Gene

KWMTBOMO02855

Annotation

PREDICTED:_protein_N-terminal_glutamine_amidohydrolase_[Amyelois_transitella]

Location

Bomo_Chr5(+):12747234-12748852      View in EpiBrowser

Full name

Protein N-terminal glutamine amidohydrolase      

Alternative Name

Protein NH2-terminal glutamine deamidase
Protein tungus

Location in the cell

Nuclear   Reliability : 2.812

CDS

ATGCATTTAAACAGCAATGCAAATATTATAAAGAGTGATAAAACTATAATAAAACCTTTATTCCCTAAACGTGAGGAATGTTCTCATGTGTCCTGTTATTGTGAGGAAAACGTTTGGAAACTTTGCCAAGACGTTTCATTGAGAGTACCCGAGGAATTGGATAGATGCTATGTCGTTTTCATTTCGAACCCTTGCCGCACAGTGCCTCTTTGGAAACAAAGGGCCGGGCGTGAAGAAGATCGTCTCGTCATATGGGATTATCATGTGATATTCCTGTATTCTGTGGATATCAAGTCTTGTCTTGTATATGATCTTGATTCAGAATTACCATTTCCAACATTTTTCCACAAATATGTAACAGAAACTTTTCGCACAGACCAAGTCCTCAAATCAGATTTCCACAGGTTCTTTCGTGTTGTGACTGCAAAACAATTTCTGCAACTTTTTTCATCAGATAGACGTCATATGAAAAGACCAGATGGTTCATGGATTAAACCCCCACCACCCTACCCAGCAATAAGCACTTCAGTCTCAACACACAACTTGGATGAGTACATCAATATGGATGTAGACACAGGACCTGGGCAGGTCTACAACTTGACAGATTTTGTCCAACGTTTCTACAAAATTAACAAGTAG

Protein

MHLNSNANIIKSDKTIIKPLFPKREECSHVSCYCEENVWKLCQDVSLRVPEELDRCYVVFISNPCRTVPLWKQRAGREEDRLVIWDYHVIFLYSVDIKSCLVYDLDSELPFPTFFHKYVTETFRTDQVLKSDFHRFFRVVTAKQFLQLFSSDRRHMKRPDGSWIKPPPPYPAISTSVSTHNLDEYINMDVDTGPGQVYNLTDFVQRFYKINK

Description

Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position.

Catalytic Activity

H2O + N-terminal L-glutaminyl-[protein] = N-terminal L-glutamyl-[protein] + NH4(+)

Subunit

Monomer.

Similarity

Belongs to the NTAQ1 family.

Keywords

Complete proteome   Hydrolase   Reference proteome  

Feature

chain  Protein N-terminal glutamine amidohydrolase

Uniprot

A0A2A4J6B1   A0A2H1VYX9   A0A194QTR1   A0A212EK23   A0A1E1W9Q8   A0A194PNH3   + More
D6WRJ5   A0A1Y1KY22   A0A067QP63   H9J1Z1   A0A1W4ULI2   Q7Q968   B4J8A0   A0A084WJ98   A0A0J9RDF7   B4P6V4   B4QGZ1   B4HSF8   B3NQ86   A0A0B4K882   Q7K2Y9   W8BW00   A0A034VK98   A0A0K8UUZ4   A0A0Q9X7D5   B4KPY6   A0A0A1WH88   B4MQL4   A0A0Q9W0P2   B4MDT2   B3MCF3   A0A1I8NU78   A0A0M3QUL4   Q28WL0   A0A1I8ML72   A0A3B0IXX0   A0A1J1HZC4   B4H701   A0A026WLJ5   E0VBN0   A0A232F4M8   K7IQY2   A0A182WS28   A0A182RQE3   A0A195BJD2   A0A158NQ10   A0A195DFQ1   A0A195CVY2   F4WT76   A0A195FNE7   A0A182WML3   A0A151XG06   A0A182SFM4   A0A182JWU6   A0A182NNL3   W5JMZ8   E2AWL5   A0A0T6BA81   A0A182FEB1   A0A182IK86   A0A088AA24   A0A0L7R6U5   A0A1L8DA99   Q173D8   A0A336MTL6   A0A2A3EIU9   V9IBJ3   A0A1A9VPZ4   A0A0C9RD30   A0A1A9X3U0   A0A182QQ51   A0A182LHY3   A0A182HXS3   A0A182VHF6   A0A182TN87   D3PGL7   A0A0P4VPD3   A0A182PV43   A0A154P5A8   A0A182LSF0   A0A336M3I3   A0A0M9AAF9   E2BVQ0   A0A1B0ES12   B0X1U8   A0A0C9QVY8   A0A226EII0   A0A2R5LAZ0   A0A1A9ZNF1   A0A1B0CN57   A0A293L7T8   A0A1B6JUJ8   A0A1Z5L9H9   A0A1E1X6B2   A0A1B6G201   A0A1B6GML7   A0A3B4BUU8   G3MR17   A0A3P8TNN6  

