Gene

KWMTBOMO03027  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA003597

Annotation

ras_small_monomeric_GTPase_Rab6_[Bombyx_mori]

Location

Bomo_Chr5(+):16089865-16111712      View in EpiBrowser

Full name

Ras-related protein Rab6      

Alternative Name

Protein warthog

Location in the cell

Nuclear   Reliability : 2.305

CDS

ATGTCTACATCGGGTGAATTTGGTAATCCTTTACGCAAATTCAAGCTTGTCTTTCTCGGCGAACAGAGTGTTGGGAAGACGTCTCTCATCACTAGATTCATGTACGACAGCTTCGACAATACTTATCAGGCAACAATTGGAATAGATTTTCTATCGAAGACTATGTACTTGGAAGACCGTACGGTGCGACTCCAGCTGTGGGACACTGCGGGCCAAGAGCGGTTCCGGTCCCTCATACCTTCATACATAAGAGATTCGACTGTGGCGGTTGTTGTTTATGATATCACTAACGCGAACTCATTCCACCAGACTTCGAAATGGATCGACGACGTTCGCACGGAGCGTGGTTCTGACGTCATCATCATGTTGGTCGGCAACAAGACCGATCTCTCGGACAAGAGGCAGGTCTCGACCGAGGAAGGCGACAAGAAGGCCAAGGAACTGAACGTGATGTTCATAGAGACAAGCGCCAAAGCTGGTTACAATGTTAAACAGTTATTCCGAAGAGTAGCTGCTGCCCTGCCTGGCATGGACTCTGCCGAAAACAAACCTCCCGAAGACATGCACGAGGTGATCTTGAGACAATCGCCCGGCGACAACAAGGAGCAGGACAGCAGTTGTGTTTGTTAG

Protein

MSTSGEFGNPLRKFKLVFLGEQSVGKTSLITRFMYDSFDNTYQATIGIDFLSKTMYLEDRTVRLQLWDTAGQERFRSLIPSYIRDSTVAVVVYDITNANSFHQTSKWIDDVRTERGSDVIIMLVGNKTDLSDKRQVSTEEGDKKAKELNVMFIETSAKAGYNVKQLFRRVAAALPGMDSAENKPPEDMHEVILRQSPGDNKEQDSSCVC

Description

Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Mediates membrane trafficking during egg chamber growth and organization, possibly upstream of exocyst component Sec5. Also during oogenesis, plays a role, together with BicD but independently of Sec5, in the polarization of the oocyte microtubule cytoskeleton, in the localization of oskar mRNA and in the anterodorsal secretion of grk. Required for anterograde opsin transport through the ER-Golgi complex. Plays a role, together with Rich, in regulating CadN transport in photoreceptor cells which is required for the formation of normal synaptic connections between axons from the inner photoreceptor cells in the eye and postsynaptic cells in the brain medulla layer M6. Necessary for proper development of bristle shafts of macrochaete and microchaete on the head, thorax and scutellum. Modulates Notch signaling. As a key regulator of vesicular traffic, plays a critical role in the regulation of actin organization and is required for normal rates of phagocytic uptake during phagocytosis involved in defense against viral and fungal infection.

Subunit

Interacts with Rich and Act5C. Interacts with BicD (via C-terminal domain). Interacts (in GTP-bound) with GCC1/CG10703 and cbs.

Similarity

Belongs to the small GTPase superfamily. Rab family.

Keywords

3D-structure   Actin-binding   Cell junction   Complete proteome   ER-Golgi transport   Golgi apparatus   GTP-binding   Membrane   Nucleotide-binding   Reference proteome   Synapse   Transport  

