Gene

KWMTBOMO03115  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA005770

Annotation

hypothetical_protein_KGM_03201_[Danaus_plexippus]

Location

Bomo_Chr5(+):18552213-18562917      View in EpiBrowser

Full name

Scm-like with four MBT domains protein 2      

Location in the cell

Cytoplasmic   Reliability : 2.525

CDS

ATGGCTGAATTCGATTGGAACAATTATTTGGAGACAAGCAAATCTGTTGCAGTGCCAGAAGAATTATTTTCTCATGTGGAAACCAGCCTCTATAATGGAATCAAACAGAACATGCTTCTTGAGGTCTGTCACAGGAACAATCCAGATGTATACTGGATAGCAGAGATCACGATGGTATGTGGTCATGTCCTTAGGATCAAGTTCATTGGAGCAGAGAGTGATTTCTGGTGTGATATATCCAATACAAAAGTTCATCCTTTAGGATGGTGTGGTAAATATGATGAATTGATTGAGCCCCCTGATGCAATAAATGAGAAATATGGAGATAAGATTATTGATATAATGAAAAATGCTCTGATGGATGGCCAGTCTGTTTCCATAGAGGCTTTAAATAATAAAGGACTATCTCCAATAGACAGGATCAAAGTTGGCATGAAGGTTGAAGTGCAGAATCTCATCGATCCATACAGATATTGGATAGCCACTGTGTGCGAGAACGTCGGGGGCAGGCTGCTGGTGCGGTACGACGGCTGCGACGAGGACCTACAGCAGCTCTGGATATTTTTCTCTAACCCACGGCTGAGCAGCTTCGGCTACGTCACGAATAAGGGCTCACCGTGGCAGTTCAAATACCCCGGGAAAGTGAACAAGTTTTCGTGCAAGAACAAACTGAGCGCTCAGCTCCGACAGAGCGCCGAGGAGGCCATCAAGGAACCCACGCCGCCTGATCTCTTCGTGCCAAATCAGAGCTTGGAGGCGCATAACTTCGTAACAGGTATGAAGTTAGAGGCCCTGTGCCCTCAGGACATGAGGACGGTGCGACCGGCCACCGTCTCCAAGGTGTTCAACAACTTCCATTTCCTCGTCGCTCTGGACGACCACGCCGACGACTACGAGGACGCCAACGCCGCCTGGCTGTGCGACTCCATGCACCCCTACATCTACCCGATAGGCTGGGCTCAAAGACACGGCCTCGCCTTCAAGAGCCCCAAGGCGTGGAAGGAGGGCCCCTTCGACTGGGACGAGTACCTGTCCGCCACGTCATCCGTGCCGGCCCCCGACTACTGCTTCGGAACCAAACAGCCTCTGAAGGGAATCGAAGTGAACATGAAGCTGGAAGCGGTGAACCCACAGAACCACGAGGAGATCCACGTGGCCCGCGTGGACTGCGTCGCGGAGCACATGGTGTGCGTGGAGCTGCTGCCGCTGGGCGAGAAGTACTGGTTCGCGCAGCGCAGCGACCTGCTGCTGCCGGCCGGCTGGTGCGACGCCAACAACTACGCGCTGCACATCCCCGACGTCAGCGCCGCCAAGCAACAACCCGTCGAGGAGGTCAAACTGATCAAAGACGACATCAAGAATTCCGAAGAGTGGTGCGACAGAATATACTTTAACTACAAATGCTACGCCGGCCCCTCTATCAGCAGGAACAAATTGTCGCAGTTGCCCAAGCACGTGGGTCCGGGGCCGCTGACCTTGGTGCTGAAGGAAGTCCTCAACAAGATCATCTCTGCGTCGTACAAGCCTGCCAAGCTCCTGAAGGACTGGGAGACCGAGGGTCCCCCCGAGGAAGGCATGCGACTGGAGATGCTCAGAGCTAAGTTGAAGAGCAGCACGTACCACGCCTACGTGCCCATCGCCACGCGCCGCGCGCAGGTGCCCGCCTTCTGCCGCGCCGCCTGCGTGCGTCTGCAGGCCTGCCCCGCGCTCTTCGGCACCCACCACTACTCCCGCCCCCGCGCCGCCTGCCCGCACGCCTGCCACCAGGTCGACAAGGCCACCTTCCATAACGGCACGGAGCGCCGCGGCCGACCCAAGGGCAGCGTCAACGGCAAGAAGAAGAAGAAGAAGGGCGCGCACGAGAAGCGAGACAAGGAGCAGCCCTCGCAGGAGCGCGAGAAGGAGCCCGGCGAGTGCTCCCCGCGGCCGGTGCGCGCCGTGCGCAAGCGGGCGTCCCCGGACAGCGACACGGAGACCAGCTCCACGTCGCGCGACAAGCGCATCTCGGACGTGTCGGACGCCGAGGAGCCCGAGCTCAAGAAGCTCCGCGGCGCCCGGGACGCCCCCCGCCCCTTCGAGCGGGACCTCGCCCTCGAGCTGAAGCTGTCCCGCAACCCGCTGGACTGGAGCGTGGACGACGTGTACGCCTACCTGAGCAGCACGGACGACTGCAAGCCCGTCGCCGAGCGCATGAAGCGGGAGGAGATCGACGGCGAGGCCTTCGTCATGCTGGACCTGCCCGTCATCAGAGACTTCCTGCACATGAAGAAGGAGTTCGCGCTGCAGCTCAGCAAGCACATCGCCATCGTGCGCTGGTACACGCACAACTTCGAGCAGAACTGCGGCTCGTGA

