Silkworm Genome Informatics Database

Gene

KWMTBOMO02876 Validated by peptides from experiments

Pre Gene Modal

BGIBMGA003659

Annotation

PREDICTED:_protein_hook_[Papilio_machaon]

Location

Bomo_Chr5(-):13064289-13077493 View in EpiBrowser

Full name

Protein hook

Alternative Name

dHK

Location in the cell

Cytoplasmic Reliability : 2.3

CDS

ATGGAAGGGAATGGTGCAGTATTGTGTGACAATCTAATCAATTGGCTACAAACGCTAAATCTTAAGGCCAAACATGGAAATCCAATGGAACTCTCAGATGGAGTGGCAATAGCTGAAGCTTTGACCCAGATAGCCCCTGAATATTTCACTCCATCATGGAATACAAAAATAAAGACAGATGTTGGAAACAACTGGAGACTAAAAGTTAGTAATTTAAAGAAAATATTGGAGGGTGTTGTTGATTACCATCAAGACATTTTGAATTTGAGTCTTCAAGAATTTCCAAGACCTGATGTAGTCAACATTGCTGAAACAGCCGACCCGTCTGACTTAAGAAGGTTGCTACAATTAGTTTTAAGTTGTGCAGTAAACTGTATTAAGAAGGAAGAGTACATAACAAGAATAATGGAAATGGAGTTATCTTGTCAAAGATCTATAATGCAAGCTATACAGGAATTGGAGACGTTGACTTTGGGAGCGAATCGTGGGAGTTTGCATTCAGAAGACATAGGCATTGAACATTCCGATGCTGAGATGAGAGAAATTTTGGCGCAAAGATGCCATGAGTTGGATACACAGGTAAAAATCCTTCAAGAGGAAAAGATGACGCTTCTGAGCGAGGTGGCGCGGCTGACGGCGGCCCGAGACGCGGCGAGCGCGGCCGCCGACGACGTCGACCTCGACGACGGCGGCGAGTCCCTGGGGCCCGCCCACGCCGGCACCCTCCGCTACAGCAACATGCGGGCCCAGCTCGACGCGCTCAAAGACGAACTGGACAAAGTCGAGCTGCAGAGGGACGATCAGAGGGCACGAAGCGACGCCCTCGAAAGGGAGTTGGCCATTTTAAAATTACGCAACGAGGAGCTACAGATAGCGGCCCAAGAGAACGTGGCTCTGAAAGACGAAGTGGATGCTTTGCGCGAGACGGCGGCGAAGGCGGTCGCGTTGGAGACCACAGTGGCATCGTATAAAAAGCGGATGGAGGAATATGTTGATTTAAAAAAACAGGTTAAGTTACTAGAGCACGCCAACACAGAGTACGTTCAACGCACCATAGAGTACGAGCAGGCGGCCGCGCGAGCGAACGCAGTGCGGGTGCAACTCGATATTTACAAGAAACAGGTGACGGATCTGAATGAAAAATTAGACGCGGAAATAACGAAAGCCGATAAATTGGAGATTGAAAACAAGAAGTTGAGTAGTCGCGCTGCCTCCCTGCAGAGGGAGAGGGACGCGCTCGTTGAGGAAAAGAGTATGCTCCGTGAGACCGTCGACGAACTGCGGTGCTCCACGATGACCACGGACGCAAGTAAAGACAATGTCTCAAGGGAGCTAATGCCGAATGACGTCAAGGAGCGCTTGATCAGGCTGGAGCACGAAAATAAACTGCTGAGGCAGAACCAGAGTGCGCCGTTTGACGAGGCTCTAATCGAGGACTACAGGGCTCGACTCGAGAAGCAACGCGCCGAGAACCGCGAGGCGAGCCAGCGGATCATGCAGCTCGAGGCCACGCTCGAAGCTCCTCATCCTAGACTTGCCTCTGCCATAGAGGACAACCAGAGAAAATCTCTCCAAGTCGAAGAGCTCCAGAACGCTCTGAGCGAAGAGAGGCGTCGCTCCGCCAAGCTGCAGGAGGACGTCGCCGCACGAGACGCGGACCTGCTGGCGCTCGAGGACAAGTACAAGAAGTACGTCGAGAAGGCCAAGGAAGTCATCAGGACTCTCGACCCGAAAACTACAGGTCAACAGTCAATATCTGATCCGACACAAGGTAACGCCGGCGCCGCTAATGCGTCACGGCCGGACCCCACGGCCACAAACAACAATAGACACGAGTGA

