Gene

KWMTBOMO02889  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA003537

Annotation

PREDICTED:_gamma-glutamylcyclotransferase-like_[Papilio_machaon]

Location

Bomo_Chr5(+):13184204-13185157      View in EpiBrowser

Full name

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit      

Location in the cell

Cytoplasmic   Reliability : 2.044

CDS

ATGGATCCGATCAAAGATACCTTTTTGTATTTTGCGTATGGGAGTAATTTGTTTAAAAAACGTATCCGTATCAACAATCCAACAGCTGAGTTTTTAGGAGTTGGCAGACTTGATAATCATCAATTAGATTTTATAAAATATTCTGAACATTGGAGAGGCGCATCAGCAACTATTATACCCACTGAACATGCCCATGTTTGGGGAGCAATATGGAGACTACATGATCAAGATTTACCATCATTAGACAGACAAGAAGGTGTTGATACAAACTGGTATTTTGCTAAATCTGTAAATGTTATGACTTCTGATGGTGTTTCAGTTCAATGTCGAACATATCAACAAACTATTAATCCACCTTTACGGAAAAATGGTGAAGAATTACCTCTCGAAAGAAGGCCTTGCATTACTTATTTAGATTGTATTATTAAGGGAGCTGTTGAGTGTGAATTACCTGAATATTATATTGAAGAGCTTAAAAAAATACCCCACAATGGACAAATAGCTTCAGCTAAAATGTTAGAGAAATTAAATTCACAGTAA

Protein

MDPIKDTFLYFAYGSNLFKKRIRINNPTAEFLGVGRLDNHQLDFIKYSEHWRGASATIIPTEHAHVWGAIWRLHDQDLPSLDRQEGVDTNWYFAKSVNVMTSDGVSVQCRTYQQTINPPLRKNGEELPLERRPCITYLDCIIKGAVECELPEYYIEELKKIPHNGQIASAKMLEKLNSQ

Description

Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).

Subunit

Component of the oligosaccharyltransferase (OST) complex.

Similarity

Belongs to the DDOST 48 kDa subunit family.

Uniprot

H9J200   A0A2A4JU99   A0A194QT24   A0A2H1W0E7   I4DNI1   A0A212FLB4   + More
A0A1E1WEN0   S4PD14   A0A2H1VCP2   A0A0L7LJ98   A0A026WGK4   A0A1W4WF99   A0A1B6HPP5   A0A1B6EVR6   A0A1B6FE71   A0A1B6FJ09   A0A1B6KQE3   A0A2W1BMS6   A0A067R9R2   D6X2L3   A0A151X828   F4WXF9   A0A232FK28   A0A195DCH6   A0A158NLI6   A0A195F4U9   A0A212FEM7   K7IV94   A0A1L8DAL4   J3JXA1   A0A1L8DAL0   A0A2A4JV31   A0A1L8DNZ1   A0A154PIW2   E2B3X7   A0A0L7RCU4   A0A1Q3FPB7   Q17PV6   A0A1Q3FPQ2   A0A1B0EWK2   A0A2J7RIJ3   U5ESW8   R4WJD8   B0WP18   A0A023EJ24   A0A212ELL9   N6TFJ8   A0A1S3D8W9   U4UEL4   A0A182W3U3   A0A2A3EBX9   A0A088ARA8   A0A232FJW1   A0A182RJQ0   A0A182PSC3   A0A2H1VNJ0   A0A0M8ZZL8   A0A084VDC3   A0A2M4AR97   A0A2M4AR02   A0A2M4AQU5   A0A2P8YQ23   A0A2M3ZD75   A0A067XL26   T1E875   W5JWM6   K7IV95   A0A2W1BRY2   A0A182XS70   A0A182NDM6   A0A2M4C0A0   A0A2M4C021   A0A2M3ZDC4   A0A2M4C124   A0A182FM54   A0A1S4H4Z9   Q7QDV9   E0VAM3   A0A1W4WAV5   A0A0A1XNN3   A0A1I8Q5R1   A0A0K8UFE0   A0A0K8TXE7   A0A194PV46   A0A0C9QWR6   A0A2A4JJA1   A0A2S2PM76   A0A2H8TSU9   A0A2H8TD47   W8BLZ2   A0A1I8M3K5   A0A0J9RXR1   A0A3B0J9I3   A0A1I8M3K9   T1PHF4   A0A1I8PKM5   W8BQN4   Q2LYZ1   A0A2R7WKD3  

