Gene
KWMTBOMO02878
Annotation
PREDICTED:_gem-associated_protein_2-like_[Papilio_polytes]
Full name
Gem-associated protein 2
Alternative Name
Component of gems 2
Survival of motor neuron protein-interacting protein 1
Survival of motor neuron protein-interacting protein 1
Location in the cell
Nuclear Reliability : 2.398
Sequence
CDS
ATGTCATTGAAAAAGTACTTGAAAACAATGAAGGATGATGAAGATAATTTGGATATAGTATCACCGTGCTTCAAAATAAGTCCTGATGTGCAATTAAAAGAGGTTCCAACGAACGGTGAAGAATATTTACTTAAAGTCATAAAGGAGCGTAAAAACATTGCAGCAGTTACGAAATGCAACAAAGATTATTCAAAGTTTGCCGAAAATCAGTCTCAGTATGTGCATGAGTTCCCGAGGCTATCAGTACCTGAGAAGTTAAAACCTACAATTGAGTGGCAAAACATGCAAGTAGCAGATTTCTCAGAAACTCGAATGTACATATCTCGTTTGCTGTCAAAAAGGAAAATATGGAAAAACAATATTAATATTATAGAAATAAAACCAACCTGTGTAATTGAATGGAAACAGTTCTTCAGTACCCATATTCCAACATTATCATGCGTGCTCGGATTACAACATGCATTACTAGACCAAGGTTTAGAAGTACTTACTGATATTATTAGTAGAACGAAACCTGGTAATACTATAGAACATAAAACAGGTCAATGGGTATATGCGTTTTTGGCCTGTACCCAACTACCTCTATTGTCTGATACAACAAGTATTCTAAGAAATTTAGCTCGAAAGTGTGCTGAAATAAGGTTTAGGCTAAACCCTGATGAAGAAAATGCTATTACTGCAGCAACACCTTTAAATATATTTATATGTTTAGTGGCAAGATATTTTAGACAGTATGATCTAGCAGACTGA
Protein
MSLKKYLKTMKDDEDNLDIVSPCFKISPDVQLKEVPTNGEEYLLKVIKERKNIAAVTKCNKDYSKFAENQSQYVHEFPRLSVPEKLKPTIEWQNMQVADFSETRMYISRLLSKRKIWKNNINIIEIKPTCVIEWKQFFSTHIPTLSCVLGLQHALLDQGLEVLTDIISRTKPGNTIEHKTGQWVYAFLACTQLPLLSDTTSILRNLARKCAEIRFRLNPDEENAITAATPLNIFICLVARYFRQYDLAD
Summary
Description
The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs.
The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins are trapped in an inactive complex. The SMN complex triggers the assembly of core snRNPs and their transport to the nucleus.
The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins are trapped in an inactive complex. The SMN complex triggers the assembly of core snRNPs and their transport to the nucleus.
Subunit
Part of the core SMN complex.
Forms a stable heteromeric complex with survival of motor neuron protein (SMN), GEMIN3 and GEMIN4. The SMN complex is associated with the spliceosomal snRNAs U1 and U5 in the cytoplasm of oocytes.
Forms a stable heteromeric complex with survival of motor neuron protein (SMN), GEMIN3 and GEMIN4. The SMN complex is associated with the spliceosomal snRNAs U1 and U5 in the cytoplasm of oocytes.
Similarity
Belongs to the gemin-2 family.
