Gene

KWMTBOMO02938  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA003561

Annotation

p38_map_kinase_[Bombyx_mori]

Location

Bomo_Chr5(+):14174536-14187470      View in EpiBrowser

Full name

Mitogen-activated protein kinase      

Location in the cell

Cytoplasmic   Reliability : 1.89 Mitochondrial   Reliability : 1.657

CDS

ATGCCTCGTTTCCATAAAGTAGAAATTAATAAAACTGAATGGATAGTCCCGGAGCGATATCAGATGCTTACACCTGTAGGTTCCGGCGCTTACGGTCAGGTTTGTTCTGCAATAGATGCCCAACATAGTATGAAAGTGGCTATTAAAAAGTTAGCCAGACCTTTTCAATCAGCTGTTCATGCAAAGAGAACATACAGAGAGTTGCGAATGTTGAAACATATGAACCATGAGAATGTTATTGGATTGCTGGATGTGTTTACACCGGAGAAAACATTAGAAGATTTTCAGCAAGTATACTTAGTGACCCATCTAATGGGTGCTGATCTGAATAACATCGTACGGACACAGAAGCTTTCTGATGACCACGTTCAGTTTCTGGTATACCAGATTTTACGTGGACTCAAATACATACATTCGGCTGGCATCATTCATAGGGATTTAAAACCCTCTAACATAGCTGTGAATGAGGACTGTGAGTTAAAAATCTTAGATTTTGGCTTGGCGAGACCCACTGAGACTGAAATGACAGGTTATGTGGCAACAAGATGGTATCGTGCGCCAGAGATAATGCTCAATTGGATGCATTATAACCAAACTGTGGACATTTGGTCTGTGGGTTGTATTATGGCTGAGTTGCTGACAGGAAGAACTTTGTTCCCCGGTACTGACCATATTCATCAATTGAATTTAATCATGGAGATACTCGGCACGCCCGCTCAGGAGTTTATGCAGAAAATATCGTCCGAGTCTGCACGTAACTACATCCAGTCTCTGCCGGCTTTGAAGAGACGCGACTTCCGCGAGGTGTTCCGCGGCGCGAACCCACTCGCCATCAACCTGTTGGAACTGATGCTCGAACTGGATGCCGATAAACGCATAACGGCAGAACAAGCGCTCGCGCACGAGTACTTGGCCCAGTACGCGGACCCGACCGACGAGCCGGTTTCTGCGCCCTACGACCAGAGCTTCGAAGACATGGAGCTGCCTGTAGACAAGTGGAAAGGTGATTTTTTTTATTGCACATATAGGTGGACGAGCTCTCACAGCCCACCTGGTGTAAATGCCGCCACCCACCTTGAGATATGA

Protein

MPRFHKVEINKTEWIVPERYQMLTPVGSGAYGQVCSAIDAQHSMKVAIKKLARPFQSAVHAKRTYRELRMLKHMNHENVIGLLDVFTPEKTLEDFQQVYLVTHLMGADLNNIVRTQKLSDDHVQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELKILDFGLARPTETEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIHQLNLIMEILGTPAQEFMQKISSESARNYIQSLPALKRRDFREVFRGANPLAINLLELMLELDADKRITAEQALAHEYLAQYADPTDEPVSAPYDQSFEDMELPVDKWKGDFFYCTYRWTSSHSPPGVNAATHLEI

Catalytic Activity

ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]

Cofactor

Mg(2+)

Uniprot

Q3C2E3   A0A2A4K4K7   A0A212FF41   A0A023JNR8   A0A1B0YTK4   A0A0N1PHN0   + More
A0A2J7QC17   A0A2Z5U1Y0   A0A310SHK9   E2B3L1   A0A154P726   F8QQF2   F4X361   E2AIS5   E0VR05   A0A158NPL5   A0A1B6CXK1   A0A0C9QVW1   A0A195FFU9   A0A067RWU2   A0A0J7NCT8   A0A087ZYD6   A0A023EQK1   A0A1Q3FXJ6   Q1L0R1   A0A2J7QC09   U5EY70   A0A151IDR9   A0A1B6FMW4   A0A2H1V829   A0A182JIC7   A0A026WTT7   A0A084WM35   A0A195BEV0   A0A151IVK5   A0A151WEG4   A0A182X017   A0A182US54   A0A182KT27   A0A182HPR1   A0A336M6U7   A0A2H8TSD8   A0A2S2QW05   A0A1B6KES4   A0A182QL11   J9KAX7   A0A2A3E4W9   A0A2M3ZFN3   A0A2M4A467   A0A182FVA0   A0A2M4BS21   G3F9Y2   A0A2M4CTJ6   A0A0K8TPY2   A0A3L8DZU2   A0A1B6EAR8   T1E3S8   A0A165A8C5   A0A0P6IIL7   A0A0M8ZU21   A0A069DTG8   A0A023FAE4   A0A0P6BVV9   E9FQM3   A0A0P5VMX5   A0A1L8DKN4   A0A0P5VMX8   A0A0P4VP85   R4G4C2   A0A1W4WYL0   A0A0V0GAP6   A0A182YC55   A0A1Y1NHD4   Q16YY2   A0A182GRN6   A0A1J1IIP5   L7X0J9   A0A0P5ZL25   A0A0A7D769   A0A2S2NND6   A0A0P4WBX5   A0A023JBY8   A0A0P5SFK8   A0A1B6EUA3   A0A0P5HV78   A0A0P5SSW0   A0A146LVE3   A0A1A9W850   A0A221I025   A0A0P5SPW4   A0A0L0C6N3   A0A0P5DZD2   A0A288ZBA2   A7BHS5   A0A1I8NA24   A0A1L8EC74   A0A1B0A5N9   A0A1B0GB82   A0A2P2I1S0   A0A1B6MB35  

