Gene

KWMTBOMO02856

Pre Gene Modal

BGIBMGA003663

Annotation

PREDICTED:_methionine_aminopeptidase_1D?_mitochondrial_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr5(-):12751348-12757813      View in EpiBrowser

Full name

Methionine aminopeptidase      

Location in the cell

Cytoplasmic   Reliability : 1.432 Mitochondrial   Reliability : 1.131

CDS

ATGAGGGTGCCGAAAGCCGTTAATCCCAGGAAACGGCTTCAGTTGTTGAAAAAGTTTGGTATTTACGAAAAAGTTTTACCTGTAGAAACAACTCCAAGTCGAGTTGTACCAGATACCATTGAAAGACCTGATTATTTAGCTAGAGGAAAACAATTGACATTACCATGTTTACCGGAGATTAAAGATGATAATCAATTGAAAGGAATGAGAACTAGCTGTAAATTGGCTTCTACTATTCTATCACAAGTGCAAAATTTTATAAAGCCTGGAGTTACAACAGATGACATTGATCAACTAGTCCATTCGTTAATAATTAAAGCTGGAGCATACCCTTCACCACTTCATTATAAGGGATTCCCAAAAAGTATTTGTACATCTGTCAATAATGTGGCTGTGCATGGTATTCCTGATCTAAGGCCACTATCTGATGGGGATATTGTCAATGTTGATATAACAGTATTTTTACATGGTTTTCATGGCGATTGCTCAAAAACTTTCAAAGTTGGTAATGTAGACGACAGAGGTCTACAACTAGTTGAAATCACCGAGCAATGTCTTGGAATCGGAATCGGAACATGCGGGCCAGGAGTACCATTCAGTGAAATCGGCGCCAGCATTCAAAGGCACGCACGTAGAAATGGCCTCACTGTTATACCATCGATTGTGGGTCATGGAATTGGACAGTATTTTCATGGGCCACCAGATATTTATCACATAAGAAACCGTTATCCAGGAGTAATGAAAGCAGGAATGACATTTACAATAGAACCAGTCGTTTCACATGGGACTCAAAATACTGTCTTATTAGATGATGGCTGGACGATTTTAACAGAGGACGGATCGAGAACATCTCAGATCGAACATACCGTATTAATTACTGATGATGGAGTAGAAATCTTAACGAAATGA

Protein

MRVPKAVNPRKRLQLLKKFGIYEKVLPVETTPSRVVPDTIERPDYLARGKQLTLPCLPEIKDDNQLKGMRTSCKLASTILSQVQNFIKPGVTTDDIDQLVHSLIIKAGAYPSPLHYKGFPKSICTSVNNVAVHGIPDLRPLSDGDIVNVDITVFLHGFHGDCSKTFKVGNVDDRGLQLVEITEQCLGIGIGTCGPGVPFSEIGASIQRHARRNGLTVIPSIVGHGIGQYFHGPPDIYHIRNRYPGVMKAGMTFTIEPVVSHGTQNTVLLDDGWTILTEDGSRTSQIEHTVLITDDGVEILTK

Description

Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

Catalytic Activity

Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.

Similarity

Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
Belongs to the peptidase M24A family.

Feature

chain  Methionine aminopeptidase

Uniprot

A0A194QT48   A0A2W1BIT7   A0A2A4J6L5   A0A194PV21   A0A2H1W0H7   A0A139WFT0   + More
A0A1Y1LLJ2   A0A0T6B2D2   A0A0M9A8W1   A0A2A3EJC5   A0A2J7QKU0   K7IPQ7   A0A158P1G2   A0A310SL33   N6TD21   A0A195F3D6   U4UFB3   A0A232ERQ6   A0A182RLC3   A0A151I2D3   A0A182K2U9   A0A182I7M7   F4WYJ4   A0A195CU66   A0A182QAV1   A0A182NBE8   A0A182SVX6   A0A1B6LTB6   E2BNX3   A0A182VE41   A0A1B6IGF3   A0A182U821   E2AWR2   A0A182LMD7   A0A1B6F8M9   A0A1B6JTD1   E9IJM3   A0A182ISS7   A0A1B6IFU2   Q7PWC9   A0A067QPD7   A0A182GI67   Q16K07   A0A026X1V3   A0A151X7C0   A0A182GBE7   A0A182VU20   B0XHA3   A0A369SEK8   A0A1L8E2W7   A0A0P5P536   A0A0P5J527   B3RPM1   A0A195E2Q4   A0A084VKI8   A0A1W4UT93   A0A1A9W0P3   A0A1Q3FDL9   E0VVC1   A0A1I8NDJ9   A0A1A9UDC1   A0A2J7QKR7   W5J3I3   A0A1I8PHN9   A0A0L0CGW9   A0A1B0FEQ1   D3TL49   A0A1B0DPY8   A0A0V0G995   A0A2S2QR89   A0A0Q9W8A1   B4MUC6   A0A2R7X0H5   A0A0P4WD60   A0A224XV30   A0A226F6J1   A0A1B0BV25   A0A182WXR4   A0A2H8TF84   A0A154P1I2   A0A0Q9W9E6   B4HWP5   A0A0C9QZP1   A0A1W4WW54   A0A2P8XKX7   A0A0P6JSW7   A0A0P6BVH9   A0A0P4VWL1   R4G8V2   A0A0L7RD34   A0A0Q9WFK2   H1UUC3   A0A1W4WKA7   C3XSK2   Q9VKV9   R7UJT7   A0A1B6E9Y8   B4KHR7   A0A069DRZ4  

