Silkworm Genome Informatics Database

Gene

KWMTBOMO03101

Pre Gene Modal

BGIBMGA000836

Annotation

PREDICTED:_oxysterol-binding_protein-related_protein_1-like_[Bombyx_mori]

Location

Bomo_Chr5(-):18098586-18105060 View in EpiBrowser

Full name

Oxysterol-binding protein + More
Oxysterol-binding protein-related protein 1

Location in the cell

Cytoplasmic Reliability : 1.512 Mitochondrial Reliability : 1.22

CDS

ATGTCGAAAGAAGACGAAAATGCGGGTCTAGAAGCCCAAGAGTCGCTTCTGTATTCAGCTAGGCACGGTGAATTACTAGTGGTCAAATCGCTCTTGGAAGCCAAATCGGAAGGAAAACTTTCATTAGATATTAACTGCAAAGGTAAAGCTAAAAGCAACTTAGGATGGACACCGCTTCACTTGGCAACCTATTTTGGTCATGTGGATGTAGTCAAGGCACTGATAGATGCGGGAGCGAATGTAGATGAGGTTAATGACACTGGTGATACAGCACTACACAAAGCTTCATTCGTTGGGAATGAGGAACTAGTAATACTTCTACTCAACAAGAAAGCAGATGTAAATATTATGAACGGTGAAGGTCGGACAGCTTGTGATGTTTCAAAGACAAGGGATGTTCAGAGATTATTGGAAGCTGCAAAAAAGTCTGAGAGAAATGAACAAGAGAGAAAGCTGCTCACTGCCGCTAAAGAAGGCAGGATTGACGATATACAGATTCTGCTAAGCGGTCCCAATCCGCCTAACATAAACTGTGTAGACGCGCAGGGAAACACGTGCCTCCACTGTGCCGCCTACCGTGGACACACGAGACTCGCCATTCTGTTGTTGCAGCACGGTGTGGACACCACACTCAGGAATAATAGTGGGCAGCTGGCCACGGAGCTGTCCCGAGACGCGGAGATGCGCGAGGTGCTGTCGGTGCGGCCCGTGCAGCGCCTGCAGCACGCCGCCTCCCGCCACCACGGGCCTCTCCTCAAGCGGGCCAGGTTCCTGGGCTGGAGACCTGTCTGGGCGGTGTTGCAGCGCGGCGTGCTGCTGTACTACAGCAACAAGGCGGCGGCCCGGGACAGCGGGCGCTGGAGGAGCCGGAAGTACCTGGACGGAGCGACGCTGGCCGCGCCCGCCGCCGAGCCCGCCATCATCACGCTCAGCTTCAGCGACGGCGACTCGCACAAGCTGGCCGTGCCGCCCGTCGAAGATATAGCTGCAGCGCGACAGGCGTGGGTGACAGCCTTAAACGAGCACATCGCGTACTCCGGACACTACCTGTGGGCCGGGGCGTCGCCCGACACGGCCAAGGAAGCCACCGAGGAGTTGGATGAGGAGACTAAGCCACTGGGTACCATGCAGGATGCGCTGACGGCCGCGACGAACAGTCTGGCGCTGCTGGACACGCAGCTGCGGGAGTGCTCCGCCATCGTGGCGGCTCTGGACAAAACGGTCAACGTCAGTAATTCCCTGCACCATTCGGCGTACATGCGGTTCCAACACGCGAGCGGCAGCGGGCAGGCGGCGCTGGCGGCGCTGCGGCACGGCGCGGCGCTGGTGCAGCAAGCTCGCGACGCGGCCGGCGCCAGACTCGCCCGGGAGGTACGCCGCCATTACGATATCTATGTACGCAATGATTGA

