Gene

KWMTBOMO03112  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA005798

Annotation

PREDICTED:_centromere/kinetochore_protein_zw10_homolog_[Amyelois_transitella]

Location

Bomo_Chr5(-):18524829-18529842      View in EpiBrowser

Full name

Centromere/kinetochore protein zw10 homolog      

Location in the cell

Cytoplasmic   Reliability : 3.494

CDS

ATGACAGATAAAGAAGATGTCGACAATAAACCTGAAAATGTTCCTATAGATGACGAAGCCCTAGAGAAGTTGGCTGTTGAAGAACTGATACGTGAAGCTGTTCAAGGCGCCGCTAGAGCTGAAATCGTTGGTCCGTCAGGTTGGGTTAAAGCCCCTCCTCAAAAAACCAACAAACGTTTTCTGATAAGTCAAAAAGAAAACGTTAAAATGGAGAGTTATGATATAGAAGAAGTTTTAAAAAATATATTTGATTGTAATGAAACAAACTGGAAACCAGCTGACAAAATACCCCTTCTAACCAAAGAAATAGAACTGTTAAAAATAGATTTAAAATCTTATTTGGAAACTTGTGAGTATAATGTAGATTCAGTTTTGGAGGAGAGTAAAATATTGTTTGTGGATAGTAAAGCCGTTGTTGATGAACTTGAAAAATGCAAGAAGGAAATAGAAGAGCACACAATGGCAGAAGTGCTCAAATCCATCGAAACCCATGACCAGATCACTAAAGAGTTGCAGCATGTTAATTTTGCACTGAACATTGTGTATGATGTTGGACAGTGTGGTAAACTTGTGAAGCAATTTGAAGAAGGAAGACAGGCACAAAGTTACACACGTGCTGTGGAGGCTGTGTATGATTTACTCCAATATATAGAGCTACCTGCTGAAGGTTTCAAATATTTAGATATATATGCTAACACAAAACATACAGCTCAACTTATACTGGATAAACTCCTGCAAGACCTGTATACAGAATGGACAAGACTTGTGTCATGGAATACTAAAGTCAGCTCAAAGAAATCAGTAGTTAAAATTACTTTGAAAATTGAAGATACACCATTTGTTATCGATGTGATAAGAGCATTGGATAAAAATAAAAATTTGAAAGAAAAAGTTAGTGAGTTCTCTCAGTTCTTGTATAAAGAAGTTCTACAGCCAATCATTTATAACGACTGTATAGTTTTCCCAGAAACTGAAGAGCTATTGACAGTAACAATAAATTACAAGCAAAATTATAAGCCTCCTTATGATCAAGTTATAGCCAACTTTAGGTTACTTTTCCATCACTTGAGTTCCAAATTGAAATTTGAATATGATAAGAATTGTAGTATTATGAAGTTGATTGGGAATGAAATTAGCGGACCGTTCAGTGAGCTGATCATGAAAGACTGTTTCATAGACACAATCCCAAATAATATTATAGATCTACAAACATATGGTAAAATTACTTCAGAGATAGAAAAATTTCAGCATTTCCTTTTCATTGTGAAGTTCTTTACAGAAGATATATCTATATTAAAATACATAGAAGATATAGATATCTTATTCTCAAAGAAATCTAGTGATCACTTCTTGAAGACAGCTAGAGACATAATGCTGAAAGACCTAAGTGTTTGTATGTCTATTGGTGTTGAGAATATTTCTGATGAAGAAGAATCAAGTGATGATTATGGAAAGGCAGCTGAAGCCTTGAGAATACTTGAAAAGACAATACCAAAGAGTTTATTCTACTTTCCGAGGTGTATGATATCAAAAACAGCTCAAGAGCTTCTAGATTTGATTTATGTCATAATGGAGCAAGCTGTGCAGTGTTCTGATGTAGTTTGTAAGAAATTATATCAGACCACCAGGTTAATATTTGAGCTCTATGATGCAGTGATGCCATATCACCATGAAAAATACTTGCAGACTATTCCTCAGTATGTTGCATTATTCCACAACAACTGTATGTATCTTGCACACAATATGATGACCTTTGGTGATAAGTGGTTAACATTGATGGAGGGTCGAGACATCGATTATCCCATTGGCTTTGTTGATTTGGTTCAGAAGTTACGGGAACTGGGTTACAAGCACCTTACAATACATCTGCAGCAGCAGAGGAAACAAATCTTGGATAACATACGTTCTTCAGATCTCAACTGCATGGTGGTCAAAGAAGTGTTAGGCTCCAATGCTGAGGCCGCTATCCGCCAGTGCTTGCGGCAACTACAGCTTTTGAAAAATGTGTGGATAGGAGTGTTCCCTATCAATGTCTTCACAAGGTTGATGGCGACCCTAGTCAACATGTTCATCGAGGAACTCATTCACCGAGTGTGCACCGTCGAGGACATCTCAATGGAGATGGCGACACAGCTGACCGAGATATATACATTAGTAGTGCAAAAGGCACCACAATTGTTCCAGAGTTCAACAGATATAGAAACTCACGTCAAATCCTGGATAAAGCTGCAGGAGCTAATCTTTGTCCTTGGAGGGTCTCTGAAGGATATCGACAACCACTGGAAGGATGGTACCGGTCCCTTGGCGGTCCACTTCAGAACCGAAGAGTTACGGAATCTAATTAAGGCTCTCTTCCAGAATACTCAGATTCGAGCCAACTTGCTGTCTAAAATAAAGTAA

