Gene

KWMTBOMO03148

Pre Gene Modal

BGIBMGA013431

Annotation

PREDICTED:_hemicentin-2-like_[Bombyx_mori]

Location

Bomo_Chr6(+):233153-256577      View in EpiBrowser

Full name

Protogenin      

Alternative Name

Protein Shen-Dan

Location in the cell

Cytoplasmic   Reliability : 1.114

CDS

ATGAAGAAGTTCAAAAATTTACCAGTGACATGGGCTCCCGCGCGCACGCTACTGCCGTGCGTGGTACCCGACGGAGAGACGCTGGTGGTGCGCGGCCCGCCACTACTCCTCGACTCCGATGACCAGAACCGTCTCAAGCCTTACGTTTGGATTAAGGATAACAAGGAGATTAAGCAGTCGTTAACGAACGTGACCCTAGAGGTACTGCAGAAGAAGGATGGCACCAGCGAGGGGGTCTACCAGTGCGGGGTGAGGCACCATGGCCTGGTGTTGGGCTACCCCATTATTCTCAAGTTTGCCTTCATCGAAAAGTACGTCTCTGTGGTTCCTGAGAACAGCACCGTGCGCGCCGGGCAGCCGTTTGTGCTCACGTGCAACATCAGCTCGGGTCCGTCTGCCAGTATCACGTGGCTGAAAGGAGAGGAAGTCATATCAGAGAACGACAGATATTATTACATCGACAATAAGCATCAACTACTAATACTGAACGCGAAGGAACAAGATGCAGGCGTATATTGGTGTAAAGCAACCAACCCAGTGCTAAACAAGAGTAGAAACAGTAGTCCTGCTTTGGTACAGGTGGAGAGGGAGGAAGGTCAGACGGGGCTGGCCTTTCTTCCTCTGCAGCAAGACACCACTATCTACGTCTCGAAGGGGAGCAGAGTTGTACTCCCATGTCCAGTAGTGGGCTGGCCCAAGCCCGAGATTGTATGGAAGCTGACTCCATCGATCGGAAGAACCGCTGAGCAAGAGACTATAGACCAGGTGTTGGTACTGCCGAGCATGCAGGCGGATCTAGAGGGAGTCTTCTCGTGCTCAGTGGACGGGAATAATGATTTGGTTAAGACCTACAATGTTACGATTACGGAGCCAGTGAACATCACGTTGCCTCCGGCTTCAAAGCAGGTGTACCGGGCCAGCACGGTGAGATTCAACTGCACCGCCACCGGGAAACCGGCCCCGATCATCACCTGGTACAAGGACGGGAAGCCTCTGGTTCTGGCCGGCAGGAAAGTTGTACTGACTTCGTTTGAAGGGAATCGTCGAGAGCTACTCATTAGGAGTGTTACATCTGATGATGCTGGAGTGTACCAGTGCTTCGCTAGGAACGCGCTGCAGGAGCGCGGCGCGTGGGCGCGGCTGGAGGTGGCGGGCGCGGGGGCGGAGGCGCCGCGCGGGGTGCGGTGTGCGGCGGCGGGGCCCGCGCGGGTGCGCGTGTACTGGGACCTGATGGACGCCGACGTTGTGGCCTACACCGTGCAGCGGAGCGTGTCGCAAGGTACCATGTACCCTGGAGTGCCGCGAACTACCAACGAAGAAATCATCACCGTAAATGAACCATTGACTCCTTACAAATTTCAGGTGACGGCTTATATTCTGACCAAAAACAATAAGACCATAGCGAGCGATCCCTCAGAAACTGTCACCTGTCAGGGGCAGGGAGTGCCGATCAAGATAACGCGAGTGAACGACGAGAGGGTCGTGGTATCCTGGCACCAGTTTGCGGAGGAGCATCCCGGCGTGCTGCAGTGGACTCTGCAGTACAGGACCGAGGACGACAACCAGATACAGAACGTGACTTTTGATGGTTCAGTGCATCAGTACAGTTTTCAAGCATTACCGGGCACTGAGCTCCGTGTGCTGGGCTGGAAGGTCCTCGGGATACCGGAGAACTTGTCGGATGTGCCGTGGCAACGAGCGGATCTGGACCGCGTACCAGATGGGTAA

