Gene

KWMTBOMO03118  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA005794

Annotation

ubiquinone_biosynthesis_protein_COQ7-like_protein_[Bombyx_mori]

Location

Bomo_Chr5(-):18631000-18637962      View in EpiBrowser

Full name

5-demethoxyubiquinone hydroxylase, mitochondrial      

Alternative Name

Ubiquinone biosynthesis monooxygenase COQ7

Location in the cell

Mitochondrial   Reliability : 2.823

CDS

ATGCGATCACCACTGATTCAACACATCAGATTGGCGCACAGCAGCAGTCGACCTTATTGGAAGAAAAATCCACACCTTGACCAGATAATCCGAGTGGATCACGCCGGTGAATTGGGCGCGGACCGCATCTACGCGGGACAAATGGCAGTCTTGGGCCGCACAGCTGAAGGACCCCTCATCCAGCACATGTGGGACCAGGAGAAGAAGCACAGGGAGAAATTTGAGCAGCTCATCAATGAGTACAGAGTGAGACCTACTGTACTCACTCCGATATGGAATGTGGCAGGATTTGTATTAGGAGCTGGCACAGCGCTCCTCGGCAAAGAGGCGGCCATGGCCTGCACCGTCGCCGTCGAAACGGTAATCGTTGACCACTACAACGACCAGCTGCGTACACTGATGCAGGACCCAAACGTGGACAAAGAGATCCTGGAGACGATCACCAGGTTCAGGGACGAGGAGCAGGAGCACCACGACGCGGGGCTGCAGCACGGCGCCGAGCAGGCCCCCGGCTACCGCGCGCTCACCGAGCTCATCAAGGCGGGCTGCCGGGCCGCCATACAGCTCTCCAAGAAGATATAG

Protein

MRSPLIQHIRLAHSSSRPYWKKNPHLDQIIRVDHAGELGADRIYAGQMAVLGRTAEGPLIQHMWDQEKKHREKFEQLINEYRVRPTVLTPIWNVAGFVLGAGTALLGKEAAMACTVAVETVIVDHYNDQLRTLMQDPNVDKEILETITRFRDEEQEHHDAGLQHGAEQAPGYRALTELIKAGCRAAIQLSKKI

Description

Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.

Cofactor

Fe cation

Subunit

Component of a multi-subunit COQ enzyme complex.

Similarity

Belongs to the COQ7 family.

Uniprot

Q2F6B9   A0A2A4JB64   A0A2W1BBZ4   A0A2H1VMU5   A0A212EQQ7   I4DKZ7   + More
A0A194PVL0   A0A0N1IFT8   A0A1E1WKZ6   H9J8F2   A0A1L8DJA8   E9IK58   A0A151XG66   R4UMT3   A0A1W4XVY8   A0A1B0CSY8   A0A0M8ZV96   A0A151JRK3   A0A195F0T0   A0A2A3ER32   V9IGF7   A0A0L7R1M3   A0A154P525   A0A1Y1N5Q6   A0A2J7R3I1   Q6J4P7   A0A087ZZV1   D6WNX7   A0A158P3P9   A0A0J7KYZ1   A0A026VTK9   A0A0K8TQB8   J3JWI1   B4PZ79   A0A195CTL0   Q9W3W4   B4I056   Q9TVU0   B3NXV8   Q29IL9   B4H2P7   B4NCD1   A0A1A9VNF6   A0A1A9XKH5   A0A0C9RQ43   A0A1B6M125   B4M6Z8   A0A1J1HT57   A0A1B6E0A0   A0A1W4VEW4   T1P930   B3GC70   B3GC59   A0A067RG91   A0A1B6DPA5   A0A1L8EH28   A0A1W4VSB8   A0A1L8EHC1   B3GC64   D3TN00   B3GC74   A0A0M3QZE4   B3GC65   A0A182M5J4   B4JLV4   A0A182RVT7   A0A0L0CJ08   A0A182Y7U5   A0A182QV12   A0A182NAF6   A0A182PFA9   B4L522   A0A182W421   A0A0A1XJB0   A0A182S879   A0A034VEK2   A0A0K8WLN0   A0A336KLJ8   W8BPR0   A0A182V4E8   A0A182HIJ1   A0A182TFB8   A0A182WY79   Q7PRZ9   A0A084VQA9   A0A182JLU5   K7IUL8   C4WSL9   A0A232ENW1   A0A2S2PMU0   A0A2H8U054   A0A0P4WA62   A0A1S3D2H4   A0A1S3DNL0   A0A2M4AQ37   W5JEX7   A0A2M3ZJ20   A0A023F7U2   A0A0V0GBL4   A0A2M4C0J9  

