Gene

KWMTBOMO03002  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA003587

Annotation

protein_disulfide-isomerase_like_protein_ERp57_precursor_[Bombyx_mori]

Location

Bomo_Chr5(+):15504715-15516768      View in EpiBrowser

Full name

Protein disulfide-isomerase      

Location in the cell

ER   Reliability : 4.636

CDS

ATGTTCGGATCACTAAAGTTTGTTCTTTTATTAGGCATAATTTATTTATGTAAAGCGGCCGAGGAGGATGTTCTCGATCTTACAGATTCCGACTTTTCGGCTGTTTTATCTCAACATGATACAGCCCTGGTCATGTTTTACGCGCCTTGGTGCGGTCATTGTAAGAGACTAAAGCCAGAGTATGCGGTAGCCGCCGGCCTGTTAAAGACCGATGTCCCTCCGGTGGCGCTAGCTAAAGTAGACTGTACGGAAGGTGGCAAGAGTACTTGTGAACAATTCTCTGTGTCCGGATATCCTACACTGAAAATATTCAGAAAAGGAGAGCTTTCTTCCGAGTACAATGGACCAAGGGAGTCTAATGGCATTGTCAAGTACATGCGTGCCCAAGTTGGACCCAGCTCCAAGGAGCTCCTTACAGTAGCTGATTTTGAAGCTTTTACTTCTAAGGATGAAGTAGTGGTTGTCGGATTCTTCGAAAAGGAATCTGACCTGAAAGGAGAGTTCCTGAAAACAGCTGACAAATTAAGGGAGGAGGTTACTTTTGCTCATTCATCAGCCAATGAAGTTCTTGAAAAAACCGGATACAAAAACAATGTGGTCTTGTATCGTCCCAAGCGACTCCAGAACAAGTTTGAAGACTCATCTGTTGCCTTCGACGGAGACACCGAGAAAGTGTCACTCAAAGCTTTCATCAAGGAGAACTATCACGGTCTGGTCGGCGTTCGCCAAAAGGACAACATCCATGATTTCAGCAACCCCCTTATTGTCGCTTACTATGATGTTGATTATACCAAGAACCCGAAGGGCACTAACTACTGGAGGAACCGTGTCCTCAAGGTAGCCAAGGAGCAAACCGAGGCGACGTTCGCAGTCAGCGACAAGGACGACTTCACGCACGAGCTCAACGAGTTCGGCATCGACTTCGCTAAAGGCGACAAGCCCGTAGTGGCCGGCCGCGACGCAGACGGAAACAAATTCGTCATGAGCGCGGAGTTCAGCATCGAAAATCTACTAACGTTCACAAAGGACCTGCTCGATGGCAAGCTGGAGCCATTCGTGAAATCCGAGGCCATACCGGAAAACGACGGCCCAGTGAAGGTAGCCGTCGGCAAGAACTTCAAGGAACTGGTCACGGACAGCAACAGGGACGCACTCATAGAATTCTATGCGCCATGGTGCGGACACTGTCAGAAGCTTGCTCCCGTCTGGGAAGAGCTTGGTGAAAAGTTGAAAGATGAAGAAGTTGACATCATTAAGATCGATGCAACTGCAAATGACTGGCCCAAATCACAATTCGACGTTTCCGGCTTCCCCACAATCTTCTGGAAGCCTAAGGACAGCTCCAAGAAACCTCAGAGATATAATGGAGGACGTGCTCTAGAGGACTTCATCAAGTATGTTTCTGAACAAGCCACAAGCGAACTTAAGGGCTGGGACAGAAAGGGTAACGCCAAACAAGGAAAGGAAGAGTTGTAG