Protein

MSKEDENAGLEAQESLLYSARHGELLVVKSLLEAKSEGKLSLDINCKGKAKSNLGWTPLHLATYFGHVDVVKALIDAGANVDEVNDTGDTALHKASFVGNEELVILLLNKKADVNIMNGEGRTACDVSKTRDVQRLLEAAKKSERNEQERKLLTAAKEGRIDDIQILLSGPNPPNINCVDAQGNTCLHCAAYRGHTRLAILLLQHGVDTTLRNNSGQLATELSRDAEMREVLSVRPVQRLQHAASRHHGPLLKRARFLGWRPVWAVLQRGVLLYYSNKAAARDSGRWRSRKYLDGATLAAPAAEPAIITLSFSDGDSHKLAVPPVEDIAAARQAWVTALNEHIAYSGHYLWAGASPDTAKEATEELDEETKPLGTMQDALTAATNSLALLDTQLRECSAIVAALDKTVNVSNSLHHSAYMRFQHASGSGQAALAALRHGAALVQQARDAAGARLAREVRRHYDIYVRND

Description

Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate (By similarity). Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A (PubMed:16176980). Binds 25-hydroxycholesterol and cholesterol (PubMed:17428193).

Subunit

Interacts with VAPA (By similarity). Interacts with the GTP-bound form of RAB7A. Interacts with OAS1B (By similarity).

Similarity

Belongs to the OSBP family.

Keywords

3D-structure Alternative splicing ANK repeat Coiled coil Complete proteome Endosome Lipid transport Lipid-binding Phosphoprotein Polymorphism Reference proteome Repeat Transport

Feature

chain  Oxysterol-binding protein-related protein 1
splice variant  In isoform A.
sequence variant  In dbSNP:rs35693789.

Uniprot

A0A2H1VTB2 A0A2A4JSN3 A0A2A4JUE9 A0A194PVJ0 A0A2H1WY44 A0A0N1I6B5 + More
A0A2J7R8J0 A0A1B6GWR7 A0A1B6DJH8 A0A067RRW2 E0VXN6 A0A2P8XTF0 A0A0A9Y079 A0A023F0B7 A0A146LSQ9 A0A146KXB4 A0A0P4W231 A0A2R7WDP5 A0A0N7Z9U9 A0A131XMU8 A0A224Z5K7 A0A131Z0W0 A0A131XXW2 A0A1E1XCW0 A0A2L2YD60 A0A090XA86 V5HMR6 A0A2R2MP08 A0A2R5LBQ6 T2M5M8 A0A093FYR0 A0A093QE45 A0A087REE2 A0A2I0MX68 A0A093P7G8 A0A091VNI0 G1K9P2 U6DRU0 A0A146M6E8 A0A1D5P9N8 T1JHE8 A0A091JQE4 A0A210PST3 A0A091GUY4 A0A0A0AJE1 A0A091I6K0 A7S939 A0A3P4S1G3 V8PJV5 A0A093HCH7 G1ND00 R0KE75 A0A2Y9RSA0 A0A1V4KFY3 Q5U262 A0A2Y9S0I6 A0A1L8FYQ6 A0A099ZF09 K7F352 A0A2Y9S0I1 A0A2Y9S192 H0ZJV8 A0A091W7X9 A0A0P6J7J1 G5BLQ4 A0A218V1V7 A0A146N1P7 A0A2K5C9H8 A0A3M0KQZ5 A0A2I4AWK0 A0A091EY82 A0A146WQY3 W5PBY3 A0A3B4EDR3 A0A3B4EDS4 A0A2K5KG76 F7IT78 U3DXI6 F7HQD7 A0A2K5KG99 E1BLV1 A0A2Y9GR92 A0A2K5N5N5 L8IF02 A0A1W4ZS33 A0A2K6AHJ4 A0A2J8XG67 H2QED0 A8KA30 K7BQC5 B0YJ56 Q9BXW6 G7PWI9 G1PH36 A0A2K6E0R4

Pubmed

26354079 24845553 20566863 29403074 25401762 25474469 + More
26823975 28049606 28797301 26830274 28503490 26561354 25970599 25765539 24065732 23371554 15592404 28812685 17615350 24297900 20838655 27762356 17381049 20360741 21993625 20809919 25243066 19393038 22751099 16136131 11181995 15489334 11735225 11279184 11483621 14702039 16177791 16176980 17081983 17428193 18669648 20068231 21269460 21406692 23186163 22002653 21993624

