Gene

KWMTBOMO02888

Pre Gene Modal

BGIBMGA003536

Annotation

PREDICTED:_glycosaminoglycan_xylosylkinase_[Bombyx_mori]

Location

Bomo_Chr5(+):13177344-13181902      View in EpiBrowser

Full name

Glycosaminoglycan xylosylkinase homolog      

Alternative Name

Xylose kinase homolog

Location in the cell

Cytoplasmic   Reliability : 1.892

CDS

ATGCGATGGATAGCACCTGCTGTAACTATGAGGATAAATGTCGAAAATGATATTCTCCCTGTTGCGACACTCGGTTTGAAGAACACAATGGTGAAAAATGAAGTTGGTGCAACATGTATTTACGGAAAATGTTACTATTGCAAAATAAATGAGACTGTGTGCCCTGACAACACGGGGGTCCTTGAAGGGGCAGCAATATTGTACCTTGAAAAGCAGTTCAAAGTTCACAAATCACCATGGAGACGATCTTATAGTCGTAAGAAAATGGACTGGGAAAAAGATACTGACTTTTGTAAGAAATTGTCTCATACATTAAGCCTGCAACGAATTCTAAATTTGATTGACGTTGCCATATTTGATTTCTTAATACAAAACGGCGACAGACATCATTATGAAGTCTATAAAAACAGAATAGTTATACTGGACAATGGCAAAGGTTTAGGAAATCCAATGGTTGATATTTTGGATGTCTTGGCTCCACTCTATCAATGTTGCATAATTAATCTACAGACGTGGCAGAACTTACAACTGCTGTCAGGTGGAAGCCTCACTGAGACAATCAAAATTCTTTCTTCATTCCAAGGAGAAAAACTTGCCACAGAAGAACACTTTGAAGCAATTGAACGAAGACTACTTAAGGTGTACGCGACTGTACAATATTGTATTGAAAAATACGGCACTGAAAAAGTTTTTAAACATAATATTGAAGTATGA

Protein

MRWIAPAVTMRINVENDILPVATLGLKNTMVKNEVGATCIYGKCYYCKINETVCPDNTGVLEGAAILYLEKQFKVHKSPWRRSYSRKKMDWEKDTDFCKKLSHTLSLQRILNLIDVAIFDFLIQNGDRHHYEVYKNRIVILDNGKGLGNPMVDILDVLAPLYQCCIINLQTWQNLQLLSGGSLTETIKILSSFQGEKLATEEHFEAIERRLLKVYATVQYCIEKYGTEKVFKHNIEV

Description

Kylose kinase that mediates the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans.

Catalytic Activity

3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + ATP = 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + ADP + H(+)

Cofactor

Mn(2+)

Similarity

Belongs to the FAM20 family.

Keywords

ATP-binding   Complete proteome   Disulfide bond   Endoplasmic reticulum   Glycoprotein   Golgi apparatus   Kinase   Manganese   Metal-binding   Nucleotide-binding   Reference proteome   Signal   Transferase  

Feature

chain  Glycosaminoglycan xylosylkinase homolog

Uniprot

H9J1Z9   A0A194PPV6   A0A194QTN4   A0A2A4JTI0   A0A212FLA7   A0A2A4JUP2   + More
A0A212FEQ5   Q16I43   A0A1Q3FB93   A0A1S4FIL3   B0X6W5   Q16ZQ4   T1PB07   A0A182J0F3   A0A1I8MF65   A0A0L0CBS4   A0A1I8P086   A0A182SZT7   A0A084WPQ3   A0A182RIK7   A0A1W4XHD5   A0A1L8DN81   A0A182W612   A0A2M4AUP5   A0A0K8UFU9   U4UEA1   A0A182YRK3   A0A034WCY2   N6TLX2   A0A2M4BNE1   A0A1A9XRE1   A0A1B0ASK8   A0A1A9W6H6   W8AY44   A0A1A9Z780   A0A1B0GGL3   A0A182Q204   A0A0K8VIJ3   A0A1A9ULZ9   A0A182FMH9   A0A182MF75   A0A336N1B6   Q7Q2H5   B4K950   B4M172   Q29AI3   A0A0M4ELV0   W5JNP2   B4JF40   B4NJ60   A0A3B0K157   A0A336MHL6   A0A2J7QFC8   B3LWR1   D6WR00   A0A1W4W024   B4G6E5   A0A2J7QFH2   A0A1Y1M1Y3   B4PSN9   B4QZ77   B4HEI0   A0A2H8TGC0   A0A067REG8   A0A1J1HYN1   J9K7X1   Q95T10   B3P3P3   A0A0N0U7L1   A0A026W7P5   E2AHT1   A0A0L7QPJ4   K7JBI5   A0A0J7LB91   A0A088A4C4   A0A2A3E859   A0A154PJA3   A0A0T6B651   E2B9S5   F4WXJ7   A0A158NUY8   A0A195FQA9   E0VHS6   A0A195CPR2   A0A232EHY8   A0A310SGM1   A0A195BVL5   Q6GQL4   A0A1L8GMN6   A0A1B6G677   Q6P4M8   U3J2W9   W5KC72   A0A091JSH6   A0A023EQG1   A0A2Y9JXF3   G1MUV3   H3AHS6  