Protein

MEGNGAVLCDNLINWLQTLNLKAKHGNPMELSDGVAIAEALTQIAPEYFTPSWNTKIKTDVGNNWRLKVSNLKKILEGVVDYHQDILNLSLQEFPRPDVVNIAETADPSDLRRLLQLVLSCAVNCIKKEEYITRIMEMELSCQRSIMQAIQELETLTLGANRGSLHSEDIGIEHSDAEMREILAQRCHELDTQVKILQEEKMTLLSEVARLTAARDAASAAADDVDLDDGGESLGPAHAGTLRYSNMRAQLDALKDELDKVELQRDDQRARSDALERELAILKLRNEELQIAAQENVALKDEVDALRETAAKAVALETTVASYKKRMEEYVDLKKQVKLLEHANTEYVQRTIEYEQAAARANAVRVQLDIYKKQVTDLNEKLDAEITKADKLEIENKKLSSRAASLQRERDALVEEKSMLRETVDELRCSTMTTDASKDNVSRELMPNDVKERLIRLEHENKLLRQNQSAPFDEALIEDYRARLEKQRAENREASQRIMQLEATLEAPHPRLASAIEDNQRKSLQVEELQNALSEERRRSAKLQEDVAARDADLLALEDKYKKYVEKAKEVIRTLDPKTTGQQSISDPTQGNAGAANASRPDPTATNNNRHE

Description

Involved in endocytic trafficking. Probably acts as a cytoskeletal linker protein that tethers endosome vesicles to the cytoskeleton.
Involved in endocytic trafficking by stabilizing organelles of the endocytic pathway. Probably acts as a cytoskeletal linker protein required to tether endosome vesicles to the cytoskeleton. Involved in modulation of endocytosis at stages required for down-regulation of membrane proteins that control synapse size. Not involved in synaptic vesicle recycling. Required in R7 cells for boss endocytosis into multivesicular bodies (MVBs). Has a role in regulating adult longevity.

Subunit

Homodimer. Interacts with microtubules via its N-terminus.

Similarity

Belongs to the hook family.

Keywords

Coiled coil Complete proteome Cytoplasm Cytoskeleton Endocytosis Endosome Microtubule Reference proteome Cell junction Developmental protein Synapse

Feature

chain Protein hook

Uniprot

A0A2A4K1H3 A0A194PQH8 A0A2H1X4H9 A0A194QUN1 A0A212FLZ6 A0A2W1BTM1 + More
A0A2J7R974 A0A1B0DLJ1 A0A154PG53 A0A088AJ37 A0A026WP20 A0A2A3E5Q1 A0A0M8ZTN7 E2B134 A0A232FEK2 E9ISS9 A0A0C9RMG0 A0A0L7R7V2 A0A0J7L8Z1 A0A0K8TTV8 Q17AF4 A0A182H8Y4 T1PIS0 E2B3T6 A0A0L0BWW8 A0A310ST51 A0A1I8Q0D3 E0VLR9 A0A1S4JPK0 B0WPU9 A0A1B6DZC8 A0A1B6CM31 A0A1Q3FDF1 U5EZH1 K7ISG4 A0A1L8DCL3 A0A182UX75 A0A182TV00 A0A182KNI3 A0A182I738 Q7PWT9 A0A182XDJ2 A0A1A9W0N1 A0A182P9P5 A0A182SFT8 A0A182Y965 A0A069DZD1 A0A182K2D8 Q24185 B4PAF2 B4KE73 O61493 B4I5P7 A0A0J9R4L2 B4Q9E6 A0A084VYH8 A0A182IM59 A0A182MX01 A0A0V0G8S8 A0A182VU68 A0A1B0FED5 A0A0A1X6Y1 A0A2H8TUC1 A0A182Q0Q3 A0A087SZD1 B4JAL5 B3NL60 A0A182R495 W8BLJ4 B4G831 Q29N92 A0A1S3JY27 X1WI74 A0A034WSG8 A0A0M4E289 A0A0T6AY59 A0A1S3JYV2 B4N1C2 A0A1W4VXV5 A0A3B0KIG6 B3MNR6 A0A2I3RKX2 A0A1S3T6Q8 A0A060YGG2 A0A2K5REI0 A0A287BKK1 U3FCZ1 A0A3P8ZY25 A0A2K5REE4 A0A2I3G802 F6Y567 A0A3P8ZXE9 F6SN44 A0A2K6AZW3 A0A2K5P0L8 H9EMU3 A0A2K5REL4 A0A0D9RR18