Keywords
Cytoplasm
mRNA processing
mRNA splicing
Nucleus
Feature
chain Gem-associated protein 2
Uniprot
A0A194QT89
A0A1E1WIW2
A0A212FM38
I4DQG1
A0A2W1BXR7
A0A2A4K375
+ More
A0A2H1X2U6 A0A0L7KS38 A0A0L7R0J3 A0A158NPW3 A0A2A3EEG8 F4W7C7 A0A195DSS2 A0A087ZYA8 E2C9L0 A0A0M9A4D6 A0A154PRR9 K7J7Y9 E1ZZS8 A0A232FGE2 A0A0A9WAT6 A0A0A9WBZ2 A0A1Y1NGD7 A0A0A9W8Y5 A0A0A9WJ75 A0A293L5E7 B7PUC2 A0A131XW84 A0A3B1IG66 C1BYV5 A0A060WZZ2 B5XE83 A0A060WBE6 A0A3B3VXZ8 A0A3B3X2L7 A0A1W4Y485 A0A3P8XH36 F7CV43 V9L0S9 A0A1W4WL49 A0A087Y9K6 A0A3P8RS74 I3KTU5 A0A0K8TR62 A0A1Z5LD60 A0A3B3X2L1 A0A0P5SZ26 A0A0P6EWL7 A0A3B3DEE3 A0A2R5LCL9 A0A0N8EPB1 A0A0P6DHQ8 A0A067QHX6 W5MS93 A0A3B3VXY3 A0A0S7LI18 A0A3B4H996 A0A3P9BKP0 A0A2D0RKX1 A0A0P5T7H4 A0A0E9X7F6 A0A0F8AG02 A0A195ATF0 A0A0P5STV1 A0A3B4V112 B5XGF4 A0A139WC39 A0A131XDP6 A0A3P9NP64 A7SU44 A0A099YTN4 G1KRR9 A0A1A9UP86 A0A2J7Q1E4 I3M7S3 A0A2J7Q1F9 Q0D2A4 F6TG06 A0A3B4YZJ0 A0A1A9ZBW4 A0A315VBX9 A0A2I0MNJ0 O42260 A0A1L8F470 Q6DDI7 A0A1V4KFJ4 A0A151JSQ8 A0A131Y9F9 A0A0P5DBE3 H3A6P3 A5PKQ0 A0A1L8F448 A0A1B0FC22 G3PFT7 G3T5E0 G3PFU0 A0A0L8GI61 V8NR32
A0A2H1X2U6 A0A0L7KS38 A0A0L7R0J3 A0A158NPW3 A0A2A3EEG8 F4W7C7 A0A195DSS2 A0A087ZYA8 E2C9L0 A0A0M9A4D6 A0A154PRR9 K7J7Y9 E1ZZS8 A0A232FGE2 A0A0A9WAT6 A0A0A9WBZ2 A0A1Y1NGD7 A0A0A9W8Y5 A0A0A9WJ75 A0A293L5E7 B7PUC2 A0A131XW84 A0A3B1IG66 C1BYV5 A0A060WZZ2 B5XE83 A0A060WBE6 A0A3B3VXZ8 A0A3B3X2L7 A0A1W4Y485 A0A3P8XH36 F7CV43 V9L0S9 A0A1W4WL49 A0A087Y9K6 A0A3P8RS74 I3KTU5 A0A0K8TR62 A0A1Z5LD60 A0A3B3X2L1 A0A0P5SZ26 A0A0P6EWL7 A0A3B3DEE3 A0A2R5LCL9 A0A0N8EPB1 A0A0P6DHQ8 A0A067QHX6 W5MS93 A0A3B3VXY3 A0A0S7LI18 A0A3B4H996 A0A3P9BKP0 A0A2D0RKX1 A0A0P5T7H4 A0A0E9X7F6 A0A0F8AG02 A0A195ATF0 A0A0P5STV1 A0A3B4V112 B5XGF4 A0A139WC39 A0A131XDP6 A0A3P9NP64 A7SU44 A0A099YTN4 G1KRR9 A0A1A9UP86 A0A2J7Q1E4 I3M7S3 A0A2J7Q1F9 Q0D2A4 F6TG06 A0A3B4YZJ0 A0A1A9ZBW4 A0A315VBX9 A0A2I0MNJ0 O42260 A0A1L8F470 Q6DDI7 A0A1V4KFJ4 A0A151JSQ8 A0A131Y9F9 A0A0P5DBE3 H3A6P3 A5PKQ0 A0A1L8F448 A0A1B0FC22 G3PFT7 G3T5E0 G3PFU0 A0A0L8GI61 V8NR32
Pubmed
26354079
22118469
22651552
28756777
26227816
21347285
+ More
21719571 20798317 20075255 28648823 25401762 26823975 28004739 25329095 20433749 25069045 24755649 17495919 24402279 25186727 26369729 28528879 29451363 24845553 25613341 25835551 18362917 19820115 28049606 17615350 20431018 29703783 23371554 9323129 9323130 27762356 26830274 9215903 24297900