EC Number

2.7.1.-

Pubmed

19121390    26354079    22118469    17510324    25315136    26108605    + More
24438588    23537049    25244985    25348373    24495485    12364791    14747013    17210077    17994087    18057021    15632085    20920257    23761445    18362917    19820115    28004739    17550304    24845553    10731132    12537572    12537569    22900076    24508170    20798317    20075255    21719571    21347285    20566863    28648823    27762356    23749191    25329095    24945155    20838655    9215903   

EMBL

BABH01007621    KQ459597    KPI95003.1    KQ461150    KPJ08674.1    NWSH01000609    + More
PCG75345.1    AGBW02007804    OWR54535.1    PCG75344.1    AGBW02008910    OWR52214.1    CH478110    EAT33926.1    GFDL01010204    JAV24841.1    DS232427    EDS41636.1    CH477485    EAT40168.1    KA645133    AFP59762.1    JRES01000641    KNC29687.1    ATLV01025119    KE525369    KFB52197.1    GFDF01006172    JAV07912.1    GGFK01011196    MBW44517.1    GDHF01027114    GDHF01021799    GDHF01000017    JAI25200.1    JAI30515.1    JAI52297.1    KB632046    ERL88255.1    GAKP01006785    GAKP01006783    JAC52167.1    APGK01059415    KB741293    ENN70245.1    GGFJ01005373    MBW54514.1    JXJN01002847    JXJN01002848    GAMC01020789    JAB85766.1    CCAG010021196    AXCN02002453    GDHF01013954    JAI38360.1    AXCM01001949    UFQS01001874    UFQT01001874    SSX12615.1    SSX32058.1    AAAB01008973    EAA13435.2    CH933806    EDW14463.1    KRG01024.1    CH940650    EDW67483.1    CM000070    EAL27367.2    CP012526    ALC46340.1    ADMH02000836    ETN64913.1    CH916369    EDV93321.1    CH964272    EDW83853.1    OUUW01000013    SPP88035.1    UFQT01001199    SSX29450.1    NEVH01015299    PNF27295.1    CH902617    EDV42699.1    KPU79853.1    KQ971351    EFA06532.1    CH479179    EDW23903.1    PNF27293.1    GEZM01043891    JAV78680.1    CM000160    EDW97535.1    CM000364    EDX12905.1    CH480815    EDW42137.1    GFXV01001358    MBW13163.1    KK852747    KDR17281.1    CVRI01000028    CRK92436.1    ABLF02024255    AE014297    AY060387    CH954181    EDV48931.1    KQ435709    KOX79951.1    KK107356    EZA52023.1    GL439579    EFN67010.1    KQ414813    KOC60558.1    AAZX01012181    LBMM01000015    KMR05345.1    KZ288344    PBC27694.1    KQ434936    KZC11925.1    LJIG01009561    KRT82834.1    GL446605    EFN87512.1    GL888425    EGI61067.1    ADTU01026832    ADTU01026833    KQ981335    KYN42606.1    DS235171    EEB12849.1    KQ977444    KYN02728.1    NNAY01004377    OXU17979.1    KQ767728    OAD53339.1    KQ976401    KYM92622.1    BC072728    AAH72728.1    CM004472    OCT85090.1    GECZ01011829    JAS57940.1    BC063339    AAH63339.1    ADON01071394    KK531175    KFP28077.1    GAPW01001771    JAC11827.1    AFYH01157634    AFYH01157635    AFYH01157636    AFYH01157637    AFYH01157638    AFYH01157639    AFYH01157640   