Pubmed

26354079 22118469 28756777 24508170 30249741 20798317 + More
28648823 21282665 26369729 17510324 26483478 25315136 26108605 20566863 20075255 20966253 12364791 25244985 26334808 8682859 9927460 10731132 12537572 12537569 10198042 11018772 11238449 17435236 17994087 22936249 24438588 25830018 24495485 15632085 25348373 16136131 24755649 25243066 25069045 17495919 17431167 25319552

EMBL

NWSH01000238 PCG78115.1 KQ459597 KPI94994.1 ODYU01012974 SOQ59544.1 + More
KQ461150 KPJ08685.1 AGBW02007682 OWR54762.1 KZ149903 PZC78432.1 NEVH01006601 PNF37389.1 AJVK01006738 KQ434899 KZC10839.1 KK107139 QOIP01000003 EZA57765.1 RLU24945.1 KZ288368 PBC26814.1 KQ435851 KOX70727.1 GL444771 EFN60607.1 NNAY01000364 OXU28869.1 GL765434 EFZ16289.1 GBYB01008166 GBYB01014123 GBYB01014784 JAG77933.1 JAG83890.1 JAG84551.1 KQ414637 KOC66962.1 LBMM01000169 KMR04646.1 GDAI01000025 JAI17578.1 CH477336 JXUM01029776 JXUM01029777 JXUM01029778 KQ560864 KXJ80579.1 KA648000 AFP62629.1 GL445407 EFN89605.1 JRES01001220 KNC24501.1 KQ760629 OAD59735.1 DS235281 EEB14325.1 DS232030 GEDC01006289 JAS31009.1 GEDC01022870 JAS14428.1 GFDL01009537 JAV25508.1 GANO01000807 JAB59064.1 GFDF01009885 JAV04199.1 APCN01003355 AAAB01008984 GBGD01000850 JAC88039.1 U48362 AF044925 AE014134 AY069337 CM000158 CH933807 AF044926 CH940649 CH480822 CM002910 KMY90921.1 CM000361 ATLV01018368 KE525231 KFB43022.1 AXCM01001645 GECL01001577 JAP04547.1 CCAG010005326 GBXI01007636 JAD06656.1 GFXV01006040 MBW17845.1 AXCN02002096 KK112659 KFM58220.1 CH916368 CH954179 GAMC01006880 GAMC01006878 JAB99677.1 CH479180 CH379060 ABLF02025518 ABLF02025519 GAKP01001353 JAC57599.1 CP012523 ALC39666.1 LJIG01022568 KRT79883.1 CH963920 OUUW01000010 SPP86209.1 CH902620 AACZ04065546 AACZ04065547 FR910946 CDQ90801.1 AEMK02000105 GAMS01006536 GAMQ01004075 JAB16600.1 JAB37776.1 ADFV01051634 ADFV01051635 ADFV01051636 ADFV01051637 ADFV01051638 ADFV01051639 ADFV01051640 ADFV01051641 JSUE03041287 JSUE03041288 JSUE03041289 JSUE03041290 JSUE03041291 JU319946 JU473153 AFE63702.1 AFH29957.1 AQIB01117073 AQIB01117074 AQIB01117075 AQIB01117076

Proteomes

UP000218220 UP000053268 UP000053240 UP000007151 UP000235965 UP000092462 + More
UP000076502 UP000005203 UP000053097 UP000279307 UP000242457 UP000053105 UP000000311 UP000215335 UP000053825 UP000036403 UP000008820 UP000069940 UP000249989 UP000095301 UP000008237 UP000037069 UP000095300 UP000009046 UP000002320 UP000002358 UP000075903 UP000075902 UP000075882 UP000075840 UP000007062 UP000076407 UP000091820 UP000075885 UP000075901 UP000076408 UP000075881 UP000000803 UP000002282 UP000009192 UP000008792 UP000001292 UP000000304 UP000030765 UP000075880 UP000075883 UP000075920 UP000092444 UP000075886 UP000054359 UP000001070 UP000008711 UP000075900 UP000008744 UP000001819 UP000085678 UP000007819 UP000092553 UP000007798 UP000192221 UP000268350 UP000007801 UP000002277 UP000087266 UP000193380 UP000233040 UP000008227 UP000008225 UP000265140 UP000001073 UP000002280 UP000006718 UP000233120 UP000233060 UP000029965

