Gene

KWMTBOMO02957

Pre Gene Modal

BGIBMGA003568

Annotation

PREDICTED:_LOW_QUALITY_PROTEIN:_trypsin?_alkaline_C-like_[Bombyx_mori]

Location

Bomo_Chr5(+):14418295-14424842      View in EpiBrowser

Full name

Trypsin, alkaline A       + More
Trypsin, alkaline C      
Trypsin, alkaline B      
Trypsin CFT-1      

Location in the cell

Extracellular   Reliability : 4.578

CDS

ATGACACCGACGCTCGTCTTACTGCTCTTAGTTGGAGCTGTGGCTGCCATACCAGACCAGTCCTCAAGGATTGTCGGTGGGACAGCGACAACTATCGACCGGTACCCCACAATGGCAGCAGCACTTTTTTCTAGCAATATGGCCCAGTGGTGGCAAGGATGTGGCTGTTCCATTCTCAATAACAGAGCCGTCCTTACAGCCGCACATTGTATTATAGGAGATCGTGTCGGTGTTTGGAGAGTTCGCGTAGGATCTTCTTTTGGAAATAGTGGAGGTGTTGTCCATGAGGTCAACAGGCACATCATCCACCCTAATTACAATCATCGTACAAAGGACGCTGATATTGCAATCATGCGTACAGTTTTACGGATAAACTTCGTACGTAATACCGTGCAGCCAGCTCGTATTGCGGGTTCCAATTACAACCTTGCCGATAACCAAGTTGTTTGGGCAGCTGGATGGGGATCTACAAGGACTGGAAGTGGTTTTGCTGAACAGCTTCGACATGTTCAAGTTTGGACGATAAATCAGGCCATTTGTAGAGAGCGATACTCGAGAATAGATAGACCGATCACTGCCAATATGTTGTGCTCCGGCTGGCTTGACGTCGGCGGCCGCGATCAGTGTGGAGGTGATTCCGGTGGTCCTCTATACCACAACGGTGTCGTCGTCGGGGTGTGCTCGTGGGGATTCTCTTGTGGAAGTGCATTCTACCCTGGAGTAAATGTTCGCGTCTCTCGCTTCAGTTCATGGATTCAAAACAATGCTTAG

Protein

MTPTLVLLLLVGAVAAIPDQSSRIVGGTATTIDRYPTMAAALFSSNMAQWWQGCGCSILNNRAVLTAAHCIIGDRVGVWRVRVGSSFGNSGGVVHEVNRHIIHPNYNHRTKDADIAIMRTVLRINFVRNTVQPARIAGSNYNLADNQVVWAAGWGSTRTGSGFAEQLRHVQVWTINQAICRERYSRIDRPITANMLCSGWLDVGGRDQCGGDSGGPLYHNGVVVGVCSWGFSCGSAFYPGVNVRVSRFSSWIQNNA

Catalytic Activity

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Similarity

Belongs to the peptidase S1 family.

Keywords

Disulfide bond   Hydrolase   Protease   Secreted   Serine protease   Signal   Zymogen   Direct protein sequencing  

