Gene

KWMTBOMO02933

Pre Gene Modal

BGIBMGA003558

Annotation

PREDICTED:_doublesex-_and_mab-3-related_transcription_factor_2_[Amyelois_transitella]

Location

Bomo_Chr5(+):14133946-14140529      View in EpiBrowser

Full name

Doublesex- and mab-3-related transcription factor 2      

Alternative Name

Doublesex-like 2 protein
Terra

Transcription factor

DM

Location in the cell

Nuclear   Reliability : 2.933

CDS

ATGCAAAGTGAAATAAGTGAAAATAACAATAGCACTCGGAAGGCGCTGAGGACACCGAAATGCGCTCGTTGCCGGAATCACGGAGTAATCTCGTGTTTGAAAGGACACAAGCGGCTGTGTCGATGGCGGGATTGCCGTTGCCCTGGTTGTCTTCTGGTGCTAGAAAGACAGCGAGTCATGGCTGCTCAGGTTGCGCTTAGGCGACAACAAGGGGCTGGTGGCCCAGAATCGCGCAATAGCGAGGCTGCGGCACTGGCAGCTCGCAAGCGTGCCTACCGTGCAAGGCTTCGTTGCATGCAGATGTCGAGGACATATACAGTACAACCCCCTAATTTCGGAGGCAACGAGATACTATTTCCAAACGACCCTGCATGGAATGAGCGAGTACGCCGGCGCAAGGCTTTCGCAGACGCAGAACTGGAGCGCGGTGTCGGGGGTACGAACATGGCGGCACCTCCCGCGGCGCTGCTCTGCAGGAACCTCCTAGCGGCTCTCCTCACGACCTATCAACCGGCAGTCCAGGTTCCGCCGCAACGACAGAAGCTATCATTCTCCATAGAATCCATTATTGGGGTACAATAG

Protein

MQSEISENNNSTRKALRTPKCARCRNHGVISCLKGHKRLCRWRDCRCPGCLLVLERQRVMAAQVALRRQQGAGGPESRNSEAAALAARKRAYRARLRCMQMSRTYTVQPPNFGGNEILFPNDPAWNERVRRRKAFADAELERGVGGTNMAAPPAALLCRNLLAALLTTYQPAVQVPPQRQKLSFSIESIIGVQ

Description

Transcriptional activator that directly regulates early activation of the myogenic determination gene MYF5 by binding in a sequence-specific manner to the early epaxial enhancer element of it. Involved in somitogenesis during embryogenesis and somite development and differentiation into sclerotome and dermomyotome. Required for the initiation and/or maintenance of proper organization of the sclerotome, dermomyotome and myotome. Is not required for sex determination and/or differentiation in embryonic development. Also not involved in symmetric somite formation and hence does not regulate the laterality pathway that controls left-right asymmetric organ positioning.

Subunit

Homodimer.

Similarity

Belongs to the DMRT family.

Keywords

Complete proteome   DNA-binding   Metal-binding   Nucleus   Reference proteome   Transcription   Transcription regulation   Zinc  

Feature

chain  Doublesex- and mab-3-related transcription factor 2

Uniprot

H9J221   A0A2A4K450   A0A2W1BQZ4   A0A2H1V830   A0A0N0PDS8   A0A194PQ08   + More
A0A210Q2X0   A0A3M0KT89   A0A1U9W5J3   H3ATU6   A0A2I0UJ24   A0A1V4L133   A0A0Q3NZC5   A0A3B3TI56   W5N0F8   A0A2S0XSS9   W5KZ23   A0A3B1IQY8   D4A098   A0A146V6Q1   H6V7L7   A0A2P4SC27   A0A146ZNI7   A0A1B0CAE0   R4GM47   A0A0S7ERH3   Q8QGP4   A0A087X6H1   A0A3P9PG78   A0A3B3Y309   A0A1A6HS67   A0A3B3UND9   A0A3B3VUB0   D5KTC4   A0A3B3BVB7   A0A1S3PLN7   Q8BG36   A0A3P8WUJ8   A0A2G9RHP0   A0A0F8BJF6   A0A3P8WXR4   A0A3B4U1A4   A0A3P8ZUN9   A0A226PKZ7   F6RFX2   G5BXE7   A0A3P8XZL3   A4IHB2   A0A3B4YXT4   A0A1U7QB01   Q6YHU7   A0A1S3IGB7   A0A1L8HY88   I3MYT4   A0A3L7HZK7   A0A3B4CBR1   A0A3B3SL42  

Pubmed

19121390    28756777    26354079    28812685    9215903    29240929    + More
25329095    15057822    15632090    15592404    23542700    29451363    12609607    16141072    19468303    10857744    10021344    15489334    16387292    17605809    17974128    20368965    21203428    24487278    25835551    25069045    24621616    20431018    21993625    27762356    29704459   

