Gene

KWMTBOMO03145

Pre Gene Modal

BGIBMGA013475

Annotation

PREDICTED:_mothers_against_decapentaplegic_homolog_6_[Amyelois_transitella]

Location

Bomo_Chr6(-):73640-98955      View in EpiBrowser

Full name

Mothers against decapentaplegic homolog       + More
Mothers against decapentaplegic homolog 6      

Alternative Name

SMAD family member
SMAD family member 6
Mad homolog 7

Transcription factor

MH1

Location in the cell

Mitochondrial   Reliability : 1.123 Nuclear   Reliability : 1.618

CDS

ATGTTCCGGCGTCGCGCGCTGCGTCGGCGGCTGGCGTCGCTAGGAGTAGCGGCGGTGCCTGACGACGTGCTGCGAAGGCTGGCGCGGGCGCTGGACGCGGGGCCCGGCGGTGCCCTGTGCGTACCGCCCGCGCCGCCTGATGACCGTAGGCTGCGCCTCGCGCTCGCCAGGGCCTTCTGCTTCCCAGACCTGCGCGACCTGTCCGAGCTGCGTCGGATGCCTCACTGCACCGACAATTCCTGCTGCAACCCTTACCACTGGAGTCGTCTCTGCAAACCCGAAACCCCCCCGCCGCCATACACTCGTTTTGCCATGGATGACTATAAACCTAAAGATCACGGAGAGAGCACGGAAGACGCGCGGAGGACAGACCACGAGCGGTTTGACTCTGGCTCCATGGCTACTGACGGAGAAGAGCGTCAGAGTTGGGAGACAGAGTGGTGTCGGCTCGCATACTGGGAGCTGACGCAGCGCGTGGGCCGTCAGTTCGGCGTGAGGATGCGCGCCGTGGACGTGTTCGGCGGAGGAGGCGGCGCGTGCGGCTCCGGCCGGCACGGCCTGTGTCTGGACGCGCTCGACCGCGTCGACCACCGCCCCGACCTGGCGCAGCCCGACCAGGTCCGCAAGACTCGTGCCAAGATAGGGCTGGGCGTGACGCTGTCGCTGGAGGGCGACGGCGTGTGGGTGTACAACCGCGGCGCCGAGCCGGTGTTCGTGTCGTCGCCGGCGCTGGACGCGGCGGCGGCGCGGGCGCTGCTGGTGTGGCGCGTGGCGGCCGGCCACTGTCTGCGCGTGTTCCCGCCGCCCCCCTTCGCCGCGCCGCGCCCCGCCCCGCCGCGCCCCGCCCTGCCGCGCGACCCCCGCTCGGTGCGCATCTCGTTCGCGAAGGGCTGGGGGCCAAAGTACTCGCGACGTGACGTCACAGCGTGCCCGTGTTGGCTTGAGGTGCTGCTGGCGCCGCCCAGCTGA

Protein

MFRRRALRRRLASLGVAAVPDDVLRRLARALDAGPGGALCVPPAPPDDRRLRLALARAFCFPDLRDLSELRRMPHCTDNSCCNPYHWSRLCKPETPPPPYTRFAMDDYKPKDHGESTEDARRTDHERFDSGSMATDGEERQSWETEWCRLAYWELTQRVGRQFGVRMRAVDVFGGGGGACGSGRHGLCLDALDRVDHRPDLAQPDQVRKTRAKIGLGVTLSLEGDGVWVYNRGAEPVFVSSPALDAAAARALLVWRVAAGHCLRVFPPPPFAAPRPAPPRPALPRDPRSVRISFAKGWGPKYSRRDVTACPCWLEVLLAPPS

Description

Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes. May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions.
Binds to regulatory elements in target promoter regions (By similarity). May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding (By similarity). Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes.
Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling, preventing NF-kappa-B activation, and BMP-SMAD1 signaling pathway. Binds to regulatory elements in target promoter regions (By similarity).