21719571 20798317 20075255 28648823 25401762 26823975 28004739 25329095 20433749 25069045 24755649 17495919 24402279 25186727 26369729 28528879 29451363 24845553 25613341 25835551 18362917 19820115 28049606 17615350 20431018 29703783 23371554 9323129 9323130 27762356 26830274 9215903 24297900
EMBL
KQ461150
KPJ08682.1
GDQN01004253
JAT86801.1
AGBW02007682
OWR54760.1
+ More
AK404096 BAM20151.1 KZ149903 PZC78434.1 NWSH01000238 PCG78102.1 ODYU01012974 SOQ59546.1 JTDY01006341 KOB66088.1 KQ414670 KOC64369.1 ADTU01022788 KZ288266 PBC30127.1 GL887844 EGI69800.1 KQ980487 KYN15901.1 GL453868 EFN75349.1 KQ435760 KOX75619.1 KQ435090 KZC14591.1 GL435522 EFN73301.1 NNAY01000231 OXU29831.1 GBHO01038690 JAG04914.1 GBHO01038693 GBRD01010211 GBRD01010210 GDHC01002786 JAG04911.1 JAG55613.1 JAQ15843.1 GEZM01006593 GEZM01006592 JAV95695.1 GBHO01038692 JAG04912.1 GBHO01038694 GDHC01005516 JAG04910.1 JAQ13113.1 GFWV01001987 MAA26717.1 ABJB010036282 ABJB010461689 ABJB010907219 DS791940 EEC10194.1 GEFM01005496 JAP70300.1 BT079784 ACO14208.1 FR904729 CDQ70644.1 BT049352 BT125191 ACI69153.1 ADM15932.1 FR904474 CDQ64487.1 JW872727 AFP05245.1 AYCK01001347 AERX01013487 GDAI01000992 JAI16611.1 GFJQ02001628 JAW05342.1 GDIP01135958 JAL67756.1 GDIQ01057519 JAN37218.1 GGLE01003080 MBY07206.1 GDIQ01007180 JAN87557.1 GDIQ01078117 JAN16620.1 KK853376 KDR08042.1 AHAT01003895 GBYX01168055 JAO89125.1 GDIP01132210 JAL71504.1 GBXM01010817 JAH97760.1 KQ042461 KKF14667.1 KQ976745 KYM75498.1 GDIP01142712 JAL61002.1 BT050123 ACI69924.1 KQ971371 KYB25464.1 GEFH01004351 JAP64230.1 DS469807 EDO32758.1 KL886198 KGL73629.1 NEVH01019410 PNF22411.1 AGTP01026263 PNF22407.1 BC122058 AAI22059.1 AAMC01016353 NHOQ01002481 PWA16471.1 AKCR02000005 PKK31251.1 AF027151 CM004481 OCT66380.1 BC077574 AAH77574.1 LSYS01003385 OPJ83198.1 KQ982014 KYN30613.1 GEDV01012594 JAP75963.1 GDIP01174698 JAJ48704.1 AFYH01017506 BC142570 AAI42571.1 OCT66381.1 CCAG010003240 KQ421721 KOF76687.1 AZIM01002372 ETE64143.1
AK404096 BAM20151.1 KZ149903 PZC78434.1 NWSH01000238 PCG78102.1 ODYU01012974 SOQ59546.1 JTDY01006341 KOB66088.1 KQ414670 KOC64369.1 ADTU01022788 KZ288266 PBC30127.1 GL887844 EGI69800.1 KQ980487 KYN15901.1 GL453868 EFN75349.1 KQ435760 KOX75619.1 KQ435090 KZC14591.1 GL435522 EFN73301.1 NNAY01000231 OXU29831.1 GBHO01038690 JAG04914.1 GBHO01038693 GBRD01010211 GBRD01010210 GDHC01002786 JAG04911.1 JAG55613.1 JAQ15843.1 GEZM01006593 GEZM01006592 JAV95695.1 GBHO01038692 