PRIDE

A0A088AJ37 Q17AF4 B0WPU9 Q24185 B4KE73 B4G831 + More
Q29N92 B4N1C2 B3MNR6

Pfam

PF05622   HOOK        + More
PF10504   DUF2452
PF00010   HLH
PF07527   Hairy_orange

Interpro

IPR001715   CH-domain        + More
IPR036872   CH_dom_sf
IPR008636   Hook-like_fam
IPR019534   DUF2452
IPR003650   Orange_dom
IPR011598   bHLH_dom
IPR036638   HLH_DNA-bd_sf

SUPFAM

SSF47459 SSF47459

Gene 3D

1.10.418.10 4.10.280.10

CDD

cd00083 HLH

ProteinModelPortal

A0A2A4K1H3 A0A194PQH8 A0A2H1X4H9 A0A194QUN1 A0A212FLZ6 A0A2W1BTM1 + More
A0A2J7R974 A0A1B0DLJ1 A0A154PG53 A0A088AJ37 A0A026WP20 A0A2A3E5Q1 A0A0M8ZTN7 E2B134 A0A232FEK2 E9ISS9 A0A0C9RMG0 A0A0L7R7V2 A0A0J7L8Z1 A0A0K8TTV8 Q17AF4 A0A182H8Y4 T1PIS0 E2B3T6 A0A0L0BWW8 A0A310ST51 A0A1I8Q0D3 E0VLR9 A0A1S4JPK0 B0WPU9 A0A1B6DZC8 A0A1B6CM31 A0A1Q3FDF1 U5EZH1 K7ISG4 A0A1L8DCL3 A0A182UX75 A0A182TV00 A0A182KNI3 A0A182I738 Q7PWT9 A0A182XDJ2 A0A1A9W0N1 A0A182P9P5 A0A182SFT8 A0A182Y965 A0A069DZD1 A0A182K2D8 Q24185 B4PAF2 B4KE73 O61493 B4I5P7 A0A0J9R4L2 B4Q9E6 A0A084VYH8 A0A182IM59 A0A182MX01 A0A0V0G8S8 A0A182VU68 A0A1B0FED5 A0A0A1X6Y1 A0A2H8TUC1 A0A182Q0Q3 A0A087SZD1 B4JAL5 B3NL60 A0A182R495 W8BLJ4 B4G831 Q29N92 A0A1S3JY27 X1WI74 A0A034WSG8 A0A0M4E289 A0A0T6AY59 A0A1S3JYV2 B4N1C2 A0A1W4VXV5 A0A3B0KIG6 B3MNR6 A0A2I3RKX2 A0A1S3T6Q8 A0A060YGG2 A0A2K5REI0 A0A287BKK1 U3FCZ1 A0A3P8ZY25 A0A2K5REE4 A0A2I3G802 F6Y567 A0A3P8ZXE9 F6SN44 A0A2K6AZW3 A0A2K5P0L8 H9EMU3 A0A2K5REL4 A0A0D9RR18

PDB

5J8E E-value=5.88427e-36, Score=380

KEGG

101736491 K16536 protein HOOK3 | (RefSeq) protein hook-like

GO

GO:0008017 GO:0005874 GO:0030705 GO:0006897 GO:0005768 GO:0005813 GO:0031122 GO:0005737 GO:0051959 GO:0045202 GO:0008340 GO:0030054 GO:0017137 GO:0007275 GO:0003677 GO:0046983 GO:0006355 GO:0005634 GO:0005801 GO:0070695 GO:0034454 GO:0071539 GO:0042802 GO:0007032 GO:0007040 GO:0008333 GO:0034451 GO:0045503 GO:0022027 GO:0005829 GO:0045022 GO:0097150 GO:0000242 GO:0034452 GO:0030897 GO:0051645 GO:0045505 GO:0050768 GO:0005515

Subcellular location

Cytoplasm
Cytoskeleton
Endosome
Cell junction   Enriched at neuromuscular synapses, in both presynaptic and postsynaptic regions.   With evidence from 5 publications.
Synapse   Enriched at neuromuscular synapses, in both presynaptic and postsynaptic regions.   With evidence from 5 publications.
Nucleus

Length:

612

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00017

Exp number, first 60 AAs:

0.00017

Total prob of N-in:

0.00033

outside

1 - 612

Pi

237.961015

Theta

161.27571

Tajima's D

1.635984

CLR

0.535079

CSRT

0.815909204539773

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics