Gene

KWMTBOMO03109

Pre Gene Modal

BGIBMGA005801

Annotation

nicotinic_acetylcholine_receptor_subunit_alpha_6_mRNA_transcript_variant_2_[Bombyx_mori]

Location

Bomo_Chr5(-):18409125-18449742      View in EpiBrowser

Location in the cell

PlasmaMembrane   Reliability : 4.807

CDS

ATGATTGATGAAGGGAAACGGAACAAATTTCAAATTCAGACGATTGTTCTTGTTCTACCAGTGTCGGAGCAAGGTCCACACGAAAAACGTCTGCTGAACGCCCTGCTGGCGTCTTACAACACCCTGGAGCGTCCTGTGGCCAATGAGAGCGAGCCCCTAGAGGTACGCTTTGGGCTGACACTGCAACAAATCATAGATGTGGACGAGAAGAATCAACTACTTATAACCAATATATGGCTGTCATTGGAATGGAATGACTACAACCTAAGGTGGAACGAGAGCGAGTACGGAGGCGTCAAGGACTTAAGGATAACACCGAACAAACTTTGGAAACCAGACGTTCTCATGTACAACAGTGCTGACGAGGGTTTTGACGGGACATACCAGACGAACGTGGTGGTCAGAAACAACGGCAGTTGTCTGTACGTGCCCCCGGGCATTTTCAAGAGCACATGCAAGATAGATATCACGTGGTTTCCCTTCGACGACCAACACTGTGATATGAAGTTTGGTAGCTGGACATATGATGGCAATCAGCTGGACCTCATCTTGAAGGACGAAGCCGGTGGCGACCTATCAGATTTCATCACGAATGGAGAATGGTACTTAATAGGAATGCCGGGCAAAAAGAACACAATTACATACGCTTGCTGCCCAGAGCCGTACGTGGACGTCACCTTCACCATCATGATCAGGAGGAGAACGCTGTACTACTTCTTCAATCTCATCGTGCCGTGCGTTCTGATATCCTCAATGGCGCTACTAGGCTTCACGCTACCACCAGATTCTGGGGAGAAATTGACACTCGGAGTCACTATTCTACTGTCGCTGACGGTGTTTCTCAATCTGGTGGCAGAAACTCTGCCGCAGGTGTCCGATGCTATCCCCTTGTTAGGTACATATTTCAACTGTATTATGTTCATGGTGGCCTCGTCTGTGGTGCTCACCGTTGTGGTGTTGAACTACCATCATCGAACGGCTGACATCCATGAGATGCCACAATGGATAAAGACTGTGTTCCTCCAATGGCTGCCCTGGATTCTGCGTATGTCCAGGCCGGGTAAGAAGATCACGAGGAAGACCATCATGATGTCCAACAGGATGCGAGAGTTGGAGCTAAAAGAGCGTTCGTCTAAGTCGCTGTTAGCCAACGTGCTGGATATAGACGACGACTTTAGACATGCCCCGCCCCCGCCCAACAGTACTGCTTCTACAGGCAACTTGGGGCCTGGAACGGACTTTCGGCGTTCGTTCGTCCGCCCTTCGACGATGGAGGACGTGGGCGGAGGGCTCAGTAGCCACCACAGGGAGCTGCATCTCATCCTGCGCGAACTCCAGTTCATCACAGCCAGGATGAAGAAGGCCGATGAGGAGGCCGAGCTGATCAGCGACTGGAAATTCGCTGCAATGGTAGTGGACAGGTTTTGCTTGTTCGTGTTCACGTTGTTCACGATAATAGCGACGGTGGCCGTGCTGTTGTCGGCGCCGCATATCATCGTGCAGTGA

Protein

MIDEGKRNKFQIQTIVLVLPVSEQGPHEKRLLNALLASYNTLERPVANESEPLEVRFGLTLQQIIDVDEKNQLLITNIWLSLEWNDYNLRWNESEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYQTNVVVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQHCDMKFGSWTYDGNQLDLILKDEAGGDLSDFITNGEWYLIGMPGKKNTITYACCPEPYVDVTFTIMIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSGEKLTLGVTILLSLTVFLNLVAETLPQVSDAIPLLGTYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPQWIKTVFLQWLPWILRMSRPGKKITRKTIMMSNRMRELELKERSSKSLLANVLDIDDDFRHAPPPPNSTASTGNLGPGTDFRRSFVRPSTMEDVGGGLSSHHRELHLILRELQFITARMKKADEEAELISDWKFAAMVVDRFCLFVFTLFTIIATVAVLLSAPHIIVQ

Similarity

Belongs to the ligand-gated ion channel (TC 1.A.9) family.

Uniprot

A8CGL6   A1EGV5   A5A2M6   A0A2A4JGH6   A0A2W1BAC7   A1EGV4   + More
A0A0H4U7U0   Q9XZI4   A1EGV6   D8UUW8   A0A0H4TMF2   A0A0S1TL21   A0A0A7RQA0   A0A346IHV1   D8UWB3   D3JL32   A8CGM0   A0A140CTI3   D9YT57   D9YT60   D2X8R6   D9YT59   D9YT61   D9YT62   A0A139WNV9   C3TS36   A0A1S4FID0   A8DIT3   A0A0P8XXV7   C3TS34   A0A0R3NRK7   A0A1W4W8N4   A0A0J9R0C5   Q8IPE2   A0A0R1DNB2   A0A0Q5WLY3   A0A0Q9X712   C3TS35   A0A0Q9W8H3   Q7PTL9   M4H3L1   A0A0P9BRB7   Q8T7S1   A0A0R3NX37   A0A1W4VXP1   C3TS31   C3TS37   G9CU48   A8DIS9   A0A0J9QZ20   A0A0Q9XHQ5   A0A0R1DM16   A0A0P8ZHV2   B4N125   A0A0Q5WME6   Q9VL79   A0A222C753   Q16ZU4   A0A0R3NRJ6   A0A0Q9W8J0   A0A0Q9X676   A0A0J9QZJ7   A0A0N8NZG8   A0A0Q5WAA2   Q7KTF9   A0A0R1DL23   W8BEN9   A5H033   M4H3G0   G9E3J3   A0A0K0NTY9   A8DIT5   A0A1W4VXP6   A0A0R3NS12   A5H032   A0A0J9TJR6   Q7KTF7   B4NYM5   A0A0Q5WJ74   M4H3Y7   A0A1I8NYF7   A0A0P8XHK1   K4JH01   A0A1W4VXN1   A5H031   Q8T7S2   B4LQB0   A0A0R3NRG3   Q86MN8   A0A0P8Y5B5   A0A0Q9XF72   A0A0R3NWT4   Q6NNY5   A0A0J9QZI0   M9PFD8   A0A0R1DKV4   A0A0Q5WJ24   Q8T7S0   A0A0Q9W8K3   K4JF52  

Pubmed

17868469    17597521    28756777    25504620    20062520    26855198    + More
18362917    19820115    19320762    17510324    17880682    17994087    15632085    22936249    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    17550304    12364791    14747013    15676276    17210077    22898623    11973307    26109357    26109356    24495485    17439546   

EMBL

EU082082    ABV45518.1    EF127798    ABL67935.1    EF521820    ABP96888.1    + More
NWSH01001615    PCG70684.1    KZ150420    PZC70934.1    EF127797    ABL67934.1    KP711048    AKQ12744.1    AF143847    AAD32698.1    EF127799    ABL67936.1    GQ228552    ADD69773.1    KP711055    AKQ12751.1    KP771859    ALM23508.1    KP101245    AJA39821.1    MH138165    AXP17106.1    GQ247883    ADE34345.1    GU207835    KU130399    ADB84598.1    AMH87606.1    EU082083    ABV45519.1    KU130400    AMH87607.1    GU060293    ADC29632.1    GU060296    ADC29635.1    GU058050    ACY25395.1    GU060295    ADC29634.1    GU060297    ADC29636.1    GU060298    ADC29637.1    KQ971307    KYB29612.1    EU930066    ACM09861.1    EF526087    ABS86909.1    KYB29613.1    CH902624    KPU74286.1    EU930064    ACM09859.1    CH379060    KRT03800.1    CM002910    KMY89339.1    AE014134    AAN10709.2    CM000157    KRJ97981.1    CH954177    KQS70399.1    CH933807    KRG03749.1    EU930065    ACM09860.1    CH940649    KRF81069.1    AY705400    AAAB01008799    AAU12509.1    EAA03696.4    JN560169    AFN88982.1    KPU74283.1    AF321447    AAM13394.1    KRT03805.1    EU930061    ACM09856.1    EU930067    ACM09862.1    JF731243    KP725465    AEA40429.1    AKV94622.1    EF526086    EU930068    ABS86908.1    ACM09863.1    KYB29614.1    KMY89337.1    KRG03751.1    KRJ97982.1    KPU74285.1    CH963920    EDW78187.2    KQS70394.1    AF321445    AAF52817.3    AAM13392.1    KX525264    ASO96849.1    CH477484    EAT40177.1    KRT03806.1    KRF81066.1    KRG03750.1    KMY89343.1    KPU74284.1    KQS70397.1    AAS64670.1    ADV37014.1    KRJ97980.1    KRJ97983.1    GAMC01006785    JAB99770.1    DQ498131    ABJ09670.1    JN560168    AFN88981.1    JF974072    AEN03030.1    KP260561    AKO69818.1    EF526088    ABS86910.1    KYB29611.1    KRT03801.1    DQ498130    ABJ09669.1    KMY89335.1    AAS64672.1    EDW88689.2    KQS70398.1    JN560167    AFN88980.1    KPU74281.1    JX466887    AFU82558.1    DQ498129    ABJ09668.1    AF321446    AAM13393.1    EDW63360.2    KRT03809.1    AJ554209    CAD86935.1    KPU74282.1    KRG03748.1    KRT03807.1    BT011147    AAR82815.1    KMY89341.1    AGB92837.1    KRJ97979.1    KQS70395.1    AF321448    AAM13395.1    KRF81068.1    JX466888    AFU82559.1   

