Gene

KWMTBOMO02890

Pre Gene Modal

BGIBMGA003654

Annotation

PREDICTED:_insulin_receptor_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr5(-):13191397-13208893      View in EpiBrowser

Full name

Tyrosine-protein kinase receptor      

Location in the cell

Cytoplasmic   Reliability : 1.308

CDS

ATGTTTTTGAAGAAACTCAGGAAAATTATCGCGAATCCTTCAGAAGATAAAGGGGAAGCTCTGCATATAATAAACAACGAGAATCTAGAGCTGCTATGGGACTGGTCCACTTACGGACCTATAGAGATAATCGGTAGCTGCTACATACATTCGAATCCCAAGCTGTGCTACACTCAACTGATGCCGCTTATGAATATGTCGTATCCGAAAACGAATTTTACCGAACTAGAAGTGTCCCAAGACAGCAACGGGTATCAGGCATCTTGTCTCCCGGACGTCCTGAAGCTGAGCGTGTCGGAGTTAACGCAAATCGCAGTGGTACTAACTTGGGATGTGTACTGTCCCGACGACATGCGCAAGCTGCTCGGATACTCGCTGTACTTTATGGCCACCGAGAAGAACGTAACTCTGTACGATCAACGCGATGCCTGCTCTGATATATGGAAAGTACTCGACAAGCCAATAGAGGAGACTCGTAAAGTGAACCGCAACGCGAAGCCCTCTCACGCCAGGAACAAAACGGAGGTTATATTCAATCCGTGCGCCGACATGCAGCCGCTGTTCTATCCCATCACCCAGCTGAGGCCATACACCAGATACGCGGCCTACGTGAAGACCTACACCACGATACAGGACAGGAAGGGGGCCCAGAGCTCGATCATTTACTTCAGGACCTTGCCGATGCAACCGAGTCCACCCACCGCGGTCACTGTGGAGCTGTTGACGCCGCATTCGATCTTCATAAAATGGTCACCGCCGACGATGCCGAACGGTACGATCATACTGTACCACGTGGAAGTGCAAGCCAACAGCTACAACAGGCCGCAGATACTTGCCGGCAACATCAATTATTGTGGCAATCCGAGCATCTTGGCTAACATGATCAAAGCTAGTTTAGAAGAAGCGCCCGAAACTCCAGAGGAGAAAACCACCGGCGACGTGAAAAATGGTTTTTGCGCTTGCAAAGAGGAAGCCAAACCGAGTCTGAGGTTCAGCACTCGCGCCGAGGAGGAGAGGGTCGACAGCATCAATTTCGAGAACGAGTTGCAAAATCAGGTTTACAGGAAATCCGAACGAGTGAACCCGAAAATACACAAGTCTATCGACGGAACGAGCAAAGTGAAAAGGTCGGTCGACCACAGCCTCACCAGCATGCTCGTCAAACTGACCGAGAACAACAGCCCGAGACCCGGCCTCAACTACTCCAACATCACGGACGACGAAGGTTACGTGAAATCTTTATACTACGAATTGGACGGCTCGACTCGGACGTTGACCGTGAAGAACATGCGTCACTTCACCTGGTACACCGTGAACATATGGGCGTGTCGCAACAAGGACTTGAACGAAACCGATCCGGTCTACGCCGAGAACTGGTGCTCGGTTCGCGCTTATAACACGTTCCGCACCTTAGAACTGCCAAACGCAGACGTTGTGAGCAACTTCCAAGTGGAGATAATGCCGGCTAACAAGACCTTGCCCGAAGTGAACGTCACGTGGGAGCCTCCCCTCAATCCGAACGGTTTTGTGGTCGCGTACAACGTACATTACTCACGAATCGAGAACAGTGCGCAGGGCCCGGATGTAGGTTTACAGAGCTGTATAACAGTAGACGACTACGAAGCGAACGGGCACGGCTACGTGCTCAAGACCCTATCTCCGGGCAACTACAGCGTCAAGGTCACACCGGTCACCGTCAGCGGAGCAGGAAACGTTTCCGAAGAAATCTACGTATTTATACCGGAGCGAGTATCGGAGAGCGGGCACGCGTGGGCGTGGGGCGTGGGGGCGGGCGGCGTGGTGCTGGCGCTGCTGGTGGGCGCGGCCGTGTGGTACGCGCGCCGCGGCCTCATGTCCCACGCCGAGGCGAGCAAGCTCTTCGCCAGCGTCAACCCGGAGTACGTGCCCACTGTCTACGTGCCCGACGAGTGGGAGGTCACACGCGACAGCATACACTTCATCCGAGAACTCGGACAGGGATCGTTTGGCATGGTGTATGAAGGGATCGCCAAGGAAATCGTGAAAGGGAAACCGGAAACGCGCTGCGCCATCAAAACCGTTAACGAGCACGCGACAGACAGGGAGCGCATCGAGTTCCTGAACGAGGCGTCGGTGATGAAGGCGTTTGACACGTTCCACGTGGTGCGGCTGCTGGGCGTGGTCTCCCGCGGGCAGCCGACGCTCGTCGTGATGGAGCTCATGGAGCGCGGCGACCTCAAGACGTACCTGCGCTCCATGCGACCCGACGCCGAGGGCTCGCTGCCCTCCAGCCCGCCCGTGCCGCCCACGCTGCAGAACATCTTGCAGATGGCCATAGAAATAGCCGATGGGATGGCATATTTGTCGGCAAAAAAATTCGTGCACCGCGACTTAGCGGCGCGCAACTGTATGGTCGCCGGCGACCTCACCGTCAAAGTTGGGGACTTCGGCATGACCAGAGATATTTATGAGACTGATTATTATAGGAAAGGCACCAAAGGCCTAATGCCGGTGCGGTGGATGAGCCCCGAAAGCTTAAAAGACGGGGTCTTTTCCAGTAGCAGTGACGCTTGGAGTTACGGGGTTGTTTTGTGGGAGATGGCAACGCTCGCGATGCAACCCTATCAGGGGTTGTCGAACGAGCAGGTGCTGCGGTACGTGGTGGAGGGCGGGGTCATGGAGCGGCCGGAGCAGTGCCCGGACCGGCTGTACGAGCTCATGCGCGCGTGCTGGACGCACCGCCCCTCCGCGCGCCCCACCTTCCTGCAGCTGGTGGCCGACCTGGTGCCGCACGCCATGCCCTACTTCCGCCACCGCAGCTTCTTCCACTCGCCGCAGGGCCAGGAGTTGTACGCTCTCCAGCGATCTGCGCTAGATGAGGAACAAGAGCTCCCGGAGGTGGACGTGGGTGCGGTGGCGACGGGCTCCGTGTCGAACCTGTTCGGTGTGTCGGGGCGGCTCGCGTCCTGGGTGCGGGAGCTGTCCTCTCTGCGGTCCCGGGGCTCCGACGACGCGGCGGCCGAGCCTCTGCAGCCCCTCCCTCCGCCCGGCACCTCCCCCGCCCCCATACTCGCACCCGCACCGGCCATCAAGGGACCCAACGGCGTACTGCGCGACTCGCACTCTGCCCGTTTTCGAAACCACTGA

