Gene

KWMTBOMO02977

Pre Gene Modal

BGIBMGA003626

Annotation

PREDICTED:_intraflagellar_transport_protein_74_homolog_[Amyelois_transitella]

Location

Bomo_Chr5(-):14809809-14814833      View in EpiBrowser

Full name

Intraflagellar transport protein 74 homolog      

Alternative Name

Capillary morphogenesis gene 1 protein
Coiled-coil domain-containing protein 2

Location in the cell

Cytoplasmic   Reliability : 1.555 Nuclear   Reliability : 1.954

CDS

ATGCGTCCCACATCTGCATATCGAGGCAGTACCGCCTCCAGACTGACGACCGGCTTTGGTCCTGCTCCTCCAACAGCAGGCCGACAACAAACTGCCGTTACCGGTTTTTCCATGATTGATCGACCAATTACTCAACAAGGTATCTCAGGATTACGAACTGGTACTGGTCGCGGTTTTCGAACCAGACAGCTACAGGATAAACGATATTGGGAAGAATTGATGCAAGTGAAAATTAGAGAAATGAAAGCTGAAATAGCGAGGTTGAGTGAACAAGCTGAGGCAGGCGAAAGAGAGAAGTCCGCGAAAAAGCACTATGAGAAGCGGGTCAGGGAATTGGCACAAGAACTAACCGATTTACAGGGACGTCTCGCAGACTATAATACTGCAATTCGTATACTAAACGGAGAAGCGACAAAGCAATCTGTTGAGGAACAAACGAGAGAATTGGAGGCGACAAATCAGAAGATGCAAGATGAAATAGAACAAGTATTCATGGAGAAACGAAGGAAAGAAAATCAGTTACGACAGATTCGAGAGCAAATTGAAAAGGAACAATCGACGATCACAAAGATACTGGCCGAAATGACGGTGGAGCAAAAAGATCAGTATAATGAATTGCAAACTACGGCTGCAGCATTAAGAGAGGAAGTGGAGCAGAGCAGAACGCAATTAGATCTCTTGAACAGAGAGAAAGAAGAATTTGCTCGGGAAATATCGGGATCGCAGATAAAAGTGCACCTTCTAGAACTACATCGAAGGCTGGTCGCCGTCGAAGAAAAACGCGACAACATGAGAAACGAAATAAACAATCGATTGGATCCGCAGGAAGAAAGGGAGAAGTTACTGTCCCAAGTGCGAGAAGATAACGCCGCCATAGCGGTATTGGACAACAACGCTACGAATTTGAAAGAACAGATCAAGAAAGTTCAAGAATTGATTGAGCAGTCTGAACAGGATCTCGAAGAAGGCAACTCCGAACGCCATCAGAAATATCGCGAATTGAAAAAGCGAGAAGAAACAATGGACTCGTTCATGGAAACGTACGAAGAAAATCTGAGAAATGAACAAAATAAAATCGATCAATTGGAAAATGATATCGTGTTCGCTTTAGAGCACAGCAGTTCCAATATTGACTTAGATCTTAGCGAAATAGATAGTTTAAAGCAAAGGGAAGGCTACACGTCAACATATGATGAAAATAAGAAATCCATCGATGCACTCACGAAAGATTACGAACGTTTTCAAGCAAATTTGAAAAAGGCAACAGCAACACGAGAGAGGTTGGCTACTGAATTACATACTCTGCCGGAAAAGACGCGCGTCATGAAAGAAGAGTTGGTCACACTGAGCGACTTGGAAATGCTTCGAGAGCAAGGTACATAA

Protein

MRPTSAYRGSTASRLTTGFGPAPPTAGRQQTAVTGFSMIDRPITQQGISGLRTGTGRGFRTRQLQDKRYWEELMQVKIREMKAEIARLSEQAEAGEREKSAKKHYEKRVRELAQELTDLQGRLADYNTAIRILNGEATKQSVEEQTRELEATNQKMQDEIEQVFMEKRRKENQLRQIREQIEKEQSTITKILAEMTVEQKDQYNELQTTAAALREEVEQSRTQLDLLNREKEEFAREISGSQIKVHLLELHRRLVAVEEKRDNMRNEINNRLDPQEEREKLLSQVREDNAAIAVLDNNATNLKEQIKKVQELIEQSEQDLEEGNSERHQKYRELKKREETMDSFMETYEENLRNEQNKIDQLENDIVFALEHSSSNIDLDLSEIDSLKQREGYTSTYDENKKSIDALTKDYERFQANLKKATATRERLATELHTLPEKTRVMKEELVTLSDLEMLREQGT

Description

Component of the intraflagellar transport (IFT) complex B: together with IFT81, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds beta-tubulin via its basic region. Required for ciliogenesis.

