Gene

KWMTBOMO02904

Pre Gene Modal

BGIBMGA003647

Annotation

PREDICTED:_tyrosine-protein_kinase_shark_[Amyelois_transitella]

Location

Bomo_Chr5(-):13535529-13548698      View in EpiBrowser

Full name

Tyrosine-protein kinase       + More
Tyrosine-protein kinase HTK16      

Location in the cell

Nuclear   Reliability : 2.033

CDS

ATGACGTCATTCATATTACTTAAGACAAACTCTTTTTTGTTGAGGATGAATAGAGAAGACAACGTTAACTGGTTTCATGGGAAAATATCACGTGAATCCGCTGAGAAACTGTTAAAAGAGGAAGGAGAAGATGGTGTATTTTTAGTACGGGAGAGTAATACTTCGCCTGGAGATTATGTTTTGTCTGTTTTGCATCAGGGTCAAGTAGTGCATTATCAAATACGCAGACACGGTGAAGATGCATTCTTCTCTATAGAAGAGCACACAACTGTTCATGGATTGGATACTCTTATACAACATTACCGTAGTGATTCAAATGGACTTGTTACTAGGTTGTCCATTGTCTGTAAAGGAGAACCACCACCGCATGAGTCGAGGACACAGGGAACAACAAATTTACTGCACAGAGCAACGGAAGCGGGTCATTTCAACGTGGTGTCGAAGTTACTGGCAAGCGGCTACCGGAGTCGCGACGCCAAGAACCAGGACGGTCAGACCGCGGTGCACATCGCCGCGAGGGCGGGACGAGACACCATCCTCGCCGAACTCATCGAGAGCGGCTCCACTGTCAACGTTCGAGACTCCTTTGGATACACGCCCTTACACTACACATGTCAAAATAACTTGCCGAGTACAACGGAGCTTCTGATAACGAAAGGGAACGCTAACTATCAAATGCGACATGCACCTACCGGAAAAGTACCTCTGCATGACGCAGCTCAGAAAGGACACATTGAATGTATTAAGGTGCTTTTAAGATTAAAGGCGCCATCACATCCAAGAACATTAACAAAGGAAACTCCAGCAGACTTAGCAAAACAATACGGACACACAGAATGCTATCAACTATTAAAAAATTATCAACCAGAACAGCCCAATACATCAAAGAGCCAATGGTACCACGGCACGCAGAACCGCGATGAAGCTGTAAAGATACTTGAAAACTACTGTAAGCATCACAATTTGAGAGACAAAGCTTCGGACGGCGTATTCCTGGTGCGCTACAGCGAAAGGCGCACAGGCGCTGCCTACGTTTTGACGATGCTCAGTGAAAACACACCTTACAACTTCATTATTAGAAAAGAGGGCAACTGGCTTTTCATAGACGACGGTCCCTACTTGGAATCATTGGAGAGACTGATTGAACACTATAGCACTGTACCTGATGGTCTACCCACAAGGCTCACTACACCTGTTCCTCCTAAACCTAAACCACCGCTACCTGAATTTTCAACGATGCCGAGAACAAAGAAGTTATCATCAAGTCGAGCAACGAAAAATCAAACTTTATCACTTGTGAAACACGATATACTTAGCGACAAAGCCGATTTGACGTCACCTGTCTCGAATGCTTCCAACAACAACTTGCTTGATTTCTTCACTAGGAATATATCATTCTCATCAGATTTTAGTAATGATAGTATGAACAACGAAGATGACAATGACACATATAAAGTACCAGTGAACAGTTCTGTGACCGTGCCCGAGAATTACAATGAAATCTCTATAAACTCCGACGGACAGCTATCCACACTGCAAGAATTCATCCCGATGAATGAATTAACATTGGGCGCGATGATAGGAGAGGGCGAATTCGGTTCAGTACTGCGAGCGACTTACACTCCGCACGATCAGCCTCCGCAAACGGTTGCCGTGAAAACATTACACGTGCAACACACCGACACGAACAAGAAGGAGTTCCTATCCGAAGCCAAAGTAATGATGTCTTTAAGGCATCACTGTATTGTGAACTTGATTGGGGTGTCTTTGGGTCCACCACTGGCAATGGTGCAGGAGCTGGTGCCGCTGGGCTCGTTGCTAGAATACCTGTTACGGCATCCGGAATCTATATCTCCCGGCTACGAACTGCGGCTGTGGGCTTGCCAGGTCGCCGCTGGGATGCGCTACTTGGAGAAACGACGCTTTGTACACAGGGATTTAGCAGCTAGGAACATCTTGCTGGCTAACAGACATCAAGCCAAAATCAGTGACTTCGGTCTCTCCCGCGCCCTGTCCACCGACAGCTCGTACTACCGAGCGAGCCGCGGCGGGAAATGGCCCATCAAGTGGTACGCGCCCGAGTCCTACAACTACGGCACGTTCAGCCACGCCAGCGACGTGTGGAGCTACGGGGTCACGCTCTGGGAAATGTTCTCGTTCGGACAACAGCCCTACGGGGATATGAGAGGAATTGATGCAATACAACTTGTGGAAAGCGGTAAGCGTCTTGAACGCCCCGAGGACTGTCCTGACGAGATATATCAAGTGATGCTGGACTGTTGGACGTACAGTCCCGAGCACAGGCCAACCTTCAGCCACCTGGTAGATGTGTTCTCGCAGCATCCTGATTACGTCAACATAAGCCAGTTAGTCCTTGAAAATGACGAAATTAATGTGTGA

