Gene

KWMTBOMO03003  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA003609

Annotation

hypothetical_protein_KGM_19988_[Danaus_plexippus]

Location

Bomo_Chr5(-):15517413-15519324      View in EpiBrowser

Full name

Adenylate kinase isoenzyme 6 homolog       + More
Adenylate kinase isoenzyme 6      

Alternative Name

Dual activity adenylate kinase/ATPase
Coilin-interacting nuclear ATPase protein

Location in the cell

Cytoplasmic   Reliability : 1.795

CDS

ATGAATTCAGGTCGCACCCTTCCAAATGTTTTAGTAACTGGTACTCCTGGAGTAGGTAAGTCCACATTGTGCAGAAATTTAGCTGACCGAACTAAATTCGCTTGGAGGGATGTATCAAATATCGCCCAAGAACACAATTGCTTGGATGAATATGATCCTGAATATCAATGCCCGTTTTTGAATGAAGATAAGTTGCTGGACATTATGGAGGGTATGATGGCAAAAGGAGGAAACATAGTTGACTATCACAGTTGTGATTTTTTCCCTGAGCGGTGGTTTGATGGTGTATTTGTTATACGGTGCAACAATACAACACTTTATGATAGACTTGCAGCTAGGGGCTACACAGGCAAAAAACTTGAAGACAATATTCAATGCGAGATCTTTGCCACAATTTTAGATGAAGCTCAGTCATCATATAAACCGGTGATAATCCACGAATTACAAAATGACACTGAGGAACAGATACAGAAAAATGTTGATACTATTGTTGCATGGATAGAGAGGTGGAAAGAAGAAAATATATAG

Protein

MNSGRTLPNVLVTGTPGVGKSTLCRNLADRTKFAWRDVSNIAQEHNCLDEYDPEYQCPFLNEDKLLDIMEGMMAKGGNIVDYHSCDFFPERWFDGVFVIRCNNTTLYDRLAARGYTGKKLEDNIQCEIFATILDEAQSSYKPVIIHELQNDTEEQIQKNVDTIVAWIERWKEENI

Description

Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity.
Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation.
Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. AMP is the best phosphate acceptor, and CMP is also a good substrate. All nucleoside triphosphates ATP, TTP, CTP, GTP, and UTP are accepted as phosphate donors. ATP is the best phosphate donor. May have a role in nuclear energy homeostasis.

Catalytic Activity

AMP + ATP = 2 ADP

Subunit

Monomer and homodimer.
Monomer and homodimer. Interacts with COIL (via C-terminus).

Similarity

Belongs to the adenylate kinase family. AK6 subfamily.

Keywords

ATP-binding   Complete proteome   Kinase   Nucleotide-binding   Nucleus   Reference proteome   Transferase  

Feature

chain  Adenylate kinase isoenzyme 6 homolog

Uniprot

H9J272   A0A2A4JGX4   A0A212FJX0   A0A2H1VXQ8   A0A0N1IBG2   A0A194PNV0   + More
K7J5L9   A0A2P8YNW7   A0A067QUH5   A0A232FD70   A0A2J7R3Q8   R4UP19   A0A162QRD2   E9H2H6   A0A0P4XC90   A0A1W4X9H9   A0A0N8AN91   A0A154NWU2   A0A310SNM4   E2B132   A0A1Y1LKS0   A0A088AJB3   A0A0L7R7U0   A0A0J7L9S0   A0A2A3EBX3   A0A3L8DVZ0   A0A1I8MTX6   A0A1D2MT14   A0A226EJ71   A0A0N7ZAS8   B4LL06   R7U8B2   T1PGY9   A0A195CMC0   E2B3T8   G1KJZ7   A0A2B4T2W7   E0VXX0   B4J9L2   B4KQT7   A0A0K8UQ07   A0A1Q3F9H9   A0A3N0XHN6   A0A1Q3F9J1   A0A0A1WES7   Q6IQD6   A2BGQ5   W8AY38   A0A1Q3F8X2   N6TCT0   A0A2C9JNU8   A0A1W7RJN5   J3S3Y5   T1DDX0   U4USC1   A0A3B4EF73   A0A1B0ESY1   A0A1W5APP0   A0A226PRE3   B3NRY7   I3K8S1   B4HPL0   A0A2I0TRV7   A0A060Y6L0   B5X3S3   A0A3B1J7F3   A0A1A9V4T3   B5DFY2   T1GGZ5   B0WSW3   A0A1I8PUD7   Q7JYV7   H3ARI4   A0A3B0JFW4   A0A0B8RYP0   B4NMI0   U3KEG2   A0A0L0CN32   A0A1W4VCK0   A0A0M4EEA2   Q4PMA7   A0A034W190   K4FUH0   A0A3B4FF80   A0A3P8Q883   A0A3P9D2H5   A0A0F7Z748   A0A2D4JBB6   A0A098M0S9   A0A0K8RB76   A0A1Z5L813   A0A3M6T5B8   A0A182YHD3   B4QDD4   T1JDR8   F4WP18   A0A1S3HAH3   B4P581   A0A1A9WNV3   A0A1U7S8B4  

