Gene

KWMTBOMO02880  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA003656

Annotation

cystathionine_gamma-lyase_[Bombyx_mori]

Location

Bomo_Chr5(-):13095525-13104713      View in EpiBrowser

Location in the cell

Cytoplasmic   Reliability : 2.67

CDS

ATGGCAGATCACGGATTTCTAAAGCAAAAACCTGGTTTTGCTACTATCGCTATTCACGCTGGCCAAGAACCGGAAAAATGGAATTCAGCAGCCGTGGTTACACCCATTGTCACATCCACTACATTCAAACAGCCAGCACCGGCCGAACATACGGGTTTTGAATACGGTCGCTCTGGAAATCCTACTAGAAACACCCTAGAAGAATGCTTAGCTGCATTAGACGGCGGAAAATACGGTCTAACGTTCGCTTCTGGCCTCGGAGCGACCACAACTTTGGTTGCTCTGCTAAATCACGGAGATCACATCGTGTCCTCAGATGATGTATACGGCGGTACAAACAGACTATTAAGGCAAGTAATCGCAAGATTGGGAATCAACACTACATTTACGGACTTTACAAATATTGAAAAAGTAAAGAACGCCATGCAAGAAAACACCAAGATGATCTGGATAGAGACCCCAACAAATCCATTATTAAAAGTCGTTGACATTGAGGCGATCGTAAAGATCGCGAGGAGTCGCGGAGACATTATCGTTGTTGTAGACAATACCTTCTTGACGCCGTATTTACAAAGACCTTTAGATTTCGGAGCGGACATCGTTATGTACTCGCTAACGAAATATATGAATGGTCATTCTGACGTCATAATGGGAGCCGCTATTGTAAATGACAAAGCTATCGGAGACAAACTAAGATTCTTGCAAAACGCCATGGGCATCGTTCCGTCACCGATGGACTGCTATTTTGTGAACAGGAGCTTAAAGACGTTAGCATTAAGAATGGAGCATCACAAGAAGTCGTCATTGATCATTGCCAATTGGTTGGAGAAACATCCGAAAATCGTCGAAGTGCTTCACCCAGGGCTGCCAACTCACCCGCAACACGAGATAGCTAAAAAACAGATGACGGGTCACTCGGGTGTGTTCAGTTTCAAACATTCCGGAGGTCTCAAGGAATCTAGAAAATTCCTGAGCTCATTGAAAGTGTTCACGCTGGCCGAGAGCTTGGGGGGCTATGAAAGTCTCGCTGAGCTACCATCTGTGATGACACACGCATCAGTTCCGGCGCTGCAGAGGGAGGAACTCGGCATCACCGATTCGCTGGTAAGACTTTCCGTCGGTCTCGAAGATACCGAGGATCTTATCGAAGATTTAGATCAAGCTTTTAAAGCTGCATTTTAA

Protein

MADHGFLKQKPGFATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHTGFEYGRSGNPTRNTLEECLAALDGGKYGLTFASGLGATTTLVALLNHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIARSRGDIIVVVDNTFLTPYLQRPLDFGADIVMYSLTKYMNGHSDVIMGAAIVNDKAIGDKLRFLQNAMGIVPSPMDCYFVNRSLKTLALRMEHHKKSSLIIANWLEKHPKIVEVLHPGLPTHPQHEIAKKQMTGHSGVFSFKHSGGLKESRKFLSSLKVFTLAESLGGYESLAELPSVMTHASVPALQREELGITDSLVRLSVGLEDTEDLIEDLDQAFKAAF

Cofactor

pyridoxal 5'-phosphate

Similarity

Belongs to the trans-sulfuration enzymes family.

Uniprot

Q2F6B7   H9J2B9   A0A0L7LMD3   A0A194QUM6   A0A194PNV8   A0A2W1BMT7   + More
A0A2H1VG61   A0A2A4IWX7   A0A212F2K2   A0A2W1BSU2   A0A2A4K9Q2   A0A1Q3F233   A0A182HWD8   Q7QHF8   A0A182X5L1   A0A182V506   A0A182JNJ4   B0W7Q2   A0A2M4CUD7   A0A182U5L0   Q17DR0   A0A1S4F6U1   A0A2M4CUB2   A0A2M4BRB6   A0A182NZK9   A0A182M218   A0A182Q2Z1   A0A2M3Z4L3   A0A182FKJ4   A0A182RTE3   A0A023ETT3   A0A182YB36   T1DJR2   A0A182JKI4   A0A2M4BQL6   A0A182H2J4   A0A182N2C9   A0A182WDH5   A0A2M4AND2   A0A182S739   A0A2H1V2G9   A0A2M4AMA8   A0A2H1V295   A0A1A9WFW0   A0A0L0CDY9   A0A0K8TTP1   U5EJE2   A0A1I8MHH1   A0A2J7QCJ1   A0A1I8QAD5   U4U6P1   V5SIY2   N6UBY9   A0A1B0AMY2   A0A1Y1JWR5   K1R7F6   A0A1L8EC44   E9IFN6   B4MG50   B3MDE6   B4QD03   A0A1A9VUQ6   B4KJJ5   E9HXC9   B3NK88   B4HNZ0   B4JPP3   A0A0P5YPG7   A0A0A1X101   A0A0P5DQG7   D3TMY0   A0A034VR89   A0A2H1V296   B4P4B7   A0A0K8VR58   W8B0N5   B4MP07   A0A0P6HL73   A0A0P5HYY7   Q7JXZ2   A0A3B0KBQ4   T1JND1   A0A232FMQ8   K7IVZ2   W5J4H5   O97121   B4M0Z9   A0A1L8E2A6   A0A0P6B4N4   V4A6N7   A0A1W4VQN3   A0A336LSS6   A0A2P8ZKX8   E0VK61   A0A1J1I6S3   A0A084VHV3   A0A0P4ZWP4   A0A026WE10   A0A1L8E9P3   A0A1S3JF62  