Protein

MTSFILLKTNSFLLRMNREDNVNWFHGKISRESAEKLLKEEGEDGVFLVRESNTSPGDYVLSVLHQGQVVHYQIRRHGEDAFFSIEEHTTVHGLDTLIQHYRSDSNGLVTRLSIVCKGEPPPHESRTQGTTNLLHRATEAGHFNVVSKLLASGYRSRDAKNQDGQTAVHIAARAGRDTILAELIESGSTVNVRDSFGYTPLHYTCQNNLPSTTELLITKGNANYQMRHAPTGKVPLHDAAQKGHIECIKVLLRLKAPSHPRTLTKETPADLAKQYGHTECYQLLKNYQPEQPNTSKSQWYHGTQNRDEAVKILENYCKHHNLRDKASDGVFLVRYSERRTGAAYVLTMLSENTPYNFIIRKEGNWLFIDDGPYLESLERLIEHYSTVPDGLPTRLTTPVPPKPKPPLPEFSTMPRTKKLSSSRATKNQTLSLVKHDILSDKADLTSPVSNASNNNLLDFFTRNISFSSDFSNDSMNNEDDNDTYKVPVNSSVTVPENYNEISINSDGQLSTLQEFIPMNELTLGAMIGEGEFGSVLRATYTPHDQPPQTVAVKTLHVQHTDTNKKEFLSEAKVMMSLRHHCIVNLIGVSLGPPLAMVQELVPLGSLLEYLLRHPESISPGYELRLWACQVAAGMRYLEKRRFVHRDLAARNILLANRHQAKISDFGLSRALSTDSSYYRASRGGKWPIKWYAPESYNYGTFSHASDVWSYGVTLWEMFSFGQQPYGDMRGIDAIQLVESGKRLERPEDCPDEIYQVMLDCWTYSPEHRPTFSHLVDVFSQHPDYVNISQLVLENDEINV

Catalytic Activity

ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]

Similarity

Belongs to the protein kinase superfamily. Tyr protein kinase family.

Keywords

ANK repeat   ATP-binding   Kinase   Nucleotide-binding   Phosphoprotein   Repeat   SH2 domain   Transferase   Tyrosine-protein kinase  

Feature

chain  Tyrosine-protein kinase HTK16

Uniprot

H9J2B0   A0A2W1BN37   A0A2H1V047   A0A2A4K131   A0A2A4K1G1   A0A194PNY0   + More
A0A212ELJ7   A0A0L7LQZ3   A0A0N1IHA2   E0VXY7   A0A1W4WT21   A0A023F2P2   A0A0T6AXF7   A0A1Y1MBH7   A0A0A9YK68   A0A0K8TI66   U4V0A3   U4TYZ0   N6TSW1   A0A1D2MX86   P53356   A0A2C9JF25   A0A0B6ZX32   A0A210PW82   T2MFB2  