EC Number

3.4.11.18

Pubmed

26354079    28756777    18362917    19820115    28004739    20075255    + More
21347285    23537049    28648823    21719571    20798317    20966253    21282665    12364791    14747013    17210077    24845553    26483478    17510324    24508170    30249741    30042472    18719581    24438588    20566863    25315136    20920257    23761445    26108605    20353571    17994087    29403074    27129103    18563158    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    23254933    26334808   

EMBL

KQ461150    KPJ08698.1    KZ150123    PZC73147.1    NWSH01003044    PCG67063.1    + More
KQ459597    KPI94980.1    ODYU01005295    SOQ46014.1    KQ971351    KYB26774.1    GEZM01058144    JAV71867.1    LJIG01016105    KRT81599.1    KQ435711    KOX79625.1    KZ288248    PBC31131.1    NEVH01013258    PNF29178.1    ADTU01006535    KQ762882    OAD55381.1    APGK01035263    KB740923    ENN78234.1    KQ981852    KYN34973.1    KB632333    ERL92669.1    NNAY01002575    OXU21017.1    KQ976538    KYM81320.1    APCN01003428    GL888450    EGI60726.1    KQ977305    KYN03679.1    AXCN02000624    GEBQ01013118    JAT26859.1    GL449511    EFN82565.1    GECU01021708    JAS85998.1    GL443403    EFN62138.1    GECZ01023181    JAS46588.1    GECU01005294    JAT02413.1    GL763868    EFZ19235.1    GECU01021920    JAS85786.1    AAAB01008984    EAA15067.5    KK853095    KDR11489.1    JXUM01065414    KQ562346    KXJ76104.1    CH477982    EAT34618.1    KK107024    QOIP01000004    EZA62257.1    RLU23434.1    KQ982450    KYQ56272.1    JXUM01052463    KQ561734    KXJ77693.1    DS233123    EDS28269.1    NOWV01000017    RDD45296.1    GFDF01001105    JAV12979.1    GDIQ01154530    JAK97195.1    GDIQ01206924    LRGB01001036    JAK44801.1    KZS13678.1    DS985242    EDV28214.1    KQ979709    KYN19445.1    ATLV01014226    KE524948    KFB38482.1    GFDL01009467    JAV25578.1    DS235809    EEB17327.1    PNF29177.1    ADMH02002194    ETN57883.1    JRES01000410    KNC31486.1    CCAG010014451    EZ422149    ADD18344.1    AJVK01008353    GECL01001728    JAP04396.1    GGMS01011083    MBY80286.1    CH940649    KRF81032.1    CH963857    EDW76052.2    KK856248    PTY25293.1    GDRN01072657    JAI63524.1    GFTR01004587    JAW11839.1    LNIX01000001    OXA64821.1    JXJN01021048    GFXV01000961    MBW12766.1    KQ434796    KZC05799.1    KRF81030.1    CH480818    EDW52440.1    GBYB01006172    JAG75939.1    PYGN01001820    PSN32658.1    GDIQ01009739    JAN84998.1    GDIP01016931    JAM86784.1    GDKW01002612    JAI53983.1    GAHY01000327    JAA77183.1    KQ414615    KOC68671.1    KRF81031.1    BT133007    AEX66193.1    GG666459    EEN68923.1    AE014134    AAF52949.2    AMQN01008410    KB303059    ELU03517.1    GEDC01002557    JAS34741.1    CH933807    EDW13354.2    GBGD01002408    JAC86481.1   