EC Number

3.5.1.122

Pubmed

26354079    22118469    18362917    19820115    28004739    24845553    + More
19121390    12364791    17994087    24438588    22936249    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    12537569    12593794    24495485    25348373    25830018    18057021    15632085    25315136    24508170    30249741    20566863    28648823    20075255    21347285    21719571    20920257    23761445    20798317    17510324    20966253    28528879    28503490    22216098   

EMBL

NWSH01003044    PCG67064.1    ODYU01005295    SOQ46013.1    KQ461150    KPJ08699.1    + More
AGBW02014356    OWR41824.1    GDQN01007341    JAT83713.1    KQ459597    KPI94981.1    KQ971351    EFA06576.1    GEZM01072779    JAV65401.1    KK853098    KDR11405.1    BABH01007715    AAAB01008905    CH916367    ATLV01024001    ATLV01024002    KE525348    KFB50292.1    CM002911    KMY94093.1    CM000158    CM000362    CH480816    CH954179    AE013599    AFH08105.1    AFH08106.1    AHN56265.1    AY060439    GAMC01003128    JAC03428.1    GAKP01016028    JAC42924.1    GDHF01022149    GDHF01017573    GDHF01013676    GDHF01000109    JAI30165.1    JAI34741.1    JAI38638.1    JAI52205.1    CH933808    KRG03893.1    GBXI01015898    GBXI01012613    GBXI01005499    JAC98393.1    JAD01679.1    JAD08793.1    CH963849    CH940662    KRF78406.1    KRF78407.1    CH902619    CP012524    ALC40833.1    CM000071    OUUW01000001    SPP72724.1    CVRI01000035    CRK92676.1    CH479216    EDW33637.1    KK107154    QOIP01000001    EZA56915.1    RLU26313.1    DS235033    EEB10786.1    NNAY01001025    OXU25439.1    KQ976464    KYM84479.1    ADTU01022847    KQ980934    KYN11294.1    KQ977279    KYN04314.1    GL888332    EGI62605.1    KQ981382    KYN42090.1    KQ982182    KYQ59245.1    ADMH02000584    ETN65752.1    GL443346    EFN62179.1    LJIG01002696    KRT84244.1    KQ414646    KOC66476.1    GFDF01010693    JAV03391.1    CH477426    EAT41148.1    UFQT01002270    SSX33055.1    KZ288249    PBC31116.1    JR037861    JR037862    AEY58002.1    AEY58003.1    GBYB01004811    JAG74578.1    AXCN02001920    APCN01005343    BT120773    ADD24413.1    GDRN01124910    JAI56693.1    KQ434822    KZC07116.1    AXCM01018848    UFQS01000501    UFQT01000501    SSX04448.1    SSX24812.1    KQ435700    KOX80535.1    GL450924    EFN80233.1    CCAG010023106    DS232270    EDS38826.1    GBYB01004810    GBYB01004812    JAG74577.1    JAG74579.1    LNIX01000004    OXA56356.1    GGLE01002565    MBY06691.1    AJWK01019817    GFWV01004077    MAA28807.1    GECU01036938    GECU01017668    GECU01004818    JAS70768.1    JAS90038.1    JAT02889.1    GFJQ02003359    JAW03611.1    GFAC01004398    JAT94790.1    GECZ01013358    JAS56411.1    GECZ01017225    GECZ01006112    JAS52544.1    JAS63657.1    JO844318    AEO35935.1   