EMBL

BABH01007538    NWSH01000167    PCG78839.1    KZ149992    PZC75557.1    ODYU01001155    + More
SOQ36971.1    KQ460226    KPJ16459.1    KQ459597    KPI95053.1    NEDP02005174    OWF43062.1    QRBI01000103    RMC16383.1    KY670720    AQY19163.1    AFYH01118506    AFYH01118507    KZ505731    PKU46008.1    LSYS01000242    OPJ90429.1    LMAW01003178    KQK73619.1    AHAT01017177    MF287963    AWC26113.1    AABR07006639    CH473953    EDM13054.1    GCES01073281    JAR13042.1    JN802284    AFA46801.1    PPHD01066932    POI21631.1    GCES01018911    JAR67412.1    AJWK01003679    AC192785    GBYX01475283    JAO06392.1    AF350428    AAL83920.1    AYCK01002565    LZPO01017309    OBS80850.1    GU594226    ADD97887.1    AF539811    AK044891    AK140337    AK140347    AC124540    AC132140    CH466534    AJ276456    AJ276459    AF080623    BC027669    AAD38425.1    AAH27669.1    AAN77205.1    BAC32130.1    BAE24344.1    CAB93343.1    EDL41636.1    KV940594    PIO27397.1    KQ042810    KKF10330.1    AWGT02000044    OXB80786.1    AAMC01109606    AAMC01109607    JH172326    EHB13950.1    BC135447    AAI35448.1    AY149606    AAN78446.1    CM004466    OCU01065.1    AGTP01031919    RAZU01000133    RLQ71110.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000053268    UP000242188    UP000269221    + More
UP000008672    UP000190648    UP000051836    UP000261540    UP000018468    UP000018467    UP000002494    UP000092461    UP000000539    UP000002852    UP000028760    UP000242638    UP000261480    UP000092124    UP000261500    UP000261560    UP000087266    UP000000589    UP000265120    UP000261420    UP000265140    UP000198419    UP000008143    UP000006813    UP000261360    UP000189706    UP000085678    UP000186698    UP000005215    UP000273346    UP000261440   

PRIDE

H9J221    D4A098    Q8BG36   

Pfam

PF00751   DM        + More
PF03474   DMA

Interpro

IPR026607   DMRT/dsx/mab-3        + More
IPR001275   DM_DNA-bd       
IPR036407   DM_DNA-bd_sf       
IPR005173   DMA       
IPR009060   UBA-like_sf       

SUPFAM

SSF82927   SSF82927        + More
SSF46934   SSF46934       

Gene 3D

4.10.1040.10    

ProteinModelPortal

H9J221   A0A2A4K450   A0A2W1BQZ4   A0A2H1V830   A0A0N0PDS8   A0A194PQ08   + More
A0A210Q2X0   A0A3M0KT89   A0A1U9W5J3   H3ATU6   A0A2I0UJ24   A0A1V4L133   A0A0Q3NZC5   A0A3B3TI56   W5N0F8   A0A2S0XSS9   W5KZ23   A0A3B1IQY8   D4A098   A0A146V6Q1   H6V7L7   A0A2P4SC27   A0A146ZNI7   A0A1B0CAE0   R4GM47   A0A0S7ERH3   Q8QGP4   A0A087X6H1   A0A3P9PG78   A0A3B3Y309   A0A1A6HS67   A0A3B3UND9   A0A3B3VUB0   D5KTC4   A0A3B3BVB7   A0A1S3PLN7   Q8BG36   A0A3P8WUJ8   A0A2G9RHP0   A0A0F8BJF6   A0A3P8WXR4   A0A3B4U1A4   A0A3P8ZUN9   A0A226PKZ7   F6RFX2   G5BXE7   A0A3P8XZL3   A4IHB2   A0A3B4YXT4   A0A1U7QB01   Q6YHU7   A0A1S3IGB7   A0A1L8HY88   I3MYT4   A0A3L7HZK7   A0A3B4CBR1   A0A3B3SL42  

PDB

4YJ0     E-value=2.82128e-16,     Score=204

KEGG

101745391    K19489 doublesex- and mab-3-related transcription factor 2 | (RefSeq) doublesex- and mab-3-related t

GO

GO:0046872   GO:0005634   GO:0043565   GO:0003700   GO:0003677   GO:0006915   GO:0007368   GO:2000287   GO:0000977   GO:0042803   GO:0045944   GO:0014807   GO:0048706   GO:0001228   GO:0006355   GO:0005524   GO:0006281   GO:0006310   GO:0003909   GO:0051103   GO:0048384  

PANTHER

PTHR12322  

Subcellular location

Nucleus  

Length:

193

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.06959

Exp number, first 60 AAs:

0

Total prob of N-in:

0.16956

outside

1  -  193

 

 

Pi

156.168611

Theta

136.199751

Tajima's D

0.059201

CLR

3.579599

CSRT

0.383130843457827

Interpretation

Uncertain