EC Number

2.7.4.3

Pubmed

19121390    22118469    26354079    20075255    29403074    24845553    + More
28648823    21292972    20798317    28004739    30249741    25315136    27289101    17994087    23254933    20566863    25830018    23594743    24495485    23537049    15562597    26358130    23025625    23758969    25727380    24621616    25186727    24755649    20433749    25329095    19878547    10731132    12537572    12537569    18294127    9215903    25476704    26108605    16431279    25348373    23056606    28528879    30382153    25244985    22936249    21719571    17550304   

EMBL

BABH01007426    NWSH01001631    PCG70642.1    AGBW02008204    OWR54038.1    ODYU01005095    + More
ODYU01005096    SOQ45630.1    SOQ45631.1    KQ461187    KPJ07348.1    KQ459597    KPI95106.1    PYGN01000459    PSN45946.1    KK852921    KDR13775.1    NNAY01000406    OXU28615.1    NEVH01007818    PNF35468.1    KC741101    AGM32925.1    LRGB01000311    KZS19889.1    GL732586    EFX73979.1    GDIP01246309    JAI77092.1    GDIQ01259131    JAJ92593.1    KQ434777    KZC04155.1    KQ760629    OAD59716.1    GL444771    EFN60605.1    GEZM01054636    JAV73511.1    KQ414637    KOC66947.1    LBMM01000169    KMR04647.1    KZ288290    PBC29235.1    QOIP01000003    RLU24624.1    LJIJ01000591    ODM96041.1    LNIX01000003    OXA57682.1    GDRN01094692    JAI59688.1    CH940648    EDW61813.1    AMQN01008735    KB303858    ELU02620.1    KA648026    AFP62655.1    KQ977574    KYN01876.1    GL445407    EFN89607.1    LSMT01000001    PFX34945.1    DS235841    EEB18226.1    CH916367    EDW02519.1    CH933808    EDW09286.2    GDHF01023567    JAI28747.1    GFDL01010872    JAV24173.1    RJVU01073043    ROI27746.1    GFDL01010877    JAV24168.1    GBXI01016900    JAC97391.1    BC071472    AAH71472.1    BX510923    GAMC01016812    JAB89743.1    GFDL01011020    JAV24025.1    APGK01042948    KB741011    ENN75528.1    GDAY02000076    JAV51337.1    JU173826    GBEX01000115    AFJ49352.1    JAI14445.1    GAAZ01000084    GBKC01000121    GBKD01000066    JAA97859.1    JAG45949.1    JAG47552.1    KB632341    ERL92995.1    CCAG010009655    AWGT02000023    OXB82645.1    CH954179    EDV56289.1    AERX01043732    CH480816    EDW47594.1    KZ507572    PKU36546.1    FR906552    CDQ84775.1    BT045692    ACI33954.1    BT043541    ACH70656.1    CAQQ02130197    DS232077    EDS34091.1    AE013599    AY071739    AFYH01150850    AFYH01150851    AFYH01150852    AFYH01150853    OUUW01000001    SPP74230.1    GBSH01000217    JAG68807.1    CH964282    EDW85569.1    AGTO01001569    JRES01000173    KNC33622.1    CP012524    ALC42377.1    ABJB010790574    DQ066220    DS870657    AAY66857.1    EEC14596.1    GAKP01009631    GAKP01009628    GAKP01009623    JAC49321.1    JX052906    AFK11134.1    GBEW01000041    JAI10324.1    IACK01169284    LAA93772.1    GBSI01000172    JAC96323.1    GADI01006084    JAA67724.1    GFJQ02003796    JAW03174.1    RCHS01004268    RMX36626.1    CM000362    CM002911    EDX06799.1    KMY93250.1    JH432108    GL888243    EGI63949.1    CM000158    EDW90743.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000053240    UP000053268    UP000002358    + More
UP000245037    UP000027135    UP000215335    UP000235965    UP000076858    UP000000305    UP000192223    UP000076502    UP000000311    UP000005203    UP000053825    UP000036403    UP000242457    UP000279307    UP000095301    UP000094527    UP000198287    UP000008792    UP000014760    UP000078542    UP000008237    UP000001646    UP000225706    UP000009046    UP000001070    UP000009192    UP000000437    UP000019118    UP000076420    UP000030742    UP000261440    UP000092444    UP000192224    UP000198419    UP000008711    UP000005207    UP000001292    UP000193380    UP000087266    UP000018467    UP000078200    UP000015102    UP000002320    UP000095300    UP000000803    UP000008672    UP000268350    UP000007798    UP000016665    UP000037069    UP000192221    UP000092553    UP000001555    UP000261460    UP000265100    UP000265160    UP000275408    UP000076408    UP000000304    UP000007755    UP000085678    UP000002282    UP000091820    UP000189705   