Protein

MTDKEDVDNKPENVPIDDEALEKLAVEELIREAVQGAARAEIVGPSGWVKAPPQKTNKRFLISQKENVKMESYDIEEVLKNIFDCNETNWKPADKIPLLTKEIELLKIDLKSYLETCEYNVDSVLEESKILFVDSKAVVDELEKCKKEIEEHTMAEVLKSIETHDQITKELQHVNFALNIVYDVGQCGKLVKQFEEGRQAQSYTRAVEAVYDLLQYIELPAEGFKYLDIYANTKHTAQLILDKLLQDLYTEWTRLVSWNTKVSSKKSVVKITLKIEDTPFVIDVIRALDKNKNLKEKVSEFSQFLYKEVLQPIIYNDCIVFPETEELLTVTINYKQNYKPPYDQVIANFRLLFHHLSSKLKFEYDKNCSIMKLIGNEISGPFSELIMKDCFIDTIPNNIIDLQTYGKITSEIEKFQHFLFIVKFFTEDISILKYIEDIDILFSKKSSDHFLKTARDIMLKDLSVCMSIGVENISDEEESSDDYGKAAEALRILEKTIPKSLFYFPRCMISKTAQELLDLIYVIMEQAVQCSDVVCKKLYQTTRLIFELYDAVMPYHHEKYLQTIPQYVALFHNNCMYLAHNMMTFGDKWLTLMEGRDIDYPIGFVDLVQKLRELGYKHLTIHLQQQRKQILDNIRSSDLNCMVVKEVLGSNAEAAIRQCLRQLQLLKNVWIGVFPINVFTRLMATLVNMFIEELIHRVCTVEDISMEMATQLTEIYTLVVQKAPQLFQSSTDIETHVKSWIKLQELIFVLGGSLKDIDNHWKDGTGPLAVHFRTEELRNLIKALFQNTQIRANLLSKIK

Description

Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex. Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the interphase NRZ complex which is believed to play a role in SNARE assembly at the ER (By similarity).

Subunit

Interacts with NBAS and KNTC1/ROD; the interactions are mutually exclusive and indicative for its association in two different vesicle tethering complexes. Component of the RZZ complex composed of KNTC1/ROD, ZW10 and ZWILCH. Component of the NRZ complex composed of NBAS, ZW10 and RINT1/TIP20L; NRZ associates with SNAREs STX18, USE1L, BNIP1/SEC20L and SEC22B (the assembly has been described as syntaxin 18 complex). Interacts directly with RINT1/TIP20L bound to BNIP1/SEC20L. Interacts with C19orf25 and ZWINT STOPPED Associated with a SNARE complex consisting of STX18, USE1L, BNIP1/SEC20L, and SEC22B through direct interaction with RINT1/TIP20L bound to BNIP1/SEC20L. Component of the RZZ complex composed of KNTC1/ROD, ZW10 and ZWILCH. Interacts with C19orf25, KNTC1 and ZWINT.

Similarity

Belongs to the peptidase C19 family.
Belongs to the ZW10 family.

