Gene

KWMTBOMO02862

Pre Gene Modal

BGIBMGA003529

Annotation

PREDICTED:_nicotinic_acetylcholine_receptor_subunit_alpha_5_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr5(+):12813774-12851821      View in EpiBrowser

Location in the cell

PlasmaMembrane   Reliability : 4.422

CDS

ATGTTTTATTCCTTATGTTGCGATGAGGAGTACAGATTAGTTCGTCACCTCATGCAAAAGTATGATGCATCAGTTCGGCCCGTGGAGAACTCTTCGCATCCTCTCCTTGTGACATTTGGAGTTTCACTTCATCATATCATCGATGTGGAGGAGAAAGATCAGCTGTTAACAACAAACTGTTGGATTACGCAAATATGGACGGATTTTCATTTGCGATGGAACACTAGTGACTTCGACGGTATCAGCGTCATTCGAATACCATATGAGAGGGTCTGGAGACCAGACATTATTTTGTATAACAATGCGGATCCAAACTATCGTTCAGCGGTTATTAATACGAACGTAATAGTTAAGTACACTGGCGAAGTGACCTGGCTGAGTCATGGGATTTATGTGTCTGTATGCGATATCAATGTGGAGCAGTTCCCTTTTGATGTGCAACTCTGTACCATGAAATGGGCGTCTTGGACCTACGACGGATTTCAGTTGGATTTAAAAAAGCAATTCGACGAAGGTGATACTACCAACTATCAAACCAACGGTGAATTTGATTTGGTCAGCTTCGAGGCTATCAGACATGATCAGTACTACTCTTGCTGCGTTGAACCCTACCCTGATATAACGTATGTAATTAAGTTACGTAGGAGACCGATGTTCTACGTGTTCAACCTTATTCTTCCATGTTTACTCATCAACGGAATTGCACTCCTTGTTTTCTACGTGCCGTCGGAATCCGGAGAAAAAGTGACATTGGGGATAAGCGCATTATTATCCATGACCGTCTTCCTGATGACAATTAGAGATACATTACCGCCAACTGAAAAGACTCCGCTAATAAGTTTGTACTACGGAGTCAGCACGTGCCTAGTTTCATTTTCAGCTTCACTATCCGTGGTCACCCTCAACATATCTTACAGAGGAGTGAGAGGGCAGCCTGTACCGGCGGTGGTGCGTGACGTCGTGCTGCATCGACTCGCGCGTCTTCTGTTCATCAACTTCGACATTGACGCAAAGGGTGACAGCAGGGCACAGAGCAGTGTGCCAGTGAACCCTCGTACAGGTTCGCGGTTGAAAGCAGAAGTTCGTTGCGATGGAGTACCACTGACTCCAGCCTCGCCCAGATTTGTGCGCCACAATCAAAATCATCTAGCTGGGGCAGCTGCCACAGTTGGGGGGGCTAGCACAACAAGCAGTGAGCCGGTCTGTGTCGCCTCCTGCGCCCGGTGCGTTTGCTGCGGTTGCACGCTGCGAGAGGCCGCAGCCAGACATGAACAACGAGTCGCCGCCAATGAAAGACTCGAGCGAGCCAATTTAGAATGGAAACAGGTGGCAGTGGTAGCAGATCGAGCCCTGCTGGCAGTATTTGTTCTAGTCACAACCATAGCTACGGCGGCCATCTTACTCCCACAGTTGAACAACCTACACGTCGGCAACACACCTCTCAAACCACCCATTTAG