Proteomes

UP000053240    UP000218220    UP000053268    UP000007266    UP000053105    UP000242457    + More
UP000235965    UP000002358    UP000005205    UP000019118    UP000078541    UP000030742    UP000215335    UP000075900    UP000078540    UP000075881    UP000075840    UP000007755    UP000078542    UP000075886    UP000075884    UP000075901    UP000008237    UP000075903    UP000075902    UP000000311    UP000075882    UP000075880    UP000007062    UP000027135    UP000069940    UP000249989    UP000008820    UP000053097    UP000279307    UP000075809    UP000075920    UP000002320    UP000253843    UP000076858    UP000009022    UP000078492    UP000030765    UP000192221    UP000091820    UP000009046    UP000095301    UP000078200    UP000000673    UP000095300    UP000037069    UP000092444    UP000092462    UP000008792    UP000007798    UP000198287    UP000092460    UP000076407    UP000076502    UP000001292    UP000192223    UP000245037    UP000053825    UP000001554    UP000000803    UP000014760    UP000009192   

PRIDE

Q9VKV9   

Pfam

PF04419   4F5        + More
PF00557   Peptidase_M24
PF08774   VRR_NUC

Interpro

IPR001714   Pept_M24_MAP        + More
IPR002467   Pept_M24A_MAP1       
IPR007513   Uncharacterised_SERF_N       
IPR036005   Creatinase/aminopeptidase-like       
IPR000994   Pept_M24       
IPR014883   VRR_NUC       

SUPFAM

SSF55920   SSF55920       

CDD

cd01086  MetAP1

ProteinModelPortal

A0A194QT48   A0A2W1BIT7   A0A2A4J6L5   A0A194PV21   A0A2H1W0H7   A0A139WFT0   + More
A0A1Y1LLJ2   A0A0T6B2D2   A0A0M9A8W1   A0A2A3EJC5   A0A2J7QKU0   K7IPQ7   A0A158P1G2   A0A310SL33   N6TD21   A0A195F3D6   U4UFB3   A0A232ERQ6   A0A182RLC3   A0A151I2D3   A0A182K2U9   A0A182I7M7   F4WYJ4   A0A195CU66   A0A182QAV1   A0A182NBE8   A0A182SVX6   A0A1B6LTB6   E2BNX3   A0A182VE41   A0A1B6IGF3   A0A182U821   E2AWR2   A0A182LMD7   A0A1B6F8M9   A0A1B6JTD1   E9IJM3   A0A182ISS7   A0A1B6IFU2   Q7PWC9   A0A067QPD7   A0A182GI67   Q16K07   A0A026X1V3   A0A151X7C0   A0A182GBE7   A0A182VU20   B0XHA3   A0A369SEK8   A0A1L8E2W7   A0A0P5P536   A0A0P5J527   B3RPM1   A0A195E2Q4   A0A084VKI8   A0A1W4UT93   A0A1A9W0P3   A0A1Q3FDL9   E0VVC1   A0A1I8NDJ9   A0A1A9UDC1   A0A2J7QKR7   W5J3I3   A0A1I8PHN9   A0A0L0CGW9   A0A1B0FEQ1   D3TL49   A0A1B0DPY8   A0A0V0G995   A0A2S2QR89   A0A0Q9W8A1   B4MUC6   A0A2R7X0H5   A0A0P4WD60   A0A224XV30   A0A226F6J1   A0A1B0BV25   A0A182WXR4   A0A2H8TF84   A0A154P1I2   A0A0Q9W9E6   B4HWP5   A0A0C9QZP1   A0A1W4WW54   A0A2P8XKX7   A0A0P6JSW7   A0A0P6BVH9   A0A0P4VWL1   R4G8V2   A0A0L7RD34   A0A0Q9WFK2   H1UUC3   A0A1W4WKA7   C3XSK2   Q9VKV9   R7UJT7   A0A1B6E9Y8   B4KHR7   A0A069DRZ4  

PDB

4IU6     E-value=4.50264e-71,     Score=679

KEGG

101745776    K01265 methionyl aminopeptidase [EC:3.4.11.18] | (RefSeq) methionine aminopeptidase 1D, mitochondria

GO

GO:0070006   GO:0046872   GO:0070084   GO:0008235   GO:0004177   GO:0016021   GO:0016788   GO:0006508   GO:0016020   GO:0006241   GO:0030286   GO:0005216   GO:0045211   GO:0006281   GO:0048384  

Length:

302

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.1113

Exp number, first 60 AAs:

0.00017

Total prob of N-in:

0.06720

outside

1  -  302

 

 

Pi

178.601502

Theta

138.648978

Tajima's D

0.741996

CLR

0.04236

CSRT

0.584770761461927

Interpretation

Uncertain