Gene

KWMTBOMO03013

Pre Gene Modal

BGIBMGA003591

Annotation

Lix1_protein_[Bombyx_mori]

Location

Bomo_Chr5(+):15699385-15727569      View in EpiBrowser

Full name

Protein limb expression 1 homolog      

Alternative Name

lowfat

Location in the cell

Cytoplasmic   Reliability : 1.475 Mitochondrial   Reliability : 1.084

CDS

ATGGTGTACCCGGAGCCGTCCCGCTGGGGCGCGCCCGACGCCGCGCTCGCGCCCCTCTACGACGACGTCTACAGAGCTGATGGAGTCCTCTCGACTGTGAATGTAGTGGAAGCCCTCCAAGAGTTTTGGCAGGTGAAGGCGGCACGAGGCGGGGGCGCGGCGGGCGGCGCCCTCGTCATCTACGAGTCTGTGCCGGCTGCTCATCCGCCCTACGTCTGCTACGTCACGCTCCCCGGTGGAGCGTGCTTTGGCAGTTTTCAAAACTGCCCAACTAAAGCGGAAGCAAGACGCAGCGCCGCTAAAATAGCATTAATGAACAGCGTATTCAACGAGCACGAATCTCGGCGGATATCCGACCATTTCATCGAGAAGGCGGTGGCGGAGGCACGCGCGTCCTTCGCCGGAGACACGAGCAACCCACACCAGGACCCCAGCGCTGGTATCGCTGCGTTTAGGTTCATGCTGGAGGCGAACAAAGGTCGGACGATGCTGGAATTCCAGGAGCTGATGACGGTATTCCAGCTGCTCCACTGGAACGGGTCGCTGAGAGCGATGCGCGAGCGGCAATGCTCGCGGCAGGAAGTCGTAGCGCACTACTCGGCCCGGGCACTAGACGACGCGATGCGGGAACAGATGGCGCGAGAATGGGCCACCAGGGAGCGTGAAGCGTCTTCGTCCGGTGGCGGAGTACTACGCGCGGAGCTGGCGAGATCTGAACGCGAGCTTCGGGCCGCGAGGCTGGCGGCACGTGAGCTTCGCTTCCCTAAAGAAAAGCGCGACATCCTCCAACTGGCCGCCCGTCTAGCGCCGCCGCCGCAACCGTGA

Protein

MVYPEPSRWGAPDAALAPLYDDVYRADGVLSTVNVVEALQEFWQVKAARGGGAAGGALVIYESVPAAHPPYVCYVTLPGGACFGSFQNCPTKAEARRSAAKIALMNSVFNEHESRRISDHFIEKAVAEARASFAGDTSNPHQDPSAGIAAFRFMLEANKGRTMLEFQELMTVFQLLHWNGSLRAMRERQCSRQEVVAHYSARALDDAMREQMAREWATREREASSSGGGVLRAELARSERELRAARLAARELRFPKEKRDILQLAARLAPPPQP

Description

Component of the Fat (ft) signaling pathway that functions in normal development of various organs such as the wing and leg (PubMed:19710173, PubMed:21379328). In developing imaginal disks, involved in regulating both the protein levels and apical localization of ft and ds (PubMed:19710173). Involved in establishing planar cell polarity (PCP) along the anterior-posterior axis of the wing (the early Fz signaling event), probably by acting upstream of ds and ft to regulate Fz activity (PubMed:21379328).

Subunit

Interacts with ft (via intracellular domain) and ds (via intracellular domain).

Similarity

Belongs to the LIX1 family.