Catalytic Activity

ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]

Subunit

Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88 (PubMed:23990561). Interacts with IFT81; the interaction is direct: within the IFT complex B, IFT74 and IFT81 mediate the transport of tubulin within the cilium (PubMed:15955805, PubMed:23990561). Interacts (via basic region) with beta-tubulin (via acidic region); interaction is direct (PubMed:23990561). Interacts with ARL13B and IFT88 (PubMed:24339792). Interacts (via the IFT74/IFT81 heterodimer) with RABL2B (PubMed:28428259, PubMed:28625565).

Similarity

Belongs to the protein kinase superfamily. Tyr protein kinase family.
Belongs to the IFT74 family.

Keywords

Alternative splicing   Bardet-Biedl syndrome   Cell projection   Ciliopathy   Cilium   Coiled coil   Complete proteome   Cytoplasmic vesicle   Methylation   Obesity   Phosphoprotein   Polymorphism   Reference proteome  

Feature

chain  Intraflagellar transport protein 74 homolog
splice variant  In isoform 2.
sequence variant  In dbSNP:rs10812505.

Uniprot

H9J289   A0A2A4IW04   A0A194PQ41   A0A0N0PDI5   A0A212FGF8   A0A2H1W1P9   + More
A0A2J7RII1   E0VFJ8   A0A1B6E0D9   G1P9Y3   A0A1S3D654   A0A287BMM9   F1SP83   F6S5R5   A7E3B8   L8I2K4   A0A182YI62   K9IMM1   W5PYR9   M3WRS6   A0A1B6J0A1   A0A336M7S0   H0WTY6   F1N626   A0A2K6JZQ5   A0A182WAT4   L9L6G3   A0A2K6NW87   A0A2K6JZP7   A0A336MRL9   A0A2U4BBB4   F6UBH2   A0A2Y9E7N1   A0A2K5J8M2   A0A2K5J8V3   A0A1J1II15   A0A383ZP68   A0A182JZ19   A0A182PNF5   E2RG29   B0X4V5   A0A182R2T6   L5LEU4   A0A091DIV9   A0A2K5YFN2   A0A341C6U9   Q8IUV3   A0A340X3R7   A0A2Y9LK26   A0A2I2Y7N7   A0A2K5LZZ4   A0A2Y9EVY4   A0A2K5D2I3   A0A182FLZ6   A0A0D9RBM3   Q4R679   H9EXI8   G1S2T2   A0A2U4BBL7   V9KI69   A0A383ZPQ1   G5BPW8   Q5RFM5   A0PJM7   A0A2J8XIK1   A0A2K5RJH9   A0A2K5RJF7   Q96LB3   A0A182NND3   A0A2Y9GCJ6   G9K5B1   M3YWX4   B0X734   A0A182WTK1   A0A0P6K7U1   A0A2U3Y042   A0A2Y9L9S3   F6ZUJ5   S7NNW4   A0A2P8XZ35   A0A2I0M5F0   G3T996   H2QX35   A0A250Y390   A0A1U7RYF4   A0A2U3ZXI0   U3DW94   A0A026VXT6   A0A384CEQ4   A0A182G2Z3   A0A1V4KZ65   I3MKM9   G7NFQ0   H2V5Z2   Q5XIR2   L5KX83  

Pubmed

19121390    26354079    22118469    20566863    21993624    30723633    + More
19892987    22751099    25244985    20809919    17975172    19393038    23385571    25362486    17495919    16341006    15489334    22398555    15944441    22002653    17431167    25319552    24402279    21993625    11683410    14702039    15164053    15024030    15955805    24339792    23990561    24129315    27486776    28625565    28428259    23236062    25243066    29403074    23371554    16136131    28087693    24508170    30249741    24813606    26483478    21551351    15057822    15632090    22673903    23258410   

