SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO02899
Annotation
PREDICTED:_protein_patched_[Papilio_xuthus]
Full name
Protein patched       + More
Pyruvate kinase      
Alternative Name
Hedgehog receptor
Location in the cell
PlasmaMembrane   Reliability : 3.839
 

Sequence

CDS
ATGGTGGCTCCCAATTCCGAGGCTCCTTCGAATCCTCGGATAGTATCTAGTACACAGGAGAGTCCCTCTGCCGCTGAGGCGCGCCACAGCGCCGATCTCTACATACGCACCAGCTGGATAGACGCTGCCCTAGCACTTTCTGAACTCGAAAAGGGTAACATCGAAGGTGGAAGGACGTCGCTTTGGATCCGAGCCTGGCTACAGGAACAGCTCTTTATACTAGGCTGCTTTTTGCAAGGAGACGCGGGGAAAGTGCTGTTTGTCGCAATATTGGTGCTCTCGACTTTCTGTGTTGGACTAAAATCGGCACAGATACACTCGAGGGTCGACCAGCTCTGGGTTCAAGAGGGAGGTAGATTAGAAGCTGAACTGAAGTACACGGCAGAAGCGTTGGGCGAAGCGGACTCATCAACGCATCAGCTTATTATCCAAACGGCCAAGGACCCCGACGTGTCCTTATTACACGCGGGGGCTCTACTCGAACACCTAAAGGTGGTGCACGCGGCAACCCGAGTGACGGTTCACATGTACGACATCGAGTGGCGTCTGAAAGACTTATGCTACAGCCCCAGCATACCTAACTTCGAGGCTTATCACATCGAGAAGATCTTCGAAAACATCATTCCTTGCGCCATCATTACACCACTAGACTGTTTCTGGGAAGGCTCAAAACTCCTCGGACCCGATTATCCTATTTACGTTCCTAATCTCAAACAAAAGCTACAATGGACGCATTTGAACCCGCAAGAAGTTTTAGAAGAAGTAAAGCAATTGAAGTTTCAGTTTCCTTACGGGACGGTAGAAGCGTACATGAAGAGAGCTGGTATCACCTCCGCTTACATGAAGAAGCCTTGCTTGGACCCAAACGACGCGCACTGCCCAAAAACGGCTCCCAACAAAAAATCGCGACATGTTCCGGATGTGGCAGCAGAGTTGTCTCACGGCTGTTACGGCTTCGCAGCAGCGTACATGCACTGGCCGGAGCAGCTGATAGTAGGAGGCGCTACCAGGAATTCCACTTCGGTGCTGAGGAGTGCGAAGGCCCTGCAGACGGTCGTACAGCTGATGGGAGAACGAGAGATGTACGAGTATTGGGCAGATCACTACAAAGTGCACCACGTTGGGTGGACGCAAGAGAAAGCCGCCGTTGTACTCGACTCCTGGCAGAGAAAGTTCGCTGCAGAGGTGCGTAAGATGACCACTTCTGGCAAAGTGTCCGCCGCCTACAGTTTCTACCCGTTCTCGTCGTCCACGCTCAACGATATTCTCGGAAAATTCTCGGAACTCTCGCTCAAGAACATTATTTTGGGATACGTGTTCATGTTAGTTTATGTTTCGGTGACGCTGATGCAATGGAGCGACCCGGTGCGGTCGCAGGCCGGCGTCGGCATCGCGGGCGTGATGCTGTTGTCCATCACCGTAGCTGCCGGTCTGGGCTTTTGCGCTTTGTTAGGCATACCGTTCAACGCTTCGAGCACGCAGATCGTTCCGTTCCTAGCGCTCGGACTGGGAGTGCAGGACATGTTCCTTCTCGCTCACACGTACGTGGAACAAGCGGGAGACGTGCCCCGGGAAGAACGAACCGGTCTCGTGCTGAAGAAGAGCGGCCTCAGTGTGCTTCTGGCGTCGCTCTGCAACGTGTTGGCGTTCTTGGCAGCCGCACTGCTTCCGATACCCGCGCTACGAGTCTTCTGTCTTCAAGCCGCCATCCTCTTGCTGTTCAATTTGGGTTCAATGCTGATAGTGTTCCCGGCAATGATTTCGCTGGACTTGAGGCGTCGGTCTGCAGCGCGGTCTGACGTGCTGTGCTGCATCATGCCCGAGAACCCAGTGCCCAAGCGACGAGTCACCGACAGGACCAGGAACAGAGGAAGCAATACTAAAAATAGCTGGAAAGACGCGACGCGACAACCGCTGGATCCTGAAGAAACGGGAGATGAATCCAAAGTGTCATGCATCAGTCTGTCCTTGACGAAATGGGCAAAGAATCATTACGCTCCTTTCATTATGAGACCATCAATGAAGGTAACATCGATGCTAGCGTTGATCGCCGTGATACTGGCCAGTGTCTGGGGCGCGACAAAAGTCAGGGACGGCCTAGACCTCACCGACATAGTGCCAGAAAATACTGACGAACACCAATTCTTGTACCGACAAGAGAAGTACTTTGGCTTCTACAACATGTACGCGGTCACAAAGGGCGACTTCGAGTACCCGACCAATCAGAGGCTGCTGTACGAATACCACGACCAGTTTGTCAGGATACCTAACATCATAAAGAACGACAACGGCGGCCTCACGAAATTCTGGTTGACTCTGTTCCGCGACTGGCTCTTAGATCTGCAAGCGGTGTTCGATAAAGAAGTGGAAAGCGGCTGCATCACTCAGGAGTACTGGTGCAAAAACGCAAGCGACGAGGCCATTTTAGCATACAAACTCATGGTGCAGACGGGTCACGTGGACACTCCCATCGACAAGTCACTGATCACCGCGGACAGAGCGAGCGGCCATAGACTTGTGGGCAAAGACGGCATCATCAACACGGACGCGTTCTACAACTACTTGTCGGCTTGGGCCACAAACGACGCGTTGGCCTACGGAGCGTCACAAGGCAATCTGAAACCGCAACCGAAAAAATGGACGCACTCTTCTAGCGACATGGACCTGGAAATACCCAAGTCGTCTCCCTTGATTTATACCCAGCTGCCCTTTTACCTGGCAGGGTTAAGTGACACGGAGAGTATAAAGGCTTTGATAACGTCCGTCAGGGAGCTGTGCTTGAAGTTCGAAGCGAAGGGATTGTCCAATTTCCCGTCTGGTATTCCTTTCCTGTTTTGGGAGCAGTATCTGTATCTGAGAACGTCGTTATCGCTGGCCCTCGCTTGCGCCCTGTCTGCTGTGTTTGTGGCTGTAATGGTATTGCTGCTGAACGTGTGGGCGGCGGTGCTCGTGACGCTCGCGCTGGCTGTGCTGGTGCTCCAGTTGCTCGGCACGATGGCGCTACTTGGCATTAAGCTGTCCGCCATACCGGCAGTCCTACTTGTACTGGCCATCGGTCGAGGAGTGCATTTCACCGTCCATTTGTGCTTGGGCTTCGTAACGTCGATCGGTTGCAAGCGGCGTCGGGCCTCGCTCGCGCTGGAGTCTGTGCTGGCGCCGGTGGTGCACGGCGCCGTCGCGGCCGCGCTGGCCGCGTCGATGCTGGCGACCAGCGAGTTCGGTTTCGTCGCCAGACTGTTCCTGAAATTACTACTGGCTCTCATCGTTCTGGGATTCGTCGACGGTCTACTGTTCTTCCCGGTTGTACTGGCGATACTCGGACCGGCCGCGGAGGTGAGGCCGCTGGAGCACGGCGAGCGGCTGCCGACCCCGTCCCCGGTGCGGTCGCCGGTGTGGGCGCGGCGGGGGGCGGGCGCGGGGGGCGCCGCCGAGCGGACGCGCTGCAAGGGCCCTCCGCGCGCCGCGCCCTCCCTCACAACCATCACCGAGGAGCCCCCAAGCTGGCACAGCTCGGCGCCCTCCGTACAGTCTTCCATGCAGTCCATCCTAGTGCAGCCAGAGCTCGTCGTCGAGACCACCACCTACAATGGCAGTGACTCCACTTCCGGACGCTCTACTCCCACCTCCAAGACTACTCACACGGGCGCCATCACTACCAAGGTGACGGCCACTGCAAACATCAAAGTGGAGGTGGTCACGCCGAGCGACAGGAAAACTCGACGCTCCTATCACTATTACGACCGCCGTAGAGACCGCGACGACGATCGGGACAGAGACCGCGACCGAGACCGAGATAGAGACAGAGACCGCGAGAGATCGAGAGAGAGAGACCGCAGAGACCGGCACAGAGACGAGAGGGAGCATCGCGCGTCGCCGCGGGAGAACGGCCGCGACTCCGGACACGAGAGCGACTCCTCTCGCCACTGA
Protein
MVAPNSEAPSNPRIVSSTQESPSAAEARHSADLYIRTSWIDAALALSELEKGNIEGGRTSLWIRAWLQEQLFILGCFLQGDAGKVLFVAILVLSTFCVGLKSAQIHSRVDQLWVQEGGRLEAELKYTAEALGEADSSTHQLIIQTAKDPDVSLLHAGALLEHLKVVHAATRVTVHMYDIEWRLKDLCYSPSIPNFEAYHIEKIFENIIPCAIITPLDCFWEGSKLLGPDYPIYVPNLKQKLQWTHLNPQEVLEEVKQLKFQFPYGTVEAYMKRAGITSAYMKKPCLDPNDAHCPKTAPNKKSRHVPDVAAELSHGCYGFAAAYMHWPEQLIVGGATRNSTSVLRSAKALQTVVQLMGEREMYEYWADHYKVHHVGWTQEKAAVVLDSWQRKFAAEVRKMTTSGKVSAAYSFYPFSSSTLNDILGKFSELSLKNIILGYVFMLVYVSVTLMQWSDPVRSQAGVGIAGVMLLSITVAAGLGFCALLGIPFNASSTQIVPFLALGLGVQDMFLLAHTYVEQAGDVPREERTGLVLKKSGLSVLLASLCNVLAFLAAALLPIPALRVFCLQAAILLLFNLGSMLIVFPAMISLDLRRRSAARSDVLCCIMPENPVPKRRVTDRTRNRGSNTKNSWKDATRQPLDPEETGDESKVSCISLSLTKWAKNHYAPFIMRPSMKVTSMLALIAVILASVWGATKVRDGLDLTDIVPENTDEHQFLYRQEKYFGFYNMYAVTKGDFEYPTNQRLLYEYHDQFVRIPNIIKNDNGGLTKFWLTLFRDWLLDLQAVFDKEVESGCITQEYWCKNASDEAILAYKLMVQTGHVDTPIDKSLITADRASGHRLVGKDGIINTDAFYNYLSAWATNDALAYGASQGNLKPQPKKWTHSSSDMDLEIPKSSPLIYTQLPFYLAGLSDTESIKALITSVRELCLKFEAKGLSNFPSGIPFLFWEQYLYLRTSLSLALACALSAVFVAVMVLLLNVWAAVLVTLALAVLVLQLLGTMALLGIKLSAIPAVLLVLAIGRGVHFTVHLCLGFVTSIGCKRRRASLALESVLAPVVHGAVAAALAASMLATSEFGFVARLFLKLLLALIVLGFVDGLLFFPVVLAILGPAAEVRPLEHGERLPTPSPVRSPVWARRGAGAGGAAERTRCKGPPRAAPSLTTITEEPPSWHSSAPSVQSSMQSILVQPELVVETTTYNGSDSTSGRSTPTSKTTHTGAITTKVTATANIKVEVVTPSDRKTRRSYHYYDRRRDRDDDRDRDRDRDRDRDRDRERSRERDRRDRHRDEREHRASPRENGRDSGHESDSSRH