Feature

chain  Ras-related protein Rab6

Uniprot

Q2F5M6   A0A1W4XEI2   A0A182RVF5   A0NFB8   A0A1B0ESL7   A0A1B6MNR3   + More
A0A1B6K103   A0A1B6EJX1   F4WI27   E2C2N6   E1ZXW8   A0A026WFV8   A0A0T6B024   A0A1B0D599   A0A1L8DV43   V5GZN3   D6W6M3   A0A165VG92   T1DF28   A0A1Q3EU93   A0A2M4CT06   A0A2M3Z5J9   A0A2M4AFE0   Q177M1   A0A023EJK9   A0A1Y1M2E5   U5EM20   A0A1B6C3V6   K7J5U5   A0A084WAI1   A0A1J1J8U8   A0A154PNG7   T1E8Y3   V9IE33   A0A087ZVJ9   A0A224XXK9   A0A0P4VRT7   A0A069DQ39   R4G4K2   A0A0K8TSA5   A0A0V0G547   A0A1D2NH59   W8B2S9   A0A0A1WFX3   A0A0K8VVR2   A0A034VFY5   A0A0A9YJ69   B4N777   A0A2S2PZ90   A0A1W4VAL0   B4LSG0   A0A0J9R165   A0A3B0JGK2   Q29N73   X2J5T3   B4G858   B4P1Z0   A0A0M4E9J8   B3MVH2   B4IE68   B4JBU2   B3N3W8   O18334   A0A2H8TH80   C4WSP6   A0A0L7QPD0   B4KJL2   E0VCF9   A0A151JW87   A0A158NMH8   A0A151WV77   A0A1B6JES8   A0A1B6CUW6   A0A3L8DKL2   A0A1B6KWL2   A0A2A4K800   Q177M3   A0A0A9YLW3   A0A067RKJ4   A0A1W4XQ64   A0A1J1J4Q5   A0A2A3EQR5   A0A0N1I7M1   A0A2S2P430   A0A1L8EDX3   V4B3K0   A0A0B4UC48   C4WSP5   A0A1S3I222   A0A194PVG5   E9GDK0   A0A0N8EDG6   A0A1I8PBK8   A0A1W0X968   A0A146L146   A0A2J7QC65   R4UK51   A0A0P4W491   T1PEU1   H9J260  

Pubmed

12364791    14747013    17210077    21719571    20798317    24508170    + More
18362917    19820115    24330624    17510324    24945155    26483478    28004739    20075255    24438588    27129103    26334808    26369729    27289101    24495485    25830018    25348373    25401762    17994087    22936249    15632085    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    17550304    9074639    9685396    10459009    12537569    17329360    17827179    19001129    18833296    22000105    21835342    22928698    21795785    20566863    21347285    30249741    26823975    24845553    26354079    23254933    25542378    26383154    21292972    25315136    19121390   

