Gene

KWMTBOMO03116  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA005772

Annotation

neuroglian_[Mythimna_separata]

Location

Bomo_Chr5(+):18566213-18606277      View in EpiBrowser

Full name

Neuroglian      

Location in the cell

Cytoplasmic   Reliability : 1.05 Extracellular   Reliability : 1.055

CDS

ATGGATACGAGCAGAATTCTGTGTTTCATAGCGTTAGTCTCGCAGGCCGCTGCTTTATTAACATCTCCACCAAAAATCGTGAAGCAACCGACTCAGGAAGAAATCCTGTTCCAAGTGGCGCAACAGGGAGAAGTGGATAAACCTTTTATTATAGAGTGCGAGGCTGAAGGAGAACCAGCACCTAAGTACAAATGGATCAAAAACGGCAAATCATTCGAATACTCGAGCTACGACAACCGTATCTCGCAACAAACCGGTCGAGGTACTCTCGTCATCAGCAAGCCCAAGGAGGAAGATCTGGGACAGTACCAGTGCTTCGCCTACAACGAGTGGGGAACCGCTGCATCCAACTCGGTCTTTGTAAGGAGAGCCGAGCTCAATTCCTTCAAGGAAACCGATGGTCAGCAAGTTGTGAGAGCTGAAGAAGGTAAACCTTATAAGCTGACGTGCGAGCCCCCGGACGGTCATCCGAAGCCCAAGGTCTACTGGATGTTGCAAGGGGACCAGGGTCAGCTGAAGACGATCAACAACTCTCGTATGACACTCGACCCGGAAGGAAACCTCTGGTTCTCCAACGTGACCCAAAACGACGCCAGCGAAGATTACGCGTACATCTGCACGGCCAACTCCGGCTTCAGAAATGAATACAAAGTTGGGAACAAGATCTACCTTCAGGTCATCCCGACCGGCATCTCGCCGACACTCAACCGACACGAGCCTGTGCGCCAGTACACCACCAGGAAGATCGAGAGAGGCCTCAAGGGTCAGCGCGTGGAGCTCTACTGCATCTACGGCGGAACGCCGCTCCCTCAGATCGTATGGAAGAAGAACGGGCGCAGCATCTTGTGGTCTCAGAGCATCACCCAGGACAACTACGGGAAGACTTTAGTGATCAAGTATCCGACGTACGACGACCAGGGCACGTACACGTGCGAGGTCAGCAACGGTGTGGGCTCGGCGCAGTCCAACTCCATCCAACTCAACATCGAAGCTGCGCCATTCTTCACGGTGGAACCAGAGATCCAGAACCTAGCCGAGGGCGAGACCGCGGTCATCCGCTGCGAGGCGGACGGCACCCCGGCGCCGAAGATATCCTGGATCCACAACGGGAAGCCGATCGAGCAGGCCGAGCTGAACCCGCGCCGCCAAGTCAGCGCCAACTCCATCGTCATCACCGACCTCGTGAAGAAGGACACGGGCAACTACGGCTGCAACGCCACCAGCGCCATCGGCTACGTCTACAAGGACGTCTACATCAACGTGCAGTCCATTCCCCCTGAAATCAAGGAGGGTCCCATGAACCTGACCAACGTGGACGGCTCCGAGGCTGTGCTCAAGTGCAGAGTCTTTGGAGCACCGAAACCTATCGTTAAATGGATGAAGGACAACGTCGACGTCACAGGAGGGAAATACAACATAACGGCGGAGGGCGACCTCGTGATCCGCGACGTGTCGTTCACTGACGTGGGCACGTACCAGTGCTACGCCAAGAACAAGTTCGGCGAGACCTCCGCCTACGGATCGCTGGTGGTCAAGAAGCACACGGTGATCACGGACAAGCCGGAGCACTACGAGGTGGCGGCGGGCTCGTCGGCCACGTTCCGCTGCAACGCCAACGCGGACGACTCGCTGCCGCTGCAAATCATCTGGCTCAACGACGGCCAGCAGATCGACTTCGAGAGCCAGCCGCGCTTCCGCATGACCAACGACTACTCGCTGCTCATCTCCGACACCAGCGAGCTCGACTCCGGCCAGTACACCTGCATCGCCAGGACGCCCGTCGACGAGGCGCGCGCCCAGGCCACGCTCACCGTCCAAGGGTGTGGAGCTTGGTATTTGAGTGTGAGTGTGTGTGCAGACAAGCCGAACCCGCCGGTGCTGACGGGCGCGGAGTGCGGCGCGCGCACGGCCACGGTGCGGTGGCGGGCGGCGGGCGACAACCGCGCGCCCATCCTGCGCTACTCGCTGCACTACAACACCAGCTTCACGCCGCACGTGTGGGCCGTCGCCGCCGCCGCCGTGCCGCCAGTAGACTCCGCCTGGACCGCCGCGCTCAGCCCCTGGGCCAACTACACCTTCCGCGTGGTGGCGCACAACAAGATCGGCCCGTCAGCGCCCTCGGGCCACTCCGACGTGTGCACCACGCAGCCCGACGTGCCCTACAAGAACCCCGACAACGTGAAGGGCGAGGGCACCGACCCCACCAACATGCTCATATCGTGGACGAAAATGCCTCAAATCGAACACAACGGCCCCGGGTTCTACTATCTGGTGTCGTGGCGCCGGAACATCACGGGACAACCCTGGGAAGAGCACCAGGTCCGGGACTGGCAGCAAACCGAACACCTGGTGACCAACACCCCCACCTTCCAGCCCTACAAGATCAAGGTGACGGCGGTGAACTTCAAAGGAACATCGAACGTGACTCCCATTGAAGTGATCGGCTGGTCCGGAGAGGACCGACCCACTCAGGCTCCGGGCAACCTCAGCCTGTCCCAGGTGACGTCCGGCACCAGCGCCGTGCTCAGCTGGACTCCCGTGGCGCCGGAGTCACTGCGGGGGCACTTCAAAGGATACAAAATCCAGACCTGGACCGACGCCGAGGAGGACCGGCTCAAGGAGATCTTTGTGGAGTCCGACGCGACCAGCGCCCTCGTCAACAAGTTCAAGCCCTTCAAGAAGAACAACGTGCGCATCCTCGCCTACAACGGCCGCTTCAACGGGCCCGCCAGCGACACCCTCAGCTTCGTCACCCCCGAGGGACAGCCCTCCACCGTTCGCTCCTTCGAGGCCTACCCTATCGGCTCCTCCGCCATGCTGCTCAAGTGGGAGAAGCCCATGGAGGAGAACGGCGTCCTCACCGGCTACAAGATCTACTACAGCAAGGTGATCGCCACGGCCGTGGAGACTCCGAAGGAGCGCAAGAAGGAGATCGACCCCAAGTTCGACCGCGCCAAGCTCGCCGGCCTCGAGCCCAACACCAAGTACAGGATCGAGATCCGCGCCAAGACCAAGGCCGGCGAGGGCAAGGGCTACTACGTGGAGCAGTCCACCAACAACGTGCTCACCGCGCAGCCCGACGTGCCCGCCTTCGAGACCGAGACGCTGCCCGGGAAGGAGGGCACGGCCCACGTCATAGTCCGCTGGATCCCCTCGCTCGACGGACACGCGGGGACGCACTTCGTGGCCTGGTACCGGCTCAAGGGGCACCCCGACTGGCAGCGGACCAACGACATCACCGAGGACGACTTCGTGATCCTGACGGGGCTGGAGCCCGGCCAGCTGTACGAGGTCAAGGTCACGGTGCACGACGGCCACTACTTCAGCACCAGCGAGCTGCGGACGGTCGACACCTCCATAGTAGACGGACCGATAGTGAAGCCGGACGAGAAGATCGCGACCGCGGGCTGGTTCATCGGCGTGATGCTGGCGCTGGCCTTCCTGCTGCTGCTGCTGGTGCTGGTGTGCGTGCTGCGCAGGAACCGCGGCGGCAAGTACGACGTGCACGACCGCGAGCTGGCGCACGGCCGCAGGGACTACCCCGACGCCGGCTTCCACGAGTACACGCACCCATTGGACAACAAGTCTCGCCATTCGATGAGCAGCGGCACCAAGCCGGGGCCCGAGAGCGACACGGACTCGATGGCGGAGTACGGCGACGGAGAGACGGCCGGCATGAACGAGGACGGCTCCTTCATCGGACAGTACGGCCGGAAACGACGTCCGCCAACATCCGGCCAGCCGGACTCAGCCTCGCAAGCATTTGCAACGCTCGTTTAA