Feature

propeptide  Activation peptide
chain  Trypsin, alkaline A

Uniprot

H9J231   P35045   P35047   Q56IB6   P35046   Q56IB5   + More
Q56IB8   Q56IB4   Q6R561   Q56IB7   Q1HQA7   I6TMW8   H9J229   J7JYV8   A0A2A4K6F3   H9J232   Q9TXE6   A0A2A4K5F8   H9J230   A0A2W1BKV8   J7IJ83   V9M0R7   B4X995   A0A2A4K5G7   A0A2A4K6E9   A0A2A4K6E3   A0A194PNR6   Q27540   I3UII8   B4X996   P35042   A0A2A4K6W3   O18447   I7DEI4   A0A2H1VJ41   A0A2A4K648   A0A2W1BSA6   A0A194PVB6   A0A2W1BQW9   A0A194PQQ0   A0A1C9M3A1   A0A194PQQ5   B4X9A1   W5X3N9   A0A194PNR3   Q961Y0   J7IF09   A0A2A4K6U2   J7IFG7   T1QDI0   E7D004   A0A2W1B606   A0A0L7KUC9   A0A2W1BA14   I7E449   O18434   A0A2A4K747   O18436   A0A1B0RHN7   A0A2W1BGQ7   A0A2W1BF78   A0A194PP33   S5PVP1   A0A0K8SII3   A0A2H1V0W3   C4PFX2   C9W8F7   A0A2A4K769   A0A2W1BP39   B3F884   O76954   A0A2U8NFD7   A0A0N1PHJ0   A0A2W1B1G1   A0A2W1BKF9   A0A2A4K5I4   Q4L1K4   D7S002   A9P3S8   H9J243   B4X9A0   V9LL27   O18441   D7S000   A0A2A4K6F8   A0A2W1BE44   A0A2W1BL45   O62598   O18435   Q4L1K6   A0A345H7U4   D7S001   A0A2H1W4N7   A0A0N1I947   A0A2A4K5I0   A0A2W1BKR8   A0A2W1BGR2   A0A2W1BP46   I3UII6   A0A1E1WNA7  

EC Number

3.4.21.4

Pubmed

19121390    8205142    16469064    15944081    8462672    28756777    + More
23247047    26354079    7550246    22432944    8294037    8353523    9404008    22824002    12110299    23955944    26227816    19146482    23606528    20545748    20824821    15979001    10672067   

EMBL

BABH01007514    BABH01007515    L16805    L16807    AY953061    AAX62034.1    + More
L16806    AY953062    AAX62035.1    AY953059    AAX62032.1    AY953063    AAX62036.1    AY513649    AAR98918.1    AY953060    AAX62033.1    DQ443145    ABF51234.1    JQ904123    AFM77753.1    BABH01007520    JX312360    AFQ59994.1    NWSH01000106    PCG79484.1    PCG79475.1    BABH01007517    KZ149992    PZC75528.1    JX195651    AFQ37934.1    JX866720    AGB93875.1    EF531631    EF531633    ABR88242.1    ABR88244.1    PCG79485.1    PCG79488.1    PCG79474.1    KQ459597    KPI95071.1    U12917    AAA84423.1    JN315762    AFK64826.1    EF531632    ABR88243.1    L04749    PCG79493.1    HM209426    Y12283    KZ150104    ADI32887.1    CAA72962.1    PZC73444.1    JN793539    AFO68319.1    ODYU01002655    SOQ40442.1    PCG79486.1    PZC75526.1    KPI95070.1    PZC75527.1    KPI95069.1    KU302250    AOQ30448.1    KPI95074.1    EF531637    ABR88248.1    KF779933    AHI07442.1    KPI95066.1    AY040819    AAK81696.1    JX195649    AFQ37932.1    PCG79473.1    JX195652    AFQ37935.1    JQ429438    AFW03963.1    HM990174    ADT80822.1    KZ150747    PZC70335.1    JTDY01005557    KOB66887.1    PZC70337.1    JX046916    AFO83992.1    Y12269    CAA72948.1    PZC73449.1    PCG79472.1    EF104916    Y12271    ABP96918.1    CAA72950.1    KM360188    AKH49604.1    PZC73441.1    PZC73448.1    KPI95067.1    KC175562    AGR92345.1    GBRD01013231    JAG52595.1    ODYU01000133    SOQ34396.1    FJ940726    ODYU01006287    ACR25157.1    SOQ47996.1    FJ205402    ACR15970.1    PCG79490.1    PZC73443.1    EF635223    ABU96714.1    AJ007706    CAA07611.1    MF407317    AWL83213.1    KQ460226    KPJ16473.1    PZC70338.1    PZC75529.1    PCG79487.1    AY587161    AAT95353.1    HM209425    ADI32886.1    EF104917    ABP96919.1    BABH01007473    EF531636    ABR88247.1    PCG79483.1    JQ340915    AFP74111.1    Y12276    CAA72955.1    PZC70339.1    HM209423    ADI32884.1    PCG79498.1    PZC73442.1    PZC73450.1    AF064525    AF064526    AAC36247.1    AAC36248.1    Y12270    CAA72949.1    AY587159    AAT95351.1    MF770251    AXG72654.1    HM209424    ADI32885.1    ODYU01007611    SOQ47997.1    SOQ50538.1    KPJ16474.1    PCG79481.1    PZC73446.1    PZC73451.1    PZC73453.1    JN315760    AFK64824.1    GDQN01002626    JAT88428.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000037510    UP000053240   

