Gene

KWMTBOMO03079

Pre Gene Modal

BGIBMGA005817

Annotation

PREDICTED:_aquaporin-2-like_[Papilio_xuthus]

Location

Bomo_Chr5(-):17624605-17638653      View in EpiBrowser

Full name

Neurogenic protein big brain      

Location in the cell

PlasmaMembrane   Reliability : 2.397

CDS

ATGGGCGAACAAACGTTTACCATACCAGACGATAATCTGGAACAGCACATTGTGACTTTGTTTGAGAAATTGGAAATTTTACGCCGGGACGCGAATACGAATGGGGACAATTTGGCGGGCAGGATTCCAGCTAGATTAGAGCTGAGGACTTTGTCCCTCTGGAAGGCCGTGGTCGCAGAATGTGTGGCGTCGTTCCTTTATGTTTTCATAGTGTGCGGGGCGGCTGGTGGGGCGGGTGTGGGCGCCTCAGCCTCAGCAGTCCTTCTATCTACGGCACTGGCTTCAGGATGTGCTATAGCAACCCTCACCATGTGCTTCGTTAATATCTCTGGTGCTCACGTGAACCCGGCAGTATCGGCAGCACTGTGCATCCGAAGACACGTGTCTCCGCTCCGAGCCGCGTTGTACGTCATGGCACAGTGCGGAGGTGCGATCGCAGGAGCGGCCGCCATTTACGGGTAA

Protein

MGEQTFTIPDDNLEQHIVTLFEKLEILRRDANTNGDNLAGRIPARLELRTLSLWKAVVAECVASFLYVFIVCGAAGGAGVGASASAVLLSTALASGCAIATLTMCFVNISGAHVNPAVSAALCIRRHVSPLRAALYVMAQCGGAIAGAAAIYG

Description

Essential for proper differentiation of ectoderm. Acts synergistically with neurogenic locus proteins Notch and Delta during the separation of neural and epidermal cell lineages in response to the lateral inhibition signal. Voltage-insensitive monovalent cation channel. Ion transport is blocked by the presence of divalent cations.

Miscellaneous

Separation of neuroblasts from the ectoderm into the inner part of embryo is one of the first steps of CNS development in insects, this process is under control of the neurogenic genes. Mutation in bib gene underlies "big brain" development defect.

Similarity

Belongs to the MIP/aquaporin (TC 1.A.8) family.

Keywords

Complete proteome   Developmental protein   Differentiation   Ion channel   Ion transport   Membrane   Neurogenesis   Phosphoprotein   Reference proteome   Repeat   Transmembrane   Transmembrane helix   Transport  

Feature

chain  Neurogenic protein big brain

Uniprot

A0A2H1VDQ3   A0A194PP89   A0A0N1IEB0   A0A2A4K7Y4   A0A212EKV3   H9J8H5   + More
A0A0L7LBI9   A0A1W4USY7   B4Q8B5   P23645   B4NYR0   M9PB86   B3N909   A0A0J9QZM1   A0A1B0BJI5   A0A1A9YA33   A0A3B0JU36   A0A1I8Q664   A0A1I8M1G5   A0A1B0D6Y8   L7P705   B4G7T7   B0XAC5   W5J377   Q29NF9   B4M9F0   A0A1A9WW00   B4HWE5   B4JCH1   A0A0L0CGT1   O17044   B4KH40   B3MPC6   A0A0M4EC41   Q17BX1   A0A1I8JSJ9   A0A182JXF3   A0A034VYC6   A0A0M4E804   A0A2K6VB93   A0A182M7A1   A0A0K8UVA6   W8C2H2   A0A182S9X3   A0A182TUN2   A0A182KWM9   Q7Q873   A0A084VMQ5   A0A240PMK8   A0A3F2YW06   A0A1Y9IVN1   A0A1Y9GKD2   A0A1I8JU95   A0A168SE93   A0A1S4GZW8   A0A240PPM5   B4MX36   A0A182Y8J3   A0A182QNB7   A0A0T6ATC6   A0A182VKX8   A0A336M7F0   A0A1Y9J072   A0A182X4Z5   A0A182Y8J1   A0A182MBR0   A0A182IT42   A0A182UCW2   A0A165Y505   A0A067R979   A0A146LC65   A0A182NZ12   A0A0A9XE43   A0A0A9XMC6   A0A146LG91   Q7Q872   A0A084VMQ6   A0A182FZQ0   A0A182PYX1   A0A182II08   A0A1S4GZY8   A0A182VC62   A0A182WQK0   A0A182KWN1   A0A182S4K2   A0A182R1E8   D6W7H3   E0W4C7   A0A346A6C0   A0A0B6VQ56   U4UMC4   A0A0P6IWW3   A0A0P4WPZ7   A0A1J1ILL8   N6U0L5   A0A165AE12   A0A0P6FHE8   A0A0P4WBD5   A0A2P6KTE2   E9GCI3  