Summary

Catalytic Activity
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate
Similarity
Belongs to the patched family.
Belongs to the pyruvate kinase family.
Keywords
Complete proteome   Developmental protein   Glycoprotein   Membrane   Receptor   Reference proteome   Segmentation polarity protein   Transmembrane   Transmembrane helix  
Feature
chain  Protein patched
EC Number
2.7.1.40
EMBL
NWSH01000285    PCG77761.1    AF117898    AAD31595.1    KQ459597    KPI95022.1    + More
AGBW02014037    OWR42368.1    KZ149960    PZC76362.1    JTDY01000491    KOB76937.1    KQ982625    KYQ53474.1    KQ414745    KOC61900.1    QOIP01000010    RLU17567.1    DS235442    EEB15809.1    KQ980724    KYN14043.1    KQ981523    KYN40373.1    KK853332    KDR08387.1    ADTU01006986    ADTU01006987    ADTU01006988    ADTU01006989    ADTU01006990    ADTU01006991    KK107957    EZA47071.1    UFQT01000641    SSX26018.1    GDHC01014486    JAQ04143.1    SSX26017.1    JXUM01005577    KQ560195    KXJ83889.1    KQ976731    KYM76225.1    JXUM01080101    KQ563165    KXJ74359.1    DS231853    EDS37845.1    CH477254    EAT45937.1    GEDC01007932    JAS29366.1    GGFJ01000629    MBW49770.1    GL438568    EFN68781.1    GL453976    EFN75077.1    AXCN02002107    NNAY01002276    OXU21649.1    AAAB01008966    EAA13037.4    AXCM01003252    KQ976755    KYN08569.1    GBBI01003904    JAC14808.1    GBYB01004656    JAG74423.1    GL732523    EFX90375.1    ADMH02000429    ETN66540.1    GDIP01044580    JAM59135.1    GDIQ01041499    JAN53238.1    APCN01001970    ATLV01022301    KE525331    KFB47406.1    JRES01000195    KNC33440.1    CCAG010005926    ACPB03005987    GDIP01089980    JAM13735.1    GDIQ01229723    JAK22002.1    CH916367    EDW02094.1    GDIQ01038597    JAN56140.1    CH940648    EDW61065.1    GBXI01016610    JAC97681.1    CM000071    EAL26097.1    GDIP01213359    JAJ10043.1    GDHF01024168    JAI28146.1    GAMC01010976    JAB95579.1    OUUW01000001    SPP74305.1    JXJN01023493    CH480816    EDW46969.1    CM002911    KMY92295.1    M28999    M28418    X17558    AE013599    CM000157    EDW89379.1    CH954177    EDV59493.1    GDIP01133418    JAL70296.1    CH933808    EDW09908.2    CH902619    EDV35635.1    AJVK01017086    AJVK01017087    GL887707    EGI70272.1    CP012524    ALC41959.1    CH963849    EDW74066.1    CH479181    EDW32491.1    AB433900    BAI83404.1    GDIQ01173591    JAK78134.1    GDIQ01253571    JAJ98153.1    KZ288209    PBC33005.1   
Pfam
PF02460   Patched        + More
PF00632   HECT
PF00612   IQ
PF12349   Sterol-sensing
PF00198   2-oxoacid_dh
PF00364   Biotin_lipoyl
PF07782   DC_STAMP
PF00137   ATP-synt_C
PF15070   GOLGA2L5
PF02887   PK_C
PF00224   PK
Interpro
IPR003392   Ptc/Disp        + More
IPR000731   SSD       
IPR000569   HECT_dom       
IPR000048   IQ_motif_EF-hand-BS       
IPR035983   Hect_E3_ubiquitin_ligase       
IPR004766   TM_rcpt_patched       
IPR020846   MFS_dom       
IPR011053   Single_hybrid_motif       
IPR000089   Biotin_lipoyl       
IPR003016   2-oxoA_DH_lipoyl-BS       
IPR023213   CAT-like_dom_sf       
IPR001078   2-oxoacid_DH_actylTfrase       
IPR006255   SucB       
IPR012858   DC_STAMP-like       
IPR000454   ATP_synth_F0_csu       
IPR035921   F/V-ATP_Csub_sf       
IPR020537   ATP_synth_F0_csu_DDCD_BS       
IPR038662   ATP_synth_F0_csu_sf       
IPR002379   ATPase_proteolipid_c-like_dom       
IPR024858   Golgin_A       
IPR018209   Pyrv_Knase_AS       
IPR001697   Pyr_Knase       
IPR015795   Pyrv_Knase_C       
IPR015793   Pyrv_Knase_brl       
IPR040442   Pyrv_Kinase-like_dom_sf       
IPR015813   Pyrv/PenolPyrv_Kinase-like_dom       
IPR015806   Pyrv_Knase_insert_dom_sf       
IPR036918   Pyrv_Knase_C_sf       
IPR011037   Pyrv_Knase-like_insert_dom_sf       
SUPFAM
SSF56204   SSF56204        + More
SSF51230   SSF51230       
SSF81333   SSF81333       
SSF52935   SSF52935       
SSF50800   SSF50800       
SSF51621   SSF51621       
PDB
6MG8     E-value=0,     Score=2030

Ontologies

Topology

Subcellular location
Membrane  
Length:
1308
Number of predicted TMHs:
11
Exp number of AAs in TMHs:
240.972810000001
Exp number, first 60 AAs:
0.0007
Total prob of N-in:
0.07351
outside
1  -  432
TMhelix
433  -  450
inside
451  -  461
TMhelix
462  -  484
outside
485  -  493
TMhelix
494  -  516
inside
517  -  535
TMhelix
536  -  558
outside
559  -  562
TMhelix
563  -  585
inside
586  -  675
TMhelix
676  -  693
outside
694  -  954
TMhelix
955  -  977
inside
978  -  978
TMhelix
979  -  1001
outside
1002  -  1010
TMhelix
1011  -  1033
inside
1034  -  1045
TMhelix
1046  -  1068
outside
1069  -  1082
TMhelix
1083  -  1105
inside
1106  -  1308
 
 

Population Genetic Test Statistics

Pi
220.321856
Theta
170.556395
Tajima's D
0.650823
CLR
0.63316
CSRT
0.555422228888556
Interpretation
Uncertain
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