Protein

MFLKKLRKIIANPSEDKGEALHIINNENLELLWDWSTYGPIEIIGSCYIHSNPKLCYTQLMPLMNMSYPKTNFTELEVSQDSNGYQASCLPDVLKLSVSELTQIAVVLTWDVYCPDDMRKLLGYSLYFMATEKNVTLYDQRDACSDIWKVLDKPIEETRKVNRNAKPSHARNKTEVIFNPCADMQPLFYPITQLRPYTRYAAYVKTYTTIQDRKGAQSSIIYFRTLPMQPSPPTAVTVELLTPHSIFIKWSPPTMPNGTIILYHVEVQANSYNRPQILAGNINYCGNPSILANMIKASLEEAPETPEEKTTGDVKNGFCACKEEAKPSLRFSTRAEEERVDSINFENELQNQVYRKSERVNPKIHKSIDGTSKVKRSVDHSLTSMLVKLTENNSPRPGLNYSNITDDEGYVKSLYYELDGSTRTLTVKNMRHFTWYTVNIWACRNKDLNETDPVYAENWCSVRAYNTFRTLELPNADVVSNFQVEIMPANKTLPEVNVTWEPPLNPNGFVVAYNVHYSRIENSAQGPDVGLQSCITVDDYEANGHGYVLKTLSPGNYSVKVTPVTVSGAGNVSEEIYVFIPERVSESGHAWAWGVGAGGVVLALLVGAAVWYARRGLMSHAEASKLFASVNPEYVPTVYVPDEWEVTRDSIHFIRELGQGSFGMVYEGIAKEIVKGKPETRCAIKTVNEHATDRERIEFLNEASVMKAFDTFHVVRLLGVVSRGQPTLVVMELMERGDLKTYLRSMRPDAEGSLPSSPPVPPTLQNILQMAIEIADGMAYLSAKKFVHRDLAARNCMVAGDLTVKVGDFGMTRDIYETDYYRKGTKGLMPVRWMSPESLKDGVFSSSSDAWSYGVVLWEMATLAMQPYQGLSNEQVLRYVVEGGVMERPEQCPDRLYELMRACWTHRPSARPTFLQLVADLVPHAMPYFRHRSFFHSPQGQELYALQRSALDEEQELPEVDVGAVATGSVSNLFGVSGRLASWVRELSSLRSRGSDDAAAEPLQPLPPPGTSPAPILAPAPAIKGPNGVLRDSHSARFRNH