Subunit

Interacts with NEDD4L (By similarity). Interacts with WWP1 (By similarity). Interacts with STAMBP and PRKX. Interacts with RNF111 and AXIN1. Interacts with TGF-beta type I receptor superfamily members, including ACVR1B, BMPR1B and TGFBR1. In response to BMP2, but not to TGFB treatment, interacts with SMAD1, but not with SMAD2, nor with SMAD4; this interaction may inhibit SMAD1 binding to SMAD4. Interacts with HOXC8 and HOXC9. Interacts with PELI1; this interaction interferes with PELI1 complex formation with TRAF6, IRAK1, IRAK4 and MYD88 in response to IL1B and hence negatively regulates IL1R-TLR signaling.
Interacts with NEDD4L. Interacts with WWP1. Interacts with STAMBP and PRKX (By similarity). Interacts with RNF111 and AXIN1. Interacts with TGF-beta type I receptor superfamily members, including ACVR1B, BMPR1B and TGFBR1. In response to BMP2 treatment, interacts with SMAD1; this interaction may inhibit SMAD1-binding to SMAD4. Interacts with HOXC8 and HOXC9 (By similarity). Interacts with PELI1; this interaction interferes with PELI1 complex formation with TRAF6, IRAK1, IRAK4 and MYD88 in response to IL1B and hence negatively regulates IL1R-TLR signaling.

Similarity

Belongs to the dwarfin/SMAD family.

Keywords

Alternative splicing   Complete proteome   Craniosynostosis   Disease mutation   DNA-binding   Isopeptide bond   Metal-binding   Methylation   Nucleus   Phosphoprotein   Polymorphism   Reference proteome   Transcription   Transcription regulation   Ubl conjugation   Zinc  

Feature

chain  Mothers against decapentaplegic homolog
splice variant  In isoform B.
sequence variant  In CRS7; associated with disease susceptibility.

Uniprot

A0A2A4JL28   A0A194Q1S7   A0A067QH14   A0A1B6D1W7   A0A1B6KBR2   A0A1B6HX09   + More
A0A1B6FLX6   A0A2H8TWX8   J9KAL4   A0A1W4WBD3   A0A088AG08   A0A158NLE2   A0A1Y1KHV7   A0A2S2R9Z4   A0A0L7QLV9   A0A2S2QEW2   A0A195CZP9   A0A3L8D728   A0A154NYQ8   A0A195F1C0   A0A151XCF7   A0A0A9WFP9   A0A0K8S971   A0A1S3EPF8   F6ZM58   A0A383YTH8   H2NNK1   G9KQ25   A0A1D5QSL6   F6RB41   A0A2K5VS10   A0A1D5Q8K4   G3RB41   G3W192   I3LX61   A0A2K6M3E1   A0A218V124   A0A2I3HZI2   U6DB10   U3KEF4   A0A2K5KI94   A0A1S3K878   A0A2J8UC48   A0A2J8NR46   O43541   A0A2K6CDL1   A0A0D9RLC6   A0A1A8RIW1   A0A2K6EJ18   K6ZBV0   A0A2K5QQR8   A0A2K5C913   M3WGP4   A0A2I0MD85   U3B961   A0A2R8MQJ0   A0A2Y9HJN0   K7CVP9   A0A151M8V2   A0A1U8C050   E1BH37   A0A2Y9FP97   O35182   A0A340WME7   F1SJJ2   A0A2Y9NWK6   L5K1U7   L5LF53   A0A2U3WYJ5   H0XD56   Q80ZV9   A0A2I3NFA6   A0A2Y9K338   M3XMK5   F6RFA7   W5QA49   A0A1D5PB14   A0A3L8SK14   Q9W734   C3U1W5   A0A0Q3UPN4   A0A2Y9FZG9   A0A1V4JE69   G3TB12   G3T436   A0A1A8K1D1   A0A1A8PC92   A0A1A8I2H9   A0A1A8PBR8   A0A1A8D859   A0A1A7ZSU1   H3A8S2   A0A0S7HG99   A0A3P8TU61  

Pubmed

26354079    24845553    21347285    28004739    30249741    25401762    + More
26823975    19892987    23236062    17431167    22398555    21709235    8673135    9436979    9712726    15489334    9759503    10647776    10708948    10708949    10722652    11284962    11483516    14657019    16601693    16951688    16491121    22275001    23455153    27606499    16136131    17975172    23371554    25243066    22293439    19393038    9335505    16141072    15221015    15496141    23747011    23610558    30723633    23258410    17495919    20809919    15592404    30282656    10525349    19352514    9215903   