Keywords

Acetylation   Cell cycle   Cell division   Centromere   Chromosome   Coiled coil   Complete proteome   Cytoplasm   Cytoskeleton   Endoplasmic reticulum   ER-Golgi transport   Kinetochore   Membrane   Mitosis   Phosphoprotein   Protein transport   Reference proteome   Transport  

Feature

chain  Centromere/kinetochore protein zw10 homolog

Uniprot

H9J8F6   A0A2W1BEN9   A0A2H1VMR4   A0A1E1WK00   A0A0N1PFC5   A0A212EP10   + More
A0A194PVK0   A0A0L7LNX8   A0A2A4JBB9   A0A067R1H8   A0A2J7R4X7   A0A154PD87   A0A088ADK1   A0A2J7R4Y7   A0A232F9F2   K7IZY4   A0A3L8DW78   A0A0C9R7R5   A0A0L7RGC3   F4WFS7   A0A151JRX3   A0A158NYR6   E2C1W0   A0A026WMT4   A0A195CIN0   A0A1B6DLN4   E2AR01   A0A1B6K948   E9IYQ5   A0A1B6HJZ5   A0A195CW51   A0A195BTF8   A0A151X3F9   A0A0M8ZP20   E0VWF2   A0A093QFG8   K1PVH5   V4B230   V9KF16   A0A1L8DX26   A0A091R5P9   L5KMC6   R0M7L5   A0A091MXR0   A0A023EY20   A0A3Q0GZ42   A0A210QXB8   G3WIT0   A0A151P0I0   A0A093EZ14   M3W382   A0A0K8TM68   A0A093TJZ0   A0A091KDI5   A0A2I0LQY5   A0A093CLN2   U3IRS3   A0A091RB81   A0A087QSR9   A0A091TNP4   A0A384C086   A0A091WUP7   F6U6L7   A0A091M5E7   A0A0A0A176   A0A1W4XM69   A0A091J057   A0A0V0GA94   F6UZG3   A0A2T7NYV5   Q4V8C2   A0A091T0H9   M3XXR3   G3SN94   A0A069DZH5   B1H3L7   A0A1W2WAN0   A0A1V4J916   A0A0P5SCK6   H0YPQ8   A0A0P6I7F2   A0A091Q497   A0A1S3IFT2   A0A164QZG2   A0A094LHK6   H9GEQ3  

Pubmed

19121390    28756777    26354079    22118469    26227816    24845553    + More
28648823    20075255    30249741    21719571    21347285    20798317    24508170    21282665    20566863    22992520    23254933    24402279    23258410    25474469    28812685    21709235    22293439    17975172    26369729    23371554    23749191    24813606    17495919    16341006    15489334    26334808    20360741    21881562   

EMBL

BABH01027343    KZ150156    PZC72781.1    ODYU01003405    SOQ42119.1    GDQN01003721    + More
JAT87333.1    KQ460970    KPJ10200.1    AGBW02013553    OWR43219.1    KQ459597    KPI95155.1    JTDY01000494    KOB76926.1    NWSH01002243    PCG68844.1    KK852777    KDR16765.1    NEVH01007399    PNF35887.1    KQ434875    KZC09767.1    PNF35889.1    NNAY01000597    OXU27491.1    QOIP01000003    RLU24714.1    GBYB01002786    JAG72553.1    KQ414596    KOC70027.1    GL888122    EGI66970.1    KQ978566    KYN30123.1    ADTU01004235    GL452008    EFN78072.1    KK107151    EZA57238.1    KQ977696    KYN00573.1    GEDC01010709    JAS26589.1    GL441846    EFN64147.1    GEBQ01032000    JAT07977.1    GL767043    EFZ14278.1    GECU01032755    JAS74951.1    KQ977220    KYN04906.1    KQ976407    KYM91386.1    KQ982566    KYQ54748.1    KQ435944    KOX68210.1    DS235819    EEB17703.1    KL672246    KFW85130.1    JH818606    EKC28357.1    KB200454    ESP01626.1    JW863892    AFO96409.1    GFDF01003074    JAV11010.1    KK713957    KFQ35143.1    KB030667    ELK11906.1    KB742431    EOB08693.1    KK838361    KFP81419.1    GBBI01004781    JAC13931.1    NEDP02001349    OWF53385.1    AEFK01114682    AEFK01114683    AEFK01114684    AKHW03001374    KYO42657.1    KK378720    KFV47216.1    AANG04000369    GDAI01002377    JAI15226.1    KL442499    KFW94564.1    KK552259    KFP34128.1    AKCR02000134    PKK19841.1    KL462244    KFV13869.1    ADON01004108    ADON01004109    KK813349    KFQ37113.1    KL225870    KFM04273.1    KK459094    KFQ78064.1    KL411261    KFR05171.1    KK521647    KFP66646.1    KL870337    KGL87717.1    KK501366    KFP14354.1    GECL01001267    JAP04857.1    AAEX03003483    AAEX03003484    PZQS01000008    PVD26313.1    BC097452    KK494687    KFQ64909.1    AEYP01026721    GBGD01000630    JAC88259.1    BC161442    AAI61442.1    LSYS01008642    OPJ68267.1    GDIQ01095484    JAL56242.1    ABQF01045786    ABQF01045787    ABQF01045788    GDIQ01009472    JAN85265.1    KK685443    KFQ14376.1    LRGB01002285    KZS08205.1    KL357880    KFZ63424.1    AAWZ02025845    AAWZ02025846    AAWZ02025847    AAWZ02025848   

