Gene

KWMTBOMO02912

Pre Gene Modal

BGIBMGA003546

Annotation

hypothetical_protein_KGM_17655_[Danaus_plexippus]

Location

Bomo_Chr5(+):13690227-13698155      View in EpiBrowser

Full name

Alkaline ceramidase      

Alternative Name

Alkaline N-acylsphingosine amidohydrolase
Alkaline acylsphingosine deacylase
Protein brainwashing

Location in the cell

PlasmaMembrane   Reliability : 4.999

CDS

ATGTGGTCACATCTGGAACGTGGAAGCTCTCCGGTGGATTGGTGTGAATCAAATTATTCCATATCTCCTTTGATAGCAGAATTCGTTAACACTGTGAGCAATATTTTGTTCTTTCTGTTCCCACCAGTGTTGATTCATCTTTTCCAAGAATATTCAAAATTCTTCAATCCTGCTATCAATGTATTATGGGTTCTGTTGATGATTGTTGGACTTAGTTCAGCTTATTTTCATGCAACTTTGAGCTTAGTGGGTCAGTTATTAGATGAACTTGCAATATTGTGGGTATTTATGGCAGCATTTGCTATGTTCTTGCCTAAAAGATATTTTCCGAAATTTTTGGGAGGAAACAGGAGAATACTTGCACTGTACTCCAGTGTATTTTCGGTCATGTCGACTGGATTTCTCGTAATGCATCCAGCAGCTAATGCGTTCGCATTAATGACACTAGCTTTACCCGCCATGGGATTCTTGTGCAAGGAATTGACCAGAGTTAAATGCGCTCGTGTGTACCGTCTCGGGCTACGGTGTGTCGCTATCTGCTTCCTCGCAATGTTCTGTTGGATTATCGACCGTGTGTTTTGCGATGCTTGGCTCTCTATCAGCTTCCCTTACATGCACGGAATCTGGCATGTACTAATATTCATCGCCAGTTATACAGCACTCGTGCTTTTCGCGTATTTCAATGTCTCCGAGGAAAGGCCCGAACAAAAACCTCAATTGAAATATTGGCCGAGAAATGACTTTGAATTAGGCATACCTTATATAACCATAAAGCATCCTTGCAAAAAAGATTATAATATAGCAATATAG

Protein

MWSHLERGSSPVDWCESNYSISPLIAEFVNTVSNILFFLFPPVLIHLFQEYSKFFNPAINVLWVLLMIVGLSSAYFHATLSLVGQLLDELAILWVFMAAFAMFLPKRYFPKFLGGNRRILALYSSVFSVMSTGFLVMHPAANAFALMTLALPAMGFLCKELTRVKCARVYRLGLRCVAICFLAMFCWIIDRVFCDAWLSISFPYMHGIWHVLIFIASYTALVLFAYFNVSEERPEQKPQLKYWPRNDFELGIPYITIKHPCKKDYNIAI

Description

Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.

Catalytic Activity

an N-acylsphing-4-enine + H2O = a fatty acid + sphing-4-enine

Cofactor

Zn(2+)

Similarity

Belongs to the alkaline ceramidase family.

Keywords

Calcium   Complete proteome   Hydrolase   Lipid metabolism   Membrane   Metal-binding   Reference proteome   Transmembrane   Transmembrane helix   Zinc  

Feature

chain  Alkaline ceramidase

Uniprot

A0A212F961   A0A1E1WIZ4   A0A2A4J8D4   A0A2W1BQ00   A0A0N1IIJ1   H9J209   + More
A0A067R9H6   A0A2J7PVS8   A0A310S639   A0A2A3ETE4   A0A088AJ78   E2BKT4   A0A232FN24   K7ITD4   A0A0L7RBV0   A0A154PLS3   A0A026WJ17   E9J4P4   A0A151HY84   A0A158NWA3   A0A195ET48   F4X4U0   A0A084VMJ7   A0A2M4BW77   A0A2M4AQ06   A0A182JGR3   A0A182F3S4   A0A2M3Z5F0   A0A2M4BWF2   A0A1Q3FNY5   A0A182U5B2   W5JTY4   A0A182K4W9   A0A182YLP2   A0A182KWH6   A0A182QHD4   A0A182R416   A0A182X684   Q7Q8A0   A0A182IBA5   A0A182NBB5   A0A182PVX1   B0W1A1   A0A182LWS7   Q17KM2   A0A182H840   A0A182VTH7   A0A1Y1LLY6   B3NL07   B4N7P1   B4PBH3   M9PDG7   A0A0J9R550   A0A1W4VK85   A0A1B0A1K4   D3TL44   I2CMG3   A0A1A9V9G9   A0A1A9XL29   A0A1B0B7Q0   B4I628   Q9VIP7   Q29KK7   B3ML29   A0A3B0JV50   A0A1I8PR19   A0A1A9W074   A0A336ML14   A0A336MLI1   B4KEP3   B4M9L6   B4JQ89   A0A0K8VIV9   A0A034VBN0   A0A0A1X4X2   A0A2P8YQ06   A0A151IC19   A0A151X5V1   A0A1I8MM63   E0VFL8   U5EWL1   A0A087SZP1   A0A1S3H206   A0A2L2YHP7   A0A2I9LNR0   A0A1D2N317   W5K4R2   M3ZUE7   A0A1W5AQM7   A0A0Q9X4L7   A0A0P9BNW0   A0A3B4E6G5   A0A1A7XQM8   A0A3B5L6N8   A0A2I4B6H7   A0A1A8ENS4   A0A1A8NBS1   A0A1A8JHJ8  