EMBL

BABH01007474    NWSH01005531    PCG64147.1    KQ459597    KPI95083.1    KQ460226    + More
KPJ16488.1    AGBW02008676    OWR52822.1    ODYU01005773    SOQ46988.1    NEVH01003500    PNF40637.1    DS235114    EEB12154.1    GEDC01005913    JAS31385.1    AAPE02042260    AAPE02042261    AAPE02042262    AAPE02042263    AAPE02042264    AEMK02000004    DQIR01310302    HDC65780.1    BC151793    AAI51794.1    JH882365    ELR49744.1    GABZ01005113    JAA48412.1    AMGL01050795    AMGL01050796    AMGL01050797    AMGL01050798    AMGL01050799    AMGL01050800    AMGL01050801    AANG04001372    GECU01015099    JAS92607.1    UFQT01000229    SSX22088.1    AAQR03013702    AAQR03013703    AAQR03013704    AAQR03013705    AAQR03013706    KB320502    ELW70234.1    UFQS01001037    UFQT01001037    SSX08683.1    SSX28598.1    CVRI01000054    CRK99903.1    AAEX03007920    AAEX03007921    AAEX03007922    DS232356    EDS40570.1    KB112608    ELK24727.1    KN122223    KFO32074.1    BC023634    AAH23634.3    CABD030063257    CABD030063258    AQIB01021916    AQIB01021917    AQIB01021918    AQIB01021919    AQIA01024426    AQIA01024427    AQIA01024428    AQIA01024429    AQIA01024430    AQIA01024431    AQIA01024432    AB169310    CM001290    BAE01396.1    EHH57335.1    JSUE03014910    JSUE03014911    JU323341    JV044965    AFE67097.1    AFI35036.1    ADFV01019401    ADFV01019402    ADFV01019403    ADFV01019404    ADFV01019405    ADFV01019406    ADFV01019407    ADFV01019408    ADFV01019409    ADFV01019410    JW865211    AFO97728.1    JH171307    EHB11329.1    CR857130    CAH89432.1    BC113524    AAI13525.1    ABGA01153574    ABGA01153575    ABGA01153576    ABGA01153577    ABGA01153578    ABGA01153579    ABGA01153580    ABGA01153581    ABGA01153582    ABGA01153583    NDHI03003365    PNJ81840.1    PNJ81843.1    PNJ81844.1    AY040325    AK023707    AK026274    AL355432    AL356133    CH471071    BC107742    BX436367    JP011488    AES00086.1    AEYP01053621    AEYP01053622    AEYP01053623    AEYP01053624    DS232436    EDS41728.1    GEBF01001025    JAO02608.1    GAMS01010482    GAMR01008957    GAMP01009057    JAB12654.1    JAB24975.1    JAB43698.1    KE164664    EPQ19384.1    PYGN01001146    PSN37184.1    AKCR02000037    PKK24899.1    AACZ04057533    GABC01004380    GABF01009587    GABD01009946    NBAG03000018    JAA06958.1    JAA12558.1    JAA23154.1    PNI99276.1    PNI99279.1    PNI99280.1    GFFV01001848    JAV38097.1    GAMT01007758    GAMQ01007617    JAB04103.1    JAB34234.1    KK107599    QOIP01000012    EZA48582.1    RLU15856.1    JXUM01040646    KQ561253    KXJ79210.1    LSYS01001315    OPJ89217.1    AGTP01075965    AGTP01075966    AGTP01075967    AGTP01075968    AGTP01075969    CM001267    EHH24057.1    AC119437    AC133043    BC083611    CH473998    AAH83611.1    EDL97758.1    KB030516    ELK15805.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000053240    UP000007151    UP000235965    + More
UP000009046    UP000001074    UP000079169    UP000008227    UP000002281    UP000076408    UP000002356    UP000011712    UP000005225    UP000009136    UP000233180    UP000075920    UP000011518    UP000233200    UP000245320    UP000002280    UP000248480    UP000233080    UP000183832    UP000261681    UP000075881    UP000075885    UP000002254    UP000002320    UP000075900    UP000028990    UP000233140    UP000252040    UP000265300    UP000248483    UP000001519    UP000233060    UP000248484    UP000233020    UP000069272    UP000029965    UP000009130    UP000233100    UP000006718    UP000001073    UP000006813    UP000001595    UP000233040    UP000005640    UP000075884    UP000248481    UP000000715    UP000076407    UP000245341    UP000248482    UP000008225    UP000245037    UP000053872    UP000007646    UP000002277    UP000189705    UP000245340    UP000053097    UP000279307    UP000261680    UP000291021    UP000069940    UP000249989    UP000190648    UP000005215    UP000005226    UP000002494    UP000010552   

PRIDE

H9J289    F1SP83    Q8IUV3    A0PJM7    Q96LB3   

Pfam

PF15549   PGC7_Stella        + More
PF07714   Pkinase_Tyr
PF10430   Ig_Tie2_1
PF00041   fn3