Protein

MFGSLKFVLLLGIIYLCKAAEEDVLDLTDSDFSAVLSQHDTALVMFYAPWCGHCKRLKPEYAVAAGLLKTDVPPVALAKVDCTEGGKSTCEQFSVSGYPTLKIFRKGELSSEYNGPRESNGIVKYMRAQVGPSSKELLTVADFEAFTSKDEVVVVGFFEKESDLKGEFLKTADKLREEVTFAHSSANEVLEKTGYKNNVVLYRPKRLQNKFEDSSVAFDGDTEKVSLKAFIKENYHGLVGVRQKDNIHDFSNPLIVAYYDVDYTKNPKGTNYWRNRVLKVAKEQTEATFAVSDKDDFTHELNEFGIDFAKGDKPVVAGRDADGNKFVMSAEFSIENLLTFTKDLLDGKLEPFVKSEAIPENDGPVKVAVGKNFKELVTDSNRDALIEFYAPWCGHCQKLAPVWEELGEKLKDEEVDIIKIDATANDWPKSQFDVSGFPTIFWKPKDSSKKPQRYNGGRALEDFIKYVSEQATSELKGWDRKGNAKQGKEEL

Catalytic Activity

Catalyzes the rearrangement of -S-S- bonds in proteins.

Similarity

Belongs to the protein disulfide isomerase family.

Feature

chain  Protein disulfide-isomerase

Uniprot

Q587N3   Q587N4   A0A2A4JF99   A0A0N1PHN3   H9J250   A0A194PVF1   + More
A0A212FGT6   I4DIY4   S4PKX7   A0A2J7R3Z5   A0A1V0QBC3   A0A0K8TPP3   D6W727   G9C5C9   E0VQN7   A0A1B6CLZ3   A0A1Y1K4Q8   A0A1B6EMG6   Q17L92   A0A1B6HL77   A0A1W4WNQ6   A0A1J1IH13   A0A1S4EYS5   A0A2M3YY74   A0A0P4WFJ6   B2ZPN7   A0A2M3ZZB8   A0A1L8DTR3   A0A2M3ZED9   A0A1L8DTX7   A0A023EVX9   A0A2M3ZZB6   A0A182H2M9   A0A1I9WL43   A0A023EU67   A0A182LV82   A0A182FHJ0   A0A336KRW2   T1E811   A0A2M3ZZK8   T1DI34   T1PHC1   A0A182R7C8   W5JD33   Q3YMT9   A0A1W4VCW7   A0A023ET60   A0A1I8N351   A0A182XYR3   B4QC45   B3NSB4   A0A182WJC8   A0A084WN41   A0A182PQK0   Q3YMU0   A0A182V7X7   A0A182JR00   E9IY48   B4P5Z6   Q9TWZ1   B3MG35   B4HNU6   J3JWJ9   A0A1Q3G208   K7J8B8   A0A1Y9H9J2   A0A0J7NV70   A0A0M3QUI7   A0A240PLG7   A0A182TUT7   N6U0U4   A0A026WCE2   U4U691   A0A182NI02   A0A182X3W2   Q5TWW9   A0A182I360   J9JYS8   R4WP97   A0A182UBC7   A0A195CZV3   A0A154PLS6   A0A0P5Q3I4   A0A034WXY3   A0A0P6E5T3   A0A195BRK6   A0A0T6BBT9   A0A0P5L3J3   A0A151X3E7   A0A2H8TTB8   A0A3B0JHX0   B4MYN2   A0A0P6FVC3   A0A158NWU6   A0A0A1XSS1   A0A0P5MWN5   A0A1I8NRA8   A0A0K8U8G4   F4WQS3  

EC Number

5.3.4.1

Pubmed

26354079    19121390    22118469    22651552    23622113    28356351    + More
26369729    18362917    19820115    21835214    20566863    28004739    17510324    24945155    26483478    27538518    24330624    20920257    23761445    15917496    25315136    25244985    17994087    22936249    24438588    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    21282665    17550304    8687406    22516182    20075255    23537049    24508170    30249741    12364791    14747013    17210077    23691247    25348373    21347285    25830018    21719571   

EMBL

AB210112    BAD93614.1    AB210111    BAD93613.1    NWSH01001631    PCG70641.1    + More
KQ461187    KPJ07347.1    BABH01007426    KQ459597    KPI95105.1    AGBW02008594    OWR52961.1    AK401252    BAM17874.1    GAIX01004300    JAA88260.1    NEVH01007818    PNF35559.1    KX683312    ARE59259.1    GDAI01001505    JAI16098.1    KQ971307    EFA11421.1    HQ851370    AEV89748.1    DS235430    EEB15693.1    GEDC01022987    JAS14311.1    GEZM01095185    JAV55471.1    GECZ01030664    GECZ01024813    GECZ01022011    GECZ01014873    GECZ01012784    JAS39105.1    JAS44956.1    JAS47758.1    JAS54896.1    JAS56985.1    CH477217    EAT47483.1    GECU01032273    JAS75433.1    CVRI01000051    CRK99496.1    GGFM01000472    MBW21223.1    GDRN01053050    JAI66204.1    EU679503    ACD44938.1    GGFK01000520    MBW33841.1    GFDF01004238    JAV09846.1    GGFM01006049    MBW26800.1    GFDF01004237    JAV09847.1    GAPW01001124    JAC12474.1    GGFK01000524    MBW33845.1    JXUM01023842    KQ560673    KXJ81333.1    KU932227    MF278688    APA33863.1    ASL04994.1    GAPW01001126    JAC12472.1    AXCM01001984    UFQS01000899    UFQT01000899    SSX07566.1    SSX27906.1    GAMD01003158    JAA98432.1    GGFK01000591    MBW33912.1    GALA01001176    JAA93676.1    KA647510    AFP62139.1    ADMH02001732    ETN61268.1    DQ062787    AAY56660.1    GAPW01001125    JAC12473.1    CM000362    CM002911    EDX06676.1    KMY93054.1    CH954179    EDV56416.1    ATLV01024562    KE525352    KFB51635.1    AE013599    DQ062786    BT099537    AAF58609.2    AAY56659.1    ACU32621.1    GL766908    EFZ14477.1    CM000158    EDW90871.1    CH902619    EDV36730.1    CH480816    EDW47461.1    BT127617    AEE62579.1    GFDL01001177    JAV33868.1    AAZX01014127    AXCN02000386    LBMM01001449    KMQ96290.1    CP012524    ALC40739.1    APGK01047206    KB741077    ENN74226.1    KK107274    QOIP01000008    EZA53740.1    RLU19705.1    KB631792    ERL86146.1    AAAB01008807    EAL41801.2    APCN01000199    ABLF02031932    AK417486    BAN20701.1    KQ977041    KYN06137.1    KQ434977    KZC12816.1    GDIQ01140688    JAL11038.1    GAKP01000304    JAC58648.1    GDIQ01068613    GDIQ01045929    LRGB01001764    JAN26124.1    KZS10564.1    KQ976424    KYM88584.1    LJIG01002144    KRT84796.1    GDIQ01176906    JAK74819.1    KQ982562    KYQ54933.1    GFXV01005642    MBW17447.1    OUUW01000001    SPP74980.1    CH963894    EDW77221.1    GDIQ01043869    JAN50868.1    ADTU01028568    GBXI01000352    JAD13940.1    GDIQ01154428    JAK97297.1    GDHF01029674    GDHF01023347    GDHF01002536    JAI22640.1    JAI28967.1    JAI49778.1    GL888275    EGI63436.1   

Proteomes

UP000218220    UP000053240    UP000005204    UP000053268    UP000007151    UP000235965    + More
UP000007266    UP000009046    UP000008820    UP000192223    UP000183832    UP000069940    UP000249989    UP000075883    UP000069272    UP000075900    UP000000673    UP000192221    UP000095301    UP000076408    UP000000304    UP000008711    UP000075920    UP000030765    UP000075885    UP000000803    UP000075903    UP000075881    UP000002282    UP000007801    UP000001292    UP000002358    UP000075886    UP000036403    UP000092553    UP000075880    UP000075902    UP000019118    UP000053097    UP000279307    UP000030742    UP000075884    UP000076407    UP000007062    UP000075840    UP000007819    UP000078542    UP000076502    UP000076858    UP000078540    UP000075809    UP000268350    UP000007798    UP000005205    UP000095300    UP000007755   

