Gene

KWMTBOMO03162

Pre Gene Modal

BGIBMGA013468

Annotation

choline_acetyltransferase?_partial_[Bombyx_mori]

Location

Bomo_Chr6(-):518432-542032      View in EpiBrowser

Full name

Choline O-acetyltransferase      

Location in the cell

Cytoplasmic   Reliability : 2.413

CDS

ATGAGAAATTCAGTGAAAATCGGATTTTGTTCGAAATTCTTATTTTTGTTGCGGATTCCAGCATGGGGAGAGTCTCTGCTCTCGCTGTCGAAGCGGTGGCTCAGCACCCAGCTCCACAGCACCGACGACGAAGAATTTCAGAATGTACAGCTGCCCAAATTGCCGGTGCCAGATCTGCAGATGACCATGGACAGCTACTTGGAGTTCGCCTCCGTAGTCGTGAGTCATCAGCAACTGGAACACTCCAAGGGATTGGTTCGAGGGTTTATGGAAGAGTTGGGCCCACAGCTTCAGGAATCACTGCTGGATAGGCAAAAGGAGATGGAGAATTGGGTGACTGAGTGGTGGTTGGATGACATGTACTTGAAGGTACGACTGCCTTTGCCGATCAACTCGAACCCAGGGATGGTGTTCCCTCGTCGCCACTTCGTCAAGATGGAGGAGGTTGCTGACCTTGGAGCCTTGTTCATCGATGATCTGCTTGACTACAAAGAAATGTTGGACAGAGGTGAGCTTCCTCTGGAGAGGGCCACGAGTCGCGAGAAAGGCCAGCCACTATGCATGGAGCAGTTCTACAAGCTGCTGGGAGTCTGTCGCGTTCCAGAAGTGGGGAGGGACCGTCTCGAAATGCCACGAGCGGGAGACGGAATCGAGGAGACAGAGGAACTGATTGTGGTCGCGTGCAGGAACTATTTCTATCCGATCCCAGTAAAGGCAGTTGACCGCGGAAGGCTGACTCCAGGTGAAATCCAAGCTCAGCTATTACACGCCTTGGTGGATGCGGCTGGTGCTCCTCCAGCGCCCAGAGTCGGACTTCTCACCAGTATGAATAGAGACCACTGGGCTAGAGCCAGAGAGCAACTTATTAAAGACGAGAACAACCGCACTAACTTGGAGTTGATCTCGCGCGCTCTCTGCATACTGTGCCTCGACGAGGCGGGGGGAGATCGGGCTGATGCTGATGCCGACACTAACGCGATGCTGAGGGCCATGCATGGAGCGGGCACCAAACACCACTCCGCTAATAGGTGGTTCGACAAAACGGTGCAGCTGATCATATCATCCGATGGCACCGTGGGCATGTGCTACGAGCACAGTGCTGCAGAAGGAGTGGCAGTTATCAGGTTGGCTGAACGAGCCCTCGCCCGCGCTGAAGTCGCTGACAGACCTGCCCCCCCACCGGCGCTGCTGCCGGCTCCTCAGAGTATGAGATGGAAGATCACCCCGGACGTACACAGGAGCATTGATCAAGCTGCTAGGGAGTTGGATCGTGCCATATCTGATTTGGACTTCAAAGTTTACACGTACCGCGGCTACGGGCGGGAGTTCATGAAGTCCTGTCGCACCAGCCCTGACGTCTACATCCAGCTGGCGCTGCAGTATGCTTACTACAAGATGTACGGGTACCTGGTGTCTACATACGAGTCAGCTTCACTGCGGCGGTTCCGTCACGGGCGCGTGGACAACATCCGGTCCGCCCACAGCGCCGCGGACGCGTGGGCGGCCGCCATGTGTGCCGCCGAGACTCCGCCACTCAACGACAGCAGCGACGATGGACAGAAGAAAGTCTCCTTCAATTTATATGGGGAACAAAAGAAGCTAGAACTATTCGAAGAAGCGGCCCGTAAGCAGACTTCTATCATGGAAGCCAACATTCTTGGCAAAGGCATCGACAACCACCTGCTGGGACTCCGCGAGGCGGCTCGCGAGACTCTGGGTGAACTGCCCCAGATCTTCACTGATGAAACTTACAAGCAAATGATGCAGTTCAAGCTCAGTACTAGTCAGGTGGCCACCACAACAGAAGGTACATTTATGGGCTACGGAGCGGTAGTCCCTGATGGCTACGGCTGCAGCTACAACCCTAAGAAAGATTGCGTCATCTTCTGTATTTCCTCGTTCAGCTCATCGAGCGTCACTAACACAGAAGCCTTCCGCCAGTCCTTAGAAGAAGCCTTAGATTCAATGAAGCTAATGTTTCAGGCCAAGGTCGAAGAAAAAGCTTAA