Proteomes

UP000005204    UP000053268    UP000053240    UP000218220    UP000007151    UP000008820    + More
UP000002320    UP000075880    UP000095301    UP000037069    UP000095300    UP000075901    UP000030765    UP000075900    UP000192223    UP000075920    UP000030742    UP000076408    UP000019118    UP000092443    UP000092460    UP000091820    UP000092445    UP000092444    UP000075886    UP000078200    UP000069272    UP000075883    UP000007062    UP000009192    UP000008792    UP000001819    UP000092553    UP000000673    UP000001070    UP000007798    UP000268350    UP000235965    UP000007801    UP000007266    UP000192221    UP000008744    UP000002282    UP000000304    UP000001292    UP000027135    UP000183832    UP000007819    UP000000803    UP000008711    UP000053105    UP000053097    UP000000311    UP000053825    UP000002358    UP000036403    UP000005203    UP000242457    UP000076502    UP000008237    UP000007755    UP000005205    UP000078541    UP000009046    UP000078542    UP000215335    UP000078540    UP000186698    UP000016666    UP000018467    UP000248482    UP000001645    UP000008672   

PRIDE

H9J1Z9    Q95T10   

Pfam

PF06702   Fam20C        + More
PF00083   Sugar_tr
PF03371   PRP38

Interpro

IPR024869   FAM20        + More
IPR009581   FAM20_C       
IPR036568   GGCT-like_sf       
IPR013024   GGCT-like       
IPR036259   MFS_trans_sf       
IPR020846   MFS_dom       
IPR005828   MFS_sugar_transport-like       
IPR000859   CUB_dom       
IPR035914   Sperma_CUB_dom_sf       
IPR005037   PRP38       

SUPFAM

SSF110857   SSF110857        + More
SSF103473   SSF103473       
SSF49854   SSF49854       

CDD

cd06661  GGCT_like
cd06174  MFS

ProteinModelPortal

H9J1Z9   A0A194PPV6   A0A194QTN4   A0A2A4JTI0   A0A212FLA7   A0A2A4JUP2   + More
A0A212FEQ5   Q16I43   A0A1Q3FB93   A0A1S4FIL3   B0X6W5   Q16ZQ4   T1PB07   A0A182J0F3   A0A1I8MF65   A0A0L0CBS4   A0A1I8P086   A0A182SZT7   A0A084WPQ3   A0A182RIK7   A0A1W4XHD5   A0A1L8DN81   A0A182W612   A0A2M4AUP5   A0A0K8UFU9   U4UEA1   A0A182YRK3   A0A034WCY2   N6TLX2   A0A2M4BNE1   A0A1A9XRE1   A0A1B0ASK8   A0A1A9W6H6   W8AY44   A0A1A9Z780   A0A1B0GGL3   A0A182Q204   A0A0K8VIJ3   A0A1A9ULZ9   A0A182FMH9   A0A182MF75   A0A336N1B6   Q7Q2H5   B4K950   B4M172   Q29AI3   A0A0M4ELV0   W5JNP2   B4JF40   B4NJ60   A0A3B0K157   A0A336MHL6   A0A2J7QFC8   B3LWR1   D6WR00   A0A1W4W024   B4G6E5   A0A2J7QFH2   A0A1Y1M1Y3   B4PSN9   B4QZ77   B4HEI0   A0A2H8TGC0   A0A067REG8   A0A1J1HYN1   J9K7X1   Q95T10   B3P3P3   A0A0N0U7L1   A0A026W7P5   E2AHT1   A0A0L7QPJ4   K7JBI5   A0A0J7LB91   A0A088A4C4   A0A2A3E859   A0A154PJA3   A0A0T6B651   E2B9S5   F4WXJ7   A0A158NUY8   A0A195FQA9   E0VHS6   A0A195CPR2   A0A232EHY8   A0A310SGM1   A0A195BVL5   Q6GQL4   A0A1L8GMN6   A0A1B6G677   Q6P4M8   U3J2W9   W5KC72   A0A091JSH6   A0A023EQG1   A0A2Y9JXF3   G1MUV3   H3AHS6  

PDB

5XOO     E-value=9.11701e-36,     Score=374

KEGG

101735841    K20825 glycosaminoglycan xylosylkinase [EC:2.7.1.-] | (RefSeq) glycosaminoglycan xylosylkinase

GO

GO:0016301   GO:0016021   GO:0016773   GO:0006468   GO:0005794   GO:0005783   GO:0022857   GO:0005524   GO:0046872   GO:0004672   GO:0030166   GO:0005654   GO:0048701  

PANTHER

PTHR12450  

Subcellular location

Golgi apparatus  
Endoplasmic reticulum  

Length:

237

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01694

Exp number, first 60 AAs:

0.00166

Total prob of N-in:

0.08334

outside

1  -  237

 

 

Pi

192.426178

Theta

175.283418

Tajima's D

0.325672

CLR

0.156124

CSRT

0.466276686165692

Interpretation

Uncertain