Gene

KWMTBOMO02891

Pre Gene Modal

BGIBMGA003654

Annotation

PREDICTED:_insulin_receptor_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr5(-):13209890-13262163      View in EpiBrowser

Full name

Tyrosine-protein kinase receptor       + More
Insulin-like receptor      

Location in the cell

Extracellular   Reliability : 2.361

CDS

ATGGACCTACGAAACAATCCGGACCAGATCAGACGTTTGGAAGGATGTCGGGTGATCGAGGGTCAGCTCAGTATCGTTCTGATGGAGCGGGCCACAAATCAAATATTCGACAACATGAGCTTCCCGCAGTTAAGGGAAGTTACCGGCTATATATTGATATATAGAACTAAGGGCTTGCGCAATCTTGGTGATCTGTTCCCAAACCTCACCGTGGTGCGAGGGATGCAGCTCTTCAAGGATTTCGCTCTTGTAATATTTGACAATGAACATCTAGAGGCGCTTGGACTGAATTCGTTGATGAAGATCGAGCGAGGAGGCGTCCGTATTCAGCACAACGATCGACTCTGCTATACTAACACCATAGACTGGTCGCGAATCACACGCGATGATGCTGAAATCATCGTCAGGTCTAACTATGATACCAGACTGTGCGGCTTGTGCCCCAACGCTCAGAGTCGCGTTGAGGAGGACCATCGGCAATCGTTGCCGCAATGTCCCGCTGACACCAAAGGGAAGCTGCTTTGCTGGGACGAGAAACACTGCCAAAAGATATGTCCGAGCGCTTGCGGCGACCACGGCTGTATGTCGAACGGCACGTGCTGCAACTCCGCCTGTCTCGGAGGATGCGACGGACCGCTCGCGAGCAATTGCTTCGTCTGCAAGAAGTTCTCGTTTGAATACGGGTCCGAGATGACTTGTATGGAGTCCTGCCCCGGTGGTACTTACGAGTTGTCCCGGAGATGTGTGACGGAACAGGAGTGTCGCTCGATGTCCCCCCCGCCGCAGCCGGTCGGCGCCGCGGACTCCACGTACTTCCGGTTCGCGATCAAGGTGCCCGCCTATAAGACATTCAACAGCAGCCGCTGTCTGTTCATGTGTCCGAGTGGCTACATGGAGGTGGGTAACGAGACTAACGCGACGTGCCAGCCGTGCCCGCGGTCCGGCTGCGTGCGCGAGTGCCTCGGCGGGAAGATCGACTCGGTCGCCACCGCGGAGCAGTTCCGGGGCTGCACGCACATTAAGGGCAAAATGGAATTCACGCTTCGCTCCAGCGGAGGTACGTTTATACTGGACCATAGCACTGTTTCGAATTCAAGACATGAGGGATGA

Protein

MDLRNNPDQIRRLEGCRVIEGQLSIVLMERATNQIFDNMSFPQLREVTGYILIYRTKGLRNLGDLFPNLTVVRGMQLFKDFALVIFDNEHLEALGLNSLMKIERGGVRIQHNDRLCYTNTIDWSRITRDDAEIIVRSNYDTRLCGLCPNAQSRVEEDHRQSLPQCPADTKGKLLCWDEKHCQKICPSACGDHGCMSNGTCCNSACLGGCDGPLASNCFVCKKFSFEYGSEMTCMESCPGGTYELSRRCVTEQECRSMSPPPQPVGAADSTYFRFAIKVPAYKTFNSSRCLFMCPSGYMEVGNETNATCQPCPRSGCVRECLGGKIDSVATAEQFRGCTHIKGKMEFTLRSSGGTFILDHSTVSNSRHEG

Description

This receptor probably binds an insulin related protein and has a tyrosine-protein kinase activity.

Catalytic Activity

ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]

Cofactor

Mn(2+)

Subunit

Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain (By similarity).

Similarity

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.