JAG04912.1 GBHO01038694 GDHC01005516 JAG04910.1 JAQ13113.1 GFWV01001987 MAA26717.1 ABJB010036282 ABJB010461689 ABJB010907219 DS791940 EEC10194.1 GEFM01005496 JAP70300.1 BT079784 ACO14208.1 FR904729 CDQ70644.1 BT049352 BT125191 ACI69153.1 ADM15932.1 FR904474 CDQ64487.1 JW872727 AFP05245.1 AYCK01001347 AERX01013487 GDAI01000992 JAI16611.1 GFJQ02001628 JAW05342.1 GDIP01135958 JAL67756.1 GDIQ01057519 JAN37218.1 GGLE01003080 MBY07206.1 GDIQ01007180 JAN87557.1 GDIQ01078117 JAN16620.1 KK853376 KDR08042.1 AHAT01003895 GBYX01168055 JAO89125.1 GDIP01132210 JAL71504.1 GBXM01010817 JAH97760.1 KQ042461 KKF14667.1 KQ976745 KYM75498.1 GDIP01142712 JAL61002.1 BT050123 ACI69924.1 KQ971371 KYB25464.1 GEFH01004351 JAP64230.1 DS469807 EDO32758.1 KL886198 KGL73629.1 NEVH01019410 PNF22411.1 AGTP01026263 PNF22407.1 BC122058 AAI22059.1 AAMC01016353 NHOQ01002481 PWA16471.1 AKCR02000005 PKK31251.1 AF027151 CM004481 OCT66380.1 BC077574 AAH77574.1 LSYS01003385 OPJ83198.1 KQ982014 KYN30613.1 GEDV01012594 JAP75963.1 GDIP01174698 JAJ48704.1 AFYH01017506 BC142570 AAI42571.1 OCT66381.1 CCAG010003240 KQ421721 KOF76687.1 AZIM01002372 ETE64143.1
Proteomes
UP000053240
UP000007151
UP000218220
UP000037510
UP000053825
UP000005205
+ More
UP000242457 UP000007755 UP000078492 UP000005203 UP000008237 UP000053105 UP000076502 UP000002358 UP000000311 UP000215335 UP000001555 UP000018467 UP000265140 UP000193380 UP000087266 UP000261500 UP000261480 UP000192224 UP000002280 UP000192223 UP000028760 UP000265080 UP000005207 UP000261560 UP000027135 UP000018468 UP000261460 UP000265160 UP000221080 UP000078540 UP000261420 UP000007266 UP000242638 UP000001593 UP000053641 UP000001646 UP000078200 UP000235965 UP000005215 UP000008143 UP000261400 UP000092445 UP000053872 UP000186698 UP000190648 UP000078541 UP000008672 UP000092444 UP000007635 UP000007646 UP000053454
UP000242457 UP000007755 UP000078492 UP000005203 UP000008237 UP000053105 UP000076502 UP000002358 UP000000311 UP000215335 UP000001555 UP000018467 UP000265140 UP000193380 UP000087266 UP000261500 UP000261480 UP000192224 UP000002280 UP000192223 UP000028760 UP000265080 UP000005207 UP000261560 UP000027135 UP000018468 UP000261460 UP000265160 UP000221080 UP000078540 UP000261420 UP000007266 UP000242638 UP000001593 UP000053641 UP000001646 UP000078200 UP000235965 UP000005215 UP000008143 UP000261400 UP000092445 UP000053872 UP000186698 UP000190648 UP000078541 UP000008672 UP000092444 UP000007635 UP000007646 UP000053454
