Gene

KWMTBOMO02845  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA003522

Annotation

peptidyl-prolyl_cis-trans_isomerase_[Bombyx_mori]

Location

Bomo_Chr5(+):12414316-12416534      View in EpiBrowser

Full name

Peptidyl-prolyl cis-trans isomerase      

Alternative Name

Cyclophilin
Cyclosporin A-binding protein
Rotamase

Location in the cell

Cytoplasmic   Reliability : 2.938

CDS

ATGATACCGGTATCAATGCTTCGGCGAACTTTAGTCAATGGGACAATATACTCTGCTGCAGCACTTCGTTTTGCTTCGACTCAACCTGATAAACAAGTTTATTTCGATGTAACTGCTGACGGAGAGCCATTGGGACGTATAGTCATAAAATTGAACACGGATGAAGTACCGAAAACTGCTGAGAACTTTAGAGCTCTGTGTACTGGTGAAAAAGGTTTTGGGTACAAGGGTTCATCATTTCATAGAATAATACCAGACTTCATGTGTCAAGGTGGAGATTTTACCAATCACAACGGTACCGGCGGAAAGTCTATTTACGGGCGTACCTTCTCAGATGAGAATTTCAAATTAAAGCATACTGGGCCTGGAATTTTATCAATGGCGAATGCTGGACCGAATACAAATGGGTCTCAATTTTTTATAACCACAGTTCCGACTCCTTGGTTGGATAGAAAACATGTAGTATTTGGGTCTGTGGTTGAAGGTATGGATGTTGTGCAGAAAATGGAAAAACTTGGTTCTAAAAGTGGTAAACCAATAAAGAAAGTTGTCATCTCAGATTCAGGTGATTATCATGAAGAACTAATTTTGAAGAGTGCAGATTGA

Protein

MIPVSMLRRTLVNGTIYSAAALRFASTQPDKQVYFDVTADGEPLGRIVIKLNTDEVPKTAENFRALCTGEKGFGYKGSSFHRIIPDFMCQGGDFTNHNGTGGKSIYGRTFSDENFKLKHTGPGILSMANAGPNTNGSQFFITTVPTPWLDRKHVVFGSVVEGMDVVQKMEKLGSKSGKPIKKVVISDSGDYHEELILKSAD

Description

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Catalytic Activity

[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)

Similarity

Belongs to the cyclophilin-type PPIase family.
Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.

Keywords

Cytoplasm   Isomerase   Rotamase   Complete proteome   Direct protein sequencing   Phosphoprotein   Reference proteome  

Feature

chain  Peptidyl-prolyl cis-trans isomerase

Uniprot

Q2F624   H9J1Y5   A0A212F1Y8   A0A222AJ14   A0A194QTB5   S4P3Q0   + More
A0A2H1X2S4   A0A0L7LTJ9   A0A2A4JZ62   A0A2W1BTU8   I4DK44   A0A1Y1L1V2   R4UW88   A0A3B3YI88   A0A1L8EEJ3   A0A1L8E8Y7   A0A1L8EEP6   M3ZRY3   A0A3B5M1H5   A0A023FFI9   A0A3B3UWM9   A0A087XTP2   T1PHF9   A0A1E1X7M1   A0A1D2N7H2   A0A232FLD2   A0A1L8EF36   A0A1Y1L5L4   A0A023FGK4   A0A023GH41   A0A023FXC1   L7M4A5   K7IM71   A0A1Y2HML4   A0A0M4ENB3   N6UJM4   A0A1L8E8G0   B4L5M3   A0A1L8E917   A0A224YFI0   A0A131YUP7   A0A067QY82   A0A2J7RN34   L7WSJ0   D3TMT7   A0A2P8Z1V1   A2I3U7   A0A0K8S607   K7J0P3   A0A0T6AV63   C3Z1U8   A0A131XLA0   A0A026WVJ3   A0A2I4B5Z2   A0A194RNK0   A0A0C9RAF3   A0A034WM88   A0A220XK87   F4WLL7   A0A0K8VZ87   E9IVQ3   A0A0A1XC91   A0A0K8VBA9   A0A1Z5KXX2   B4M328   P54985   A0A3B0K1Q9   C9W1E8   A0A1W4W1Y2   A0A0P6IS29   E2AKH8   A0A1L4AAU0   A0A195CSZ2   A0A3M7QSA4   A0A1A8Q475   A0A1A8LL28   A0A146NVB1   R4FMV8   A0A2A3EAB9   V9IIN8   A0A088A8D4   A0A1H6YZM6   I4DJA1   D3WFS2   A0A2I4CE58   B3N0T9   B4IF57   A0A0S7LK77   A0A3G1T1D0   I4DMT7   A0A195AUN3   A0A151XAA5   A0A1I8PXH6   A0A3P9PYV6   A0A170Z8D8   A0A1B6KQK8   A0A1B6G2X9   A8E774   P25007   A0A1I8PXJ9  