EC Number

2.7.10.2

Pubmed

19121390    28756777    26354079    22118469    26227816    20566863    + More
25474469    28004739    25401762    26823975    23537049    27289101    8134129    15562597    28812685    24065732   

EMBL

BABH01007590    BABH01007591    KZ149960    PZC76358.1    ODYU01000061    SOQ34189.1    + More
NWSH01000285    PCG77769.1    PCG77768.1    KQ459597    KPI95017.1    AGBW02014037    OWR42362.1    JTDY01000296    KOB77829.1    KQ460226    KPJ16424.1    DS235842    EEB18243.1    GBBI01003117    JAC15595.1    LJIG01022614    KRT79627.1    GEZM01037796    GEZM01037795    JAV81930.1    GBHO01012116    GBHO01012115    GBHO01012109    GBHO01001987    GBHO01001984    GBHO01001982    GBHO01001981    GBHO01001975    GDHC01016617    GDHC01016250    GDHC01008981    JAG31488.1    JAG31489.1    JAG31495.1    JAG41617.1    JAG41620.1    JAG41622.1    JAG41623.1    JAG41629.1    JAQ02012.1    JAQ02379.1    JAQ09648.1    GBRD01000745    GBRD01000744    JAG65076.1    KI209922    ERL96111.1    KB631669    KI209508    ERL85243.1    ERL96051.1    APGK01020362    KB740193    ENN81128.1    LJIJ01000424    ODM97653.1    U00936    HACG01025455    CEK72320.1    NEDP02005455    OWF40712.1    HAAD01004721    CDG70953.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000007151    UP000037510    UP000053240    + More
UP000009046    UP000192223    UP000030742    UP000019118    UP000094527    UP000076420    UP000242188   

PRIDE

H9J2B0   

Pfam

PF07714   Pkinase_Tyr        + More
PF12796   Ank_2
PF00017   SH2
PF00023   Ank

Interpro

IPR011009   Kinase-like_dom_sf        + More
IPR001245   Ser-Thr/Tyr_kinase_cat_dom       
IPR017441   Protein_kinase_ATP_BS       
IPR002110   Ankyrin_rpt       
IPR020635   Tyr_kinase_cat_dom       
IPR036770   Ankyrin_rpt-contain_sf       
IPR036860   SH2_dom_sf       
IPR020683   Ankyrin_rpt-contain_dom       
IPR008266   Tyr_kinase_AS       
IPR000980   SH2       
IPR035061   Shark-like_SH2_N       
IPR000719   Prot_kinase_dom       

SUPFAM

SSF55550   SSF55550        + More
SSF48403   SSF48403       
SSF56112   SSF56112       

Gene 3D

1.25.40.20     3.30.505.10    

CDD

cd10347  SH2_Nterm_shark_like
cd00204  ANK

ProteinModelPortal

H9J2B0   A0A2W1BN37   A0A2H1V047   A0A2A4K131   A0A2A4K1G1   A0A194PNY0   + More
A0A212ELJ7   A0A0L7LQZ3   A0A0N1IHA2   E0VXY7   A0A1W4WT21   A0A023F2P2   A0A0T6AXF7   A0A1Y1MBH7   A0A0A9YK68   A0A0K8TI66   U4V0A3   U4TYZ0   N6TSW1   A0A1D2MX86   P53356   A0A2C9JF25   A0A0B6ZX32   A0A210PW82   T2MFB2  

PDB

1U59     E-value=1.5377e-63,     Score=619

KEGG

101742601    K17512 tyrosine-protein kinase shark [EC:2.7.10.2] | (RefSeq) tyrosine-protein kinase shark

PATHWAY

04013    MAPK signaling pathway - fly - Bombyx mori (domestic silkworm)

GO

GO:0004715   GO:0005524   GO:0005515   GO:0004713   GO:0006468   GO:0004672   GO:0007169   GO:0016020   GO:0006281   GO:0048384  

Length:

799

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00940999999999999

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00023

outside

1  -  799

 

 

Pi

239.470641

Theta

174.551589

Tajima's D

1.312464

CLR

0.137288

CSRT

0.740562971851407

Interpretation

Uncertain