Protein

MFYSLCCDEEYRLVRHLMQKYDASVRPVENSSHPLLVTFGVSLHHIIDVEEKDQLLTTNCWITQIWTDFHLRWNTSDFDGISVIRIPYERVWRPDIILYNNADPNYRSAVINTNVIVKYTGEVTWLSHGIYVSVCDINVEQFPFDVQLCTMKWASWTYDGFQLDLKKQFDEGDTTNYQTNGEFDLVSFEAIRHDQYYSCCVEPYPDITYVIKLRRRPMFYVFNLILPCLLINGIALLVFYVPSESGEKVTLGISALLSMTVFLMTIRDTLPPTEKTPLISLYYGVSTCLVSFSASLSVVTLNISYRGVRGQPVPAVVRDVVLHRLARLLFINFDIDAKGDSRAQSSVPVNPRTGSRLKAEVRCDGVPLTPASPRFVRHNQNHLAGAAATVGGASTTSSEPVCVASCARCVCCGCTLREAAARHEQRVAANERLERANLEWKQVAVVADRALLAVFVLVTTIATAAILLPQLNNLHVGNTPLKPPI

Similarity

Belongs to the ligand-gated ion channel (TC 1.A.9) family.

Uniprot

A8HTC1   A0A2W1BYV0   A0A0H4TM36   A0A194PQG9   A0A194QUP1   A0A348BSV6   + More
A8HTE9   A0A2S1B6P6   C3TS20   A0A1D8GS66   A0A067R5X7   A0A158NZD7   W6EAF4   A0A2Z4N607   A0A3L8DZY2   A0A026W9B6   A0A0P6GTI1   A0A0P6AM36   E9HUI5   A0A0L7QYL0   U4TVR2   A0A0P4YKH4   A0A0H3V1C5   Q6Q069   A0A088AFB2   A0A212F1D4   A0A023F0K8   D3UA17   K7IMH8   A0A0M8ZYQ8   T1ICY5   A0A0P6IF94   A0A154P481   A0A1L4BJY1   A0A151WKI1   F4W9W4   T1J4J6   A0A195EDQ6   A0A1D2MNN8   E2A4Q1   A0A087ZW31   A0A0P5UJU5   E9IFQ3   A0A0P6CZD4   A0A0P5BSC8   T1JEQ2   E9GWC2   A0A1L4BJY7   A0A0P5QWF3   A0A0P5UNE6   A0A0P5PRT4   A0A0P5DFI1   A0A2J7Q4L8   K1QDZ2  

Pubmed

28756777    26354079    18362917    19320762    19820115    24845553    + More
21347285    25701599    30249741    24508170    21292972    23537049    15656979    22118469    25474469    20087392    20075255    21719571    27289101    20798317    21282665    22992520   

EMBL

EU143796    ABV72687.1    KZ149903    PZC78417.1    KP711047    AKQ12743.1    + More
KQ459597    KPI94984.1    KQ461150    KPJ08695.1    LC389180    BBE49559.1    EU143805    EU930059    EU930060    KQ971338    ABV72696.1    ACM09854.1    KYB28011.1    MF197919    AWC68049.1    EU930050    ACM09845.1    KU557779    AOT81841.1    KK852672    KDR18759.1    ADTU01000884    ADTU01000885    ADTU01000886    KF873584    AHJ11213.1    MF612145    AWX65633.1    QOIP01000002    RLU25862.1    KK107321    EZA52692.1    GDIP01167615    GDIQ01029819    LRGB01000715    JAJ55787.1    JAN64918.1    KZS16441.1    GDIP01027544    JAM76171.1    GL732811    EFX64585.1    KQ414688    KOC63646.1    KB631738    ERL85674.1    GDIP01228279    JAI95122.1    KJ939592    AJE70263.1    AY569781    AAS75781.1    AGBW02010901    OWR47534.1    GBBI01004213    JAC14499.1    FJ821434    ACY82688.1    KQ435821    KOX72333.1    ACPB03013331    GDIQ01006926    JAN87811.1    KQ434803    KZC05930.1    KX021836    API81626.1    KQ983012    KYQ48368.1    GL888033    EGI69100.1    JH431845    KQ979039    KYN23338.1    LJIJ01000767    ODM94689.1    GL436716    EFN71585.1    GDIP01111883    JAL91831.1    GL762889    EFZ20594.1    GDIQ01085291    JAN09446.1    GDIP01185119    JAJ38283.1    JH432127    GL732570    EFX76216.1    KX021835    API81625.1    GDIQ01109087    JAL42639.1    GDIP01111889    JAL91825.1    GDIQ01130517    JAL21209.1    GDIP01157045    JAJ66357.1    NEVH01018378    PNF23525.1    JH815881    EKC29304.1   