EMBL

NWSH01001073    PCG72757.1    KQ459579    KPI99532.1    KK853452    KDR07534.1    + More
GEDC01017990    GEDC01017599    GEDC01000058    JAS19308.1    JAS19699.1    JAS37240.1    GEBQ01031122    JAT08855.1    GECU01028485    JAS79221.1    GECZ01018572    JAS51197.1    GFXV01006952    MBW18757.1    ABLF02021478    ADTU01019326    ADTU01019327    ADTU01019328    ADTU01019329    ADTU01019330    ADTU01019331    ADTU01019332    ADTU01019333    GEZM01086045    JAV59820.1    GGMS01016969    MBY86172.1    KQ414914    KOC59534.1    GGMS01007063    MBY76266.1    KQ977115    KYN05614.1    QOIP01000012    RLU16074.1    KQ434773    KZC04010.1    KQ981864    KYN34370.1    KQ982314    KYQ58027.1    GBHO01037378    GBHO01031713    GDHC01002996    JAG06226.1    JAG11891.1    JAQ15633.1    GBRD01015999    JAG49827.1    ABGA01218410    ABGA01218411    ABGA01218412    ABGA01218413    AC188093    JP018406    AES07004.1    JSUE03038580    AQIA01063082    CABD030096845    CABD030096846    AEFK01007919    AEFK01007920    AEFK01007921    AEFK01007922    AGTP01003289    AGTP01003290    MUZQ01000079    OWK59420.1    ADFV01035931    ADFV01035932    ADFV01035933    ADFV01035934    ADFV01035935    ADFV01035936    HAAF01007987    CCP79811.1    AGTO01020820    NDHI03003463    PNJ42857.1    NBAG03000224    PNI74239.1    U59914    AF035528    AF043640    AF037469    AF041065    AF041062    AF041063    AF041064    AM909653    BC012986    AF101474    AQIB01139235    AQIB01139236    HAEI01008661    SBS05632.1    AACZ04064628    AACZ04064629    GABC01009282    GABF01008990    GABE01005911    JAA02056.1    JAA13155.1    JAA38828.1    AANG04001761    AKCR02000019    PKK27639.1    GAMT01009747    JAB02114.1    GABD01004337    GABD01004335    JAA28765.1    AKHW03006295    KYO20946.1    AF010133    AK004671    AEMK02000004    DQIR01023642    HCZ79117.1    KB031042    ELK05307.1    KB112376    ELK24837.1    AAQR03026100    AAQR03026101    AAQR03026102    AAQR03026103    BC047280    AAH47280.1    AHZZ02031197    AEYP01046988    AMGL01101877    AMGL01101878    AADN05000047    QUSF01000015    RLW03532.1    AF165889    FJ417094    ACO82015.1    LMAW01003223    KQK73306.1    LSYS01007908    OPJ70325.1    HAEE01006016    SBR26036.1    HAEF01013011    HAEG01007335    SBR79005.1    HAED01005744    SBQ91774.1    HAEH01006250    SBR78721.1    HADZ01020883    HAEA01001827    SBQ30307.1    HADY01006550    HAEJ01003687    SBP45035.1    AFYH01123852    AFYH01123853    AFYH01123854    GBYX01441391    JAO39983.1   

Proteomes

UP000218220    UP000053268    UP000027135    UP000007819    UP000192223    UP000005203    + More
UP000005205    UP000053825    UP000078542    UP000279307    UP000076502    UP000078541    UP000075809    UP000081671    UP000002281    UP000261681    UP000001595    UP000006718    UP000233100    UP000001519    UP000007648    UP000005215    UP000233180    UP000197619    UP000001073    UP000016665    UP000233060    UP000085678    UP000005640    UP000233120    UP000029965    UP000233160    UP000002277    UP000233040    UP000233020    UP000011712    UP000053872    UP000008225    UP000248481    UP000050525    UP000189706    UP000009136    UP000248484    UP000000589    UP000265300    UP000008227    UP000248483    UP000010552    UP000245340    UP000005225    UP000028761    UP000248482    UP000000715    UP000002280    UP000002356    UP000000539    UP000276834    UP000051836    UP000248480    UP000190648    UP000007646    UP000008672    UP000265080   

PRIDE

O43541    O35182    F1SJJ2   

Pfam

PF03166   MH2        + More
PF03165   MH1
PF00240   ubiquitin
PF09817   Zwilch

Interpro

IPR003619   MAD_homology1_Dwarfin-type        + More
IPR017855   SMAD-like_dom_sf       
IPR001132   SMAD_dom_Dwarfin-type       
IPR013019   MAD_homology_MH1       
IPR036578   SMAD_MH1_sf       
IPR008984   SMAD_FHA_dom_sf       
IPR013790   Dwarfin       
IPR029071   Ubiquitin-like_domsf       
IPR000626   Ubiquitin_dom       
IPR018630   Zwilch       