Protein

MAEFDWNNYLETSKSVAVPEELFSHVETSLYNGIKQNMLLEVCHRNNPDVYWIAEITMVCGHVLRIKFIGAESDFWCDISNTKVHPLGWCGKYDELIEPPDAINEKYGDKIIDIMKNALMDGQSVSIEALNNKGLSPIDRIKVGMKVEVQNLIDPYRYWIATVCENVGGRLLVRYDGCDEDLQQLWIFFSNPRLSSFGYVTNKGSPWQFKYPGKVNKFSCKNKLSAQLRQSAEEAIKEPTPPDLFVPNQSLEAHNFVTGMKLEALCPQDMRTVRPATVSKVFNNFHFLVALDDHADDYEDANAAWLCDSMHPYIYPIGWAQRHGLAFKSPKAWKEGPFDWDEYLSATSSVPAPDYCFGTKQPLKGIEVNMKLEAVNPQNHEEIHVARVDCVAEHMVCVELLPLGEKYWFAQRSDLLLPAGWCDANNYALHIPDVSAAKQQPVEEVKLIKDDIKNSEEWCDRIYFNYKCYAGPSISRNKLSQLPKHVGPGPLTLVLKEVLNKIISASYKPAKLLKDWETEGPPEEGMRLEMLRAKLKSSTYHAYVPIATRRAQVPAFCRAACVRLQACPALFGTHHYSRPRAACPHACHQVDKATFHNGTERRGRPKGSVNGKKKKKKGAHEKRDKEQPSQEREKEPGECSPRPVRAVRKRASPDSDTETSSTSRDKRISDVSDAEEPELKKLRGARDAPRPFERDLALELKLSRNPLDWSVDDVYAYLSSTDDCKPVAERMKREEIDGEAFVMLDLPVIRDFLHMKKEFALQLSKHIAIVRWYTHNFEQNCGS

Description

Transcriptional repressor of HOXB13 gene.

Subunit

Interacts with YY1. Interacts with methylated histones H3K9me2 and H4K20me2, but not with H3K4me2, nor H3K9Ac.

Keywords

3D-structure   Complete proteome   Nucleus   Polymorphism   Reference proteome   Repeat   Repressor  

Feature

chain  Scm-like with four MBT domains protein 2
sequence variant  In dbSNP:rs3740212.

Uniprot

A0A2A4JA46   A0A2H1VMT0   A0A2W1BCS3   A0A194PQY5   A0A212EQS4   A0A0L7LMZ5   + More
A0A1B6FVM5   A0A1B6EZV3   A0A026W8T8   A0A3L8DB69   A0A151XGM8   T1J4G1   E9IK62   A0A158P3P6   E2ACP2   A0A0J7NH68   A0A195F0G6   A0A195BZ47   E2BBY6   A0A0M8ZSM4   A0A0C9QZV4   A0A232EJV1   A0A131Y0P3   A0A195CUL2   A0A147BE31   A0A1B6DV22   C3XQN1   F4X155   A0A1B6CDI0   A0A151JRJ2   A0A2R5LJP1   A0A154P2X8   A0A0L7R1P6   A0A2L2YGG6   A0A1S3K342   A0A1S3K2T4   A0A2T7NT34   A0A1S3K3J1   A0A2R2MSG6   E1BTX5   K1Q738   W5NF77   W5KEM4   A0A2K5W1Q9   F6QYE8   A0A2K6DL85   A0A0D9RM09   A0A1D5QRP9   G7N1J7   A0A2K5W1Y9   F7E6I1   A0A2I3M2I6   G7PE63   A0A2K6KI88   A0A2K5RNJ8   A0A2K5JZZ8   F7IBS7   A0A2K6UML6   A0A2K5N864   A0A2K5DHF2   A0A2J8VK49   H2N9P9   A0A2J8KTN0   Q5VUG0   W5NF80   W5NF79   G3WWV2   A0A2R9BTG2   G3QI80   A0A2I3TQM8   A0A2K6AA58   G1T537   A0A1U7RAC3   A0A151NPL7   A0A210Q4B2   A0A3B3VTV7   A0A0A0ABY7   A0A093FWL8   F6PVV9   A0A3P8XPJ7   A0A3B5PZC1   A0A091EXZ8   R0LJA9   A0A1V4JZ27   A0A093Q461   A0A091FJ09   A0A3M0KBB6   F1P4S5   A0A1E1XKN7   A0A2Y9KTG4   A0A1S3AG20   A0A3B3Y9S4   H0YV14  