Pubmed

19121390    26227816    26354079    28756777    22118469    12364791    + More
14747013    17210077    17510324    24945155    25244985    26483478    26108605    26369729    25315136    23537049    28004739    22992520    21282665    17994087    22936249    21292972    25830018    20353571    25348373    17550304    24495485    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    28648823    20075255    20920257    23761445    10319443    23254933    29403074    20566863    24438588    24508170   

EMBL

DQ311155    ABD36100.1    BABH01007644    BABH01007645    BABH01007646    JTDY01000577    + More
KOB76602.1    KQ461150    KPJ08680.1    KQ459597    KPI94997.1    KZ149960    PZC76382.1    ODYU01002386    SOQ39817.1    NWSH01006069    PCG63692.1    AGBW02010734    OWR47951.1    KZ150027    PZC74793.1    NWSH01000034    PCG80460.1    GFDL01013444    JAV21601.1    APCN01001485    AAAB01008816    EAA05138.3    DS231855    EDS38196.1    GGFL01004755    MBW68933.1    CH477291    EAT44603.1    GGFL01004756    MBW68934.1    GGFJ01006382    MBW55523.1    AXCM01000599    AXCN02001727    GGFM01002692    MBW23443.1    GAPW01001769    JAC11829.1    GAMD01001316    JAB00275.1    GGFJ01006235    MBW55376.1    JXUM01105481    JXUM01105482    KQ564969    KXJ71493.1    GGFK01008974    MBW42295.1    ODYU01000352    SOQ34966.1    GGFK01008602    MBW41923.1    SOQ34965.1    JRES01000520    KNC30451.1    GDAI01000085    JAI17518.1    GANO01002264    JAB57607.1    NEVH01016289    PNF26293.1    KB631805    ERL86281.1    KF647650    AHB50512.1    APGK01029504    KB740735    ENN79170.1    JXJN01000640    GEZM01098785    JAV53759.1    JH816312    EKC29931.1    GFDG01002594    JAV16205.1    GL762880    EFZ20610.1    CH940671    EDW58188.1    CH902619    EDV36394.1    CM000362    CM002911    EDX07708.1    KMY94895.1    CH933807    EDW13575.2    GL733029    EFX63600.1    CH954179    EDV55110.1    CH480816    EDW48492.1    CH916372    EDV98873.1    GDIP01246284    GDIP01068900    LRGB01002864    JAM34815.1    KZS05728.1    GBXI01009520    JAD04772.1    GDIP01152898    JAJ70504.1    EZ422782    ADD19058.1    GAKP01014330    JAC44622.1    SOQ34967.1    CM000158    EDW91603.1    GDHF01010952    JAI41362.1    GAMC01011900    JAB94655.1    CH963848    EDW73846.1    GDIQ01025914    JAN68823.1    GDIQ01226758    JAK24967.1    AE013599    AY089545    AAF57663.1    AAL90283.1    AHN56373.1    OUUW01000010    SPP85600.1    JH431789    NNAY01000040    OXU31647.1    ADMH02002090    ETN59372.1    AF095822    AAD17839.1    CH940650    EDW67410.1    GFDF01001214    JAV12870.1    GDIP01022176    JAM81539.1    KB202094    ESO92362.1    UFQT01000155    SSX20980.1    PYGN01000026    PSN57157.1    DS235239    EEB13767.1    CVRI01000041    CRK95268.1    ATLV01013237    KE524847    KFB37547.1    GDIP01211341    JAJ12061.1    KK107262    EZA53916.1    GFDG01003352    JAV15447.1   

