Gene

KWMTBOMO02992  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA003583

Annotation

PREDICTED:_proteasome_inhibitor_PI31_subunit_[Plutella_xylostella]

Location

Bomo_Chr5(+):15278166-15285790      View in EpiBrowser

Full name

Proteasome inhibitor PI31 subunit      

Location in the cell

Cytoplasmic   Reliability : 1.621 Nuclear   Reliability : 1.252

CDS

ATGGCATCAGACCCGCTGTTTGGCTGGGATTTAACATTCAAAACAATTGAGAGGGATATAAAAAAACAGTCTGACATAATAATTGCTTTTATTCACTGGAATTTAACAAGGAGGGGTTTTCGAAGCATCGGCTTAAGTGATGAGAGAACAATCACTGGCGATGAACCTAAAAGTGAGCTACTTCCTGAAGGATGGAACGACACTGAGAACTACAGAATAAGATATGTTCTCGAATCTAAACTCTATATTCTACATGGCTTAAACACTGATGGAAATTTAATTGTAAATTTAATGAGATCTGAAGACCTTGCTGTTACGAACATAGGTGTAAAGATAGACGAAATACTGAAAGAATCAAATGGAACCATAGACGTCATGATGCCGAATTACAAAGATTTCATTTTTGTTATAAAGCGAGATCTAATTGATAGCATCACAGACAAGCCAACAGCTACTTCGGAAACACAGACTGCATCAGATCATTCAAACACTAGAAGGCCTTCAGATGATCCACTGAGAATTCCTCCCAGACCCAGACCCGGAGTTAATCCCGATTCACAAGATCTATGGGCAGTTCCTCCTGGCCGTAACGTTGGCCATTCAGATCTCGATCCGTTCTCTCCTTTCGGGGGTGGAATGATATTTAACCCGTTTGCTCCACGTCGAGACATTGAGAACCCAGGCCTGGGTGTTCCAGGTGGATTGCCAAGAGCTGCGGTTCCCCCGGGGGCACGTTTCGATCCGTTTGCGCCCCCCGGTGTTGGTGAACCCATCCCGGGAAGAAGGCCACCTCCTGACGCTGATCACCTTCCACCTCCAGGAGGCTTTAATGAGAATATGTTCATGTAA

Protein

MASDPLFGWDLTFKTIERDIKKQSDIIIAFIHWNLTRRGFRSIGLSDERTITGDEPKSELLPEGWNDTENYRIRYVLESKLYILHGLNTDGNLIVNLMRSEDLAVTNIGVKIDEILKESNGTIDVMMPNYKDFIFVIKRDLIDSITDKPTATSETQTASDHSNTRRPSDDPLRIPPRPRPGVNPDSQDLWAVPPGRNVGHSDLDPFSPFGGGMIFNPFAPRRDIENPGLGVPGGLPRAAVPPGARFDPFAPPGVGEPIPGRRPPPDADHLPPPGGFNENMFM

Description

Plays an important role in the control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Enhances 26S proteasome function by promoting its assembly through the interaction with the assembly chaperones PSMD9 and PMSD5. Functions together with ntc to control non-apoptotic caspase activation during sperm individualization. In testis, is required for proper protein degradation and germline cell cycle progression.

Subunit

Interacts with ntc. Interacts with Tnks (via ANK repeats). Interacts with 20S proteasome subunits Prosalpha1, Prosalpha3, Prosalpha4 and Prosalpha6, but not with Prosalpha2 and Prosalpha5. The interaction with Prosalpha4 is reduced by PI31 ADP-ribosylation. Interacts with the 19S assembly chaperones PSMD5 and PSMD9; these interactions are increased by PI31 ADP-ribosylation.

Similarity

Belongs to the proteasome inhibitor PI31 family.

Keywords

ADP-ribosylation   Complete proteome   Cytoplasm   Developmental protein   Phosphoprotein   Proteasome   Reference proteome  