PRIDE
Pfam
PF04938 SIP1
ProteinModelPortal
A0A194QT89
A0A1E1WIW2
A0A212FM38
I4DQG1
A0A2W1BXR7
A0A2A4K375
+ More
A0A2H1X2U6 A0A0L7KS38 A0A0L7R0J3 A0A158NPW3 A0A2A3EEG8 F4W7C7 A0A195DSS2 A0A087ZYA8 E2C9L0 A0A0M9A4D6 A0A154PRR9 K7J7Y9 E1ZZS8 A0A232FGE2 A0A0A9WAT6 A0A0A9WBZ2 A0A1Y1NGD7 A0A0A9W8Y5 A0A0A9WJ75 A0A293L5E7 B7PUC2 A0A131XW84 A0A3B1IG66 C1BYV5 A0A060WZZ2 B5XE83 A0A060WBE6 A0A3B3VXZ8 A0A3B3X2L7 A0A1W4Y485 A0A3P8XH36 F7CV43 V9L0S9 A0A1W4WL49 A0A087Y9K6 A0A3P8RS74 I3KTU5 A0A0K8TR62 A0A1Z5LD60 A0A3B3X2L1 A0A0P5SZ26 A0A0P6EWL7 A0A3B3DEE3 A0A2R5LCL9 A0A0N8EPB1 A0A0P6DHQ8 A0A067QHX6 W5MS93 A0A3B3VXY3 A0A0S7LI18 A0A3B4H996 A0A3P9BKP0 A0A2D0RKX1 A0A0P5T7H4 A0A0E9X7F6 A0A0F8AG02 A0A195ATF0 A0A0P5STV1 A0A3B4V112 B5XGF4 A0A139WC39 A0A131XDP6 A0A3P9NP64 A7SU44 A0A099YTN4 G1KRR9 A0A1A9UP86 A0A2J7Q1E4 I3M7S3 A0A2J7Q1F9 Q0D2A4 F6TG06 A0A3B4YZJ0 A0A1A9ZBW4 A0A315VBX9 A0A2I0MNJ0 O42260 A0A1L8F470 Q6DDI7 A0A1V4KFJ4 A0A151JSQ8 A0A131Y9F9 A0A0P5DBE3 H3A6P3 A5PKQ0 A0A1L8F448 A0A1B0FC22 G3PFT7 G3T5E0 G3PFU0 A0A0L8GI61 V8NR32
A0A2H1X2U6 A0A0L7KS38 A0A0L7R0J3 A0A158NPW3 A0A2A3EEG8 F4W7C7 A0A195DSS2 A0A087ZYA8 E2C9L0 A0A0M9A4D6 A0A154PRR9 K7J7Y9 E1ZZS8 A0A232FGE2 A0A0A9WAT6 A0A0A9WBZ2 A0A1Y1NGD7 A0A0A9W8Y5 A0A0A9WJ75 A0A293L5E7 B7PUC2 A0A131XW84 A0A3B1IG66 C1BYV5 A0A060WZZ2 B5XE83 A0A060WBE6 A0A3B3VXZ8 A0A3B3X2L7 A0A1W4Y485 A0A3P8XH36 F7CV43 V9L0S9 A0A1W4WL49 A0A087Y9K6 A0A3P8RS74 I3KTU5 A0A0K8TR62 A0A1Z5LD60 A0A3B3X2L1 A0A0P5SZ26 A0A0P6EWL7 A0A3B3DEE3 A0A2R5LCL9 A0A0N8EPB1 A0A0P6DHQ8 A0A067QHX6 W5MS93 A0A3B3VXY3 A0A0S7LI18 A0A3B4H996 A0A3P9BKP0 A0A2D0RKX1 A0A0P5T7H4 A0A0E9X7F6 A0A0F8AG02 A0A195ATF0 A0A0P5STV1 A0A3B4V112 B5XGF4 A0A139WC39 A0A131XDP6 A0A3P9NP64 A7SU44 A0A099YTN4 G1KRR9 A0A1A9UP86 A0A2J7Q1E4 I3M7S3 A0A2J7Q1F9 Q0D2A4 F6TG06 A0A3B4YZJ0 A0A1A9ZBW4 A0A315VBX9 A0A2I0MNJ0 O42260 A0A1L8F470 Q6DDI7 A0A1V4KFJ4 A0A151JSQ8 A0A131Y9F9 A0A0P5DBE3 H3A6P3 A5PKQ0 A0A1L8F448 A0A1B0FC22 G3PFT7 G3T5E0 G3PFU0 A0A0L8GI61 V8NR32
PDB
4V98
E-value=3.53544e-16,
Score=205
Ontologies
GO
Topology
Subcellular location
Nucleus
Gem
Cytoplasm
Gem
Cytoplasm
Length:
249
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
3.39796
Exp number, first 60 AAs:
0
Total prob of N-in:
0.14097
outside
1 - 249
Population Genetic Test Statistics
Pi
274.860384
Theta
201.741311
Tajima's D
1.330205
CLR
0.128539
CSRT
0.743762811859407
Interpretation
Uncertain