Keywords

ATP-binding   Cleavage on pair of basic residues   Complete proteome   Disulfide bond   Glycoprotein   Kinase   Manganese   Membrane   Metal-binding   Nucleotide-binding   Phosphoprotein   Receptor   Reference proteome   Repeat   Signal   Transferase   Transmembrane   Transmembrane helix   Tyrosine-protein kinase  

Feature

chain  Tyrosine-protein kinase receptor

Uniprot

H9J2B7   Q9U5A8   A0A2H1W0I4   A0A2A4JUH3   A0A2W1BQ19   A0A212ELK6   + More
A0A194PNX0   A0A2D3E1C8   A0A194QUL6   A0A1B6FCK7   E2A530   A0A1B6KAQ3   A0A2J7R3R6   A0A195CNS3   A0A151JYW9   A0A195BAD2   A0A158NFV3   A0A151X3W9   A0A3L8D597   A0A151IYJ9   A0A067QUW8   A0A0C9QS61   A0A0G4DDB6   A0A1L8DJW7   G3ER33   A0A2S2R3F4   A0A1Y1KXL1   W4VRQ3   A0A088AUM7   G2J5R2   A0A2R4G8S9   A0A1Q3G5F2   A0A1Q3G5E9   A0A0C4UQS4   A0A2R4G8T0   A0A1B6DYS9   A0A1Q3G5E6   A0A1Q3G5E7   A0A1Q3G5I4   A0A1Q3G5E5   A0A2P8YHI3   A0A182JT77   A0A182MVW1   A0A1B1UZE9   A0A1W4XBR9   A0A2S2NHA9   A0A1B0C601   A0A146L9I6   A0A182Y1F3   A0A1B0AJ67   A0A146KY69   R4IJT3   A0A2S2N7Z7   A0A2M4A0Z5   A0A1A9UWD9   A0A2M4A0A1   A0A2M4A0F2   A0A2H8TMN4   A0A182RD25   A0A2M4A3E1   A0A310SXM6   A0A2M4A092   A0A182WEW1   A0A0L7R7M6   A0A0A9YBQ5   J9K8T8   A0A1A9YHT5   A0A1V0JFF9   Q7Q0F6   A0A0B4L064   D6W7P5   A0A0N0BDV4   A0A182FBB5   A0A1J1J845   Q93105   W8BST3   A0A2P1CYK5   A0A1S4F1J9   A0A034UZV1   A0A0K8V795   A0A0K8TY52   A0A0K0PQK7   W5JGL8   A0A0T6BFY0   A0A2M3YYA3   A0A182MYU2   A0A2M4B938   A0A2M4B8W8   A0A2R7WTX2   A0A1A9WJ29   N6T8W2   U4UVJ9   A0A182QRS4   A0A0A1WF79   K9M126   T1D5Z9   A0A0P5CRI0   V9KI02   A0A0P5EVH0   A0A336M6T9  

EC Number

2.7.10.1

Pubmed

19121390    28756777    22118469    26354079    20798317    21347285    + More
30249741    24845553    24657890    21797944    28004739    25799997    29403074    26823975    25244985    23499946    25401762    28230772    12364791    18362917    19820115    9099579    17510324    24495485    25348373    26812356    20920257    23761445    23537049    25830018    23136112    24330624    24402279   