Protein

MRNSVKIGFCSKFLFLLRIPAWGESLLSLSKRWLSTQLHSTDDEEFQNVQLPKLPVPDLQMTMDSYLEFASVVVSHQQLEHSKGLVRGFMEELGPQLQESLLDRQKEMENWVTEWWLDDMYLKVRLPLPINSNPGMVFPRRHFVKMEEVADLGALFIDDLLDYKEMLDRGELPLERATSREKGQPLCMEQFYKLLGVCRVPEVGRDRLEMPRAGDGIEETEELIVVACRNYFYPIPVKAVDRGRLTPGEIQAQLLHALVDAAGAPPAPRVGLLTSMNRDHWARAREQLIKDENNRTNLELISRALCILCLDEAGGDRADADADTNAMLRAMHGAGTKHHSANRWFDKTVQLIISSDGTVGMCYEHSAAEGVAVIRLAERALARAEVADRPAPPPALLPAPQSMRWKITPDVHRSIDQAARELDRAISDLDFKVYTYRGYGREFMKSCRTSPDVYIQLALQYAYYKMYGYLVSTYESASLRRFRHGRVDNIRSAHSAADAWAAAMCAAETPPLNDSSDDGQKKVSFNLYGEQKKLELFEEAARKQTSIMEANILGKGIDNHLLGLREAARETLGELPQIFTDETYKQMMQFKLSTSQVATTTEGTFMGYGAVVPDGYGCSYNPKKDCVIFCISSFSSSSVTNTEAFRQSLEEALDSMKLMFQAKVEEKA

Description

Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.

Catalytic Activity

acetyl-CoA + choline = acetylcholine + CoA

Similarity

Belongs to the carnitine/choline acetyltransferase family.

Keywords

Acyltransferase   Complete proteome   Neurotransmitter biosynthesis   Phosphoprotein   Reference proteome   Transferase  

Feature

chain  Choline O-acetyltransferase

Uniprot

V5Z1S9   A0A2W1BQF5   H9JVA5   A0A2H1VIB0   A0A2A4J498   A0A212FCP1   + More
A0A0L7LEC0   A0A0N1IQ67   A0A194Q3G4   B4MBC4   B4JS76   A0A182MVP7   A0A0M5J8U6   A0A1I8PS00   B4K1G0   A0A2S2NPE3   J9JKC1   A0A2S1WM72   A0A1A9W5V2   W5NVP3   F6Z7S5   F1MLQ5   A0A2K6F555   G1TI83   A0A2K6F541   L8ICG8   F6ZG92   A0A093GGG6   A0A093R0Y7   A0A341AWH8   A0A091IJH3   H0Z6F1   A0A091PZ59   K7F7S3   Q8BQN4   A0A091KPB6   Q8BQV2   R0L575   A0A091V3N7   G1NW88   A0A091NKZ0   Q03059   A0A0Q3MR52   A0A091MLK9   A0A087R8Z2   A0A093QVI6   A0A091IEQ5   A0A093LIK2   A0A091DS96   E9G3N0   A0A0A0B0G8   A0A093H3Y8   F1P393   U3IXL3   A0A093C4K3   G5B0X0   A0A087V7Q7   A0A091RMG2   A0A091RCC4   A0A094L0C3   A0A093Q9N3   G1MTK0   A0A2I0MFD4   A0A091GGE2   A0A1V4KJR9   Q90YJ9   A0A091F770   A0A091VKF7   U3JWD1   A0A099Z784   R0LW10   W5M2G0   U3IHS8   A0A091NWE4   B2KI80   A0A0Q3XAP2   A0A3M0J3E8   A0A094KAK3   A0A093QV25   A0A091V990   A0A091H866   A0A091Q9P8   A0A087VBR3   A0A093CDM5   A0A087RGW9   A0A093R480   A0A091URB4   A0A091NAZ4   L5LJM2   A0A2D0QMQ8   U3JFD7   A0A091HV91   A0A093FFB8   K7GIT1   G1PHY2   A0A091TVY1   S7Q1J8   A0A091IL79   A0A3B3BDK0  

