Gene

KWMTBOMO02875

Annotation

PREDICTED:_cytosolic_carboxypeptidase_4-like_[Bombyx_mori]

Location

Bomo_Chr5(+):13034744-13057510      View in EpiBrowser

Full name

Cytosolic carboxypeptidase 1      

Alternative Name

ATP/GTP-binding protein 1

Location in the cell

Extracellular   Reliability : 1.087 Nuclear   Reliability : 1.444

CDS

ATGTTGCCAGCCTTGATGCACAGAATATCACCTGCTTTTGCACTCGGTTCGTGTTCTTTCCGTGTAGAAAGAGAAAGGGAGAGTACCGCTCGGGTAACGGTATGGAGACACCTTGGTGTTACGCGCTCTTACACAATGGAAGCCTCTTTCTGCGGTTTCGATCGTGGACCTTTTAAGGGTTTCCACCTGAACACCCAGCACCTGCAGAATGTCGGCAGCGACTTTTGTGAAGCTCTTAATGGATTGAACGACAGCGCTGCTAATGTCGACATTCAGCTAACGAAAGACCTGAATGGCGAGGCAGCGGTGGAAAGCGAACTGGGCTCCGGCTCTGATAGCGTTCTGAAAACCGATTCAGATGAAGACTTTGATTAG

Protein

MLPALMHRISPAFALGSCSFRVERERESTARVTVWRHLGVTRSYTMEASFCGFDRGPFKGFHLNTQHLQNVGSDFCEALNGLNDSAANVDIQLTKDLNGEAAVESELGSGSDSVLKTDSDEDFD

Description

Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate.

Cofactor

Zn(2+)

Similarity

Belongs to the peptidase M14 family.

Keywords

Carboxypeptidase   Complete proteome   Cytoplasm   Hydrolase   Metal-binding   Metalloprotease   Mitochondrion   Nucleus   Protease   Reference proteome   Zinc  

Feature

chain  Cytosolic carboxypeptidase 1

Uniprot

A0A2W1BVR6   A0A212FLY7   A0A2H1X2J4   A0A2A4K1G4   A0A2A4K2V9   A0A194QYM5   + More
A0A194PPU5   A0A0L7LG24   A0A0C9QI19   A0A0L7RBK9   A0A2A3EUK7   A0A154PLW7   A0A310SG35   A0A088ACX1   A0A3L8DG93   A0A195BPK7   A0A091NAW7   A0A093FAN0   A0A091MH26   A0A094L4A4   U3IVU6   A0A2P4SWC8   H0YXY9   A0A091MZ86   Q80TL9   A0A1S3JTQ9   A0A226NB39   A0A226PKT4   A0A3P8W1W9   A0A2D4JYU8   A0A2H6N9Y7   A0A286YDV2   A0A3P8VZ54   A0A1B6K6N5   G3NXR8   E1C3P4   A0A1S3JTZ6   A0A1S3JTA4   R9PXP2   U3JLV1   G1N3X3   G1N3Y3   A0A2C9KMQ5   A0A2I0UGW3   A0A2C9KMW1   A0A3P9LD14   A0A3P9HHF1   A0A2C9KMQ7   A0A3P9J2P8   H2LKZ5   A0A218V952   H2LKZ4   H2LKZ6   A0A091TTM2   A0A3P9LD56  

EC Number

3.4.17.-

Pubmed

28756777    22118469    26354079    26227816    30249741    20360741    + More
12693553    24621616    24487278    19468303    21183079    15592404    20838655    15562597    17554307   