Proteomes

UP000005204    UP000053240    UP000007151    UP000053268    UP000037510    UP000218220    + More
UP000027135    UP000235965    UP000076502    UP000005203    UP000215335    UP000002358    UP000279307    UP000053825    UP000007755    UP000078492    UP000005205    UP000008237    UP000053097    UP000078542    UP000000311    UP000078540    UP000075809    UP000053105    UP000009046    UP000053258    UP000005408    UP000030746    UP000010552    UP000189705    UP000242188    UP000007648    UP000050525    UP000011712    UP000053872    UP000016666    UP000053286    UP000261680    UP000291021    UP000053283    UP000002280    UP000053858    UP000192223    UP000053119    UP000002254    UP000245119    UP000002494    UP000000715    UP000007646    UP000190648    UP000007754    UP000085678    UP000076858    UP000001646   

PRIDE

H9J8F6    Q4V8C2   

Pfam

PF06248   Zw10        + More
PF00415   RCC1
PF00443   UCH

Interpro

IPR009361   RZZ-complex_Zw10        + More
IPR000408   Reg_chr_condens       
IPR009091   RCC1/BLIP-II       
IPR009060   UBA-like_sf       
IPR028889   USP_dom       
IPR038765   Papain-like_cys_pep_sf       
IPR018200   USP_CS       
IPR001394   Peptidase_C19_UCH       

SUPFAM

SSF50985   SSF50985        + More
SSF46934   SSF46934       
SSF54001   SSF54001       

Gene 3D

2.130.10.30    

ProteinModelPortal

H9J8F6   A0A2W1BEN9   A0A2H1VMR4   A0A1E1WK00   A0A0N1PFC5   A0A212EP10   + More
A0A194PVK0   A0A0L7LNX8   A0A2A4JBB9   A0A067R1H8   A0A2J7R4X7   A0A154PD87   A0A088ADK1   A0A2J7R4Y7   A0A232F9F2   K7IZY4   A0A3L8DW78   A0A0C9R7R5   A0A0L7RGC3   F4WFS7   A0A151JRX3   A0A158NYR6   E2C1W0   A0A026WMT4   A0A195CIN0   A0A1B6DLN4   E2AR01   A0A1B6K948   E9IYQ5   A0A1B6HJZ5   A0A195CW51   A0A195BTF8   A0A151X3F9   A0A0M8ZP20   E0VWF2   A0A093QFG8   K1PVH5   V4B230   V9KF16   A0A1L8DX26   A0A091R5P9   L5KMC6   R0M7L5   A0A091MXR0   A0A023EY20   A0A3Q0GZ42   A0A210QXB8   G3WIT0   A0A151P0I0   A0A093EZ14   M3W382   A0A0K8TM68   A0A093TJZ0   A0A091KDI5   A0A2I0LQY5   A0A093CLN2   U3IRS3   A0A091RB81   A0A087QSR9   A0A091TNP4   A0A384C086   A0A091WUP7   F6U6L7   A0A091M5E7   A0A0A0A176   A0A1W4XM69   A0A091J057   A0A0V0GA94   F6UZG3   A0A2T7NYV5   Q4V8C2   A0A091T0H9   M3XXR3   G3SN94   A0A069DZH5   B1H3L7   A0A1W2WAN0   A0A1V4J916   A0A0P5SCK6   H0YPQ8   A0A0P6I7F2   A0A091Q497   A0A1S3IFT2   A0A164QZG2   A0A094LHK6   H9GEQ3  