EC Number

2.3.1.6

Pubmed

28756777    19121390    22118469    26227816    26354079    17994087    + More
20809919    18464734    19393038    21993624    22751099    20431018    20360741    17381049    10349636    11042159    11076861    11217851    12466851    16141073    15489334    19468303    2160042    1400357    21292972    15592404    23749191    21993625    20838655    23371554    15469882    29451363   

EMBL

AB853902    BAO23491.1    KZ149979    PZC75854.1    BABH01037368    ODYU01002720    + More
SOQ40577.1    NWSH01003475    PCG66222.1    AGBW02009155    OWR51509.1    JTDY01001459    KOB73817.1    KQ459753    KPJ20171.1    KQ459579    KPI99554.1    CH940656    EDW58395.2    CH916373    EDV94616.1    AXCM01000067    CP012526    ALC45474.1    CH917259    EDW05048.1    GGMR01006007    MBY18626.1    ABLF02025152    ABLF02025153    ABLF02025154    ABLF02025155    ABLF02025156    MG973416    AWJ68269.1    AMGL01072014    AMGL01072015    AAPN01421012    AAPN01421013    AAPN01421014    AAPN01421015    AAPN01421016    AAPN01421017    AAPN01421018    AAPN01421019    AAGW02068962    AAGW02068963    AAGW02068964    JH881665    ELR52882.1    AAMC01027976    AAMC01027977    AAMC01027978    KL216210    KFV68298.1    KL433835    KFW92315.1    KK500543    KFP08839.1    ABQF01025326    KK652586    KFQ02664.1    AGCU01014807    AGCU01014808    AGCU01014809    AGCU01014810    AGCU01014811    AGCU01014812    AGCU01014813    AGCU01014814    AK047708    BAC33133.2    KK753148    KFP42444.1    AC167565    BC119322    BC120589    AK046406    AAI19323.1    BAC32710.1    KB743944    EOA96564.1    KL410604    KFQ97648.1    AAPE02034545    AAPE02034546    AAPE02034547    KL384984    KFP89574.1    D12487    D12486    D12488    D12489    D12490    D12491    D12492    D12493    LMAW01000936    KQK84949.1    KK509162    KFP62435.1    KL226221    KFM09946.1    KL224692    KFW62714.1    KL218578    KFP06752.1    KK573214    KFW08811.1    KN122033    KFO33972.1    GL732531    EFX85954.1    KL873655    KGL99687.1    KL205760    KFV74130.1    AADN05000334    ADON01116514    ADON01116515    ADON01116516    KL234565    KFV07984.1    JH167903    EHB02931.1    KL483032    KFO08649.1    KK821898    KFQ40442.1    KK716321    KFQ36594.1    KL359217    KFZ64295.1    KL672327    KFW85643.1    AKCR02000016    PKK28384.1    KL448184    KFO81043.1    LSYS01003057    OPJ84613.1    AY044155    KK719753    KFO65998.1    KK734017    KFR02918.1    AGTO01010261    KL889304    KGL76650.1    KB742651    EOB05945.1    AHAT01021663    AHAT01021664    ADON01030708    KK642495    KFP96810.1    DP000711    ACC64540.1    LMAW01000170    KQL60244.1    QRBI01000209    RMB93433.1    KL346826    KFZ56370.1    KL425653    KFW90195.1    KK733774    KFQ99354.1    KL448313    KFO82457.1    KK690201    KFQ16291.1    KL487361    KFO10055.1    KL462552    KFV14015.1    KL226358    KFM12723.1    KL224938    KFW65839.1    KL409973    KFQ92942.1    KL379332    KFP86222.1    KB110951    ELK26549.1    AGTO01010820    KL217813    KFO99052.1    KK624942    KFV52954.1    AGCU01121635    AGCU01121636    AAPE02046840    AAPE02046841    KK466917    KFQ82391.1    KE164341    EPQ17148.1    KK500579    KFP09087.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000037510    UP000053240    UP000053268    + More
UP000008792    UP000001070    UP000075883    UP000092553    UP000095300    UP000007819    UP000091820    UP000002356    UP000002279    UP000009136    UP000233160    UP000001811    UP000008143    UP000053875    UP000252040    UP000053119    UP000007754    UP000007267    UP000000589    UP000053283    UP000001074    UP000051836    UP000053286    UP000054081    UP000054308    UP000028990    UP000000305    UP000053858    UP000053584    UP000000539    UP000016666    UP000006813    UP000053258    UP000001645    UP000053872    UP000053760    UP000190648    UP000052976    UP000053605    UP000016665    UP000053641    UP000018468    UP000269221    UP000221080    UP000261560   