PRIDE

H9J231    P35045    P35047    Q1HQA7    H9J229    J7JYV8    + More
H9J232    Q9TXE6    H9J230    P35042    H9J243   

Pfam

PF00089   Trypsin

Interpro

IPR033116   TRYPSIN_SER        + More
IPR009003   Peptidase_S1_PA       
IPR001314   Peptidase_S1A       
IPR018114   TRYPSIN_HIS       
IPR001254   Trypsin_dom       

SUPFAM

SSF50494   SSF50494       

CDD

cd00190  Tryp_SPc

ProteinModelPortal

H9J231   P35045   P35047   Q56IB6   P35046   Q56IB5   + More
Q56IB8   Q56IB4   Q6R561   Q56IB7   Q1HQA7   I6TMW8   H9J229   J7JYV8   A0A2A4K6F3   H9J232   Q9TXE6   A0A2A4K5F8   H9J230   A0A2W1BKV8   J7IJ83   V9M0R7   B4X995   A0A2A4K5G7   A0A2A4K6E9   A0A2A4K6E3   A0A194PNR6   Q27540   I3UII8   B4X996   P35042   A0A2A4K6W3   O18447   I7DEI4   A0A2H1VJ41   A0A2A4K648   A0A2W1BSA6   A0A194PVB6   A0A2W1BQW9   A0A194PQQ0   A0A1C9M3A1   A0A194PQQ5   B4X9A1   W5X3N9   A0A194PNR3   Q961Y0   J7IF09   A0A2A4K6U2   J7IFG7   T1QDI0   E7D004   A0A2W1B606   A0A0L7KUC9   A0A2W1BA14   I7E449   O18434   A0A2A4K747   O18436   A0A1B0RHN7   A0A2W1BGQ7   A0A2W1BF78   A0A194PP33   S5PVP1   A0A0K8SII3   A0A2H1V0W3   C4PFX2   C9W8F7   A0A2A4K769   A0A2W1BP39   B3F884   O76954   A0A2U8NFD7   A0A0N1PHJ0   A0A2W1B1G1   A0A2W1BKF9   A0A2A4K5I4   Q4L1K4   D7S002   A9P3S8   H9J243   B4X9A0   V9LL27   O18441   D7S000   A0A2A4K6F8   A0A2W1BE44   A0A2W1BL45   O62598   O18435   Q4L1K6   A0A345H7U4   D7S001   A0A2H1W4N7   A0A0N1I947   A0A2A4K5I0   A0A2W1BKR8   A0A2W1BGR2   A0A2W1BP46   I3UII6   A0A1E1WNA7  

PDB

3W94     E-value=1.11563e-15,     Score=201

KEGG

101738495    K01312 trypsin [EC:3.4.21.4] | (RefSeq) trypsin, alkaline A-like

PATHWAY

04080    Neuroactive ligand-receptor interaction - Bombyx mori (domestic silkworm)

GO

GO:0004252   GO:0005615   GO:0006508   GO:0006811   GO:0015379   GO:0016021   GO:0003909   GO:0051103   GO:0003677   GO:0006281   GO:0048384  

Subcellular location

  

SignalP

Position:   1 - 16,         Likelihood:  0.993118

 

 

Length:

256

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

1.4131

Exp number, first 60 AAs:

0.31354

Total prob of N-in:

0.01288

outside

1  -  256

 

 

Pi

163.867894

Theta

142.288582

Tajima's D

0.453834

CLR

0.137013

CSRT

0.497825108744563

Interpretation

Uncertain