Proteomes

UP000218220    UP000053240    UP000007151    UP000053268    UP000007266    UP000027135    + More
UP000005204    UP000192221    UP000007062    UP000001070    UP000030765    UP000002282    UP000000304    UP000001292    UP000008711    UP000000803    UP000009192    UP000007798    UP000008792    UP000007801    UP000095300    UP000092553    UP000001819    UP000095301    UP000268350    UP000183832    UP000008744    UP000053097    UP000279307    UP000009046    UP000215335    UP000002358    UP000076407    UP000075900    UP000078540    UP000005205    UP000078492    UP000078542    UP000007755    UP000078541    UP000075920    UP000075809    UP000075901    UP000075881    UP000075884    UP000000673    UP000000311    UP000069272    UP000075880    UP000005203    UP000053825    UP000008820    UP000242457    UP000078200    UP000091820    UP000075886    UP000075882    UP000075840    UP000075903    UP000075902    UP000075885    UP000076502    UP000075883    UP000053105    UP000008237    UP000092444    UP000002320    UP000198287    UP000092445    UP000092461    UP000261440    UP000265080   

PRIDE

H9J1Z1    Q7K2Y9   

Pfam

PF09764   Nt_Gln_amidase        + More
PF03281   Mab-21

Interpro

IPR037132   N_Gln_amidohydro_ab_roll_sf        + More
IPR023128   Prot_N_Gln_amidohydro_ab_roll       
IPR039733   NTAQ1       
IPR024810   Mab-21_dom       

Gene 3D

3.10.620.10    

ProteinModelPortal

A0A2A4J6B1   A0A2H1VYX9   A0A194QTR1   A0A212EK23   A0A1E1W9Q8   A0A194PNH3   + More
D6WRJ5   A0A1Y1KY22   A0A067QP63   H9J1Z1   A0A1W4ULI2   Q7Q968   B4J8A0   A0A084WJ98   A0A0J9RDF7   B4P6V4   B4QGZ1   B4HSF8   B3NQ86   A0A0B4K882   Q7K2Y9   W8BW00   A0A034VK98   A0A0K8UUZ4   A0A0Q9X7D5   B4KPY6   A0A0A1WH88   B4MQL4   A0A0Q9W0P2   B4MDT2   B3MCF3   A0A1I8NU78   A0A0M3QUL4   Q28WL0   A0A1I8ML72   A0A3B0IXX0   A0A1J1HZC4   B4H701   A0A026WLJ5   E0VBN0   A0A232F4M8   K7IQY2   A0A182WS28   A0A182RQE3   A0A195BJD2   A0A158NQ10   A0A195DFQ1   A0A195CVY2   F4WT76   A0A195FNE7   A0A182WML3   A0A151XG06   A0A182SFM4   A0A182JWU6   A0A182NNL3   W5JMZ8   E2AWL5   A0A0T6BA81   A0A182FEB1   A0A182IK86   A0A088AA24   A0A0L7R6U5   A0A1L8DA99   Q173D8   A0A336MTL6   A0A2A3EIU9   V9IBJ3   A0A1A9VPZ4   A0A0C9RD30   A0A1A9X3U0   A0A182QQ51   A0A182LHY3   A0A182HXS3   A0A182VHF6   A0A182TN87   D3PGL7   A0A0P4VPD3   A0A182PV43   A0A154P5A8   A0A182LSF0   A0A336M3I3   A0A0M9AAF9   E2BVQ0   A0A1B0ES12   B0X1U8   A0A0C9QVY8   A0A226EII0   A0A2R5LAZ0   A0A1A9ZNF1   A0A1B0CN57   A0A293L7T8   A0A1B6JUJ8   A0A1Z5L9H9   A0A1E1X6B2   A0A1B6G201   A0A1B6GML7   A0A3B4BUU8   G3MR17   A0A3P8TNN6  

PDB

4W79     E-value=2.50946e-47,     Score=473

KEGG

101746116    K21286 protein N-terminal glutamine amidohydrolase [EC:3.5.1.122] | (RefSeq) protein N-terminal glut

GO

GO:0008418   GO:0070773   GO:0005829   GO:0005634   GO:0006464   GO:0016811   GO:0006629   GO:0006810   GO:0016020   GO:0006241   GO:0030286   GO:0005216   GO:0045211   GO:0006281   GO:0048384  

PANTHER

PTHR13035  

Length:

212

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0206

Exp number, first 60 AAs:

0

Total prob of N-in:

0.15431

outside

1  -  212

 

 

Pi

246.17576

Theta

177.977735

Tajima's D

1.244517

CLR

0

CSRT

0.726813659317034

Interpretation

Possibly Positive selection