Protein

MDTSRILCFIALVSQAAALLTSPPKIVKQPTQEEILFQVAQQGEVDKPFIIECEAEGEPAPKYKWIKNGKSFEYSSYDNRISQQTGRGTLVISKPKEEDLGQYQCFAYNEWGTAASNSVFVRRAELNSFKETDGQQVVRAEEGKPYKLTCEPPDGHPKPKVYWMLQGDQGQLKTINNSRMTLDPEGNLWFSNVTQNDASEDYAYICTANSGFRNEYKVGNKIYLQVIPTGISPTLNRHEPVRQYTTRKIERGLKGQRVELYCIYGGTPLPQIVWKKNGRSILWSQSITQDNYGKTLVIKYPTYDDQGTYTCEVSNGVGSAQSNSIQLNIEAAPFFTVEPEIQNLAEGETAVIRCEADGTPAPKISWIHNGKPIEQAELNPRRQVSANSIVITDLVKKDTGNYGCNATSAIGYVYKDVYINVQSIPPEIKEGPMNLTNVDGSEAVLKCRVFGAPKPIVKWMKDNVDVTGGKYNITAEGDLVIRDVSFTDVGTYQCYAKNKFGETSAYGSLVVKKHTVITDKPEHYEVAAGSSATFRCNANADDSLPLQIIWLNDGQQIDFESQPRFRMTNDYSLLISDTSELDSGQYTCIARTPVDEARAQATLTVQGCGAWYLSVSVCADKPNPPVLTGAECGARTATVRWRAAGDNRAPILRYSLHYNTSFTPHVWAVAAAAVPPVDSAWTAALSPWANYTFRVVAHNKIGPSAPSGHSDVCTTQPDVPYKNPDNVKGEGTDPTNMLISWTKMPQIEHNGPGFYYLVSWRRNITGQPWEEHQVRDWQQTEHLVTNTPTFQPYKIKVTAVNFKGTSNVTPIEVIGWSGEDRPTQAPGNLSLSQVTSGTSAVLSWTPVAPESLRGHFKGYKIQTWTDAEEDRLKEIFVESDATSALVNKFKPFKKNNVRILAYNGRFNGPASDTLSFVTPEGQPSTVRSFEAYPIGSSAMLLKWEKPMEENGVLTGYKIYYSKVIATAVETPKERKKEIDPKFDRAKLAGLEPNTKYRIEIRAKTKAGEGKGYYVEQSTNNVLTAQPDVPAFETETLPGKEGTAHVIVRWIPSLDGHAGTHFVAWYRLKGHPDWQRTNDITEDDFVILTGLEPGQLYEVKVTVHDGHYFSTSELRTVDTSIVDGPIVKPDEKIATAGWFIGVMLALAFLLLLLVLVCVLRRNRGGKYDVHDRELAHGRRDYPDAGFHEYTHPLDNKSRHSMSSGTKPGPESDTDSMAEYGDGETAGMNEDGSFIGQYGRKRRPPTSGQPDSASQAFATLV

Description

The long isoform may play a role in neural and glial cell adhesion in the developing embryo. The short isoform may be a more general cell adhesion molecule involved in other tissues and imaginal disk morphogenesis. Vital for embryonic development. Essential for septate junctions. Septate junctions, which are the equivalent of vertebrates tight junctions, are characterized by regular arrays of transverse structures that span the intermembrane space and form a physical barrier to diffusion. Required for the blood-brain barrier formation.

Subunit

Forms a complex with Nrx and Cont.

Keywords

3D-structure   Alternative splicing   Cell adhesion   Cell junction   Cell membrane   Complete proteome   Developmental protein   Direct protein sequencing   Disulfide bond   Glycoprotein   Immunoglobulin domain   Membrane   Reference proteome   Repeat   Signal   Tight junction   Transmembrane   Transmembrane helix  

Feature

chain  Neuroglian
splice variant  In isoform A.