PRIDE

Q587N3    Q587N4    H9J250    Q3YMU0    Q9TWZ1   

Pfam

PF00085   Thioredoxin

Interpro

IPR036249   Thioredoxin-like_sf        + More
IPR017937   Thioredoxin_CS       
IPR005792   Prot_disulphide_isomerase       
IPR041868   PDIA3_PDI_b       
IPR013766   Thioredoxin_domain       
IPR005788   Disulphide_isomerase       

SUPFAM

SSF52833   SSF52833       

CDD

cd03069  PDI_b_ERp57

ProteinModelPortal

Q587N3   Q587N4   A0A2A4JF99   A0A0N1PHN3   H9J250   A0A194PVF1   + More
A0A212FGT6   I4DIY4   S4PKX7   A0A2J7R3Z5   A0A1V0QBC3   A0A0K8TPP3   D6W727   G9C5C9   E0VQN7   A0A1B6CLZ3   A0A1Y1K4Q8   A0A1B6EMG6   Q17L92   A0A1B6HL77   A0A1W4WNQ6   A0A1J1IH13   A0A1S4EYS5   A0A2M3YY74   A0A0P4WFJ6   B2ZPN7   A0A2M3ZZB8   A0A1L8DTR3   A0A2M3ZED9   A0A1L8DTX7   A0A023EVX9   A0A2M3ZZB6   A0A182H2M9   A0A1I9WL43   A0A023EU67   A0A182LV82   A0A182FHJ0   A0A336KRW2   T1E811   A0A2M3ZZK8   T1DI34   T1PHC1   A0A182R7C8   W5JD33   Q3YMT9   A0A1W4VCW7   A0A023ET60   A0A1I8N351   A0A182XYR3   B4QC45   B3NSB4   A0A182WJC8   A0A084WN41   A0A182PQK0   Q3YMU0   A0A182V7X7   A0A182JR00   E9IY48   B4P5Z6   Q9TWZ1   B3MG35   B4HNU6   J3JWJ9   A0A1Q3G208   K7J8B8   A0A1Y9H9J2   A0A0J7NV70   A0A0M3QUI7   A0A240PLG7   A0A182TUT7   N6U0U4   A0A026WCE2   U4U691   A0A182NI02   A0A182X3W2   Q5TWW9   A0A182I360   J9JYS8   R4WP97   A0A182UBC7   A0A195CZV3   A0A154PLS6   A0A0P5Q3I4   A0A034WXY3   A0A0P6E5T3   A0A195BRK6   A0A0T6BBT9   A0A0P5L3J3   A0A151X3E7   A0A2H8TTB8   A0A3B0JHX0   B4MYN2   A0A0P6FVC3   A0A158NWU6   A0A0A1XSS1   A0A0P5MWN5   A0A1I8NRA8   A0A0K8U8G4   F4WQS3  

PDB

6ENY     E-value=2.69245e-114,     Score=1055

KEGG

692546    K08056 protein disulfide-isomerase A3 [EC:5.3.4.1] | (RefSeq) ERp57; protein disulfide-isomerase lik

PATHWAY

04141    Protein processing in endoplasmic reticulum - Bombyx mori (domestic silkworm)

GO

GO:0005623   GO:0045454   GO:0003756   GO:0005783   GO:0034976   GO:0006457   GO:0016757   GO:0012505   GO:0015037   GO:0016853   GO:0006955   GO:0016020   GO:0051103   GO:0003677   GO:0006281   GO:0048384  

SignalP

Position:   1 - 19,         Likelihood:  0.990476

 

 

Length:

491

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00827999999999999

Exp number, first 60 AAs:

0.00827999999999999

Total prob of N-in:

0.00060

outside

1  -  491

 

 

Pi

238.91798

Theta

167.885338

Tajima's D

1.190783

CLR

0.2673

CSRT

0.714464276786161

Interpretation

Uncertain