EC Number

5.2.1.8

Pubmed

19121390    22118469    26354079    23622113    26227816    28756777    + More
22651552    28004739    23542700    25315136    28503490    27289101    28648823    25576852    20075255    23537049    17994087    28797301    26830274    24845553    23326229    20353571    29403074    18563158    28049606    24508170    30249741    25348373    21719571    21282665    25830018    28528879    8529654    20650005    24029695    20798317    27895657    30375419    20147296    10731132    12537572    1707759    8500545    18327897   

EMBL

DQ311248    ABD36193.1    BABH01007734    AGBW02010786    OWR47746.1    KY563889    + More
ASO76362.1    KQ461150    KPJ08707.1    GAIX01009397    JAA83163.1    ODYU01013029    SOQ59660.1    JTDY01000112    KOB78790.1    NWSH01000356    PCG77066.1    KZ150007    PZC75163.1    AK401662    KQ459597    BAM18284.1    KPI94971.1    GEZM01066883    JAV67669.1    KC740692    AGM32516.1    GFDG01001688    JAV17111.1    GFDG01003675    JAV15124.1    GFDG01001653    JAV17146.1    GBBK01004617    JAC19865.1    AYCK01021168    KA647328    AFP61957.1    GFAC01003935    JAT95253.1    LJIJ01000175    ODN01025.1    NNAY01000049    OXU31554.1    GFDG01001515    JAV17284.1    GEZM01066882    JAV67670.1    GBBK01004624    JAC19858.1    GBBM01003383    JAC32035.1    GBBL01001965    JAC25355.1    GACK01006164    JAA58870.1    MCFL01000020    ORZ35830.1    CP012526    ALC47077.1    APGK01021421    KB740322    KB631815    ENN80871.1    ERL86427.1    GFDG01003906    JAV14893.1    CH933811    EDW06482.2    GFDG01003700    JAV15099.1    GFPF01004579    MAA15725.1    GEDV01006295    JAP82262.1    KK852834    KDR15281.1    NEVH01002545    PNF42238.1    KC118982    AGC84404.1    EZ422739    ADD19015.1    PYGN01000238    PSN50434.1    PSN50460.1    EF070450    ABM55516.1    GBRD01017243    JAG48584.1    LJIG01022734    KRT78986.1    GG666573    EEN53465.1    GEFH01001641    JAP66940.1    KK107085    QOIP01000008    EZA60013.1    RLU19871.1    KQ459984    KPJ18989.1    GBYB01010057    JAG79824.1    GAKP01003682    JAC55270.1    KY273928    ASL05640.1    GL888208    EGI64953.1    GDHF01008122    JAI44192.1    GL766328    EFZ15350.1    GBXI01005258    JAD09034.1    GDHF01016509    JAI35805.1    GFJQ02007329    JAV99640.1    CH940651    EDW65203.1    X87418    OUUW01000011    SPP86602.1    EZ406096    ACX53895.1    GDIQ01002400    JAN92337.1    GL440281    EFN66029.1    KX268378    API65179.1    KQ977372    KYN03244.1    REGN01005313    RNA13848.1    HAEI01001586    HAEH01009885    SBR88301.1    HAEF01007610    HAEG01007631    SBR45031.1    GCES01150890    JAQ35432.1    GAHY01000813    JAA76697.1    KZ288325    PBC28011.1    JR049570    AEY61003.1    FNYJ01000003    SEJ42832.1    AK401369    KQ459220    BAM17991.1    KPJ02870.1    GU046311    ADC80505.1    CH902644    EDV34818.2    CH480832    EDW46111.1    GBYX01166845    JAO89403.1    MG846936    AXY94788.1    AK402605    BAM19227.1    KQ976738    KYM75891.1    KQ982351    KYQ57250.1    GEMB01002505    JAS00681.1    GEBQ01026251    JAT13726.1    GECZ01012974    JAS56795.1    BT031016    ABV82398.1    AE014298    BT009946    M62398   