Uniprot

D0VY44   A0A2W1BGE0   A0A2H1VMQ7   P91767   A0A212EQR2   A0A194PPC6   + More
A0A0N1IE92   A0A1B6K0I8   A0A1L8DM81   A0A2J7PJ24   U5EU82   A0A2J7PJ23   A0A2J7PJ28   E0VWB3   A0A0A9Z9I6   A0A0A9Y9L8   A0A0L0C8N9   A0A1Q3FJR5   A0A1Q3FJL7   A0A1Q3FJH2   A0A1Q3FJF3   A0A1Q3FJP3   A0A0A9YFP0   A0A0V0G851   A0A0A9ZCK9   A0A1W4VUK4   A0A182V2N1   A0A182X573   A0A0Q9WUV5   B3NVG5   Q7PG72   P20241-2   A0A1W4VGI6   A0A2A3EQC2   B4NCI8   E1JJF9   A0A0Q5T3I4   A0A1I8M4Q6   B4Q0A3   A0A0R3P7J0   E1JJF8   P20241   Q29FM1   A0A0P8ZS96   A0A0R1EHH6   A0A3B0JXM4   A0A1I8PSB9   A0A3B0J8C5   B3N0B0   A0A1I8PS80   A0A182MZQ2   A0A224XGR9   A0A1Q3FJG2   A0A084VVR8   A0A1Q3FJI5   B4HA25   A0A088A0C7   A0A336L9G0   A0A0Q9X0E4   A0A2M3YYL2   F5HJW6   A0A0L7R1U9   A0A0A1XPS4   A0A2M4BA85   B4L315   W8ARL3   W5J7Y4   A0A154P2X8   B4JP14   A0A0Q5THL2   A0A0N1IT65   M9NEZ5   A0A2M3YYL5   A0A2M3YYM0   A0A2M4A1U8   A0A1W4X2R0   B4M1M9   A0A0R1EHL1   A0A2M4BA33   A0A158P3P7   A0A0K8WB81   A0A0K8W814   A0A2M4BA73   A0A2M4A1U2   A0A034V7N8   A0A3B0J7M4   A0A2M3YYJ9   A0A1A9V6L8   B4IJX8   A0A1A9WVD0   A0A0M5J3D9   A0A1B0G439   A0A1B0AXR8   A0A1B0GMP2   A0A151XGE0   A0A182FML2   Q16Z16   K7IUL4   A0A0Q9WVH7   A0A336MRR8  

Pubmed

28756777    9015260    22118469    26354079    20566863    25401762    + More
26823975    26108605    17994087    12364791    14747013    17210077    2805067    9666073    10731132    12537572    12537569    1693086    15459097    17893096    19349973    7512815    12537568    12537573    12537574    16110336    17569856    17569867    26109357    26109356    25315136    17550304    15632085    23185243    18057021    24438588    25830018    24495485    20920257    23761445    21347285    25348373    17510324    20075255   