KEGG

101738562    K11578 protein transport protein DSL1/ZW10 | (RefSeq) centromere/kinetochore protein zw10 homolog

GO

GO:0000278   GO:0005634   GO:0000775   GO:0065003   GO:0006888   GO:1990423   GO:0005828   GO:0070939   GO:0007093   GO:0007080   GO:0000132   GO:0000922   GO:0034501   GO:0005829   GO:0007030   GO:0007096   GO:0007094   GO:0005737   GO:0016579   GO:0036459   GO:0006511   GO:0005783   GO:0051301   GO:0000777   GO:0000776   GO:0015031   GO:0000070   GO:0005789   GO:0007067   GO:0004889   GO:0005216   GO:0006811   GO:0016021   GO:0045211   GO:0006281   GO:0048384  

Subcellular location

Cytoplasm   Dynamic pattern of localization during the cell cycle. In most cells at interphase, present diffusely in the cytoplasm. In prometaphase, associated with the kinetochore. At metaphase, detected both at the kinetochores and, most prominently, at the spindle, particularly at the spindle poles. In very early anaphase, detected on segregating kinetochores. In late anaphase and telophase, accumulates at the spindle midzone.   With evidence from 1 publications.
Endoplasmic reticulum membrane   Dynamic pattern of localization during the cell cycle. In most cells at interphase, present diffusely in the cytoplasm. In prometaphase, associated with the kinetochore. At metaphase, detected both at the kinetochores and, most prominently, at the spindle, particularly at the spindle poles. In very early anaphase, detected on segregating kinetochores. In late anaphase and telophase, accumulates at the spindle midzone.   With evidence from 1 publications.
Chromosome   Dynamic pattern of localization during the cell cycle. In most cells at interphase, present diffusely in the cytoplasm. In prometaphase, associated with the kinetochore. At metaphase, detected both at the kinetochores and, most prominently, at the spindle, particularly at the spindle poles. In very early anaphase, detected on segregating kinetochores. In late anaphase and telophase, accumulates at the spindle midzone.   With evidence from 1 publications.
Centromere   Dynamic pattern of localization during the cell cycle. In most cells at interphase, present diffusely in the cytoplasm. In prometaphase, associated with the kinetochore. At metaphase, detected both at the kinetochores and, most prominently, at the spindle, particularly at the spindle poles. In very early anaphase, detected on segregating kinetochores. In late anaphase and telophase, accumulates at the spindle midzone.   With evidence from 1 publications.
Kinetochore   Dynamic pattern of localization during the cell cycle. In most cells at interphase, present diffusely in the cytoplasm. In prometaphase, associated with the kinetochore. At metaphase, detected both at the kinetochores and, most prominently, at the spindle, particularly at the spindle poles. In very early anaphase, detected on segregating kinetochores. In late anaphase and telophase, accumulates at the spindle midzone.   With evidence from 1 publications.
Cytoskeleton   Dynamic pattern of localization during the cell cycle. In most cells at interphase, present diffusely in the cytoplasm. In prometaphase, associated with the kinetochore. At metaphase, detected both at the kinetochores and, most prominently, at the spindle, particularly at the spindle poles. In very early anaphase, detected on segregating kinetochores. In late anaphase and telophase, accumulates at the spindle midzone.   With evidence from 1 publications.
Spindle   Dynamic pattern of localization during the cell cycle. In most cells at interphase, present diffusely in the cytoplasm. In prometaphase, associated with the kinetochore. At metaphase, detected both at the kinetochores and, most prominently, at the spindle, particularly at the spindle poles. In very early anaphase, detected on segregating kinetochores. In late anaphase and telophase, accumulates at the spindle midzone.   With evidence from 1 publications.

Length:

799

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

2.98119

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00184

outside

1  -  799

 

 

Pi

17.69931

Theta

18.525685

Tajima's D

-0.703782

CLR

0.524532

CSRT

0.201389930503475

Interpretation

Uncertain