Proteomes

UP000005204    UP000007151    UP000053240    UP000037510    UP000218220    UP000053268    + More
UP000261480    UP000002852    UP000261380    UP000261500    UP000028760    UP000095301    UP000094527    UP000215335    UP000002358    UP000193411    UP000092553    UP000019118    UP000030742    UP000009192    UP000027135    UP000235965    UP000245037    UP000001554    UP000053097    UP000279307    UP000192220    UP000007755    UP000008792    UP000268350    UP000192221    UP000000311    UP000078542    UP000276133    UP000242457    UP000005203    UP000199219    UP000007801    UP000001292    UP000078540    UP000075809    UP000095300    UP000242638    UP000000803   

PRIDE

Q2F624    H9J1Y5    P54985    C9W1E8    A0A088A8D4    A8E774    + More
P25007   

Pfam

PF00160   Pro_isomerase

Interpro

IPR020892   Cyclophilin-type_PPIase_CS        + More
IPR029000   Cyclophilin-like_dom_sf       
IPR002130   Cyclophilin-type_PPIase_dom       
IPR024936   Cyclophilin-type_PPIase       

SUPFAM

SSF50891   SSF50891       

Gene 3D

2.40.100.10    

ProteinModelPortal

Q2F624   H9J1Y5   A0A212F1Y8   A0A222AJ14   A0A194QTB5   S4P3Q0   + More
A0A2H1X2S4   A0A0L7LTJ9   A0A2A4JZ62   A0A2W1BTU8   I4DK44   A0A1Y1L1V2   R4UW88   A0A3B3YI88   A0A1L8EEJ3   A0A1L8E8Y7   A0A1L8EEP6   M3ZRY3   A0A3B5M1H5   A0A023FFI9   A0A3B3UWM9   A0A087XTP2   T1PHF9   A0A1E1X7M1   A0A1D2N7H2   A0A232FLD2   A0A1L8EF36   A0A1Y1L5L4   A0A023FGK4   A0A023GH41   A0A023FXC1   L7M4A5   K7IM71   A0A1Y2HML4   A0A0M4ENB3   N6UJM4   A0A1L8E8G0   B4L5M3   A0A1L8E917   A0A224YFI0   A0A131YUP7   A0A067QY82   A0A2J7RN34   L7WSJ0   D3TMT7   A0A2P8Z1V1   A2I3U7   A0A0K8S607   K7J0P3   A0A0T6AV63   C3Z1U8   A0A131XLA0   A0A026WVJ3   A0A2I4B5Z2   A0A194RNK0   A0A0C9RAF3   A0A034WM88   A0A220XK87   F4WLL7   A0A0K8VZ87   E9IVQ3   A0A0A1XC91   A0A0K8VBA9   A0A1Z5KXX2   B4M328   P54985   A0A3B0K1Q9   C9W1E8   A0A1W4W1Y2   A0A0P6IS29   E2AKH8   A0A1L4AAU0   A0A195CSZ2   A0A3M7QSA4   A0A1A8Q475   A0A1A8LL28   A0A146NVB1   R4FMV8   A0A2A3EAB9   V9IIN8   A0A088A8D4   A0A1H6YZM6   I4DJA1   D3WFS2   A0A2I4CE58   B3N0T9   B4IF57   A0A0S7LK77   A0A3G1T1D0   I4DMT7   A0A195AUN3   A0A151XAA5   A0A1I8PXH6   A0A3P9PYV6   A0A170Z8D8   A0A1B6KQK8   A0A1B6G2X9   A8E774   P25007   A0A1I8PXJ9  

PDB

4TOT     E-value=2.85359e-69,     Score=661

KEGG

692862    K09565 peptidyl-prolyl isomerase F (cyclophilin D) [EC:5.2.1.8] | (RefSeq) peptidyl-prolyl cis-trans

GO

GO:0003755   GO:0006457   GO:0051082   GO:0016018   GO:0042026   GO:0005737   GO:0005634   GO:0005829   GO:0000413   GO:0008270   GO:0006241   GO:0030286   GO:0005216   GO:0045211   GO:0006281   GO:0048384  

Subcellular location

Cytoplasm  

Length:

201

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.02994

Exp number, first 60 AAs:

0.02817

Total prob of N-in:

0.09771

outside

1  -  201

 

 

Pi

171.493425

Theta

150.613604

Tajima's D

0.308434

CLR

0.093179

CSRT

0.459927003649818

Interpretation

Possibly Positive selection