Protein

MKKFKNLPVTWAPARTLLPCVVPDGETLVVRGPPLLLDSDDQNRLKPYVWIKDNKEIKQSLTNVTLEVLQKKDGTSEGVYQCGVRHHGLVLGYPIILKFAFIEKYVSVVPENSTVRAGQPFVLTCNISSGPSASITWLKGEEVISENDRYYYIDNKHQLLILNAKEQDAGVYWCKATNPVLNKSRNSSPALVQVEREEGQTGLAFLPLQQDTTIYVSKGSRVVLPCPVVGWPKPEIVWKLTPSIGRTAEQETIDQVLVLPSMQADLEGVFSCSVDGNNDLVKTYNVTITEPVNITLPPASKQVYRASTVRFNCTATGKPAPIITWYKDGKPLVLAGRKVVLTSFEGNRRELLIRSVTSDDAGVYQCFARNALQERGAWARLEVAGAGAEAPRGVRCAAAGPARVRVYWDLMDADVVAYTVQRSVSQGTMYPGVPRTTNEEIITVNEPLTPYKFQVTAYILTKNNKTIASDPSETVTCQGQGVPIKITRVNDERVVVSWHQFAEEHPGVLQWTLQYRTEDDNQIQNVTFDGSVHQYSFQALPGTELRVLGWKVLGIPENLSDVPWQRADLDRVPDG

Description

May play a role in anteroposterior axis elongation.

Similarity

Belongs to the immunoglobulin superfamily. DCC family.

Keywords

Complete proteome   Developmental protein   Disulfide bond   Glycoprotein   Immunoglobulin domain   Membrane   Reference proteome   Repeat   Signal   Transmembrane   Transmembrane helix  

Feature

chain  Protogenin

Uniprot

H9JV68   A0A2W1B6J0   A0A2H1VA08   A0A194QPT3   A0A212EUR8   A0A194Q7Y9   + More
A0A1B6CPK8   A0A0A9YRL0   A0A146LZX6   A0A154PAX5   J9K5G9   A0A151ICH3   E2ACC0   A0A232FFW8   T1I3G6   A0A151XAF1   A0A026WYR5   A0A158NH66   A0A3L8DR13   A0A195B7T0   A0A0L7RGL8   K7J2J3   A0A195DYD2   E9ILA7   A0A2A3EDT2   A0A195FGB5   A0A224XB00   A0A0N0U2W3   F4WZW8   A0A2H8TTV7   A0A2S2PYT6   A0A2S2R0E9   E2BAR8   A0A0C9RAR6   A0A0C9Q7N4   A0A210PQC4   K1QDZ3   E0VB26   A0A1W4WN68   A0A1W4WNF4   A0A1W4WM82   A0A1I8M4Q9   A0A315W3T1   A0A2I4BMP9   M3ZWX6   A0A087XDF7   V4B3D1   A0A3P9KPA6   A0A1L8H0F6   A0A1L8GT09   A0A1A7ZPX9   H2V9N8   H2LL58   A0A3B3UKM6   A0A3P9KVP9   A0A3B3XK00   A0A3P9IUK2   H0ZFQ2   Q2EY15   W5LKD3   L5K259   H2LVL0   A0A3P9H6W3   D2XNJ9   Q8JI27   A0A341D954   A0A2R8Q867   A0A3B3C995   Q801M2   A0A0R4IIB3   A0A2Y9NVR6   A0A2Y9HIH3   A0A340WH06   A0A2U4CMM3   H0ZFQ6   A0A0R4IP15   A0A384B646   A0A2U3XKT0   U3K682   A0A2Y9T0U4   M3WJ04   A0A2K5ZSF1   A4JYE1   A0A3B4Y0A0   F1LNL1   Q08CP3   G3GRK7   Q2VWP9   A0A3B3QHH1   F6U1B6   A0A2K6T1I7   F6W492   A0A146QEZ4   A0A3B4VEF8   A0A146QVT3  