EMBL

AB490501    BAI49425.1    KZ150156    PZC72775.1    ODYU01003405    SOQ42125.1    + More
U50719    AAC47451.1    AGBW02013246    OWR43836.1    KQ459597    KPI95162.1    KQ460970    KPJ10193.1    GECU01002740    JAT04967.1    GFDF01006522    JAV07562.1    NEVH01024950    PNF16340.1    GANO01002435    JAB57436.1    PNF16341.1    PNF16342.1    DS235818    EEB17669.1    GBHO01002530    GBRD01018117    GDHC01017353    GDHC01003765    JAG41074.1    JAG47710.1    JAQ01276.1    JAQ14864.1    GBHO01015288    GBRD01017682    GDHC01016665    JAG28316.1    JAG48145.1    JAQ01964.1    JRES01000755    KNC28615.1    GFDL01007303    JAV27742.1    GFDL01007330    JAV27715.1    GFDL01007275    JAV27770.1    GFDL01007295    JAV27750.1    GFDL01007323    JAV27722.1    GBHO01015279    JAG28325.1    GECL01001809    JAP04315.1    GBHO01002526    JAG41078.1    CH964239    KRF99636.1    CH954180    EDV46357.1    AAAB01008847    EAA45046.5    M28231    AF050085    AF050084    AE014298    AY058284    BT024971    X76243    X76244    KZ288194    PBC33965.1    EDW82547.1    ACZ95239.1    ACZ95241.1    AGB95180.1    KQS29945.1    CM000162    EDX02240.1    KRK06659.1    CH379066    KRT07328.1    ACZ95240.1    AGB95181.1    EAL31379.2    KRT07327.1    CH902640    KPU77357.1    KRK06660.1    OUUW01000003    SPP78106.1    SPP78105.1    EDV38314.2    KPU77356.1    GFTR01008644    JAW07782.1    GFDL01007336    JAV27709.1    ATLV01017216    KE525157    KFB42062.1    GFDL01007361    JAV27684.1    CH479235    EDW36693.1    UFQS01002439    UFQT01002439    SSX14044.1    SSX33463.1    CH933810    KRF94266.1    GGFM01000594    MBW21345.1    EGK96582.1    KQ414667    KOC64766.1    GBXI01000988    JAD13304.1    GGFJ01000760    MBW49901.1    EDW07901.2    KRF94267.1    GAMC01019325    GAMC01019324    GAMC01019323    GAMC01019322    JAB87233.1    ADMH02001982    ETN60086.1    KQ434809    KZC06285.1    CH916371    EDV92457.1    KQS29947.1    KQ435863    KOX70321.1    AFH07295.1    GGFM01000603    MBW21354.1    GGFM01000599    MBW21350.1    GGFK01001442    MBW34763.1    CH940651    EDW65583.2    KRK06658.1    GGFJ01000748    MBW49889.1    ADTU01008311    ADTU01008312    GDHF01030716    GDHF01014633    GDHF01004025    JAI21598.1    JAI37681.1    JAI48289.1    GDHF01029359    GDHF01024218    GDHF01005058    JAI22955.1    JAI28096.1    JAI47256.1    GGFJ01000761    MBW49902.1    GGFK01001463    MBW34784.1    GAKP01020419    GAKP01020418    JAC38534.1    SPP78107.1    GGFM01000602    MBW21353.1    CH480850    EDW51334.1    CP012528    ALC49261.1    CCAG010021144    JXJN01005350    AJVK01026363    AJVK01026364    AJVK01026365    AJVK01026366    AJVK01026367    KQ982174    KYQ59371.1    CH477503    EAT39893.1    AAZX01014469    KRF94268.1    UFQT01002340    SSX33234.1   

Proteomes

UP000007151    UP000053268    UP000053240    UP000235965    UP000009046    UP000037069    + More
UP000192221    UP000075903    UP000076407    UP000007798    UP000008711    UP000007062    UP000000803    UP000242457    UP000095301    UP000002282    UP000001819    UP000007801    UP000268350    UP000095300    UP000075884    UP000030765    UP000008744    UP000005203    UP000009192    UP000053825    UP000000673    UP000076502    UP000001070    UP000053105    UP000192223    UP000008792    UP000005205    UP000078200    UP000001292    UP000091820    UP000092553    UP000092444    UP000092460    UP000092462    UP000075809    UP000069272    UP000008820    UP000002358   

PRIDE

P20241    E1JJF9    E1JJF8    M9NEZ5   

Pfam

PF00041   fn3        + More
PF07679   I-set
PF13882   Bravo_FIGEY
PF00047   ig
PF02820   MBT
PF12140   SLED

Interpro

IPR003598   Ig_sub2        + More
IPR036179   Ig-like_dom_sf       
IPR026966   Neurofascin/L1/NrCAM_C       
IPR036116   FN3_sf       
IPR013098   Ig_I-set       
IPR007110   Ig-like_dom       
IPR003599   Ig_sub       
IPR003961   FN3_dom       
IPR013783   Ig-like_fold       
IPR003529   Hematopoietin_rcpt_Gp130_CS       
IPR013151   Immunoglobulin       
IPR013106   Ig_V-set       
IPR037604   Scm-like-4MBT1/2_SAM       
IPR004092   Mbt       
IPR021987   SLED       
IPR038348   SLED_sf       
IPR013761   SAM/pointed_sf       

