G4   D6W957   W5JSJ8   E2AGH2   A0A1B6EBI2   J9KAD4   A0A2H8THZ3   A0A2S2Q3S9   E9G3N6   A0A0P5DK19   A0A0P6FYM0   A0A336JYC9   A0A0P6IIM9   A0A182TVE5   A0A182RYG9   A0A1D2N665   A0A3S3PK89   Q16YT6   A0A132A6Y8   A0A1V9XZS3   A0A147BPX9  

Pubmed

22118469    28756777    15607656    26354079    26227816    24495485    + More
17994087    25244985    20966253    12364791    14747013    17210077    26108605    15632085    18057021    17550304    10731132    12537572    12537569    25315136    26483478    20566863    21719571    21347285    21282665    30249741    24508170    24438588    20075255    24845553    28648823    25401762    18362917    19820115    20920257    23761445    20798317    21292972    27289101    17510324    26555130    28327890    29652888   

EMBL

AGBW02009155    OWR51514.1    NWSH01001644    PCG70587.1    KZ149979    PZC75856.1    + More
AY629593    AAT88074.1    KQ459579    KPI99548.1    KQ459753    KPJ20167.1    KP657648    AKL78873.1    JTDY01000546    KOB76718.1    GAMC01006336    JAC00220.1    GDHF01026886    JAI25428.1    CH964272    EDW83673.1    CH933806    EDW16924.1    AAAB01008859    EAA07459.3    APCN01000429    APCN01000430    APCN01000431    AXCN02000058    AXCN02000059    CP012526    ALC45471.1    JXJN01020370    JXJN01020371    JRES01000062    KNC34473.1    CH916373    EDV94622.1    CM000070    EAL27593.1    UFQT01001009    SSX28452.1    CH940656    EDW58390.1    KRF78256.1    CH954181    EDV48573.1    CM000364    EDX12421.1    CM000160    EDW95936.1    AE014297    AY047521    AXCM01000096    CH902617    EDV42216.1    CVRI01000065    CRL05795.1    AJWK01009066    AJWK01009067    OUUW01000005    SPP80384.1    JXUM01099816    JXUM01099817    KQ564521    KXJ72141.1    DS235866    EEB19366.1    KQ976504    KYM82926.1    KQ977771    KYM99974.1    GL888056    EGI68602.1    ADTU01023859    ADTU01023860    NEVH01017443    PNF24499.1    KQ982205    KYQ58991.1    DS231831    EDS31203.1    KQ979122    KYN22537.1    GEBQ01026853    JAT13124.1    GEBQ01028372    JAT11605.1    KQ981522    KYN40552.1    GL765283    EFZ16638.1    QOIP01000007    RLU20680.1    KK107238    EZA54678.1    ATLV01019372    ATLV01019373    KE525269    KFB44101.1    KQ414580    KOC71059.1    AAZX01000327    AAZX01000328    AAZX01014618    KK852798    KDR16364.1    JR039569    AEY58758.1    KZ288259    PBC30478.1    GEDC01004915    JAS32383.1    KQ760497    OAD60101.1    CH480820    EDW54619.1    KQ435729    KOX77599.1    GBYB01000757    JAG70524.1    KQ434812    KZC06767.1    NNAY01002694    OXU20760.1    GBHO01000380    JAG43224.1    KQ971312    EEZ98445.2    ADMH02000291    ETN67106.1    GL439310    EFN67505.1    GEDC01002025    JAS35273.1    ABLF02030995    GFXV01001921    MBW13726.1    GGMS01002659    MBY71862.1    GL732531    EFX85951.1    GDIP01156267    LRGB01001574    JAJ67135.1    KZS11610.1    GDIQ01041106    JAN53631.1    UFQS01000013    UFQT01000013    SSW97241.1    SSX17627.1    GDIQ01021329    JAN73408.1    LJIJ01000187    ODN00758.1    NCKU01000774    NCKU01000257    RWS14213.1    RWS16282.1    CH477509    EAT39796.1    JXLN01011066    KPM06722.1    MNPL01001609    OQR78985.1    GEGO01002595    JAR92809.1   

Proteomes

UP000007151    UP000218220    UP000053268    UP000053240    UP000037510    UP000007798    + More
UP000009192    UP000075903    UP000075880    UP000076408    UP000075882    UP000076407    UP000007062    UP000075840    UP000075885    UP000075920    UP000075886    UP000092553    UP000092443    UP000092460    UP000037069    UP000078200    UP000001070    UP000092445    UP000001819    UP000008792    UP000008711    UP000000304    UP000002282    UP000000803    UP000192221    UP000075883    UP000007801    UP000095301    UP000183832    UP000092461    UP000268350    UP000095300    UP000075884    UP000069940    UP000249989    UP000009046    UP000078540    UP000078542    UP000007755    UP000005205    UP000235965    UP000075809    UP000002320    UP000078492    UP000078541    UP000279307    UP000053097    UP000030765    UP000053825    UP000002358    UP000027135    UP000242457    UP000005203    UP000001292    UP000053105    UP000076502    UP000215335    UP000192223    UP000069272    UP000007266    UP000000673    UP000000311    UP000007819    UP000000305    UP000076858    UP000075902    UP000075900    UP000094527    UP000285301    UP000008820    UP000192247   