Keywords

Cell membrane   Complete proteome   Cytoplasm   Membrane   Reference proteome  

Feature

chain  Protein limb expression 1 homolog

Uniprot

Q2F5Q3   A0A212EWX0   A0A2A4J3X1   A0A0N1PEU3   A0A2H1VQY9   I4DIQ8   + More
I4DM31   A0A151JAN9   A0A026WT61   A0A0J7L158   A0A151IEX0   E2AIL0   A0A151I1Y3   A0A0L7LBN1   E9IMI8   A0A151WV28   F4X7U1   A0A195FZ79   E2BM18   A0A1J1IN57   E9G045   A0A3L8DP27   A0A2J7RCF0   A0A0P5EBI1   A0A087ZUU3   A0A154PNP7   A0A1B6D6N0   A0A2A3EQV2   A0A310SQM2   A0A2A3ESF6   A0A0T6AUI0   A0A0N8DPQ9   A0A2P8YNG0   A0A336KUA0   A0A0L7QPJ2   A0A2P2I080   A0A0P5BB77   A0A0P6IA44   A0A067RFD6   Q7PWC8   A0A146LKF0   A0A182QF76   A0A182YFS1   A0A182MGL5   A0A182SUS2   A0A182V565   W5J2B7   A0A182JZY4   A0A182U9X8   A0A182VU23   A0A084VKK4   A0A182X0E1   A0A182LMD9   A0A182FND3   A0A182RLC6   A0A182I7N0   D6W7E9   A0A0P5IR49   E0VQJ9   A0A182PEC8   A0A1B0DPY5   A0A1S4H0M2   A0A1B6IWP6   A0A1B0CHN8   A0A1B6GTP0   A0A182J049   A0A1Y1MXZ2   A0A2M4CX76   A0A336MCM1   A0A0K2UQF6   N6U889   A0A224XVN7   A0A069DRI4   A0A1A9VZR0   B4LVD6   A0A023EYA1   B0WU37   B4JPY5   T1I337   A0A0M4EA86   Q17K63   A0A182G7J9   B4MUC8   A0A1A9Y503   A0A1A9Z9D7   A0A1B0FHP0   A0A0C9R3R7   A0A1B0AWX7   A0A2R5LHD2   A0A0A9VU50   A0A1W4UFI1   B3MPS6   Q9VKY1   B4HWM2   B4Q977   B3N9M7   A0A2R2MN65  

Pubmed

22118469    26354079    22651552    24508170    20798317    26227816    + More
21282665    21719571    21292972    30249741    29403074    24845553    12364791    26823975    25244985    20920257    23761445    24438588    20966253    18362917    19820115    20566863    28004739    23537049    26334808    17994087    18057021    25474469    17510324    26483478    25401762    10731132    12537572    19710173    21379328    22936249   

EMBL

DQ311370    ABD36314.1    AGBW02011913    OWR45934.1    NWSH01003158    PCG66847.1    + More
KQ461187    KPJ07355.1    ODYU01003888    SOQ43208.1    AK401176    KQ459597    BAM17798.1    KPI95113.1    AK402349    BAM18971.1    KQ979254    KYN22101.1    KK107128    EZA58294.1    LBMM01001492    KMQ96214.1    KQ977835    KYM99367.1    GL439822    EFN66731.1    KQ976554    KYM80818.1    JTDY01001815    KOB72804.1    GL764165    EFZ18213.1    KQ982709    KYQ51779.1    GL888900    EGI57427.1    KQ981193    KYN45109.1    GL449100    EFN83267.1    CVRI01000055    CRL01186.1    GL732528    EFX86835.1    QOIP01000006    RLU21629.1    NEVH01005885    PNF38500.1    GDIP01143760    LRGB01001374    JAJ79642.1    KZS12115.1    KQ435007    KZC13505.1    GEDC01015968    JAS21330.1    KZ288193    PBC34145.1    KQ760995    OAD58510.1    PBC34146.1    LJIG01022781    KRT78748.1    GDIP01119261    GDIP01012975    JAM90740.1    PYGN01000469    PSN45782.1    UFQS01000934    UFQT01000934    SSX07842.1    SSX28076.1    KQ414832    KOC60396.1    IACF01001723    LAB67409.1    GDIP01187400    JAJ36002.1    GDIQ01007448    JAN87289.1    KK852506    KDR22477.1    AAAB01008984    EAA14824.3    GDHC01010118    JAQ08511.1    AXCN02000625    AXCM01000226    ADMH02002194    ETN57881.1    ATLV01014228    KE524948    KFB38498.1    APCN01003430    KQ971307    EFA11217.2    GDIQ01210214    JAK41511.1    DS235430    EEB15655.1    AJVK01008339    GECU01016345    JAS91361.1    AJWK01012546    GECZ01003988    JAS65781.1    GEZM01020526    JAV89255.1    GGFL01005300    MBW69478.1    SSX07840.1    SSX28074.1    HACA01023112    CDW40473.1    APGK01039147    KB740967    KB632399    ENN76866.1    ERL94646.1    GFTR01004253    JAW12173.1    GBGD01002588    JAC86301.1    CH940649    EDW63315.1    KRF81035.1    KRF81036.1    GBBI01004655    JAC14057.1    DS232100    EDS34756.1    CH916372    EDV98965.1    ACPB03024256    CP012523    ALC39264.1    CH477228    EAT47029.1    JXUM01046495    JXUM01046496    JXUM01079389    KQ563124    KQ561479    KXJ74436.1    KXJ78451.1    CH963857    EDW76054.1    CCAG010020380    GBYB01010968    GBYB01010969    JAG80735.1    JAG80736.1    JXJN01004959    GGLE01004808    MBY08934.1    GBHO01043797    GBHO01027905    GBRD01009634    GDHC01002236    JAF99806.1    JAG15699.1    JAG56190.1    JAQ16393.1    CH902620    EDV32324.1    KPU73900.1    AE014134    BT024350    ABC86412.1    CH480818    EDW52417.1    CM000361    CM002910    EDX04519.1    KMY89503.1    CH954177    EDV58522.1    KQS70432.1   