Proteomes

UP000053268    UP000053240    UP000007266    UP000027135    UP000005205    UP000279307    + More
UP000053097    UP000076858    UP000000305    UP000053825    UP000030742    UP000005203    UP000007151    UP000002358    UP000053105    UP000015103    UP000076502    UP000075809    UP000007755    UP000078492    UP000094527    UP000000311    UP000235965    UP000005408   

PRIDE

A8HTC1   

Pfam

PF02932   Neur_chan_memb        + More
PF02931   Neur_chan_LBD
PF17906   HTH_48

Interpro

IPR036719   Neuro-gated_channel_TM_sf        + More
IPR002394   Nicotinic_acetylcholine_rcpt       
IPR036734   Neur_chan_lig-bd_sf       
IPR006202   Neur_chan_lig-bd       
IPR006029   Neurotrans-gated_channel_TM       
IPR006201   Neur_channel       
IPR018000   Neurotransmitter_ion_chnl_CS       
IPR041426   Mos1_HTH       
IPR036388   WH-like_DNA-bd_sf       

SUPFAM

SSF63712   SSF63712        + More
SSF90112   SSF90112       

Gene 3D

2.70.170.10     1.10.10.10    

ProteinModelPortal

A8HTC1   A0A2W1BYV0   A0A0H4TM36   A0A194PQG9   A0A194QUP1   A0A348BSV6   + More
A8HTE9   A0A2S1B6P6   C3TS20   A0A1D8GS66   A0A067R5X7   A0A158NZD7   W6EAF4   A0A2Z4N607   A0A3L8DZY2   A0A026W9B6   A0A0P6GTI1   A0A0P6AM36   E9HUI5   A0A0L7QYL0   U4TVR2   A0A0P4YKH4   A0A0H3V1C5   Q6Q069   A0A088AFB2   A0A212F1D4   A0A023F0K8   D3UA17   K7IMH8   A0A0M8ZYQ8   T1ICY5   A0A0P6IF94   A0A154P481   A0A1L4BJY1   A0A151WKI1   F4W9W4   T1J4J6   A0A195EDQ6   A0A1D2MNN8   E2A4Q1   A0A087ZW31   A0A0P5UJU5   E9IFQ3   A0A0P6CZD4   A0A0P5BSC8   T1JEQ2   E9GWC2   A0A1L4BJY7   A0A0P5QWF3   A0A0P5UNE6   A0A0P5PRT4   A0A0P5DFI1   A0A2J7Q4L8   K1QDZ2  

PDB

6CNK     E-value=5.05858e-71,     Score=681

KEGG

100126157    K05312 nicotinic acetylcholine receptor, invertebrate | (RefSeq) nAChRa5, Achra5; nicotinic acetylch

GO

GO:0045211   GO:0030054   GO:0022848   GO:0016021   GO:0004888   GO:0006811   GO:0007165   GO:0042391   GO:0050877   GO:0007268   GO:0034220   GO:0045202   GO:0005887   GO:0043005   GO:0005230   GO:0006810   GO:0016020   GO:0004889   GO:0005216   GO:0006281   GO:0048384  

PANTHER

PTHR18945  

Subcellular location

Cell junction  
Synapse  
Postsynaptic cell membrane  
Cell membrane  

Length:

485

Number of predicted TMHs:

4

Exp number of AAs in TMHs:

80.64925

Exp number, first 60 AAs:

0.0053

Total prob of N-in:

0.25160

outside

1  -  219

TMhelix

220  -  242

inside

243  -  248

TMhelix

249  -  266

outside

267  -  280

TMhelix

281  -  303

inside

304  -  449

TMhelix

450  -  472

outside

473  -  485

 

 

Pi

247.902762

Theta

184.720452

Tajima's D

1.097259

CLR

0.16574

CSRT

0.68281585920704

Interpretation

Uncertain