EC Number

3.5.1.-
3.5.1.23

Pubmed

22118469    28756777    26354079    19121390    24845553    20798317    + More
28648823    20075255    24508170    30249741    21282665    21347285    21719571    24438588    20920257    23761445    25244985    20966253    12364791    14747013    17210077    17510324    26483478    28004739    17994087    17550304    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    22936249    20353571    22517621    12537569    10623899    14516700    15632085    25348373    25830018    29403074    25315136    20566863    26561354    29248469    27289101    25329095    23542700   

EMBL

AGBW02009627    OWR50286.1    GDQN01004075    JAT86979.1    NWSH01002700    PCG67653.1    + More
KZ149960    PZC76351.1    KQ460226    KPJ16436.1    BABH01007576    BABH01007577    BABH01007578    BABH01007579    KK852607    KDR20337.1    NEVH01020943    PNF20442.1    KQ768636    OAD53084.1    KZ288185    PBC34977.1    GL448826    EFN83683.1    NNAY01000006    OXU32131.1    AAZX01004114    KQ414617    KOC68231.1    KQ434977    KZC12831.1    KK107198    QOIP01000007    EZA55626.1    RLU21078.1    GL768112    EFZ12208.1    KQ976730    KYM76440.1    ADTU01027853    KQ981993    KYN31087.1    GL888679    EGI58513.1    ATLV01014599    KE524975    KFB39191.1    GGFJ01008194    MBW57335.1    GGFK01009555    MBW42876.1    GGFM01002991    MBW23742.1    GGFJ01008193    MBW57334.1    GFDL01005735    JAV29310.1    ADMH02000386    ETN66753.1    AXCN02000628    AAAB01008944    EAA10121.2    APCN01000661    DS231821    EDS44971.1    AXCM01000660    CH477223    EAT47204.1    JXUM01028611    KQ560826    KXJ80726.1    GEZM01051820    JAV74684.1    CH954179    EDV54585.2    CH964214    EDW80380.2    CM000158    EDW90487.2    AE014134    AGB93151.1    CM002910    KMY91121.1    EZ422142    ADD18339.1    CCAG010023642    JQ308541    AFJ68096.1    JXJN01009696    CH480822    EDW55834.1    AF323976    AY071232    CH379061    EAL33167.3    CH902620    EDV31647.2    OUUW01000010    SPP85975.1    UFQS01001128    UFQT01001128    SSX09146.1    SSX29057.1    UFQT01001296    SSX29879.1    CH933807    EDW11922.2    CH940654    EDW57892.2    CH916372    EDV99069.1    GDHF01013522    JAI38792.1    GAKP01019032    GAKP01019030    GAKP01019028    JAC39924.1    GBXI01008376    JAD05916.1    PYGN01000440    PSN46340.1    KQ978069    KYM97350.1    KQ982491    KYQ55756.1    DS235116    EEB12174.1    GANO01002907    JAB56964.1    KK112700    KFM58330.1    IAAA01021503    IAAA01021504    LAA07557.1    GFWZ01000033    MBW20023.1    LJIJ01000263    ODM99673.1    KRG02971.1    KPU73525.1    HADW01018981    SBP20381.1    HAEB01002288    SBQ48815.1    HAEH01001253    SBR66530.1    HAED01022679    HAEE01006814    SBR09443.1   