Pubmed

28756777    26354079    22118469    26227816    24508170    30249741    + More
21282665    21347285    20798317    28648823    29652888    18563158    21719571    26561354    15592404    22992520    25329095    17431167    22002653    17495919    10997877    15164054    15489334    23385818    21709235    22722832    22398555    16136131    21993624    22293439    28812685    18464734    25069045    23542700    29209593    20360741   

EMBL

NWSH01002243    PCG68841.1    ODYU01003405    SOQ42123.1    KZ150156    PZC72778.1    + More
KQ459597    KPI95159.1    AGBW02013246    OWR43838.1    JTDY01000494    KOB76923.1    GECZ01015555    JAS54214.1    GECZ01026294    JAS43475.1    KK107356    EZA52051.1    QOIP01000010    RLU17561.1    KQ982174    KYQ59370.1    JH431845    GL763924    EFZ19080.1    ADTU01008311    GL438568    EFN68786.1    LBMM01005044    KMQ91870.1    KQ981880    KYN33968.1    KQ976394    KYM93201.1    GL447175    EFN86810.1    KQ435863    KOX70320.1    GBYB01001245    JAG71012.1    NNAY01003929    OXU18640.1    GEFM01004230    JAP71566.1    KQ977304    KYN03829.1    GEGO01006393    JAR89011.1    GEDC01009240    GEDC01007770    JAS28058.1    JAS29528.1    GG666455    EEN69607.1    GL888526    EGI59822.1    GEDC01025796    JAS11502.1    KQ978589    KYN29976.1    GGLE01005512    MBY09638.1    KQ434809    KZC06285.1    KQ414667    KOC64767.1    IAAA01029107    LAA07244.1    PZQS01000009    PVD24335.1    AADN05000356    JH817059    EKC24670.1    AHAT01016168    AHAT01016169    AQIA01069936    AQIA01069937    JSUE03042789    JSUE03042790    JSUE03042791    AQIB01160813    AQIB01160814    CM001261    EHH18874.1    AHZZ02034747    AHZZ02034748    AHZZ02034749    AHZZ02034750    AHZZ02034751    CM001284    EHH64542.1    NDHI03003418    PNJ57906.1    PNJ57907.1    ABGA01158577    ABGA01158578    ABGA01158579    ABGA01158580    ABGA01158581    ABGA01158582    ABGA01158583    ABGA01158584    ABGA01158585    ABGA01158586    NBAG03000340    PNI38370.1    AB046837    AL590095    AL158046    AL139125    AL138771    CH471072    BC152430    AEFK01194432    AEFK01194433    AEFK01194434    AEFK01194435    AEFK01194436    AEFK01194437    AEFK01194438    AEFK01194439    AEFK01194440    AEFK01194441    AJFE02097884    AJFE02097885    AJFE02097886    AJFE02097887    AJFE02097888    AJFE02097889    CABD030067830    CABD030067831    CABD030067832    CABD030067833    CABD030067834    CABD030067835    CABD030067836    AACZ04030394    AACZ04030395    AAGW02026856    AAGW02026857    AAGW02026858    AKHW03002440    KYO38782.1    NEDP02005055    OWF43580.1    KL871261    KGL91626.1    KK636470    KFV58714.1    KK719333    KFO62773.1    KB742662    EOB05779.1    LSYS01005474    OPJ77480.1    KL671667    KFW83431.1    KL447178    KFO70510.1    QRBI01000112    RMC10489.1    AADN05000100    GFAA01003537    JAT99897.1    ABQF01038454    ABQF01038455   