EMBL

BABH01007614    BABH01007615    BABH01007616    AF025542    AAF21243.1    ODYU01005566    + More
SOQ46537.1    NWSH01000609    PCG75348.1    KZ149960    PZC76371.1    AGBW02014037    OWR42372.1    KQ459597    KPI95007.1    MF443095    ATU31392.1    KQ461150    KPJ08670.1    GECZ01022086    JAS47683.1    GL436794    EFN71461.1    GEBQ01031456    JAT08521.1    NEVH01007818    PNF35477.1    KQ977481    KYN02366.1    KQ981463    KYN41515.1    KQ976532    KYM81501.1    ADTU01000013    ADTU01000014    ADTU01000015    KQ982557    KYQ55071.1    QOIP01000012    RLU15667.1    KQ980763    KYN13503.1    KK852921    KDR13786.1    GBYB01006589    JAG76356.1    HG518668    CDI30232.1    GFDF01007444    JAV06640.1    JF304722    ADZ56366.1    GGMS01015326    MBY84529.1    GEZM01075366    JAV64116.1    GANO01000511    JAB59360.1    BK008012    DAA34971.1    MF620042    AVT56264.1    GFDL01000018    JAV35027.1    GFDL01000017    JAV35028.1    KF974333    AIY24638.1    MF620044    AVT56266.1    GEDC01006489    JAS30809.1    GFDL01000014    JAV35031.1    GFDL01000013    JAV35032.1    GFDL01000016    JAV35029.1    GFDL01000015    JAV35030.1    PYGN01000591    PSN43728.1    AXCM01007680    KX428482    ANW09593.1    GGMR01003889    MBY16508.1    JXJN01026385    GDHC01013621    JAQ05008.1    GDHC01018543    GDHC01006354    JAQ00086.1    JAQ12275.1    JX291127    AFQ01096.1    GGMR01000678    MBY13297.1    GGFK01000987    MBW34308.1    GGFK01000923    MBW34244.1    GGFK01000963    MBW34284.1    GFXV01003618    MBW15423.1    GGFK01002015    MBW35336.1    KQ759862    OAD62524.1    GGFK01000819    MBW34140.1    KQ414638    KOC66875.1    GBHO01041436    GBHO01014558    GBRD01008020    JAG02168.1    JAG29046.1    JAG57801.1    ABLF02025445    ABLF02025449    KX507134    ARD07921.1    AAAB01008986    EAA00322.3    KF922648    AHF20214.1    KQ971307    EFA11583.2    KQ435850    KOX70962.1    CVRI01000074    CRL08130.1    U72939    CH477238    GAMC01014291    JAB92264.1    KY992933    AVK43099.1    GAKP01022416    JAC36536.1    GDHF01017583    GDHF01012251    GDHF01000334    JAI34731.1    JAI40063.1    JAI51980.1    GDHF01033113    JAI19201.1    KP331063    KT355584    AKQ48960.1    ALV82503.1    ADMH02001279    ETN63231.1    LJIG01000694    KRT86246.1    GGFM01000502    MBW21253.1    GGFJ01000379    MBW49520.1    GGFJ01000338    MBW49479.1    KK855531    PTY22998.1    APGK01047122    KB741077    ENN74143.1    KB632384    ERL94276.1    AXCN02001027    GBXI01017152    GBXI01014387    GBXI01010478    JAC97139.1    JAC99904.1    JAD03814.1    JN711464    AFQ20827.1    GALA01000303    JAA94549.1    GDIP01167714    JAJ55688.1    JW865004    AFO97521.1    GDIQ01271234    JAJ80490.1    UFQT01000641    SSX26014.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000053268    UP000053240    UP000000311    + More
UP000235965    UP000078542    UP000078541    UP000078540    UP000005205    UP000075809    UP000279307    UP000078492    UP000027135    UP000005203    UP000245037    UP000075881    UP000075883    UP000192223    UP000092460    UP000076408    UP000092445    UP000078200    UP000075900    UP000075920    UP000053825    UP000007819    UP000092443    UP000007062    UP000007266    UP000053105    UP000069272    UP000183832    UP000008820    UP000000673    UP000075884    UP000091820    UP000019118    UP000030742    UP000075886   

PRIDE

H9J2B7    Q9U5A8   

Pfam

PF00757   Furin-like        + More
PF01030   Recep_L_domain
PF07714   Pkinase_Tyr
PF00041   fn3
PF00595   PDZ

Interpro

IPR002011   Tyr_kinase_rcpt_2_CS        + More
IPR006212   Furin_repeat       
IPR008266   Tyr_kinase_AS       
IPR020635   Tyr_kinase_cat_dom       
IPR000494   Rcpt_L-dom       
IPR006211   Furin-like_Cys-rich_dom       
IPR036941   Rcpt_L-dom_sf       
IPR000719   Prot_kinase_dom       
IPR001245   Ser-Thr/Tyr_kinase_cat_dom       
IPR036116   FN3_sf       
IPR011009   Kinase-like_dom_sf       
IPR017441   Protein_kinase_ATP_BS       
IPR013783   Ig-like_fold       
IPR016246   Tyr_kinase_insulin-like_rcpt       
IPR009030   Growth_fac_rcpt_cys_sf       
IPR003961   FN3_dom       
IPR036034   PDZ_sf       
IPR001478   PDZ       
IPR028792   INSRR       
IPR017896   4Fe4S_Fe-S-bd       