EMBL

DQ311397    ABD36341.1    AAAB01008966    EAU76291.2    AJWK01005351    GEBQ01002436    + More
JAT37541.1    GECU01002581    JAT05126.1    GECZ01031539    GECZ01009848    JAS38230.1    JAS59921.1    GL888172    EGI66120.1    GL452201    EFN77792.1    GL435155    EFN73950.1    KK107238    EZA54818.1    LJIG01022460    KRT80461.1    AJVK01003446    GFDF01003795    JAV10289.1    GALX01001059    JAB67407.1    KQ971307    EFA10825.1    KT984812    AMZ00364.1    GALA01000822    JAA94030.1    GFDL01016172    JAV18873.1    GGFL01004217    MBW68395.1    GGFM01003023    MBW23774.1    GGFK01006188    MBW39509.1    CH477374    EAT42344.1    EJY57618.1    JXUM01126665    JXUM01126666    JXUM01126667    JXUM01126668    GAPW01004382    KQ567094    JAC09216.1    KXJ69621.1    GEZM01044963    GEZM01044962    JAV78016.1    GANO01001186    JAB58685.1    GEDC01029117    JAS08181.1    AAZX01005701    ATLV01022193    KE525329    KFB47225.1    CVRI01000070    CRL07385.1    KQ435007    KZC13416.1    GAMD01002353    JAA99237.1    JR039970    AEY58927.1    GFTR01003513    JAW12913.1    GDKW01000814    JAI55781.1    GBGD01002929    JAC85960.1    ACPB03009762    GAHY01000701    JAA76809.1    GDAI01000361    JAI17242.1    GECL01003316    JAP02808.1    LJIJ01000040    ODN04577.1    GAMC01013703    JAB92852.1    GBXI01016515    JAC97776.1    GDHF01034016    GDHF01023315    GDHF01015814    GDHF01009346    JAI18298.1    JAI28999.1    JAI36500.1    JAI42968.1    GAKP01017921    GAKP01017920    JAC41032.1    GBHO01011360    GBRD01011254    JAG32244.1    JAG54570.1    CH964182    EDW80218.1    GGMS01001536    MBY70739.1    CH940649    EDW64782.1    CM002910    KMY89881.1    OUUW01000004    SPP79833.1    CH379060    EAL33470.1    AE014134    AHN54383.1    CH479180    EDW28538.1    CM000157    EDW88161.1    CP012523    ALC38888.1    CH902624    EDV33237.1    CH480831    EDW45895.1    CH916368    EDW04045.1    CH954177    EDV58820.1    D84314    AY060261    AAF53168.1    AAL25300.1    BAA21707.1    GFXV01001604    MBW13409.1    ABLF02034466    AK340278    BAH70916.1    KQ414817    KOC60498.1    CH933807    EDW11457.1    DS235053    EEB11065.1    KQ981676    KYN38145.1    ADTU01020505    ADTU01020506    ADTU01020507    KQ982727    KYQ51601.1    GECU01010273    JAS97433.1    GEDC01020275    JAS17023.1    QOIP01000007    RLU20970.1    GEBQ01024162    JAT15815.1    NWSH01000041    PCG80351.1    EAT42345.1    GBHO01009547    GBRD01011252    GDHC01012143    JAG34057.1    JAG54572.1    JAQ06486.1    KK852415    KDR24391.1    CRL07384.1    KZ288193    PBC34133.1    KQ460968    KPJ10239.1    GGMR01011556    MBY24175.1    GFDG01001879    JAV16920.1    KB199651    ESP04938.1    KP216757    AJC97114.1    AK340277    BAH70915.1    KQ459597    KPI95120.1    GL732540    EFX82462.1    GDIQ01037540    LRGB01000687    JAN57197.1    KZS16682.1    MTYJ01000008    OQV24077.1    GDHC01017154    JAQ01475.1    NEVH01016292    PNF26171.1    KC571970    AGM32469.1    GDRN01085795    JAI61285.1    KA646433    AFP61062.1    BABH01007360    BABH01007361    BABH01007362   

Proteomes

UP000192223    UP000075900    UP000007062    UP000092461    UP000007755    UP000008237    + More
UP000000311    UP000053097    UP000092462    UP000007266    UP000008820    UP000069940    UP000249989    UP000002358    UP000030765    UP000183832    UP000076502    UP000005203    UP000015103    UP000094527    UP000007798    UP000192221    UP000008792    UP000268350    UP000001819    UP000000803    UP000008744    UP000002282    UP000092553    UP000007801    UP000001292    UP000001070    UP000008711    UP000007819    UP000053825    UP000009192    UP000009046    UP000078541    UP000005205    UP000075809    UP000279307    UP000218220    UP000027135    UP000242457    UP000053240    UP000030746    UP000085678    UP000053268    UP000000305    UP000076858    UP000095300    UP000235965    UP000095301    UP000005204   

PRIDE

Q2F5M6    X2J5T3    O18334    H9J260   

Pfam

PF00071   Ras

Interpro

IPR027417   P-loop_NTPase        + More
IPR001806   Small_GTPase       
IPR005225   Small_GTP-bd_dom       

SUPFAM

SSF52540   SSF52540       

ProteinModelPortal

Q2F5M6   A0A1W4XEI2   A0A182RVF5   A0NFB8   A0A1B0ESL7   A0A1B6MNR3   + More
A0A1B6K103   A0A1B6EJX1   F4WI27   E2C2N6   E1ZXW8   A0A026WFV8   A0A0T6B024   A0A1B0D599   A0A1L8DV43   V5GZN3   D6W6M3   A0A165VG92   T1DF28   A0A1Q3EU93   A0A2M4CT06   A0A2M3Z5J9   A0A2M4AFE0   Q177M1   A0A023EJK9   A0A1Y1M2E5   U5EM20   A0A1B6C3V6   K7J5U5   A0A084WAI1   A0A1J1J8U8   A0A154PNG7   T1E8Y3   V9IE33   A0A087ZVJ9   A0A224XXK9   A0A0P4VRT7   A0A069DQ39   R4G4K2   A0A0K8TSA5   A0A0V0G547   A0A1D2NH59   W8B2S9   A0A0A1WFX3   A0A0K8VVR2   A0A034VFY5   A0A0A9YJ69   B4N777   A0A2S2PZ90   A0A1W4VAL0   B4LSG0   A0A0J9R165   A0A3B0JGK2   Q29N73   X2J5T3   B4G858   B4P1Z0   A0A0M4E9J8   B3MVH2   B4IE68   B4JBU2   B3N3W8   O18334   A0A2H8TH80   C4WSP6   A0A0L7QPD0   B4KJL2   E0VCF9   A0A151JW87   A0A158NMH8   A0A151WV77   A0A1B6JES8   A0A1B6CUW6   A0A3L8DKL2   A0A1B6KWL2   A0A2A4K800   Q177M3   A0A0A9YLW3   A0A067RKJ4   A0A1W4XQ64   A0A1J1J4Q5   A0A2A3EQR5   A0A0N1I7M1   A0A2S2P430   A0A1L8EDX3   V4B3K0   A0A0B4UC48   C4WSP5   A0A1S3I222   A0A194PVG5   E9GDK0   A0A0N8EDG6   A0A1I8PBK8   A0A1W0X968   A0A146L146   A0A2J7QC65   R4UK51   A0A0P4W491   T1PEU1   H9J260  

PDB

3BBP     E-value=6.17874e-94,     Score=874

KEGG

692966    K07893 Ras-related protein Rab-6A | (RefSeq) ras small monomeric GTPase Rab6

GO

GO:0003924   GO:0005525   GO:0006890   GO:0006891   GO:0006886   GO:0005829   GO:0042147   GO:0032482   GO:0005794   GO:0008103   GO:0006887   GO:0031410   GO:0060078   GO:0045451   GO:0007411   GO:0007602   GO:0007293   GO:0045467   GO:0050832   GO:0043204   GO:0031982   GO:0001745   GO:0030054   GO:0045202   GO:0016192   GO:0003779   GO:0043025   GO:0000139   GO:0007264   GO:0003676   GO:0000166   GO:0006414   GO:0016020   GO:0051103   GO:0003677   GO:0006281   GO:0048384  

Subcellular location

Golgi apparatus membrane   Colocalizes with Rich at the Golgi apparatus. During oogenesis, first accumulates transiently in a central position during stages 7-8, then is uniformly distributed at the beginning of stage 9 to end up juxtaposed to the entire oocyte cortex.   With evidence from 7 publications.
Cell junction   Colocalizes with Rich at the Golgi apparatus. During oogenesis, first accumulates transiently in a central position during stages 7-8, then is uniformly distributed at the beginning of stage 9 to end up juxtaposed to the entire oocyte cortex.   With evidence from 7 publications.
Synapse   Colocalizes with Rich at the Golgi apparatus. During oogenesis, first accumulates transiently in a central position during stages 7-8, then is uniformly distributed at the beginning of stage 9 to end up juxtaposed to the entire oocyte cortex.   With evidence from 7 publications.
Perikaryon   Colocalizes with Rich at the Golgi apparatus. During oogenesis, first accumulates transiently in a central position during stages 7-8, then is uniformly distributed at the beginning of stage 9 to end up juxtaposed to the entire oocyte cortex.   With evidence from 7 publications.

Length:

209

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00425

Exp number, first 60 AAs:

0.00341

Total prob of N-in:

0.02138

outside

1  -  209

 

 

Pi

221.618184

Theta

180.990716

Tajima's D

0.232953

CLR

0.847072

CSRT

0.43602819859007

Interpretation

Uncertain