Pubmed

26354079    22118469    19121390    26227816    17994087    1692392    + More
10731132    12537572    12537569    1483394    9367444    11923418    14990474    18327897    17550304    12537568    12537573    12537574    16110336    17569856    17569867    22936249    25315136    20920257    15632085    26108605    9461417    17510324    25348373    24495485    20966253    12364791    24438588    25244985    24845553    26823975    25401762    18362917    19820115    20566863    23537049    21292972   

EMBL

ODYU01002000    SOQ38959.1    KQ459597    KPI95122.1    KQ460968    KPJ10237.1    + More
NWSH01000041    PCG80347.1    AGBW02014213    OWR42105.1    BABH01027418    JTDY01001796    KOB72857.1    CM000361    EDX04437.1    X53275    AE014134    AY051981    CM000157    EDW88724.2    AGB92848.1    CH954177    EDV58444.2    CM002910    KMY89381.1    JXJN01015406    JXJN01015407    OUUW01000010    SPP85627.1    AJVK01003811    AJVK01003812    CCAG010007822    JN685590    AFP49901.1    CH479180    EDW28435.1    DS232578    EDS43622.1    ADMH02002211    ETN57778.1    CH379060    EAL33383.3    CH940654    EDW57826.2    CH480818    EDW52340.1    CH916368    EDW03125.1    JRES01000418    KNC31445.1    AH006466    AF023135    AF023136    AAC38845.1    CH933807    EDW12251.2    CH902620    EDV32245.2    CP012523    ALC39135.1    CH477314    EAT43849.1    GAKP01011518    JAC47434.1    ALC38990.1    AXCM01002339    GDHF01021685    JAI30629.1    GAMC01000473    JAC06083.1    AAAB01008944    EAA10082.4    ATLV01014618    KE524975    KFB39249.1    APCN01000643    KU055612    ANC68080.1    CH963857    EDW76675.2    AXCN02000636    LJIG01022862    KRT78338.1    UFQT01000438    SSX24307.1    AXCM01004643    KT981952    AMZ04828.1    KK852854    KDR15027.1    GDHC01012768    JAQ05861.1    GBHO01025345    JAG18259.1    GBHO01025344    JAG18260.1    GDHC01012060    JAQ06569.1    EAA10273.4    ATLV01014619    KFB39250.1    AXCN02000637    KQ971307    EFA11295.1    DS235886    EEB20483.1    MF467212    AXK92489.1    AB986245    BAQ25604.1    KB632384    ERL94267.1    GDIQ01003277    JAN91460.1    GDRN01072352    JAI63565.1    CVRI01000054    CRL00460.1    APGK01047106    APGK01047107    KB741077    ENN74136.1    LRGB01000626    KZS17512.1    GDIQ01050144    JAN44593.1    GDRN01072349    JAI63567.1    MWRG01005575    PRD29568.1    GL732539    EFX82861.1   

Proteomes

UP000053268    UP000053240    UP000218220    UP000007151    UP000005204    UP000037510    + More
UP000192221    UP000000304    UP000000803    UP000002282    UP000008711    UP000092460    UP000092443    UP000268350    UP000095300    UP000095301    UP000092462    UP000092444    UP000008744    UP000002320    UP000000673    UP000001819    UP000008792    UP000091820    UP000001292    UP000001070    UP000037069    UP000009192    UP000007801    UP000092553    UP000008820    UP000069272    UP000075881    UP000075883    UP000075901    UP000075902    UP000075882    UP000007062    UP000030765    UP000075880    UP000075884    UP000075920    UP000075840    UP000075900    UP000075885    UP000007798    UP000076408    UP000075886    UP000075903    UP000076407    UP000027135    UP000007266    UP000009046    UP000030742    UP000183832    UP000019118    UP000076858    UP000000305   

PRIDE

H9J8H5    P23645    M9PB86   

Pfam

PF00230   MIP

Interpro

IPR023271   Aquaporin-like        + More
IPR034294   Aquaporin_transptr       
IPR000425   MIP       
IPR022357   MIP_CS       

SUPFAM

SSF81338   SSF81338       

Gene 3D

1.20.1080.10    

CDD

cd00333  MIP

ProteinModelPortal

A0A2H1VDQ3   A0A194PP89   A0A0N1IEB0   A0A2A4K7Y4   A0A212EKV3   H9J8H5   + More
A0A0L7LBI9   A0A1W4USY7   B4Q8B5   P23645   B4NYR0   M9PB86   B3N909   A0A0J9QZM1   A0A1B0BJI5   A0A1A9YA33   A0A3B0JU36   A0A1I8Q664   A0A1I8M1G5   A0A1B0D6Y8   L7P705   B4G7T7   B0XAC5   W5J377   Q29NF9   B4M9F0   A0A1A9WW00   B4HWE5   B4JCH1   A0A0L0CGT1   O17044   B4KH40   B3MPC6   A0A0M4EC41   Q17BX1   A0A1I8JSJ9   A0A182JXF3   A0A034VYC6   A0A0M4E804   A0A2K6VB93   A0A182M7A1   A0A0K8UVA6   W8C2H2   A0A182S9X3   A0A182TUN2   A0A182KWM9   Q7Q873   A0A084VMQ5   A0A240PMK8   A0A3F2YW06   A0A1Y9IVN1   A0A1Y9GKD2   A0A1I8JU95   A0A168SE93   A0A1S4GZW8   A0A240PPM5   B4MX36   A0A182Y8J3   A0A182QNB7   A0A0T6ATC6   A0A182VKX8   A0A336M7F0   A0A1Y9J072   A0A182X4Z5   A0A182Y8J1   A0A182MBR0   A0A182IT42   A0A182UCW2   A0A165Y505   A0A067R979   A0A146LC65   A0A182NZ12   A0A0A9XE43   A0A0A9XMC6   A0A146LG91   Q7Q872   A0A084VMQ6   A0A182FZQ0   A0A182PYX1   A0A182II08   A0A1S4GZY8   A0A182VC62   A0A182WQK0   A0A182KWN1   A0A182S4K2   A0A182R1E8   D6W7H3   E0W4C7   A0A346A6C0   A0A0B6VQ56   U4UMC4   A0A0P6IWW3   A0A0P4WPZ7   A0A1J1ILL8   N6U0L5   A0A165AE12   A0A0P6FHE8   A0A0P4WBD5   A0A2P6KTE2   E9GCI3  

PDB

3CN6     E-value=8.15491e-09,     Score=138

KEGG

101742091    no KO assigned | (RefSeq) neurogenic protein big brain-like

GO

GO:0015267   GO:0016021   GO:0005261   GO:0031410   GO:0007398   GO:0098609   GO:0007498   GO:0005886   GO:0005912   GO:0046331   GO:0030707   GO:0006833   GO:0044719   GO:0055085   GO:0048665   GO:0045747   GO:0015204   GO:0005215   GO:0006810   GO:0016020   GO:0043546   GO:0020037   GO:0051103   GO:0003677   GO:0006281   GO:0048384  

PANTHER

PTHR19139  

Subcellular location

Membrane  

Length:

153

Number of predicted TMHs:

3

Exp number of AAs in TMHs:

65.28954

Exp number, first 60 AAs:

2.13173

Total prob of N-in:

0.96949

inside

1  -  55

TMhelix

56  -  78

outside

79  -  87

TMhelix

88  -  110

inside

111  -  129

TMhelix

130  -  152

outside

153  -  153

 

 

Pi

281.102976

Theta

163.493554

Tajima's D

2.450601

CLR

0.43538

CSRT

0.941402929853507

Interpretation

Uncertain