EC Number

1.14.13.-

Pubmed

28756777    22118469    22651552    26354079    19121390    21282665    + More
28004739    11932240    18362917    19820115    21347285    24508170    30249741    26369729    22516182    23537049    17994087    17550304    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    15632085    25315136    18495616    24845553    20353571    26108605    25244985    25830018    25348373    24495485    12364791    14747013    17210077    24438588    20075255    28648823    20920257    23761445    25474469   

EMBL

DQ311153    ABD36098.1    NWSH01002037    PCG69347.1    KZ150156    PZC72772.1    + More
ODYU01003405    SOQ42127.1    AGBW02013246    OWR43833.1    AK401965    BAM18587.1    KQ459597    KPI95165.1    KQ460970    KPJ10192.1    GDQN01009821    GDQN01003523    GDQN01000494    JAT81233.1    JAT87531.1    JAT90560.1    BABH01027332    GFDF01007629    JAV06455.1    GL763924    EFZ19000.1    KQ982174    KYQ59373.1    KC571911    AGM32410.1    AJWK01026782    AJWK01026783    AJWK01026784    AJWK01026785    AJWK01026786    AJWK01026787    AJWK01026788    AJWK01026789    KQ435863    KOX70323.1    KQ978589    KYN29972.1    KQ981880    KYN33971.1    KZ288194    PBC33964.1    JR046381    AEY60183.1    KQ414667    KOC64765.1    KQ434809    KZC06288.1    GEZM01012102    GEZM01012101    JAV93204.1    NEVH01007819    PNF35375.1    AY601644    AAT12412.1    KQ971343    EFA04400.1    ADTU01008314    LBMM01001776    KMQ95762.1    KK107957    QOIP01000010    EZA47077.1    RLU17564.1    GDAI01001026    JAI16577.1    BT127599    KB632400    AEE62561.1    ERL94902.1    CM000162    EDX01046.2    KQ977304    KYN03832.1    AE014298    BT031015    AAF46199.2    ABV82397.1    CH480819    EDW52887.1    AJ252202    AJ252203    CAB64656.1    CH954180    EDV47409.2    CH379063    EAL32634.2    CH479204    EDW30614.1    CH964239    EDW82490.2    GBYB01009301    JAG79068.1    GEBQ01010354    JAT29623.1    CH940653    EDW62565.1    CVRI01000014    CRK89654.1    GEDC01013220    GEDC01005959    GEDC01002061    GEDC01000455    JAS24078.1    JAS31339.1    JAS35237.1    JAS36843.1    KA644655    AFP59284.1    EU669751    EU669752    EU669753    EU669754    EU669756    ACD69509.1    ACD69510.1    ACD69511.1    ACD69512.1    ACD69514.1    EU669740    EU669741    EU669742    EU669743    EU669744    EU669747    EU669748    EU669749    EU669750    ACD69498.1    ACD69499.1    ACD69500.1    ACD69501.1    ACD69502.1    ACD69505.1    ACD69506.1    ACD69507.1    ACD69508.1    KK852486    KDR22792.1    GEDC01009790    GEDC01006099    JAS27508.1    JAS31199.1    GFDG01000782    JAV18017.1    GFDG01000783    JAV18016.1    EU669745    ACD69503.1    EZ422802    ADD19078.1    EU669755    ACD69513.1    CP012528    ALC49229.1    EU669746    ACD69504.1    AXCM01006929    CH916371    EDV91715.1    JRES01000328    KNC32245.1    AXCN02002022    CH933811    EDW06281.1    GBXI01003206    JAD11086.1    GAKP01018410    JAC40542.1    GDHF01021262    GDHF01000231    JAI31052.1    JAI52083.1    UFQS01000611    UFQT01000611    SSX05369.1    SSX25730.1    GAMC01003340    JAC03216.1    APCN01003979    AAAB01008846    EAA06356.4    ATLV01015171    KE525003    KFB40153.1    AAZX01008756    ABLF02021134    AK340245    BAH70889.1    NNAY01003055    OXU20044.1    GGMR01018143    MBY30762.1    GFXV01007744    MBW19549.1    GDRN01060813    JAI65300.1    GGFK01009407    MBW42728.1    ADMH02001354    ETN62902.1    GGFM01007689    MBW28440.1    GBBI01001409    JAC17303.1    GECL01000760    JAP05364.1    GGFJ01009661    MBW58802.1   