PRIDE

Q9VE46   

Pfam

PF00474   SSF

Interpro

IPR038377   Na/Glc_symporter_sf        + More
IPR001734   Na/solute_symporter       
IPR011992   EF-hand-dom_pair       
IPR002048   EF_hand_dom       

SUPFAM

SSF47473   SSF47473       

Gene 3D

1.20.1730.10    

ProteinModelPortal

A0A212FCP7   A0A2A4JEV3   A0A2W1BT95   Q693W0   A0A194Q2I4   A0A0N0PEZ3   + More
A0A0G3VIB0   A0A0L7LMF2   W8C9U8   A0A0K8UFU7   B4NI91   B4KC51   A0A182UTY4   A0A182IUT4   A0A182Y786   A0A182LFE7   A0A182XIB9   Q7QBY8   A0A182HTA4   A0A182PA39   A0A182W2X7   A0A182Q9L8   A0A0M4EGX8   A0A1A9XDK5   A0A1B0BTV7   A0A0L0CQ40   A0A1A9VS46   B4JS82   A0A1A9ZGD7   Q299V8   A0A336MDH6   B4MBB9   B3P3C1   B4QTZ8   B4PM04   Q9VE46   A0A1W4UB27   A0A182LS72   B3M1V6   A0A1I8MHF5   A0A1J1IZV3   A0A1B0CEQ2   A0A3B0JDD0   A0A1I8PBJ6   A0A182N4P0   A0A182GZL3   E0W160   A0A195BEB5   A0A151IFN6   F4WAY2   A0A158NRC3   A0A2J7Q7E1   A0A151XF84   B0W360   A0A151JBP3   A0A1B6KPI3   A0A1B6KJK3   A0A195FJW5   E9IS26   A0A3L8DJT7   A0A026WFH4   A0A084W1K7   A0A0L7RJP5   K7J532   A0A067R0S6   V9ICA4   A0A2A3EFI4   A0A1B6E374   A0A087ZWP8   A0A310STY2   B4I262   A0A0M9A7S1   A0A0C9QJM2   A0A154P4I0   A0A232EQX6   A0A0A9ZFC7   A0A1W4WRS7   A0A182F6G4   D6W957   W5JSJ8   E2AGH2   A0A1B6EBI2   J9KAD4   A0A2H8THZ3   A0A2S2Q3S9   E9G3N6   A0A0P5DK19   A0A0P6FYM0   A0A336JYC9   A0A0P6IIM9   A0A182TVE5   A0A182RYG9   A0A1D2N665   A0A3S3PK89   Q16YT6   A0A132A6Y8   A0A1V9XZS3   A0A147BPX9  

PDB

2XQ2     E-value=2.76757e-07,     Score=133

KEGG

101742639    K14387 solute carrier family 5 (high affinity choline transporter), member 7 | (RefSeq) high-affinit

GO

GO:0016021   GO:0022857   GO:0016020   GO:0008292   GO:0015871   GO:0005307   GO:0033265   GO:0015220   GO:0003333   GO:0006814   GO:0015293   GO:0015171   GO:0005509   GO:0005215   GO:0006810   GO:0006355   GO:0007179   GO:0005515   GO:0045211   GO:0006281   GO:0048384  

Subcellular location

Membrane  

Length:

594

Number of predicted TMHs:

12

Exp number of AAs in TMHs:

275.68105

Exp number, first 60 AAs:

40.04532

Total prob of N-in:

0.36286

POSSIBLE N-term signal

sequence

inside

1  -  1

TMhelix

2  -  24

outside

25  -  38

TMhelix

39  -  61

inside

62  -  73

TMhelix

74  -  96

outside

97  -  132

TMhelix

133  -  151

inside

152  -  157

TMhelix

158  -  180

outside

181  -  183

TMhelix

184  -  203

inside

204  -  223

TMhelix

224  -  246

outside

247  -  260

TMhelix

261  -  283

inside

284  -  368

TMhelix

369  -  391

outside

392  -  394

TMhelix

395  -  417

inside

418  -  423

TMhelix

424  -  443

outside

444  -  474

TMhelix

475  -  497

inside

498  -  594

 

 

Pi

176.829002

Theta

155.096015

Tajima's D

0.564219

CLR

0.317967

CSRT

0.535523223838808

Interpretation

Uncertain