Catalytic Activity

ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]

Similarity

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.

Feature

chain  Tyrosine-protein kinase receptor

Uniprot

Q9U5A8   H9J2B7   B5U451   A0A2A4JUH3   A0A2W1BQ19   A0A194QYL1   + More
A0A194PNX0   A0A212ELK6   A0A2D3E1C8   A0A2J7R3R8   A0A2J7R3R6   A0A1Y1KXL1   A0A1W4XBR9   A0A1B1UZE9   G3ER33   F4WE54   E2A530   A0A151X3W9   A0A151IYJ9   A0A0J7KR93   A0A195BAD2   A0A158NFV3   A0A067QUW8   A0A195CNS3   A0A2P1CYK5   A0A1B6KAQ3   E2B4Y3   A0A310SXM6   A0A0K0PQK7   A0A0C9QS61   A0A3L8D597   G2J5R2   A0A088AUM7   A0A026W1L5   A0A0N0BDV4   A0A2A3ESY9   A0A2R4G8S9   A0A2R4G8T0   A0A0L7R7M6   A0A2D0RTI5   A0A1A9WJ29   K7F279   K7F278   A0A1A9YHT5   W5M9H7   A0A3B3SIB8   W5M9K1   A0A087Y256   A0A3B3Z515   A0A2M4B8W8   A0A0K0QRF3   M4AW90   A0A2M4B938   A0A146P5T1   A0A146P740   A0A075IJV4   A0A096M0W0   I3KQM7   A0A1A7Y0I0   A0A3B5PVH2   A0A096M5E1   A0A087XET4   A0A3P9DDV5   A0A1A8C426   A0A3B1J7U9   A0A3B3YP57   A0A1A8JWQ8   A0A3B3YNW5   A0A3B4FJD9   F1QNX5   B7SNG4   A0A1A8QE15   A0A2M3YYU6   A0A1A8L188   A0A1S3R4V3   A0A2M3YYA3   A0A3P8PHL2   G3WLB9   A0A146N073   A0A3B3VRB6   A0A1A7ZXN0   G1T855   G1TLR2   F1PXU6   A0A076FVY1   I3MHA3   A0A384BUF8   A0A2I4AKQ2   A0A3P8W3R3   G1PWB2   U6D754   A0A250Y7G3   G1LGG8   A0A2Y9GBI4   M3WPQ6   A0A2U3ZLZ8   A0A2U9C2U4   A0A091KYJ0  

EC Number

2.7.10.1

Pubmed

19121390    18845136    28756777    26354079    22118469    28004739    + More
21797944    21719571    20798317    21347285    24845553    26812356    30249741    24508170    17381049    29240929    26772721    23542700    24488410    25186727    25329095    23594743    18687786    21709235    21993624    16341006    25065922    24487278    28087693    20010809    17975172   