Pubmed

19121390    26354079    22651552    22118469    23622113    26227816    + More
24508170    30249741    28756777    24845553    18362917    19820115    21719571    28648823    21347285    20075255    22516182    20798317    17510324    23691247    24945155    26483478    23537049    24438588    29403074    20920257    23761445    12364791    20566863    25830018    24495485    25315136    22936249    15632085    17994087    23185243   

EMBL

BABH01007618    NWSH01000609    PCG75346.1    KQ461150    KPJ08673.1    ODYU01005566    + More
SOQ46538.1    AK402941    KQ459597    BAM19471.1    KPI95004.1    AGBW02007804    OWR54534.1    GDQN01005604    JAT85450.1    GAIX01003836    JAA88724.1    ODYU01001833    SOQ38571.1    JTDY01000966    KOB75256.1    KK107218    QOIP01000001    EZA55182.1    RLU27547.1    GECU01031048    JAS76658.1    GECZ01027976    JAS41793.1    GECZ01021278    JAS48491.1    GECZ01019581    JAS50188.1    GEBQ01026309    JAT13668.1    KZ149960    PZC76372.1    KK852796    KDR16376.1    KQ971372    EFA09461.1    KQ982431    KYQ56522.1    GL888424    EGI61125.1    NNAY01000096    OXU31022.1    KQ981042    KYN10119.1    ADTU01002153    KQ981805    KYN35610.1    AGBW02008910    OWR52215.1    AAZX01001186    GFDF01010585    JAV03499.1    BT127870    AEE62832.1    GFDF01010586    JAV03498.1    PCG75343.1    GFDF01006000    JAV08084.1    KQ434931    KZC11762.1    GL445407    EFN89646.1    KQ414615    KOC68610.1    GFDL01005594    JAV29451.1    CH477188    EAT48838.1    GFDL01005592    JAV29453.1    AJWK01028599    NEVH01003500    PNF40640.1    GANO01003052    JAB56819.1    AK417635    BAN20850.1    DS232018    EDS32045.1    JXUM01047601    GAPW01004794    KQ561527    JAC08804.1    KXJ78272.1    AGBW02014037    OWR42373.1    APGK01029461    KB740735    ENN79139.1    KB632136    ERL89051.1    KZ288289    PBC29283.1    OXU31021.1    ODYU01003511    SOQ42390.1    KQ435791    KOX74355.1    ATLV01011252    KE524658    KFB35967.1    GGFK01009996    MBW43317.1    GGFK01009896    MBW43217.1    GGFK01009830    MBW43151.1    PYGN01000439    PSN46360.1    GGFM01005743    MBW26494.1    JX399879    AGI44427.1    GAMD01002417    JAA99173.1    ADMH02000195    ETN67409.1    PZC76375.1    GGFJ01009605    MBW58746.1    GGFJ01009536    MBW58677.1    GGFM01005742    MBW26493.1    GGFJ01009547    MBW58688.1    AAAB01008849    EAA07157.4    DS235012    EEB10429.1    GBXI01001363    JAD12929.1    GDHF01026955    JAI25359.1    GDHF01033160    GDHF01025259    GDHF01023166    GDHF01005013    JAI19154.1    JAI27055.1    JAI29148.1    JAI47301.1    KPI95005.1    GBYB01008174    JAG77941.1    NWSH01001375    PCG71480.1    GGMR01017894    MBY30513.1    GFXV01005501    GFXV01008129    MBW17306.1    MBW19934.1    GFXV01000231    MBW12036.1    GAMC01012159    JAB94396.1    CM002912    KMZ00398.1    OUUW01000002    SPP77013.1    KA647323    AFP61952.1    GAMC01005184    GAMC01005183    JAC01373.1    CH379069    EAL29719.3    KRT08307.1    KK854979    PTY20082.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000053268    UP000007151    UP000037510    + More
UP000053097    UP000279307    UP000192223    UP000027135    UP000007266    UP000075809    UP000007755    UP000215335    UP000078492    UP000005205    UP000078541    UP000002358    UP000076502    UP000008237    UP000053825    UP000008820    UP000092461    UP000235965    UP000002320    UP000069940    UP000249989    UP000019118    UP000079169    UP000030742    UP000075920    UP000242457    UP000005203    UP000075900    UP000075885    UP000053105    UP000030765    UP000245037    UP000000673    UP000076407    UP000075884    UP000069272    UP000007062    UP000009046    UP000095300    UP000095301    UP000268350    UP000001819   