SUPFAM

SSF49265   SSF49265        + More
SSF48726   SSF48726       
SSF47769   SSF47769       

Gene 3D

2.60.40.10     1.10.150.50     1.20.1380.20    

CDD

cd00063  FN3
cd09581  SAM_Scm-like-4MBT1_2

ProteinModelPortal

D0VY44   A0A2W1BGE0   A0A2H1VMQ7   P91767   A0A212EQR2   A0A194PPC6   + More
A0A0N1IE92   A0A1B6K0I8   A0A1L8DM81   A0A2J7PJ24   U5EU82   A0A2J7PJ23   A0A2J7PJ28   E0VWB3   A0A0A9Z9I6   A0A0A9Y9L8   A0A0L0C8N9   A0A1Q3FJR5   A0A1Q3FJL7   A0A1Q3FJH2   A0A1Q3FJF3   A0A1Q3FJP3   A0A0A9YFP0   A0A0V0G851   A0A0A9ZCK9   A0A1W4VUK4   A0A182V2N1   A0A182X573   A0A0Q9WUV5   B3NVG5   Q7PG72   P20241-2   A0A1W4VGI6   A0A2A3EQC2   B4NCI8   E1JJF9   A0A0Q5T3I4   A0A1I8M4Q6   B4Q0A3   A0A0R3P7J0   E1JJF8   P20241   Q29FM1   A0A0P8ZS96   A0A0R1EHH6   A0A3B0JXM4   A0A1I8PSB9   A0A3B0J8C5   B3N0B0   A0A1I8PS80   A0A182MZQ2   A0A224XGR9   A0A1Q3FJG2   A0A084VVR8   A0A1Q3FJI5   B4HA25   A0A088A0C7   A0A336L9G0   A0A0Q9X0E4   A0A2M3YYL2   F5HJW6   A0A0L7R1U9   A0A0A1XPS4   A0A2M4BA85   B4L315   W8ARL3   W5J7Y4   A0A154P2X8   B4JP14   A0A0Q5THL2   A0A0N1IT65   M9NEZ5   A0A2M3YYL5   A0A2M3YYM0   A0A2M4A1U8   A0A1W4X2R0   B4M1M9   A0A0R1EHL1   A0A2M4BA33   A0A158P3P7   A0A0K8WB81   A0A0K8W814   A0A2M4BA73   A0A2M4A1U2   A0A034V7N8   A0A3B0J7M4   A0A2M3YYJ9   A0A1A9V6L8   B4IJX8   A0A1A9WVD0   A0A0M5J3D9   A0A1B0G439   A0A1B0AXR8   A0A1B0GMP2   A0A151XGE0   A0A182FML2   Q16Z16   K7IUL4   A0A0Q9WVH7   A0A336MRR8  

PDB

1CFB     E-value=6.38674e-64,     Score=624

KEGG

101742959    K06756 neuronal cell adhesion molecule | (RefSeq) neuroglian

GO

GO:0016021   GO:0004896   GO:0016319   GO:0098609   GO:0045924   GO:0072499   GO:0050808   GO:0048813   GO:0048675   GO:0007158   GO:0030175   GO:0008045   GO:0007560   GO:0048036   GO:0005918   GO:0005886   GO:0007409   GO:0019991   GO:0061343   GO:0005509   GO:0008050   GO:0021682   GO:0005923   GO:0035151   GO:0050839   GO:0005887   GO:0008049   GO:0008366   GO:0005919   GO:0060857   GO:0035011   GO:0006355   GO:0005634   GO:0042393   GO:0003714   GO:0005515   GO:0016020   GO:0004889   GO:0005216   GO:0006811   GO:0045211   GO:0006281   GO:0048384  

Subcellular location

Cell membrane  
Cell junction  
Tight junction  

SignalP

Position:   1 - 18,         Likelihood:  0.975086

 

 

Length:

1259

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

23.20957

Exp number, first 60 AAs:

0.35459

Total prob of N-in:

0.01828

outside

1  -  1135

TMhelix

1136  -  1158

inside

1159  -  1259

 

 

Pi

20.714032

Theta

19.793308

Tajima's D

0.007913

CLR

1.667313

CSRT

0.378831058447078

Interpretation

Uncertain