Interpro

IPR029602   IFT74        + More
IPR029096   Dppa3       
IPR008266   Tyr_kinase_AS       
IPR036179   Ig-like_dom_sf       
IPR000742   EGF-like_dom       
IPR013032   EGF-like_CS       
IPR020635   Tyr_kinase_cat_dom       
IPR000719   Prot_kinase_dom       
IPR036116   FN3_sf       
IPR001245   Ser-Thr/Tyr_kinase_cat_dom       
IPR011009   Kinase-like_dom_sf       
IPR013783   Ig-like_fold       
IPR017441   Protein_kinase_ATP_BS       
IPR003961   FN3_dom       
IPR007110   Ig-like_dom       
IPR018941   Tyr_kin_Tie2_Ig-like_dom-1_N       

SUPFAM

SSF49265   SSF49265        + More
SSF56112   SSF56112       
SSF48726   SSF48726       

Gene 3D

2.60.40.10    

CDD

cd00063  FN3

ProteinModelPortal

H9J289   A0A2A4IW04   A0A194PQ41   A0A0N0PDI5   A0A212FGF8   A0A2H1W1P9   + More
A0A2J7RII1   E0VFJ8   A0A1B6E0D9   G1P9Y3   A0A1S3D654   A0A287BMM9   F1SP83   F6S5R5   A7E3B8   L8I2K4   A0A182YI62   K9IMM1   W5PYR9   M3WRS6   A0A1B6J0A1   A0A336M7S0   H0WTY6   F1N626   A0A2K6JZQ5   A0A182WAT4   L9L6G3   A0A2K6NW87   A0A2K6JZP7   A0A336MRL9   A0A2U4BBB4   F6UBH2   A0A2Y9E7N1   A0A2K5J8M2   A0A2K5J8V3   A0A1J1II15   A0A383ZP68   A0A182JZ19   A0A182PNF5   E2RG29   B0X4V5   A0A182R2T6   L5LEU4   A0A091DIV9   A0A2K5YFN2   A0A341C6U9   Q8IUV3   A0A340X3R7   A0A2Y9LK26   A0A2I2Y7N7   A0A2K5LZZ4   A0A2Y9EVY4   A0A2K5D2I3   A0A182FLZ6   A0A0D9RBM3   Q4R679   H9EXI8   G1S2T2   A0A2U4BBL7   V9KI69   A0A383ZPQ1   G5BPW8   Q5RFM5   A0PJM7   A0A2J8XIK1   A0A2K5RJH9   A0A2K5RJF7   Q96LB3   A0A182NND3   A0A2Y9GCJ6   G9K5B1   M3YWX4   B0X734   A0A182WTK1   A0A0P6K7U1   A0A2U3Y042   A0A2Y9L9S3   F6ZUJ5   S7NNW4   A0A2P8XZ35   A0A2I0M5F0   G3T996   H2QX35   A0A250Y390   A0A1U7RYF4   A0A2U3ZXI0   U3DW94   A0A026VXT6   A0A384CEQ4   A0A182G2Z3   A0A1V4KZ65   I3MKM9   G7NFQ0   H2V5Z2   Q5XIR2   L5KX83  

PDB

6IAN     E-value=6.81388e-13,     Score=180

KEGG

101744094    K19679 intraflagellar transport protein 74 | (RefSeq) intraflagellar transport protein 74 homolog

GO

GO:0042073   GO:0005929   GO:0060271   GO:0030992   GO:0048487   GO:0031514   GO:0003334   GO:0050680   GO:0007507   GO:0035735   GO:0005634   GO:0007219   GO:0003682   GO:0005813   GO:0045944   GO:1905515   GO:0033630   GO:0007368   GO:0035064   GO:0004714   GO:0007169   GO:0005524   GO:0005887   GO:0097542   GO:0031410   GO:0043565   GO:0005622   GO:0007264   GO:0015379   GO:0016021   GO:0003909   GO:0051103   GO:0003677   GO:0006281   GO:0048384  

PANTHER

PTHR31432  

Subcellular location

Cell projection  
Cilium  
Cytoplasmic vesicle  

Length:

460

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0008

Exp number, first 60 AAs:

0.0008

Total prob of N-in:

0.00795

outside

1  -  460

 

 

Pi

298.64163

Theta

168.140483

Tajima's D

3.036762

CLR

0.006901

CSRT

0.979351032448378

Interpretation

Uncertain