EMBL

AF025542    AAF21243.1    BABH01007614    BABH01007615    BABH01007616    FJ169464    + More
ACI02334.1    NWSH01000609    PCG75348.1    KZ149960    PZC76371.1    KQ461150    KPJ08671.1    KQ459597    KPI95007.1    AGBW02014037    OWR42372.1    MF443095    ATU31392.1    NEVH01007818    PNF35478.1    PNF35477.1    GEZM01075366    JAV64116.1    KX428482    ANW09593.1    JF304722    ADZ56366.1    GL888102    EGI67492.1    GL436794    EFN71461.1    KQ982557    KYQ55071.1    KQ980763    KYN13503.1    LBMM01004093    KMQ92816.1    KQ976532    KYM81501.1    ADTU01000013    ADTU01000014    ADTU01000015    KK852921    KDR13786.1    KQ977481    KYN02366.1    KY992933    AVK43099.1    GEBQ01031456    JAT08521.1    GL445681    EFN89247.1    KQ759862    OAD62524.1    KP331063    KT355584    AKQ48960.1    ALV82503.1    GBYB01006589    JAG76356.1    QOIP01000012    RLU15667.1    BK008012    DAA34971.1    KK107558    EZA48949.1    KQ435850    KOX70962.1    KZ288192    PBC34259.1    MF620042    AVT56264.1    MF620044    AVT56266.1    KQ414638    KOC66875.1    AGCU01111388    AGCU01111389    AGCU01111390    AGCU01111391    AGCU01111392    AGCU01111393    AHAT01011134    AHAT01011135    AYCK01005051    AYCK01005052    AYCK01005053    GGFJ01000338    MBW49479.1    KP713801    AKR15643.1    GGFJ01000379    MBW49520.1    GCES01147150    JAQ39172.1    GCES01146635    JAQ39687.1    KF872769    AIF28000.1    AERX01019757    AERX01019758    HADW01016716    HADX01001268    SBP23500.1    AYCK01009878    AYCK01009879    AYCK01009880    HADZ01009499    SBP73440.1    HAED01020096    HAEE01004347    SBR24367.1    BX539340    EU447177    ACC77574.1    HAEH01003705    HAEI01005166    SBR92065.1    GGFM01000675    MBW21426.1    HAEF01001193    SBR38575.1    GGFM01000502    MBW21253.1    AEFK01007044    AEFK01007045    AEFK01007046    AEFK01007047    GCES01161962    JAQ24360.1    HADY01008541    SBP47026.1    AAEX03002256    AAEX03002257    AAEX03002258    AAEX03002259    KM190088    AII23383.1    AGTP01015962    AGTP01015963    AGTP01015964    AGTP01015965    AAPE02054813    AAPE02054814    AAPE02054815    HAAF01006597    CCP78421.1    GFFV01000373    JAV39572.1    ACTA01003557    ACTA01179548    ACTA01187546    ACTA01195544    AANG04000441    CP026254    AWP10941.1    KK763525    KFP45649.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000053268    UP000007151    UP000235965    + More
UP000192223    UP000007755    UP000000311    UP000075809    UP000078492    UP000036403    UP000078540    UP000005205    UP000027135    UP000078542    UP000008237    UP000279307    UP000005203    UP000053097    UP000053105    UP000242457    UP000053825    UP000221080    UP000091820    UP000007267    UP000092443    UP000018468    UP000261540    UP000028760    UP000261480    UP000002852    UP000005207    UP000265160    UP000018467    UP000261460    UP000000437    UP000087266    UP000265100    UP000007648    UP000261500    UP000001811    UP000002254    UP000005215    UP000261680    UP000192220    UP000265120    UP000001074    UP000008912    UP000248481    UP000011712    UP000245340    UP000246464   

PRIDE

Q9U5A8    H9J2B7   

Pfam

PF01030   Recep_L_domain        + More
PF07714   Pkinase_Tyr
PF00757   Furin-like
PF00041   fn3
PF00595   PDZ
PF17870   Insulin_TMD

Interpro

IPR001245   Ser-Thr/Tyr_kinase_cat_dom        + More
IPR036116   FN3_sf       
IPR017441   Protein_kinase_ATP_BS       
IPR016246   Tyr_kinase_insulin-like_rcpt       
IPR003961   FN3_dom       
IPR006212   Furin_repeat       
IPR008266   Tyr_kinase_AS       
IPR000494   Rcpt_L-dom       
IPR036941   Rcpt_L-dom_sf       
IPR011009   Kinase-like_dom_sf       
IPR013783   Ig-like_fold       
IPR009030   Growth_fac_rcpt_cys_sf       
IPR002011   Tyr_kinase_rcpt_2_CS       
IPR020635   Tyr_kinase_cat_dom       
IPR006211   Furin-like_Cys-rich_dom       
IPR000719   Prot_kinase_dom       
IPR017896   4Fe4S_Fe-S-bd       
IPR036034   PDZ_sf       
IPR001478   PDZ       
IPR028792   INSRR       
IPR036259   MFS_trans_sf       
IPR020846   MFS_dom       
IPR040969   Insulin_TMD       