Proteomes

UP000218220    UP000053268    UP000007151    UP000037510    UP000053097    UP000279307    + More
UP000075809    UP000005205    UP000000311    UP000036403    UP000078541    UP000078540    UP000008237    UP000053105    UP000215335    UP000078542    UP000001554    UP000007755    UP000078492    UP000076502    UP000053825    UP000085678    UP000245119    UP000000539    UP000005408    UP000018468    UP000018467    UP000233100    UP000006718    UP000233120    UP000029965    UP000002280    UP000028761    UP000009130    UP000233180    UP000233040    UP000233080    UP000008225    UP000233220    UP000233060    UP000233020    UP000001595    UP000005640    UP000007648    UP000240080    UP000001519    UP000002277    UP000233140    UP000001811    UP000189705    UP000050525    UP000242188    UP000261500    UP000053858    UP000002279    UP000265140    UP000002852    UP000052976    UP000190648    UP000053258    UP000053760    UP000269221    UP000248482    UP000079721    UP000261480    UP000007754   

PRIDE

Q5VUG0   

Pfam

PF02820   MBT        + More
PF12140   SLED
PF00536   SAM_1
PF13882   Bravo_FIGEY
PF00041   fn3
PF07679   I-set

Interpro

IPR004092   Mbt        + More
IPR021987   SLED       
IPR038348   SLED_sf       
IPR013761   SAM/pointed_sf       
IPR001660   SAM       
IPR037604   Scm-like-4MBT1/2_SAM       
IPR003598   Ig_sub2       
IPR036179   Ig-like_dom_sf       
IPR026966   Neurofascin/L1/NrCAM_C       
IPR036116   FN3_sf       
IPR013098   Ig_I-set       
IPR007110   Ig-like_dom       
IPR003599   Ig_sub       
IPR003961   FN3_dom       
IPR013783   Ig-like_fold       
IPR003118   Pointed_dom       

SUPFAM

SSF47769   SSF47769        + More
SSF49265   SSF49265       
SSF48726   SSF48726       

Gene 3D

1.10.150.50     1.20.1380.20     2.60.40.10    

CDD

cd09581  SAM_Scm-like-4MBT1_2
cd00063  FN3

ProteinModelPortal

A0A2A4JA46   A0A2H1VMT0   A0A2W1BCS3   A0A194PQY5   A0A212EQS4   A0A0L7LMZ5   + More
A0A1B6FVM5   A0A1B6EZV3   A0A026W8T8   A0A3L8DB69   A0A151XGM8   T1J4G1   E9IK62   A0A158P3P6   E2ACP2   A0A0J7NH68   A0A195F0G6   A0A195BZ47   E2BBY6   A0A0M8ZSM4   A0A0C9QZV4   A0A232EJV1   A0A131Y0P3   A0A195CUL2   A0A147BE31   A0A1B6DV22   C3XQN1   F4X155   A0A1B6CDI0   A0A151JRJ2   A0A2R5LJP1   A0A154P2X8   A0A0L7R1P6   A0A2L2YGG6   A0A1S3K342   A0A1S3K2T4   A0A2T7NT34   A0A1S3K3J1   A0A2R2MSG6   E1BTX5   K1Q738   W5NF77   W5KEM4   A0A2K5W1Q9   F6QYE8   A0A2K6DL85   A0A0D9RM09   A0A1D5QRP9   G7N1J7   A0A2K5W1Y9   F7E6I1   A0A2I3M2I6   G7PE63   A0A2K6KI88   A0A2K5RNJ8   A0A2K5JZZ8   F7IBS7   A0A2K6UML6   A0A2K5N864   A0A2K5DHF2   A0A2J8VK49   H2N9P9   A0A2J8KTN0   Q5VUG0   W5NF80   W5NF79   G3WWV2   A0A2R9BTG2   G3QI80   A0A2I3TQM8   A0A2K6AA58   G1T537   A0A1U7RAC3   A0A151NPL7   A0A210Q4B2   A0A3B3VTV7   A0A0A0ABY7   A0A093FWL8   F6PVV9   A0A3P8XPJ7   A0A3B5PZC1   A0A091EXZ8   R0LJA9   A0A1V4JZ27   A0A093Q461   A0A091FJ09   A0A3M0KBB6   F1P4S5   A0A1E1XKN7   A0A2Y9KTG4   A0A1S3AG20   A0A3B3Y9S4   H0YV14  

PDB

4C5I     E-value=5.65113e-39,     Score=407

KEGG

101738160    no KO assigned | (RefSeq) scm-like with four MBT domains protein 2

GO

GO:0005634   GO:0006355   GO:0003714   GO:0042393   GO:0016021   GO:0043565   GO:0016607   GO:0016235   GO:0010629   GO:0043231   GO:0007067   GO:0004889   GO:0005216   GO:0006811   GO:0045211   GO:0006281   GO:0048384  

Subcellular location

Nucleus  

Length:

783

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00611

Exp number, first 60 AAs:

0.00344

Total prob of N-in:

0.00036

outside

1  -  783

 

 

Pi

6.001505

Theta

6.803334

Tajima's D

-0.920365

CLR

2.657132

CSRT

0.149842507874606

Interpretation

Uncertain