EC Number

2.7.11.24

Pubmed

16360949    22118469    28756777    26354079    26760975    20798317    + More
21719571    20566863    21347285    24845553    24945155    17466055    17510324    24508170    24438588    20966253    26369729    30249741    24330624    26334808    25474469    21292972    27129103    25244985    28004739    26483478    23707783    25433091    26823975    26108605    17766307    25315136   

EMBL

AB208585    BAE46743.1    NWSH01000167    PCG78844.1    AGBW02008872    OWR52323.1    + More
KC895497    KZ149992    AHL46461.1    PZC75561.1    KU358549    ANO46359.1    KQ460226    KPJ16463.1    NEVH01016292    PNF26119.1    FX985764    BBA93651.1    KQ769179    OAD52922.1    GL445346    EFN89763.1    KQ434829    KZC07746.1    GU321334    GU321336    ADT91685.1    GL888609    EGI59042.1    GL439874    EFN66664.1    DS235442    EEB15811.1    ADTU01000325    GEDC01019098    JAS18200.1    GBYB01004767    JAG74534.1    KQ981606    KYN39575.1    KK852415    KDR24374.1    LBMM01006692    KMQ90390.1    GAPW01002233    JAC11365.1    GFDL01002741    JAV32304.1    DQ270546    CH477506    ABB82553.1    EAT39844.1    PNF26120.1    GANO01002169    JAB57702.1    KQ977978    KYM98399.1    GECZ01026958    GECZ01018223    GECZ01013569    GECZ01011792    GECZ01010640    GECZ01010296    GECZ01007977    GECZ01005023    JAS42811.1    JAS51546.1    JAS56200.1    JAS57977.1    JAS59129.1    JAS59473.1    JAS61792.1    JAS64746.1    ODYU01001155    SOQ36967.1    KK107106    EZA59427.1    ATLV01024368    ATLV01024369    ATLV01024370    ATLV01024371    ATLV01024372    ATLV01024373    KE525351    KFB51279.1    KQ976509    KYM82690.1    KQ980895    KYN11740.1    KQ983238    KYQ46244.1    APCN01003267    UFQT01000641    SSX26024.1    GFXV01004313    MBW16118.1    GGMS01012640    MBY81843.1    GEBQ01032215    GEBQ01030031    JAT07762.1    JAT09946.1    AXCN02001696    ABLF02021646    KZ288369    PBC26777.1    GGFM01006568    MBW27319.1    GGFK01002117    MBW35438.1    GGFJ01006735    MBW55876.1    JF505508    AEA92685.1    GGFL01004421    MBW68599.1    GDAI01001648    JAI15955.1    QOIP01000002    RLU25822.1    GEDC01002283    JAS35015.1    GALA01000100    JAA94752.1    LRGB01000642    KZS17293.1    GDIQ01021347    JAN73390.1    KQ435847    KOX71145.1    GBGD01001927    JAC86962.1    GBBI01000743    JAC17969.1    GDIP01008892    JAM94823.1    GL732523    EFX90341.1    GDIP01097858    JAM05857.1    GFDF01007157    JAV06927.1    GDIP01097859    JAM05856.1    GDKW01001783    JAI54812.1    ACPB03000101    GAHY01001495    JAA76015.1    GECL01001645    JAP04479.1    GEZM01006949    JAV95536.1    EAT39843.1    JXUM01082844    JXUM01082845    JXUM01082846    JXUM01082847    JXUM01082848    JXUM01082849    JXUM01082850    JXUM01082851    JXUM01082852    JXUM01082853    KQ563340    KXJ74011.1    CVRI01000051    CRK99642.1    KC012937    AGC92010.1    GDIP01042456    JAM61259.1    JX489772    KF582665    AGK89796.1    AII32447.1    GGMR01006082    MBY18701.1    GDRN01054823    JAI66059.1    KC711047    MH341515    AHH29322.1    QBA57530.1    GDIP01187247    GDIP01140357    JAL63357.1    GECZ01028237    JAS41532.1    GDIQ01221751    JAK29974.1    GDIQ01227819    GDIP01135756    GDIP01134405    JAK23906.1    JAL67958.1    GDHC01007460    JAQ11169.1    KY765908    ASM46958.1    GDIP01187246    GDIP01140356    JAL63358.1    JRES01000824    KNC28078.1    GDIP01149595    GDIQ01218069    GDIP01075755    JAJ73807.1    JAK33656.1    KX893515    ASU54245.1    AB277828    BAF75366.1    GFDG01002580    JAV16219.1    CCAG010011560    IACF01002270    LAB67931.1    GEBQ01006837    GEBQ01002711    JAT33140.1    JAT37266.1   