PRIDE

V5Z1S9    H9JVA5    Q03059    Q90YJ9   

Pfam

PF00755   Carn_acyltransf        + More
PF07690   MFS_1

Interpro

IPR042232   Cho/carn_acyl_trans_1        + More
IPR042231   Cho/carn_acyl_trans_2       
IPR039551   Cho/carn_acyl_trans       
IPR000542   Carn_acyl_trans       
IPR004734   Multidrug-R       
IPR020846   MFS_dom       
IPR036259   MFS_trans_sf       
IPR011701   MFS       

SUPFAM

SSF103473   SSF103473       

Gene 3D

3.30.559.40     3.30.559.70    

CDD

cd06174  MFS

ProteinModelPortal

V5Z1S9   A0A2W1BQF5   H9JVA5   A0A2H1VIB0   A0A2A4J498   A0A212FCP1   + More
A0A0L7LEC0   A0A0N1IQ67   A0A194Q3G4   B4MBC4   B4JS76   A0A182MVP7   A0A0M5J8U6   A0A1I8PS00   B4K1G0   A0A2S2NPE3   J9JKC1   A0A2S1WM72   A0A1A9W5V2   W5NVP3   F6Z7S5   F1MLQ5   A0A2K6F555   G1TI83   A0A2K6F541   L8ICG8   F6ZG92   A0A093GGG6   A0A093R0Y7   A0A341AWH8   A0A091IJH3   H0Z6F1   A0A091PZ59   K7F7S3   Q8BQN4   A0A091KPB6   Q8BQV2   R0L575   A0A091V3N7   G1NW88   A0A091NKZ0   Q03059   A0A0Q3MR52   A0A091MLK9   A0A087R8Z2   A0A093QVI6   A0A091IEQ5   A0A093LIK2   A0A091DS96   E9G3N0   A0A0A0B0G8   A0A093H3Y8   F1P393   U3IXL3   A0A093C4K3   G5B0X0   A0A087V7Q7   A0A091RMG2   A0A091RCC4   A0A094L0C3   A0A093Q9N3   G1MTK0   A0A2I0MFD4   A0A091GGE2   A0A1V4KJR9   Q90YJ9   A0A091F770   A0A091VKF7   U3JWD1   A0A099Z784   R0LW10   W5M2G0   U3IHS8   A0A091NWE4   B2KI80   A0A0Q3XAP2   A0A3M0J3E8   A0A094KAK3   A0A093QV25   A0A091V990   A0A091H866   A0A091Q9P8   A0A087VBR3   A0A093CDM5   A0A087RGW9   A0A093R480   A0A091URB4   A0A091NAZ4   L5LJM2   A0A2D0QMQ8   U3JFD7   A0A091HV91   A0A093FFB8   K7GIT1   G1PHY2   A0A091TVY1   S7Q1J8   A0A091IL79   A0A3B3BDK0  

PDB

2FY5     E-value=5.19368e-112,     Score=1036

KEGG

101743075    K00623 choline O-acetyltransferase [EC:2.3.1.6] | (RefSeq) choline O-acetyltransferase

PATHWAY

00564    Glycerophospholipid metabolism - Bombyx mori (domestic silkworm)

GO

GO:0016746   GO:0015238   GO:0016021   GO:0007274   GO:0043005   GO:0004102   GO:0005737   GO:0008292   GO:0007626   GO:0005623   GO:0060416   GO:0007622   GO:0030424   GO:0007517   GO:0007529   GO:0007268   GO:0043025   GO:0033265   GO:0005739   GO:0016358   GO:0030182   GO:0007628   GO:0043179   GO:0007613   GO:0004092   GO:0005777   GO:0019254   GO:0005102   GO:0006468   GO:0005524   GO:0006355   GO:0007179   GO:0005515   GO:0045211   GO:0006281   GO:0048384  

PANTHER

PTHR22589  

Length:

668

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.542109999999999

Exp number, first 60 AAs:

0.49473

Total prob of N-in:

0.02625

outside

1  -  668

 

 

Pi

224.454056

Theta

207.701921

Tajima's D

0.130178

CLR

0.860258

CSRT

0.404929753512324

Interpretation

Uncertain