Pubmed

19121390    28756777    26354079    22118469    25401762    26823975    + More
20798317    28648823    24508170    21347285    30249741    20075255    21282665    21719571    28812685    22992520    20566863    25315136    29703783    23542700    23254933    17554307    27762356    21551351    20360741    16881056    16141072    15489334    25329095    23258410    23594743    29451363    15081375    17975172    15057822    21804562    29240929    20431018   

EMBL

BABH01037400    BABH01037401    KZ150271    PZC71672.1    ODYU01001451    SOQ37667.1    + More
KQ461194    KPJ06975.1    AGBW02012312    OWR45238.1    KQ459579    KPI99525.1    GEDC01022065    JAS15233.1    GBHO01007967    JAG35637.1    GDHC01006552    JAQ12077.1    KQ434864    KZC08991.1    ABLF02020512    ABLF02020513    ABLF02020514    ABLF02020516    ABLF02046511    KQ978053    KYM97776.1    GL438491    EFN68910.1    NNAY01000289    OXU29453.1    ACPB03023078    KQ982339    KYQ57345.1    KK107063    EZA61185.1    ADTU01015151    QOIP01000005    RLU22847.1    KQ976574    KYM80302.1    KQ414596    KOC69974.1    KQ980107    KYN17624.1    GL764074    EFZ18650.1    KZ288292    PBC29171.1    KQ981625    KYN39059.1    GFTR01006850    JAW09576.1    KQ436008    KOX67608.1    GL888480    EGI60258.1    GFXV01005832    MBW17637.1    GGMS01001360    MBY70563.1    GGMS01014263    MBY83466.1    GL446831    EFN87203.1    GBYB01010177    JAG79944.1    GBYB01010178    JAG79945.1    NEDP02005557    OWF38700.1    JH818408    EKC35117.1    DS235021    EEB10582.1    NHOQ01000384    PWA30475.1    AYCK01018413    KB200347    ESP01846.1    CM004470    OCT89559.1    CM004471    OCT86968.1    HADY01005570    SBP44055.1    ABQF01016568    DQ360114    AY630257    AK039115    AK083540    BC116336    BC116337    AAI16337.1    AAU05740.1    ABC96181.1    BAC30243.1    BAC38947.1    KB031042    ELK05392.1    GU224220    ADB22629.1    AF394058    AAM88671.1    AL935050    BX927325    BX927344    CU463832    AY082380    AAL92552.1    AGTO01020922    AANG04001761    CU458829    CAM60069.1    AABR07070674    AABR07070675    AABR07070676    AABR07070677    AABR07073420    AC141190    BC124155    AAI24156.1    JH000003    EGV99883.1    AY630256    AAU05739.1    AAMC01079933    GCES01132112    JAQ54210.1    GCES01126123    JAQ60199.1   

Proteomes

UP000005204    UP000053240    UP000007151    UP000053268    UP000076502    UP000007819    + More
UP000078542    UP000000311    UP000215335    UP000015103    UP000075809    UP000053097    UP000005205    UP000279307    UP000078540    UP000053825    UP000002358    UP000078492    UP000242457    UP000078541    UP000053105    UP000007755    UP000008237    UP000242188    UP000005408    UP000009046    UP000192223    UP000095301    UP000192220    UP000002852    UP000028760    UP000030746    UP000265180    UP000186698    UP000005226    UP000001038    UP000261500    UP000261480    UP000265200    UP000007754    UP000000589    UP000018467    UP000010552    UP000252040    UP000000437    UP000261560    UP000248483    UP000248481    UP000265300    UP000245320    UP000245341    UP000016665    UP000248484    UP000011712    UP000233140    UP000261360    UP000002494    UP000001075    UP000261540    UP000008143    UP000233220    UP000008225    UP000261420   

PRIDE

H9JV68    Q2EY15    F1LNL1    G3GRK7    Q2VWP9   

Pfam

PF07679   I-set        + More
PF00041   fn3
PF00047   ig
PF00160   Pro_isomerase
PF13895   Ig_2
PF06583   Neogenin_C