PRIDE

H9J272    A2BGQ5    Q7JYV7   

Interpro

IPR020618   Adenyl_kinase_AK6        + More
IPR027417   P-loop_NTPase       

SUPFAM

SSF52540   SSF52540       

ProteinModelPortal

H9J272   A0A2A4JGX4   A0A212FJX0   A0A2H1VXQ8   A0A0N1IBG2   A0A194PNV0   + More
K7J5L9   A0A2P8YNW7   A0A067QUH5   A0A232FD70   A0A2J7R3Q8   R4UP19   A0A162QRD2   E9H2H6   A0A0P4XC90   A0A1W4X9H9   A0A0N8AN91   A0A154NWU2   A0A310SNM4   E2B132   A0A1Y1LKS0   A0A088AJB3   A0A0L7R7U0   A0A0J7L9S0   A0A2A3EBX3   A0A3L8DVZ0   A0A1I8MTX6   A0A1D2MT14   A0A226EJ71   A0A0N7ZAS8   B4LL06   R7U8B2   T1PGY9   A0A195CMC0   E2B3T8   G1KJZ7   A0A2B4T2W7   E0VXX0   B4J9L2   B4KQT7   A0A0K8UQ07   A0A1Q3F9H9   A0A3N0XHN6   A0A1Q3F9J1   A0A0A1WES7   Q6IQD6   A2BGQ5   W8AY38   A0A1Q3F8X2   N6TCT0   A0A2C9JNU8   A0A1W7RJN5   J3S3Y5   T1DDX0   U4USC1   A0A3B4EF73   A0A1B0ESY1   A0A1W5APP0   A0A226PRE3   B3NRY7   I3K8S1   B4HPL0   A0A2I0TRV7   A0A060Y6L0   B5X3S3   A0A3B1J7F3   A0A1A9V4T3   B5DFY2   T1GGZ5   B0WSW3   A0A1I8PUD7   Q7JYV7   H3ARI4   A0A3B0JFW4   A0A0B8RYP0   B4NMI0   U3KEG2   A0A0L0CN32   A0A1W4VCK0   A0A0M4EEA2   Q4PMA7   A0A034W190   K4FUH0   A0A3B4FF80   A0A3P8Q883   A0A3P9D2H5   A0A0F7Z748   A0A2D4JBB6   A0A098M0S9   A0A0K8RB76   A0A1Z5L813   A0A3M6T5B8   A0A182YHD3   B4QDD4   T1JDR8   F4WP18   A0A1S3HAH3   B4P581   A0A1A9WNV3   A0A1U7S8B4  

PDB

5JZV     E-value=1.90605e-49,     Score=490

KEGG

101735934    K18532 adenylate kinase [EC:2.7.4.3] | (RefSeq) adenylate kinase isoenzyme 6 homolog

PATHWAY

00230    Purine metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
03008    Ribosome biogenesis in eukaryotes - Bombyx mori (domestic silkworm)

GO

GO:0005524   GO:0016887   GO:0004017   GO:0005634   GO:0005737   GO:0005829   GO:0015030   GO:0016853   GO:0006955   GO:0016020   GO:0051103   GO:0003677   GO:0006281   GO:0048384  

PANTHER

PTHR12595:SF0  

Subcellular location

Nucleus  
Nucleoplasm   Displays widespread diffuse nucleoplasmic distribution but not detected in nucleoli. Detected in Cajal bodies but not in all cells.   With evidence from 1 publications.
Cajal body   Displays widespread diffuse nucleoplasmic distribution but not detected in nucleoli. Detected in Cajal bodies but not in all cells.   With evidence from 1 publications.

Length:

175

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01972

Exp number, first 60 AAs:

0.01953

Total prob of N-in:

0.11370

outside

1  -  175

 

 

Pi

157.560603

Theta

162.212918

Tajima's D

-0.450404

CLR

1.838224

CSRT

0.254937253137343

Interpretation

Uncertain