Proteomes

UP000007151    UP000218220    UP000053240    UP000005204    UP000027135    UP000235965    + More
UP000242457    UP000005203    UP000008237    UP000215335    UP000002358    UP000053825    UP000076502    UP000053097    UP000279307    UP000078540    UP000005205    UP000078541    UP000007755    UP000030765    UP000075880    UP000069272    UP000075902    UP000000673    UP000075881    UP000076408    UP000075882    UP000075886    UP000075900    UP000076407    UP000007062    UP000075840    UP000075884    UP000075885    UP000002320    UP000075883    UP000008820    UP000069940    UP000249989    UP000075920    UP000008711    UP000007798    UP000002282    UP000000803    UP000192221    UP000092445    UP000092444    UP000078200    UP000092443    UP000092460    UP000001292    UP000001819    UP000007801    UP000268350    UP000095300    UP000091820    UP000009192    UP000008792    UP000001070    UP000245037    UP000078542    UP000075809    UP000095301    UP000009046    UP000054359    UP000085678    UP000094527    UP000018467    UP000002852    UP000192224    UP000261440    UP000261380    UP000192220   

PRIDE

H9J209    M9PDG7    Q9VIP7   

Pfam

PF05875   Ceramidase

Interpro

IPR008901   ACER       

ProteinModelPortal

A0A212F961   A0A1E1WIZ4   A0A2A4J8D4   A0A2W1BQ00   A0A0N1IIJ1   H9J209   + More
A0A067R9H6   A0A2J7PVS8   A0A310S639   A0A2A3ETE4   A0A088AJ78   E2BKT4   A0A232FN24   K7ITD4   A0A0L7RBV0   A0A154PLS3   A0A026WJ17   E9J4P4   A0A151HY84   A0A158NWA3   A0A195ET48   F4X4U0   A0A084VMJ7   A0A2M4BW77   A0A2M4AQ06   A0A182JGR3   A0A182F3S4   A0A2M3Z5F0   A0A2M4BWF2   A0A1Q3FNY5   A0A182U5B2   W5JTY4   A0A182K4W9   A0A182YLP2   A0A182KWH6   A0A182QHD4   A0A182R416   A0A182X684   Q7Q8A0   A0A182IBA5   A0A182NBB5   A0A182PVX1   B0W1A1   A0A182LWS7   Q17KM2   A0A182H840   A0A182VTH7   A0A1Y1LLY6   B3NL07   B4N7P1   B4PBH3   M9PDG7   A0A0J9R550   A0A1W4VK85   A0A1B0A1K4   D3TL44   I2CMG3   A0A1A9V9G9   A0A1A9XL29   A0A1B0B7Q0   B4I628   Q9VIP7   Q29KK7   B3ML29   A0A3B0JV50   A0A1I8PR19   A0A1A9W074   A0A336ML14   A0A336MLI1   B4KEP3   B4M9L6   B4JQ89   A0A0K8VIV9   A0A034VBN0   A0A0A1X4X2   A0A2P8YQ06   A0A151IC19   A0A151X5V1   A0A1I8MM63   E0VFL8   U5EWL1   A0A087SZP1   A0A1S3H206   A0A2L2YHP7   A0A2I9LNR0   A0A1D2N317   W5K4R2   M3ZUE7   A0A1W5AQM7   A0A0Q9X4L7   A0A0P9BNW0   A0A3B4E6G5   A0A1A7XQM8   A0A3B5L6N8   A0A2I4B6H7   A0A1A8ENS4   A0A1A8NBS1   A0A1A8JHJ8  

PDB

6G7O     E-value=3.28877e-10,     Score=154

KEGG

101741167    K01441 alkaline ceramidase [EC:3.5.1.23] | (RefSeq) alkaline ceramidase

PATHWAY

00600    Sphingolipid metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0006672   GO:0016021   GO:0016811   GO:0102121   GO:0017040   GO:0046514   GO:0046872   GO:0007420   GO:0005783   GO:0019216   GO:0006665   GO:0005524   GO:0004672   GO:0007169   GO:0016020   GO:0004713   GO:0006281   GO:0048384  

PANTHER

PTHR46139  

Subcellular location

Membrane  

Length:

269

Number of predicted TMHs:

7

Exp number of AAs in TMHs:

143.16278

Exp number, first 60 AAs:

24.711

Total prob of N-in:

0.10452

POSSIBLE N-term signal

sequence

outside

1  -  24

TMhelix

25  -  47

inside

48  -  53

TMhelix

54  -  76

outside

77  -  90

TMhelix

91  -  110

inside

111  -  118

TMhelix

119  -  136

outside

137  -  140

TMhelix

141  -  158

inside

159  -  170

TMhelix

171  -  193

outside

194  -  207

TMhelix

208  -  230

inside

231  -  269

 

 

Pi

288.625308

Theta

169.083658

Tajima's D

2.51096

CLR

0.457631

CSRT

0.947102644867757

Interpretation

Uncertain