SUPFAM

SSF49879   SSF49879        + More
SSF56366   SSF56366       
SSF54236   SSF54236       

Gene 3D

2.60.200.10     3.90.520.10    

ProteinModelPortal

A0A2A4JL28   A0A194Q1S7   A0A067QH14   A0A1B6D1W7   A0A1B6KBR2   A0A1B6HX09   + More
A0A1B6FLX6   A0A2H8TWX8   J9KAL4   A0A1W4WBD3   A0A088AG08   A0A158NLE2   A0A1Y1KHV7   A0A2S2R9Z4   A0A0L7QLV9   A0A2S2QEW2   A0A195CZP9   A0A3L8D728   A0A154NYQ8   A0A195F1C0   A0A151XCF7   A0A0A9WFP9   A0A0K8S971   A0A1S3EPF8   F6ZM58   A0A383YTH8   H2NNK1   G9KQ25   A0A1D5QSL6   F6RB41   A0A2K5VS10   A0A1D5Q8K4   G3RB41   G3W192   I3LX61   A0A2K6M3E1   A0A218V124   A0A2I3HZI2   U6DB10   U3KEF4   A0A2K5KI94   A0A1S3K878   A0A2J8UC48   A0A2J8NR46   O43541   A0A2K6CDL1   A0A0D9RLC6   A0A1A8RIW1   A0A2K6EJ18   K6ZBV0   A0A2K5QQR8   A0A2K5C913   M3WGP4   A0A2I0MD85   U3B961   A0A2R8MQJ0   A0A2Y9HJN0   K7CVP9   A0A151M8V2   A0A1U8C050   E1BH37   A0A2Y9FP97   O35182   A0A340WME7   F1SJJ2   A0A2Y9NWK6   L5K1U7   L5LF53   A0A2U3WYJ5   H0XD56   Q80ZV9   A0A2I3NFA6   A0A2Y9K338   M3XMK5   F6RFA7   W5QA49   A0A1D5PB14   A0A3L8SK14   Q9W734   C3U1W5   A0A0Q3UPN4   A0A2Y9FZG9   A0A1V4JE69   G3TB12   G3T436   A0A1A8K1D1   A0A1A8PC92   A0A1A8I2H9   A0A1A8PBR8   A0A1A8D859   A0A1A7ZSU1   H3A8S2   A0A0S7HG99   A0A3P8TU61  

PDB

1DEV     E-value=2.03661e-09,     Score=148

KEGG

101744507    K04677 mothers against decapentaplegic homolog 6 | (RefSeq) mothers against decapentaplegic homolog

PATHWAY

04350    TGF-beta signaling pathway - Bombyx mori (domestic silkworm)

GO

GO:0003677   GO:0005634   GO:0007179   GO:0005737   GO:0003700   GO:0005667   GO:0006355   GO:0042802   GO:0008285   GO:0070411   GO:0035904   GO:0001657   GO:0003180   GO:0030509   GO:0003682   GO:0003183   GO:0030512   GO:0007352   GO:0031589   GO:0003148   GO:0010991   GO:0003184   GO:1902895   GO:0045444   GO:0005794   GO:0034616   GO:0045668   GO:0031625   GO:0060976   GO:0030617   GO:0016604   GO:0030514   GO:0070698   GO:0000978   GO:0005829   GO:0003281   GO:0043066   GO:0070410   GO:0060394   GO:0034713   GO:0006955   GO:0032496   GO:0070412   GO:0030279   GO:0032991   GO:0000981   GO:0044212   GO:0043627   GO:0046872   GO:0003170   GO:0097756   GO:0045907   GO:0060977   GO:0060948   GO:1990423   GO:0007093   GO:0032331   GO:0010693   GO:1902832   GO:0050767   GO:1902844   GO:0005768   GO:0005622   GO:0005515   GO:0016021   GO:0045211   GO:0006281   GO:0048384  

PANTHER

PTHR13703  

Subcellular location

Cytoplasm  
Nucleus  

Length:

322

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.03839

Exp number, first 60 AAs:

0.0036

Total prob of N-in:

0.15693

outside

1  -  322

 

 

Pi

208.862164

Theta

187.210304

Tajima's D

0.502859

CLR

0.749169

CSRT

0.51982400879956

Interpretation

Uncertain