EMBL

KZ149903    PZC78431.1    AGBW02007682    OWR54763.1    ODYU01012974    SOQ59543.1    + More
NWSH01000238    PCG78111.1    PCG78113.1    KQ461150    KPJ08686.1    KQ459597    KPI94993.1    JTDY01001263    KOB74350.1    GBYB01014338    JAG84105.1    KQ414617    KOC68249.1    KZ288185    PBC34962.1    KQ434977    KZC12842.1    KQ773785    OAD52362.1    QOIP01000008    RLU19331.1    KQ976424    KYM88452.1    KL379274    KFP86177.1    KK390971    KFV54722.1    KK825849    KFP72695.1    KL359261    KFZ64322.1    PPHD01019402    POI28421.1    ABQF01033238    ABQF01033239    KK840161    KFP82808.1    AK122423    BAC65705.1    MCFN01000111    OXB64804.1    AWGT02000056    OXB80122.1    IACL01025140    LAB01574.1    IACI01077717    LAA27867.1    AC135469    AC155298    GECU01036341    GECU01001020    GECU01000594    JAS71365.1    JAT06687.1    JAT07113.1    AADN02064844    AADN02064845    AADN02064846    AADN02064847    AADN02064848    AADN02064849    AADN02064850    AADN02064851    AC186856    AGTO01001391    AGTO01021630    KZ505770    PKU45270.1    MUZQ01000025    OWK62554.1    KK486085    KFQ62006.1   

Proteomes

UP000007151    UP000218220    UP000053240    UP000053268    UP000037510    UP000053825    + More
UP000242457    UP000076502    UP000005203    UP000279307    UP000078540    UP000007754    UP000085678    UP000198323    UP000198419    UP000265120    UP000000589    UP000007635    UP000000539    UP000016665    UP000001645    UP000076420    UP000265180    UP000265200    UP000001038    UP000197619   

PRIDE

E1C3P4   

Pfam

PF00246   Peptidase_M14        + More
PF18027   Pepdidase_M14_N

Interpro

IPR040626   Pepdidase_M14_N        + More
IPR000834   Peptidase_M14       
IPR016024   ARM-type_fold       
IPR011989   ARM-like       
IPR033852   Cytosolic_aminopeptidase_1       

SUPFAM

SSF48371   SSF48371       

Gene 3D

1.25.10.10    

CDD

cd06906  M14_Nna1

ProteinModelPortal

A0A2W1BVR6   A0A212FLY7   A0A2H1X2J4   A0A2A4K1G4   A0A2A4K2V9   A0A194QYM5   + More
A0A194PPU5   A0A0L7LG24   A0A0C9QI19   A0A0L7RBK9   A0A2A3EUK7   A0A154PLW7   A0A310SG35   A0A088ACX1   A0A3L8DG93   A0A195BPK7   A0A091NAW7   A0A093FAN0   A0A091MH26   A0A094L4A4   U3IVU6   A0A2P4SWC8   H0YXY9   A0A091MZ86   Q80TL9   A0A1S3JTQ9   A0A226NB39   A0A226PKT4   A0A3P8W1W9   A0A2D4JYU8   A0A2H6N9Y7   A0A286YDV2   A0A3P8VZ54   A0A1B6K6N5   G3NXR8   E1C3P4   A0A1S3JTZ6   A0A1S3JTA4   R9PXP2   U3JLV1   G1N3X3   G1N3Y3   A0A2C9KMQ5   A0A2I0UGW3   A0A2C9KMW1   A0A3P9LD14   A0A3P9HHF1   A0A2C9KMQ7   A0A3P9J2P8   H2LKZ5   A0A218V952   H2LKZ4   H2LKZ6   A0A091TTM2   A0A3P9LD56  

KEGG

101736629    K23435 cytosolic carboxypeptidase protein 1 [EC:3.4.17.-] | (RefSeq) cytosolic carboxypeptidase 4-li

GO

GO:0008270   GO:0004181   GO:0004180   GO:0021702   GO:0005829   GO:0021772   GO:0005739   GO:0005737   GO:0005634   GO:0015631   GO:0007005   GO:0035610   GO:0050905   GO:0001754   GO:0035609   GO:0042133   GO:0005730   GO:0007628   GO:0060041   GO:0016021  

Subcellular location

Cytoplasm  
Cytosol  
Nucleus  
Mitochondrion  

Length:

124

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01505

Exp number, first 60 AAs:

0.01505

Total prob of N-in:

0.07375

outside

1  -  124

 

 

Pi

272.582285

Theta

196.226926

Tajima's D

1.910352

CLR

0.198023

CSRT

0.867306634668267

Interpretation

Uncertain