Feature

chain  Proteasome inhibitor PI31 subunit

Uniprot

H9J246   A0A2A4JHI1   A0A2H1WYP4   S4NVB2   A0A194PVD6   A0A0N1PFH8   + More
A0A1E1WTV4   A0A0L7LPP5   A0A067RET4   E0W495   A0A1B6H0N6   A0A2J7Q6J5   A0A1B6LA54   A0A0A9YXU3   A0A154PCF6   A0A0V0G6M4   R4WS17   A0A232EUZ2   A0A2P8YHL3   K7J560   A0A224XHR2   A0A069DYC4   E2ACE3   A0A151JBV8   F4WZT7   A0A0M8ZNL0   A0A151IIQ7   A0A151XD28   A0A195B7F3   A0A158NGW5   E9J8A2   A0A310SCG5   A0A026VWC7   A0A1Q3FGZ4   B0VZG5   A0A1L8DSK9   A0A2A3E7I2   Q17LA8   A0A023EM48   A0A088AVV4   A0A195FER9   A0A0P4VIE1   R4G7Y8   U5EX73   V5I9I2   A0A0L7R3Q6   A0A1B6D1P0   D2A288   E2BWD8   A0A1W4WAU1   A0A0C9QED1   A0A1S3DGC0   A0A1B0EU12   N6SVV0   A2I453   A0A1Y1MTJ4   A0A182XYT0   A0A182R7E5   A0A084WN61   A0A0T6B2N9   A0A1L8EI46   A0A336K604   A0A182JA66   A0A182JT18   A0A1A9UXY4   A0A0L0CDF6   B5DGA4   A0A1I8P461   A0A0R4II16   A0A1A9W0Y6   T1GIL4   A0A2M4BXA7   A0A182WJB2   K1QP56   A0A0K8TRZ7   A0A1A9UXY7   A0A3N0YXF6   B4QC54   A0A1W4Z1S7   C0PUJ2   B4J9W0   A0A1A9UU06   B3MG42   A0A0B8RU44   A0A182MH61   A0A1A9ZUX4   A0A0B4KEK7   Q9V637   A0A060WKI2   A0A2M4CQP4   A0A1J1IIW7   A0A182FHI1   A0A1A9WE05   A0A0K8U478  

Pubmed

19121390    23622113    26354079    26227816    24845553    20566863    + More
25401762    26823975    23691247    28648823    29403074    20075255    26334808    20798317    21719571    21347285    21282665    24508170    30249741    17510324    24945155    27129103    18362917    19820115    23537049    28004739    25244985    24438588    26108605    19878547    20433749    23594743    22992520    26369729    17994087    22936249    25476704    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    12537569    17372656    18327897    21529711    23622245    24755649   

EMBL

BABH01007437    BABH01007438    NWSH01001547    PCG70893.1    ODYU01012083    SOQ58195.1    + More
GAIX01013017    JAA79543.1    KQ459597    KPI95090.1    KQ461187    KPJ07334.1    GDQN01000646    JAT90408.1    JTDY01000442    KOB77151.1    KK852549    KDR21548.1    DS235886    EEB20451.1    GECZ01001523    JAS68246.1    NEVH01017466    PNF24211.1    GEBQ01019404    JAT20573.1    GBHO01007688    GBHO01007686    GDHC01004441    JAG35916.1    JAG35918.1    JAQ14188.1    KQ434870    KZC09503.1    GECL01002462    JAP03662.1    AK417492    BAN20707.1    NNAY01002071    OXU22164.1    PYGN01000589    PSN43741.1    AAZX01014434    GFTR01004401    JAW12025.1    GBGD01002490    JAC86399.1    GL438491    EFN68933.1    KQ979114    KYN22592.1    GL888480    EGI60362.1    KQ435969    KOX67905.1    KQ977492    KYN02302.1    KQ982294    KYQ58265.1    KQ976574    KYM80177.1    ADTU01015286    GL768914    EFZ10952.1    KQ763551    OAD55004.1    KK107770    QOIP01000012    EZA47826.1    RLU15854.1    GFDL01008228    JAV26817.1    DS231814    EDS31702.1    GFDF01004655    JAV09429.1    KZ288342    PBC27723.1    CH477217    EAT47467.1    GAPW01003237    JAC10361.1    KQ981625    KYN39170.1    GDKW01002047    JAI54548.1    ACPB03021088    GAHY01001897    JAA75613.1    GANO01001075    JAB58796.1    GALX01002890    JAB65576.1    KQ414663    KOC65517.1    GEDC01017676    JAS19622.1    KQ971338    EFA02057.1    GL451103    EFN80042.1    GBYB01003015    GBYB01003017    GBYB01012768    GBYB01012769    JAG72782.1    JAG72784.1    JAG82535.1    JAG82536.1    AJWK01011174    APGK01054419    KB741250    KB632390    ENN71889.1    ERL94502.1    EF070556    ABM55622.1    GEZM01021637    JAV88889.1    ATLV01024569    KE525352    KFB51655.1    LJIG01016110    KRT81586.1    GFDG01000474    JAV18325.1    UFQS01000040    UFQT01000040    SSW98163.1    SSX18549.1    JRES01000655    KNC29504.1    BT043663    ACH70778.1    BX001037    CAQQ02001161    GGFJ01008522    MBW57663.1    JH816890    EKC23326.1    GDAI01000481    JAI17122.1    RJVU01019434    ROL50623.1    CM000362    CM002911    EDX06685.1    KMY93062.1    BT072465    ACN60283.1    CH916367    EDW01524.1    CH902619    EDV36737.1    GBSH01001980    JAG67046.1    AXCM01001831    AE013599    AGB93438.1    AGB93440.1    AY058250    FR904595    CDQ67763.1    GGFL01003407    MBW67585.1    CVRI01000051    CRK99484.1    GDHF01031008    JAI21306.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000053240    UP000037510    UP000027135    + More
UP000009046    UP000235965    UP000076502    UP000215335    UP000245037    UP000002358    UP000000311    UP000078492    UP000007755    UP000053105    UP000078542    UP000075809    UP000078540    UP000005205    UP000053097    UP000279307    UP000002320    UP000242457    UP000008820    UP000005203    UP000078541    UP000015103    UP000053825    UP000007266    UP000008237    UP000192223    UP000079169    UP000092461    UP000019118    UP000030742    UP000076408    UP000075900    UP000030765    UP000075880    UP000075881    UP000078200    UP000037069    UP000087266    UP000095300    UP000000437    UP000091820    UP000015102    UP000075920    UP000005408    UP000000304    UP000192224    UP000001070    UP000007801    UP000075883    UP000092445    UP000000803    UP000193380    UP000183832    UP000069272   