PRIDE

H9J200   

Pfam

PF03345   DDOST_48kD

Interpro

IPR017939   G-Glutamylcylcotransferase        + More
IPR013024   GGCT-like       
IPR036568   GGCT-like_sf       
IPR005013   DDOST_48_kDa_subunit       

SUPFAM

SSF110857   SSF110857       

CDD

cd06661  GGCT_like

ProteinModelPortal

H9J200   A0A2A4JU99   A0A194QT24   A0A2H1W0E7   I4DNI1   A0A212FLB4   + More
A0A1E1WEN0   S4PD14   A0A2H1VCP2   A0A0L7LJ98   A0A026WGK4   A0A1W4WF99   A0A1B6HPP5   A0A1B6EVR6   A0A1B6FE71   A0A1B6FJ09   A0A1B6KQE3   A0A2W1BMS6   A0A067R9R2   D6X2L3   A0A151X828   F4WXF9   A0A232FK28   A0A195DCH6   A0A158NLI6   A0A195F4U9   A0A212FEM7   K7IV94   A0A1L8DAL4   J3JXA1   A0A1L8DAL0   A0A2A4JV31   A0A1L8DNZ1   A0A154PIW2   E2B3X7   A0A0L7RCU4   A0A1Q3FPB7   Q17PV6   A0A1Q3FPQ2   A0A1B0EWK2   A0A2J7RIJ3   U5ESW8   R4WJD8   B0WP18   A0A023EJ24   A0A212ELL9   N6TFJ8   A0A1S3D8W9   U4UEL4   A0A182W3U3   A0A2A3EBX9   A0A088ARA8   A0A232FJW1   A0A182RJQ0   A0A182PSC3   A0A2H1VNJ0   A0A0M8ZZL8   A0A084VDC3   A0A2M4AR97   A0A2M4AR02   A0A2M4AQU5   A0A2P8YQ23   A0A2M3ZD75   A0A067XL26   T1E875   W5JWM6   K7IV95   A0A2W1BRY2   A0A182XS70   A0A182NDM6   A0A2M4C0A0   A0A2M4C021   A0A2M3ZDC4   A0A2M4C124   A0A182FM54   A0A1S4H4Z9   Q7QDV9   E0VAM3   A0A1W4WAV5   A0A0A1XNN3   A0A1I8Q5R1   A0A0K8UFE0   A0A0K8TXE7   A0A194PV46   A0A0C9QWR6   A0A2A4JJA1   A0A2S2PM76   A0A2H8TSU9   A0A2H8TD47   W8BLZ2   A0A1I8M3K5   A0A0J9RXR1   A0A3B0J9I3   A0A1I8M3K9   T1PHF4   A0A1I8PKM5   W8BQN4   Q2LYZ1   A0A2R7WKD3  

PDB

2PN7     E-value=1.56157e-26,     Score=292

KEGG

101743698    K00682 gamma-glutamylcyclotransferase [EC:4.3.2.9] | (RefSeq) gamma-glutamylcyclotransferase-like

PATHWAY

00480    Glutathione metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0003839   GO:0016740   GO:0016021   GO:0005789   GO:0018279   GO:0016746  

PANTHER

PTHR12935   PTHR10830  

Subcellular location

Endoplasmic reticulum membrane  

Length:

179

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00228

Exp number, first 60 AAs:

0.00139

Total prob of N-in:

0.07267

outside

1  -  179

 

 

Pi

320.902511

Theta

220.36258

Tajima's D

1.400216

CLR

0

CSRT

0.756862156892155

Interpretation

Uncertain