Proteomes

UP000218220    UP000007266    UP000007801    UP000001819    UP000192221    UP000000803    + More
UP000002282    UP000008711    UP000009192    UP000008792    UP000007062    UP000007798    UP000008820    UP000095300   

PRIDE

A8CGL6    A1EGV5    A5A2M6    A1EGV4    A1EGV6    A8CGM0    + More
Q8IPE2    Q8T7S1    Q9VL79    Q7KTF9    Q7KTF7    Q8T7S2    Q86MN8    Q6NNY5    Q8T7S0   

Pfam

PF02931   Neur_chan_LBD        + More
PF02932   Neur_chan_memb

Interpro

IPR036734   Neur_chan_lig-bd_sf        + More
IPR006029   Neurotrans-gated_channel_TM       
IPR006202   Neur_chan_lig-bd       
IPR036719   Neuro-gated_channel_TM_sf       
IPR002394   Nicotinic_acetylcholine_rcpt       
IPR018000   Neurotransmitter_ion_chnl_CS       
IPR006201   Neur_channel       

SUPFAM

SSF90112   SSF90112        + More
SSF63712   SSF63712       

Gene 3D

2.70.170.10    

ProteinModelPortal

A8CGL6   A1EGV5   A5A2M6   A0A2A4JGH6   A0A2W1BAC7   A1EGV4   + More
A0A0H4U7U0   Q9XZI4   A1EGV6   D8UUW8   A0A0H4TMF2   A0A0S1TL21   A0A0A7RQA0   A0A346IHV1   D8UWB3   D3JL32   A8CGM0   A0A140CTI3   D9YT57   D9YT60   D2X8R6   D9YT59   D9YT61   D9YT62   A0A139WNV9   C3TS36   A0A1S4FID0   A8DIT3   A0A0P8XXV7   C3TS34   A0A0R3NRK7   A0A1W4W8N4   A0A0J9R0C5   Q8IPE2   A0A0R1DNB2   A0A0Q5WLY3   A0A0Q9X712   C3TS35   A0A0Q9W8H3   Q7PTL9   M4H3L1   A0A0P9BRB7   Q8T7S1   A0A0R3NX37   A0A1W4VXP1   C3TS31   C3TS37   G9CU48   A8DIS9   A0A0J9QZ20   A0A0Q9XHQ5   A0A0R1DM16   A0A0P8ZHV2   B4N125   A0A0Q5WME6   Q9VL79   A0A222C753   Q16ZU4   A0A0R3NRJ6   A0A0Q9W8J0   A0A0Q9X676   A0A0J9QZJ7   A0A0N8NZG8   A0A0Q5WAA2   Q7KTF9   A0A0R1DL23   W8BEN9   A5H033   M4H3G0   G9E3J3   A0A0K0NTY9   A8DIT5   A0A1W4VXP6   A0A0R3NS12   A5H032   A0A0J9TJR6   Q7KTF7   B4NYM5   A0A0Q5WJ74   M4H3Y7   A0A1I8NYF7   A0A0P8XHK1   K4JH01   A0A1W4VXN1   A5H031   Q8T7S2   B4LQB0   A0A0R3NRG3   Q86MN8   A0A0P8Y5B5   A0A0Q9XF72   A0A0R3NWT4   Q6NNY5   A0A0J9QZI0   M9PFD8   A0A0R1DKV4   A0A0Q5WJ24   Q8T7S0   A0A0Q9W8K3   K4JF52  

PDB

4BOT     E-value=1.00787e-82,     Score=782

KEGG

100038307    K05312 nicotinic acetylcholine receptor, invertebrate | (RefSeq) nAChRa6, Achra6; nicotinic acetylch

GO

GO:0030054   GO:0045211   GO:0016021   GO:0004888   GO:0022848   GO:0050877   GO:0034220   GO:0007268   GO:0042391   GO:0007165   GO:0043005   GO:0045202   GO:0005887   GO:0046716   GO:0007271   GO:0006812   GO:0005892   GO:0017085   GO:0005230   GO:0006810   GO:0016020   GO:0004889   GO:0005216   GO:0006811   GO:0006281   GO:0048384  

PANTHER

PTHR18945  

Subcellular location

Cell junction  
Synapse  
Postsynaptic cell membrane  
Cell membrane  

Length:

501

Number of predicted TMHs:

3

Exp number of AAs in TMHs:

92.6784600000001

Exp number, first 60 AAs:

0.00035

Total prob of N-in:

0.90594

inside

1  -  236

TMhelix

237  -  259

outside

260  -  297

TMhelix

298  -  320

inside

321  -  476

TMhelix

477  -  499

outside

500  -  501

 

 

Pi

29.672132

Theta

26.302772

Tajima's D

0.390458

CLR

1.125717

CSRT

0.486375681215939

Interpretation

Uncertain