EMBL

ODYU01004321 SOQ44067.1 NWSH01000650 PCG75021.1 PCG75022.1 KQ459597 + More
KPI95145.1 ODYU01011914 SOQ57927.1 KQ460847 KPJ11973.1 NEVH01006721 PNF37145.1 GECZ01002944 JAS66825.1 GEDC01011503 JAS25795.1 KK852503 KDR22529.1 DS235833 EEB18142.1 PYGN01001376 PSN35280.1 GBHO01020664 JAG22940.1 GBBI01004443 JAC14269.1 GDHC01008932 JAQ09697.1 GDHC01019239 JAP99389.1 GDRN01109577 JAI57057.1 KK854653 PTY17668.1 GDRN01109586 GDRN01109585 GDRN01109582 JAI57056.1 GEFH01001131 JAP67450.1 GFPF01010396 MAA21542.1 GEDV01003488 JAP85069.1 GEFM01004741 JAP71055.1 GFAC01002262 JAT96926.1 IAAA01017015 IAAA01017016 LAA05947.1 GBIH01001751 JAC92959.1 GANP01009545 JAB74923.1 GGLE01002806 MBY06932.1 HAAD01001341 CDG67573.1 KL214831 KFV61963.1 KL672089 KFW84660.1 KL226334 KFM11846.1 AKCR02000001 PKK34263.1 KL225456 KFW72366.1 KL411188 KFR04003.1 HAAF01012800 CCP84623.1 GDHC01004027 JAQ14602.1 AADN05000027 JH432008 KK502398 KFP23249.1 NEDP02005522 OWF39549.1 KL447842 KFO77917.1 KL872117 KGL94624.1 KL218275 KFP03837.1 DS469601 EDO39766.1 CYRY02044885 VCX40081.1 AZIM01000002 ETE74132.1 KL205930 KFV77140.1 KB742424 EOB08731.1 LSYS01003169 OPJ83380.1 BC086265 AAH86265.1 CM004476 OCT76715.1 KL892058 KGL79420.1 AGCU01113894 AGCU01113895 AGCU01113896 AGCU01113897 AGCU01113898 AGCU01113899 AGCU01113900 AGCU01113901 AGCU01113902 AGCU01113903 ABQF01004864 ABQF01004865 ABQF01004866 ABQF01004867 ABQF01004868 ABQF01004869 KK734970 KFR11747.1 GEBF01004068 JAN99564.1 JH170966 EHB10215.1 MUZQ01000072 OWK59731.1 GCES01161000 JAQ25322.1 QRBI01000104 RMC15506.1 KK719137 KFO61537.1 GCES01054916 JAR31407.1 AMGL01066563 AMGL01066564 AMGL01066565 AMGL01066566 AMGL01066567 AMGL01066568 AMGL01066569 AMGL01066570 GAMS01008691 JAB14445.1 GAMR01000493 GAMP01005364 JAB33439.1 JAB47391.1 JH881470 ELR54129.1 NDHI03003366 PNJ81024.1 AACZ04065262 NBAG03000249 PNI61495.1 AK292895 BAF85584.1 GABC01002446 GABF01007107 GABD01002080 GABE01005898 JAA08892.1 JAA15038.1 JAA31020.1 JAA38841.1 BC136452 EF445004 CH471088 AAI36453.1 ACA06034.1 EAX01182.1 AF392449 AF392450 AF274714 AF323726 AK001079 AK301862 AC023983 AC090772 CM001293 EHH58812.1 AAPE02049798 AAPE02049799 AAPE02049800 AAPE02049801

Proteomes

UP000218220 UP000053268 UP000053240 UP000235965 UP000027135 UP000009046 + More
UP000245037 UP000085678 UP000053875 UP000053258 UP000053286 UP000053872 UP000054081 UP000053283 UP000001646 UP000000539 UP000053119 UP000242188 UP000053760 UP000053858 UP000054308 UP000001593 UP000053584 UP000001645 UP000248480 UP000190648 UP000186698 UP000053641 UP000007267 UP000007754 UP000053605 UP000006813 UP000197619 UP000233020 UP000269221 UP000192220 UP000052976 UP000002356 UP000261440 UP000233080 UP000008225 UP000009136 UP000248481 UP000233060 UP000192224 UP000233140 UP000002277 UP000005640 UP000009130 UP000001074 UP000233120