Proteomes

UP000007151    UP000218220    UP000053240    UP000053268    UP000078492    UP000053097    + More
UP000036403    UP000078542    UP000000311    UP000078540    UP000037510    UP000075809    UP000007755    UP000078541    UP000008237    UP000183832    UP000000305    UP000279307    UP000235965    UP000076858    UP000005203    UP000076502    UP000242457    UP000245037    UP000053825    UP000027135    UP000007062    UP000075886    UP000076408    UP000075883    UP000075901    UP000075903    UP000000673    UP000075881    UP000075902    UP000075920    UP000030765    UP000076407    UP000075882    UP000069272    UP000075900    UP000075840    UP000007266    UP000009046    UP000075885    UP000092462    UP000092461    UP000075880    UP000019118    UP000030742    UP000091820    UP000008792    UP000002320    UP000001070    UP000015103    UP000092553    UP000008820    UP000069940    UP000249989    UP000007798    UP000092443    UP000092445    UP000092444    UP000092460    UP000192221    UP000007801    UP000000803    UP000001292    UP000000304    UP000008711    UP000085678   

PRIDE

Q2F5Q3    Q9VKY1   

Pfam

PF14954   LIX1

Interpro

IPR029270   LIX1       

ProteinModelPortal

Q2F5Q3   A0A212EWX0   A0A2A4J3X1   A0A0N1PEU3   A0A2H1VQY9   I4DIQ8   + More
I4DM31   A0A151JAN9   A0A026WT61   A0A0J7L158   A0A151IEX0   E2AIL0   A0A151I1Y3   A0A0L7LBN1   E9IMI8   A0A151WV28   F4X7U1   A0A195FZ79   E2BM18   A0A1J1IN57   E9G045   A0A3L8DP27   A0A2J7RCF0   A0A0P5EBI1   A0A087ZUU3   A0A154PNP7   A0A1B6D6N0   A0A2A3EQV2   A0A310SQM2   A0A2A3ESF6   A0A0T6AUI0   A0A0N8DPQ9   A0A2P8YNG0   A0A336KUA0   A0A0L7QPJ2   A0A2P2I080   A0A0P5BB77   A0A0P6IA44   A0A067RFD6   Q7PWC8   A0A146LKF0   A0A182QF76   A0A182YFS1   A0A182MGL5   A0A182SUS2   A0A182V565   W5J2B7   A0A182JZY4   A0A182U9X8   A0A182VU23   A0A084VKK4   A0A182X0E1   A0A182LMD9   A0A182FND3   A0A182RLC6   A0A182I7N0   D6W7E9   A0A0P5IR49   E0VQJ9   A0A182PEC8   A0A1B0DPY5   A0A1S4H0M2   A0A1B6IWP6   A0A1B0CHN8   A0A1B6GTP0   A0A182J049   A0A1Y1MXZ2   A0A2M4CX76   A0A336MCM1   A0A0K2UQF6   N6U889   A0A224XVN7   A0A069DRI4   A0A1A9VZR0   B4LVD6   A0A023EYA1   B0WU37   B4JPY5   T1I337   A0A0M4EA86   Q17K63   A0A182G7J9   B4MUC8   A0A1A9Y503   A0A1A9Z9D7   A0A1B0FHP0   A0A0C9R3R7   A0A1B0AWX7   A0A2R5LHD2   A0A0A9VU50   A0A1W4UFI1   B3MPS6   Q9VKY1   B4HWM2   B4Q977   B3N9M7   A0A2R2MN65  

KEGG

692948    K16673 LIX1-like protein | (RefSeq) Lix1; Lix1 protein

PATHWAY

04391    Hippo signaling pathway - fly - Bombyx mori (domestic silkworm)

GO

GO:0006914   GO:0005737   GO:0097352   GO:0035003   GO:0007476   GO:0005829   GO:0016324  

Subcellular location

Apical cell membrane   In wing imaginal disks, strong cytoplasmic expression in the wing pouch but in regions of the wing hinge preferentially expressed in the sub-apical membrane.   With evidence from 1 publications.
Cytoplasm   In wing imaginal disks, strong cytoplasmic expression in the wing pouch but in regions of the wing hinge preferentially expressed in the sub-apical membrane.   With evidence from 1 publications.

Length:

274

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.07636

Exp number, first 60 AAs:

0.00601

Total prob of N-in:

0.01830

outside

1  -  274

 

 

Pi

22.019904

Theta

185.682917

Tajima's D

0.052781

CLR

1448.31441

CSRT

0.381330933453327

Interpretation

Uncertain