SUPFAM

SSF56112   SSF56112        + More
SSF49265   SSF49265       
SSF57184   SSF57184       
SSF50156   SSF50156       
SSF103473   SSF103473       

Gene 3D

2.60.40.10     3.80.20.20    

CDD

cd00063  FN3
cd00064  FU
cd06174  MFS

ProteinModelPortal

Q9U5A8   H9J2B7   B5U451   A0A2A4JUH3   A0A2W1BQ19   A0A194QYL1   + More
A0A194PNX0   A0A212ELK6   A0A2D3E1C8   A0A2J7R3R8   A0A2J7R3R6   A0A1Y1KXL1   A0A1W4XBR9   A0A1B1UZE9   G3ER33   F4WE54   E2A530   A0A151X3W9   A0A151IYJ9   A0A0J7KR93   A0A195BAD2   A0A158NFV3   A0A067QUW8   A0A195CNS3   A0A2P1CYK5   A0A1B6KAQ3   E2B4Y3   A0A310SXM6   A0A0K0PQK7   A0A0C9QS61   A0A3L8D597   G2J5R2   A0A088AUM7   A0A026W1L5   A0A0N0BDV4   A0A2A3ESY9   A0A2R4G8S9   A0A2R4G8T0   A0A0L7R7M6   A0A2D0RTI5   A0A1A9WJ29   K7F279   K7F278   A0A1A9YHT5   W5M9H7   A0A3B3SIB8   W5M9K1   A0A087Y256   A0A3B3Z515   A0A2M4B8W8   A0A0K0QRF3   M4AW90   A0A2M4B938   A0A146P5T1   A0A146P740   A0A075IJV4   A0A096M0W0   I3KQM7   A0A1A7Y0I0   A0A3B5PVH2   A0A096M5E1   A0A087XET4   A0A3P9DDV5   A0A1A8C426   A0A3B1J7U9   A0A3B3YP57   A0A1A8JWQ8   A0A3B3YNW5   A0A3B4FJD9   F1QNX5   B7SNG4   A0A1A8QE15   A0A2M3YYU6   A0A1A8L188   A0A1S3R4V3   A0A2M3YYA3   A0A3P8PHL2   G3WLB9   A0A146N073   A0A3B3VRB6   A0A1A7ZXN0   G1T855   G1TLR2   F1PXU6   A0A076FVY1   I3MHA3   A0A384BUF8   A0A2I4AKQ2   A0A3P8W3R3   G1PWB2   U6D754   A0A250Y7G3   G1LGG8   A0A2Y9GBI4   M3WPQ6   A0A2U3ZLZ8   A0A2U9C2U4   A0A091KYJ0  

PDB

3LVP     E-value=4.25598e-129,     Score=1185

KEGG

692560    K04527 insulin receptor [EC:2.7.10.1] | (RefSeq) InR, Bir; insulin receptor

GO

GO:0046777   GO:0043548   GO:0043560   GO:0016021   GO:0007169   GO:0004714   GO:0005524   GO:0071469   GO:0005887   GO:0042593   GO:0045429   GO:0043559   GO:0048639   GO:0044877   GO:0031995   GO:0005009   GO:0000187   GO:0005635   GO:0006355   GO:0030335   GO:0060267   GO:0051425   GO:0005899   GO:0031981   GO:0005901   GO:0045840   GO:0007186   GO:0005525   GO:0019087   GO:0051290   GO:0003007   GO:0008284   GO:0045821   GO:0045995   GO:0045725   GO:0032148   GO:0001540   GO:0031994   GO:0046326   GO:0005159   GO:0051897   GO:0043235   GO:0043410   GO:0048856   GO:0030424   GO:0014068   GO:0048589   GO:0043009   GO:0005886   GO:0005520   GO:0046328   GO:0005158   GO:0006955   GO:0005010   GO:0048015   GO:0051262   GO:0043066   GO:0043231   GO:0051389   GO:1904646   GO:0042802   GO:0038083   GO:0097242   GO:0035867   GO:0048009   GO:0071333   GO:0005515   GO:0004672   GO:0006468   GO:0016020   GO:0004713   GO:0006281   GO:0048384  

PANTHER

PTHR24416:SF338  

Length:

1041

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

17.76509

Exp number, first 60 AAs:

0.00192

Total prob of N-in:

0.03966

outside

1  -  1041

 

 

Pi

253.366281

Theta

186.290042

Tajima's D

1.088956

CLR

0.160238

CSRT

0.686665666716664

Interpretation

Uncertain