Proteomes

UP000218220    UP000007151    UP000053240    UP000235965    UP000008237    UP000076502    + More
UP000007755    UP000000311    UP000009046    UP000005205    UP000078541    UP000027135    UP000036403    UP000005203    UP000008820    UP000078542    UP000075880    UP000053097    UP000030765    UP000078540    UP000078492    UP000075809    UP000076407    UP000075903    UP000075882    UP000075840    UP000075886    UP000007819    UP000242457    UP000069272    UP000279307    UP000076858    UP000053105    UP000000305    UP000015103    UP000192223    UP000076408    UP000069940    UP000249989    UP000183832    UP000091820    UP000037069    UP000095301    UP000092445    UP000092444   

PRIDE

Q3C2E3   

Pfam

PF00069   Pkinase

Interpro

IPR017441   Protein_kinase_ATP_BS        + More
IPR011009   Kinase-like_dom_sf       
IPR008352   MAPK_p38-like       
IPR000719   Prot_kinase_dom       
IPR003527   MAP_kinase_CS       

SUPFAM

SSF56112   SSF56112       

ProteinModelPortal

Q3C2E3   A0A2A4K4K7   A0A212FF41   A0A023JNR8   A0A1B0YTK4   A0A0N1PHN0   + More
A0A2J7QC17   A0A2Z5U1Y0   A0A310SHK9   E2B3L1   A0A154P726   F8QQF2   F4X361   E2AIS5   E0VR05   A0A158NPL5   A0A1B6CXK1   A0A0C9QVW1   A0A195FFU9   A0A067RWU2   A0A0J7NCT8   A0A087ZYD6   A0A023EQK1   A0A1Q3FXJ6   Q1L0R1   A0A2J7QC09   U5EY70   A0A151IDR9   A0A1B6FMW4   A0A2H1V829   A0A182JIC7   A0A026WTT7   A0A084WM35   A0A195BEV0   A0A151IVK5   A0A151WEG4   A0A182X017   A0A182US54   A0A182KT27   A0A182HPR1   A0A336M6U7   A0A2H8TSD8   A0A2S2QW05   A0A1B6KES4   A0A182QL11   J9KAX7   A0A2A3E4W9   A0A2M3ZFN3   A0A2M4A467   A0A182FVA0   A0A2M4BS21   G3F9Y2   A0A2M4CTJ6   A0A0K8TPY2   A0A3L8DZU2   A0A1B6EAR8   T1E3S8   A0A165A8C5   A0A0P6IIL7   A0A0M8ZU21   A0A069DTG8   A0A023FAE4   A0A0P6BVV9   E9FQM3   A0A0P5VMX5   A0A1L8DKN4   A0A0P5VMX8   A0A0P4VP85   R4G4C2   A0A1W4WYL0   A0A0V0GAP6   A0A182YC55   A0A1Y1NHD4   Q16YY2   A0A182GRN6   A0A1J1IIP5   L7X0J9   A0A0P5ZL25   A0A0A7D769   A0A2S2NND6   A0A0P4WBX5   A0A023JBY8   A0A0P5SFK8   A0A1B6EUA3   A0A0P5HV78   A0A0P5SSW0   A0A146LVE3   A0A1A9W850   A0A221I025   A0A0P5SPW4   A0A0L0C6N3   A0A0P5DZD2   A0A288ZBA2   A7BHS5   A0A1I8NA24   A0A1L8EC74   A0A1B0A5N9   A0A1B0GB82   A0A2P2I1S0   A0A1B6MB35  

PDB

4ZTH     E-value=1.09345e-152,     Score=1384

KEGG

692545    K04441 p38 MAP kinase [EC:2.7.11.24] | (RefSeq) P38mapk; p38 map kinase

PATHWAY

04013    MAPK signaling pathway - fly - Bombyx mori (domestic silkworm)
04068    FoxO signaling pathway - Bombyx mori (domestic silkworm)
04624    Toll and Imd signaling pathway - Bombyx mori (domestic silkworm)
04933    AGE-RAGE signaling pathway in diabetic complications - Bombyx mori (domestic silkworm)

GO

GO:0004707   GO:0005524   GO:0035556   GO:0010468   GO:0071310   GO:0005634   GO:0005737   GO:0006468   GO:0004672   GO:0006310   GO:0003909   GO:0051103   GO:0003677   GO:0006281   GO:0048384  

Length:

361

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0306

Exp number, first 60 AAs:

0.00513

Total prob of N-in:

0.01499

outside

1  -  361

 

 

Pi

205.737242

Theta

168.359783

Tajima's D

0.399181

CLR

0.340902

CSRT

0.48377581120944

Interpretation

Uncertain