Proteomes

UP000005204    UP000037510    UP000053240    UP000053268    UP000218220    UP000007151    + More
UP000075840    UP000007062    UP000076407    UP000075903    UP000075881    UP000002320    UP000075902    UP000008820    UP000075885    UP000075883    UP000075886    UP000069272    UP000075900    UP000076408    UP000075880    UP000069940    UP000249989    UP000075884    UP000075920    UP000075901    UP000091820    UP000037069    UP000095301    UP000235965    UP000095300    UP000030742    UP000019118    UP000092460    UP000005408    UP000008792    UP000007801    UP000000304    UP000078200    UP000009192    UP000000305    UP000008711    UP000001292    UP000001070    UP000076858    UP000002282    UP000007798    UP000000803    UP000268350    UP000215335    UP000002358    UP000000673    UP000030746    UP000192221    UP000245037    UP000009046    UP000183832    UP000030765    UP000053097    UP000085678   

PRIDE

Q2F6B7    H9J2B9    Q7JXZ2    O97121   

Pfam

PF01053   Cys_Met_Meta_PP

Interpro

IPR000277   Cys/Met-Metab_PyrdxlP-dep_enz        + More
IPR015424   PyrdxlP-dep_Trfase       
IPR015421   PyrdxlP-dep_Trfase_major       
IPR015422   PyrdxlP-dep_Trfase_dom1       

SUPFAM

SSF53383   SSF53383       

Gene 3D

3.40.640.10     3.90.1150.10    

CDD

cd00614  CGS_like

ProteinModelPortal

Q2F6B7   H9J2B9   A0A0L7LMD3   A0A194QUM6   A0A194PNV8   A0A2W1BMT7   + More
A0A2H1VG61   A0A2A4IWX7   A0A212F2K2   A0A2W1BSU2   A0A2A4K9Q2   A0A1Q3F233   A0A182HWD8   Q7QHF8   A0A182X5L1   A0A182V506   A0A182JNJ4   B0W7Q2   A0A2M4CUD7   A0A182U5L0   Q17DR0   A0A1S4F6U1   A0A2M4CUB2   A0A2M4BRB6   A0A182NZK9   A0A182M218   A0A182Q2Z1   A0A2M3Z4L3   A0A182FKJ4   A0A182RTE3   A0A023ETT3   A0A182YB36   T1DJR2   A0A182JKI4   A0A2M4BQL6   A0A182H2J4   A0A182N2C9   A0A182WDH5   A0A2M4AND2   A0A182S739   A0A2H1V2G9   A0A2M4AMA8   A0A2H1V295   A0A1A9WFW0   A0A0L0CDY9   A0A0K8TTP1   U5EJE2   A0A1I8MHH1   A0A2J7QCJ1   A0A1I8QAD5   U4U6P1   V5SIY2   N6UBY9   A0A1B0AMY2   A0A1Y1JWR5   K1R7F6   A0A1L8EC44   E9IFN6   B4MG50   B3MDE6   B4QD03   A0A1A9VUQ6   B4KJJ5   E9HXC9   B3NK88   B4HNZ0   B4JPP3   A0A0P5YPG7   A0A0A1X101   A0A0P5DQG7   D3TMY0   A0A034VR89   A0A2H1V296   B4P4B7   A0A0K8VR58   W8B0N5   B4MP07   A0A0P6HL73   A0A0P5HYY7   Q7JXZ2   A0A3B0KBQ4   T1JND1   A0A232FMQ8   K7IVZ2   W5J4H5   O97121   B4M0Z9   A0A1L8E2A6   A0A0P6B4N4   V4A6N7   A0A1W4VQN3   A0A336LSS6   A0A2P8ZKX8   E0VK61   A0A1J1I6S3   A0A084VHV3   A0A0P4ZWP4   A0A026WE10   A0A1L8E9P3   A0A1S3JF62  

PDB

3COG     E-value=3.9948e-126,     Score=1156

KEGG

692801    K01758 cystathionine gamma-lyase [EC:4.4.1.1] | (RefSeq) cystathionine gamma-lyase

PATHWAY

00260    Glycine, serine and threonine metabolism - Bombyx mori (domestic silkworm)
00270    Cysteine and methionine metabolism - Bombyx mori (domestic silkworm)
00450    Selenocompound metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
01230    Biosynthesis of amino acids - Bombyx mori (domestic silkworm)

GO

GO:0016829   GO:0030170   GO:0003824   GO:0005737   GO:0019343   GO:0004123   GO:0019346   GO:0016846   GO:0016021   GO:0006750   GO:0003962   GO:0044540   GO:0000096   GO:0080146   GO:0005681   GO:0004888   GO:0007166   GO:0045211   GO:0006281   GO:0048384  

PANTHER

PTHR11808  

Length:

393

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0893699999999999

Exp number, first 60 AAs:

0.0002

Total prob of N-in:

0.01232

outside

1  -  393

 

 

Pi

280.512334

Theta

212.602225

Tajima's D

0.827776

CLR

0.389002

CSRT

0.610269486525674

Interpretation

Uncertain