Interpro

IPR036116   FN3_sf        + More
IPR003961   FN3_dom       
IPR007110   Ig-like_dom       
IPR003599   Ig_sub       
IPR013783   Ig-like_fold       
IPR003598   Ig_sub2       
IPR036179   Ig-like_dom_sf       
IPR013106   Ig_V-set       
IPR013098   Ig_I-set       
IPR013151   Immunoglobulin       
IPR029000   Cyclophilin-like_dom_sf       
IPR002130   Cyclophilin-type_PPIase_dom       
IPR033011   Protogenin       
IPR032983   CDO       
IPR010560   Neogenin_C       
IPR033024   Neogenin       

SUPFAM

SSF48726   SSF48726        + More
SSF49265   SSF49265       
SSF50891   SSF50891       

Gene 3D

2.60.40.10     2.40.100.10    

CDD

cd00063  FN3

ProteinModelPortal

H9JV68   A0A2W1B6J0   A0A2H1VA08   A0A194QPT3   A0A212EUR8   A0A194Q7Y9   + More
A0A1B6CPK8   A0A0A9YRL0   A0A146LZX6   A0A154PAX5   J9K5G9   A0A151ICH3   E2ACC0   A0A232FFW8   T1I3G6   A0A151XAF1   A0A026WYR5   A0A158NH66   A0A3L8DR13   A0A195B7T0   A0A0L7RGL8   K7J2J3   A0A195DYD2   E9ILA7   A0A2A3EDT2   A0A195FGB5   A0A224XB00   A0A0N0U2W3   F4WZW8   A0A2H8TTV7   A0A2S2PYT6   A0A2S2R0E9   E2BAR8   A0A0C9RAR6   A0A0C9Q7N4   A0A210PQC4   K1QDZ3   E0VB26   A0A1W4WN68   A0A1W4WNF4   A0A1W4WM82   A0A1I8M4Q9   A0A315W3T1   A0A2I4BMP9   M3ZWX6   A0A087XDF7   V4B3D1   A0A3P9KPA6   A0A1L8H0F6   A0A1L8GT09   A0A1A7ZPX9   H2V9N8   H2LL58   A0A3B3UKM6   A0A3P9KVP9   A0A3B3XK00   A0A3P9IUK2   H0ZFQ2   Q2EY15   W5LKD3   L5K259   H2LVL0   A0A3P9H6W3   D2XNJ9   Q8JI27   A0A341D954   A0A2R8Q867   A0A3B3C995   Q801M2   A0A0R4IIB3   A0A2Y9NVR6   A0A2Y9HIH3   A0A340WH06   A0A2U4CMM3   H0ZFQ6   A0A0R4IP15   A0A384B646   A0A2U3XKT0   U3K682   A0A2Y9T0U4   M3WJ04   A0A2K5ZSF1   A4JYE1   A0A3B4Y0A0   F1LNL1   Q08CP3   G3GRK7   Q2VWP9   A0A3B3QHH1   F6U1B6   A0A2K6T1I7   F6W492   A0A146QEZ4   A0A3B4VEF8   A0A146QVT3  

PDB

5E4I     E-value=2.1476e-23,     Score=271

KEGG

101744081    no KO assigned | (RefSeq) hemicentin-2-like

GO

GO:0016021   GO:0003755   GO:0007275   GO:0051260   GO:0098632   GO:0070593   GO:0007411   GO:0050768   GO:0030424   GO:0038023   GO:0005886   GO:0007156   GO:0001756   GO:0005887   GO:0030513   GO:0007399   GO:0001841   GO:0055072   GO:0005515   GO:0006457   GO:0006355   GO:0007179   GO:0045211   GO:0006281   GO:0048384  

PANTHER

PTHR13817:SF79   PTHR44170:SF1   PTHR44170:SF14  

Subcellular location

Membrane  

Length:

575

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0516500000000001

Exp number, first 60 AAs:

0.00293

Total prob of N-in:

0.00370

outside

1  -  575

 

 

Pi

213.134241

Theta

167.477516

Tajima's D

0.369528

CLR

0.326741

CSRT

0.477526123693815

Interpretation

Uncertain