SUPFAM

SSF49265   SSF49265        + More
SSF56112   SSF56112       
SSF57184   SSF57184       
SSF50156   SSF50156       

Gene 3D

2.60.40.10     3.80.20.20    

CDD

cd00064  FU
cd00063  FN3

ProteinModelPortal

H9J2B7   Q9U5A8   A0A2H1W0I4   A0A2A4JUH3   A0A2W1BQ19   A0A212ELK6   + More
A0A194PNX0   A0A2D3E1C8   A0A194QUL6   A0A1B6FCK7   E2A530   A0A1B6KAQ3   A0A2J7R3R6   A0A195CNS3   A0A151JYW9   A0A195BAD2   A0A158NFV3   A0A151X3W9   A0A3L8D597   A0A151IYJ9   A0A067QUW8   A0A0C9QS61   A0A0G4DDB6   A0A1L8DJW7   G3ER33   A0A2S2R3F4   A0A1Y1KXL1   W4VRQ3   A0A088AUM7   G2J5R2   A0A2R4G8S9   A0A1Q3G5F2   A0A1Q3G5E9   A0A0C4UQS4   A0A2R4G8T0   A0A1B6DYS9   A0A1Q3G5E6   A0A1Q3G5E7   A0A1Q3G5I4   A0A1Q3G5E5   A0A2P8YHI3   A0A182JT77   A0A182MVW1   A0A1B1UZE9   A0A1W4XBR9   A0A2S2NHA9   A0A1B0C601   A0A146L9I6   A0A182Y1F3   A0A1B0AJ67   A0A146KY69   R4IJT3   A0A2S2N7Z7   A0A2M4A0Z5   A0A1A9UWD9   A0A2M4A0A1   A0A2M4A0F2   A0A2H8TMN4   A0A182RD25   A0A2M4A3E1   A0A310SXM6   A0A2M4A092   A0A182WEW1   A0A0L7R7M6   A0A0A9YBQ5   J9K8T8   A0A1A9YHT5   A0A1V0JFF9   Q7Q0F6   A0A0B4L064   D6W7P5   A0A0N0BDV4   A0A182FBB5   A0A1J1J845   Q93105   W8BST3   A0A2P1CYK5   A0A1S4F1J9   A0A034UZV1   A0A0K8V795   A0A0K8TY52   A0A0K0PQK7   W5JGL8   A0A0T6BFY0   A0A2M3YYA3   A0A182MYU2   A0A2M4B938   A0A2M4B8W8   A0A2R7WTX2   A0A1A9WJ29   N6T8W2   U4UVJ9   A0A182QRS4   A0A0A1WF79   K9M126   T1D5Z9   A0A0P5CRI0   V9KI02   A0A0P5EVH0   A0A336M6T9  

PDB

6HN5     E-value=2.82804e-62,     Score=605

KEGG

692560    K04527 insulin receptor [EC:2.7.10.1] | (RefSeq) InR, Bir; insulin receptor

PATHWAY

04068    FoxO signaling pathway - Bombyx mori (domestic silkworm)
04150    mTOR signaling pathway - Bombyx mori (domestic silkworm)
04213    Longevity regulating pathway - multiple species - Bombyx mori (domestic silkworm)

GO

GO:0043560   GO:0007169   GO:0004714   GO:0016021   GO:0046777   GO:0043548   GO:0005524   GO:0016020   GO:0071469   GO:0005887   GO:0042802   GO:0005009   GO:0051897   GO:0014068   GO:0043410   GO:0042593   GO:0030424   GO:0005899   GO:0043235   GO:0046872   GO:0051290   GO:0008286   GO:0043559   GO:0006468   GO:0004713   GO:0006281   GO:0048384  

PANTHER

PTHR24416:SF338  

Subcellular location

Membrane  

Length:

369

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01266

Exp number, first 60 AAs:

0.00453

Total prob of N-in:

0.01774

outside

1  -  369

 

 

Pi

198.843423

Theta

175.166996

Tajima's D

0.547384

CLR

0.887191

CSRT

0.528123593820309

Interpretation

Uncertain