PRIDE

H9J246    Q9V637   

Pfam

PF11566   PI31_Prot_N        + More
PF08577   PI31_Prot_C

Interpro

IPR021625   PI31_Prot_N        + More
IPR013886   PI31_Prot_C       

ProteinModelPortal

H9J246   A0A2A4JHI1   A0A2H1WYP4   S4NVB2   A0A194PVD6   A0A0N1PFH8   + More
A0A1E1WTV4   A0A0L7LPP5   A0A067RET4   E0W495   A0A1B6H0N6   A0A2J7Q6J5   A0A1B6LA54   A0A0A9YXU3   A0A154PCF6   A0A0V0G6M4   R4WS17   A0A232EUZ2   A0A2P8YHL3   K7J560   A0A224XHR2   A0A069DYC4   E2ACE3   A0A151JBV8   F4WZT7   A0A0M8ZNL0   A0A151IIQ7   A0A151XD28   A0A195B7F3   A0A158NGW5   E9J8A2   A0A310SCG5   A0A026VWC7   A0A1Q3FGZ4   B0VZG5   A0A1L8DSK9   A0A2A3E7I2   Q17LA8   A0A023EM48   A0A088AVV4   A0A195FER9   A0A0P4VIE1   R4G7Y8   U5EX73   V5I9I2   A0A0L7R3Q6   A0A1B6D1P0   D2A288   E2BWD8   A0A1W4WAU1   A0A0C9QED1   A0A1S3DGC0   A0A1B0EU12   N6SVV0   A2I453   A0A1Y1MTJ4   A0A182XYT0   A0A182R7E5   A0A084WN61   A0A0T6B2N9   A0A1L8EI46   A0A336K604   A0A182JA66   A0A182JT18   A0A1A9UXY4   A0A0L0CDF6   B5DGA4   A0A1I8P461   A0A0R4II16   A0A1A9W0Y6   T1GIL4   A0A2M4BXA7   A0A182WJB2   K1QP56   A0A0K8TRZ7   A0A1A9UXY7   A0A3N0YXF6   B4QC54   A0A1W4Z1S7   C0PUJ2   B4J9W0   A0A1A9UU06   B3MG42   A0A0B8RU44   A0A182MH61   A0A1A9ZUX4   A0A0B4KEK7   Q9V637   A0A060WKI2   A0A2M4CQP4   A0A1J1IIW7   A0A182FHI1   A0A1A9WE05   A0A0K8U478  

PDB

4OUH     E-value=2.90965e-08,     Score=137

KEGG

101736771    K06700 proteasome inhibitor subunit 1 (PI31) | (RefSeq) proteasome inhibitor PI31 subunit

PATHWAY

03050    Proteasome - Bombyx mori (domestic silkworm)

GO

GO:0000502   GO:0006511   GO:0032436   GO:0007140   GO:0070864   GO:0043248   GO:0008584   GO:0005737  

Subcellular location

Cytoplasm  

Length:

282

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00143

Exp number, first 60 AAs:

0.00033

Total prob of N-in:

0.00772

outside

1  -  282

 

 

Pi

183.576954

Theta

19.28562

Tajima's D

-2.02405

CLR

2.77745

CSRT

0.0126493675316234

Interpretation

Possibly Positive selection