Proteomes

UP000218220    UP000007151    UP000053268    UP000053240    UP000005204    UP000075809    + More
UP000192223    UP000092461    UP000053105    UP000078492    UP000078541    UP000242457    UP000053825    UP000076502    UP000235965    UP000005203    UP000007266    UP000005205    UP000036403    UP000053097    UP000279307    UP000030742    UP000002282    UP000078542    UP000000803    UP000001292    UP000008711    UP000001819    UP000008744    UP000007798    UP000078200    UP000092443    UP000008792    UP000183832    UP000192221    UP000095301    UP000027135    UP000092553    UP000075883    UP000001070    UP000075900    UP000037069    UP000076408    UP000075886    UP000075884    UP000075885    UP000009192    UP000075920    UP000075901    UP000075903    UP000075840    UP000075902    UP000076407    UP000007062    UP000030765    UP000075880    UP000002358    UP000007819    UP000215335    UP000079169    UP000000673   

PRIDE

Q2F6B9    H9J8F2    Q9W3W4    Q9TVU0   

Pfam

PF03232   COQ7

Interpro

IPR009078   Ferritin-like_SF        + More
IPR011566   Ubq_synth_Coq7       
IPR016084   Haem_Oase-like_multi-hlx       

SUPFAM

SSF47240   SSF47240       

Gene 3D

1.20.910.10    

CDD

cd01042  DMQH

ProteinModelPortal

Q2F6B9   A0A2A4JB64   A0A2W1BBZ4   A0A2H1VMU5   A0A212EQQ7   I4DKZ7   + More
A0A194PVL0   A0A0N1IFT8   A0A1E1WKZ6   H9J8F2   A0A1L8DJA8   E9IK58   A0A151XG66   R4UMT3   A0A1W4XVY8   A0A1B0CSY8   A0A0M8ZV96   A0A151JRK3   A0A195F0T0   A0A2A3ER32   V9IGF7   A0A0L7R1M3   A0A154P525   A0A1Y1N5Q6   A0A2J7R3I1   Q6J4P7   A0A087ZZV1   D6WNX7   A0A158P3P9   A0A0J7KYZ1   A0A026VTK9   A0A0K8TQB8   J3JWI1   B4PZ79   A0A195CTL0   Q9W3W4   B4I056   Q9TVU0   B3NXV8   Q29IL9   B4H2P7   B4NCD1   A0A1A9VNF6   A0A1A9XKH5   A0A0C9RQ43   A0A1B6M125   B4M6Z8   A0A1J1HT57   A0A1B6E0A0   A0A1W4VEW4   T1P930   B3GC70   B3GC59   A0A067RG91   A0A1B6DPA5   A0A1L8EH28   A0A1W4VSB8   A0A1L8EHC1   B3GC64   D3TN00   B3GC74   A0A0M3QZE4   B3GC65   A0A182M5J4   B4JLV4   A0A182RVT7   A0A0L0CJ08   A0A182Y7U5   A0A182QV12   A0A182NAF6   A0A182PFA9   B4L522   A0A182W421   A0A0A1XJB0   A0A182S879   A0A034VEK2   A0A0K8WLN0   A0A336KLJ8   W8BPR0   A0A182V4E8   A0A182HIJ1   A0A182TFB8   A0A182WY79   Q7PRZ9   A0A084VQA9   A0A182JLU5   K7IUL8   C4WSL9   A0A232ENW1   A0A2S2PMU0   A0A2H8U054   A0A0P4WA62   A0A1S3D2H4   A0A1S3DNL0   A0A2M4AQ37   W5JEX7   A0A2M3ZJ20   A0A023F7U2   A0A0V0GBL4   A0A2M4C0J9  

KEGG

100101152    K06134 3-demethoxyubiquinol 3-hydroxylase [EC:1.14.99.60] | (RefSeq) ubiquinone biosynthesis protein

PATHWAY

00130    Ubiquinone and other terpenoid-quinone biosynthesis - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0046872   GO:0031314   GO:0006744   GO:0016709   GO:0055114   GO:2000377   GO:0005743   GO:0005634   GO:0008682   GO:0008340   GO:0010468   GO:0004896   GO:0016020   GO:0004889   GO:0005216   GO:0006811   GO:0016021   GO:0045211   GO:0006281   GO:0048384  

PANTHER

PTHR11237  

Subcellular location

Mitochondrion inner membrane  

Length:

193

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

3.92624

Exp number, first 60 AAs:

0.00115

Total prob of N-in:

0.21295

outside

1  -  193

 

 

Pi

15.925409

Theta

17.088444

Tajima's D

0.245563

CLR

1.053493

CSRT

0.450827458627069

Interpretation

Uncertain