PRIDE

A8KA30 Q9BXW6

Pfam

PF12796   Ank_2        + More
PF01237   Oxysterol_BP
PF00169   PH
PF00023   Ank

Interpro

IPR020683   Ankyrin_rpt-contain_dom        + More
IPR036770   Ankyrin_rpt-contain_sf
IPR000648   Oxysterol-bd
IPR001849   PH_domain
IPR002110   Ankyrin_rpt
IPR011993   PH-like_dom_sf
IPR037239   OSBP_sf
IPR018494   Oxysterol-bd_CS

SUPFAM

SSF48403 SSF48403 + More
SSF144000 SSF144000

Gene 3D

1.25.40.20 2.30.29.30

CDD

cd00204 ANK

ProteinModelPortal

A0A2H1VTB2 A0A2A4JSN3 A0A2A4JUE9 A0A194PVJ0 A0A2H1WY44 A0A0N1I6B5 + More
A0A2J7R8J0 A0A1B6GWR7 A0A1B6DJH8 A0A067RRW2 E0VXN6 A0A2P8XTF0 A0A0A9Y079 A0A023F0B7 A0A146LSQ9 A0A146KXB4 A0A0P4W231 A0A2R7WDP5 A0A0N7Z9U9 A0A131XMU8 A0A224Z5K7 A0A131Z0W0 A0A131XXW2 A0A1E1XCW0 A0A2L2YD60 A0A090XA86 V5HMR6 A0A2R2MP08 A0A2R5LBQ6 T2M5M8 A0A093FYR0 A0A093QE45 A0A087REE2 A0A2I0MX68 A0A093P7G8 A0A091VNI0 G1K9P2 U6DRU0 A0A146M6E8 A0A1D5P9N8 T1JHE8 A0A091JQE4 A0A210PST3 A0A091GUY4 A0A0A0AJE1 A0A091I6K0 A7S939 A0A3P4S1G3 V8PJV5 A0A093HCH7 G1ND00 R0KE75 A0A2Y9RSA0 A0A1V4KFY3 Q5U262 A0A2Y9S0I6 A0A1L8FYQ6 A0A099ZF09 K7F352 A0A2Y9S0I1 A0A2Y9S192 H0ZJV8 A0A091W7X9 A0A0P6J7J1 G5BLQ4 A0A218V1V7 A0A146N1P7 A0A2K5C9H8 A0A3M0KQZ5 A0A2I4AWK0 A0A091EY82 A0A146WQY3 W5PBY3 A0A3B4EDR3 A0A3B4EDS4 A0A2K5KG76 F7IT78 U3DXI6 F7HQD7 A0A2K5KG99 E1BLV1 A0A2Y9GR92 A0A2K5N5N5 L8IF02 A0A1W4ZS33 A0A2K6AHJ4 A0A2J8XG67 H2QED0 A8KA30 K7BQC5 B0YJ56 Q9BXW6 G7PWI9 G1PH36 A0A2K6E0R4

PDB

6IYB E-value=1.13634e-34, Score=368

KEGG

101739382 K20174 oxysterol-binding protein-related protein 1/2 | (RefSeq) oxysterol-binding protein-related pr

GO

GO:0006869 GO:0032934 GO:0015248 GO:0005829 GO:0015485 GO:0016020 GO:0043231 GO:0005770 GO:0008289 GO:0097038 GO:0005886 GO:0070062 GO:0006699 GO:0016192 GO:0019886 GO:0005543 GO:0008203 GO:0005515 GO:0008270 GO:0015074 GO:0008237 GO:0051103 GO:0003677 GO:0006281 GO:0048384

PANTHER

PTHR10972

Subcellular location

Late endosome

Length:

469

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.02448

Exp number, first 60 AAs:

0.00176

Total prob of N-in:

0.00330

outside

1 - 469

Pi

30.259728

Theta

24.04451

Tajima's D

-1.733536

CLR

1.773366

CSRT

0.0344982750862457

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics