Gene

KWMTBOMO02840  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA003669

Annotation

eukaryotic_translation_initiation_factor_3_subunit_E_[Bombyx_mori]

Location

Bomo_Chr5(-):12371250-12380905      View in EpiBrowser

Full name

Eukaryotic translation initiation factor 3 subunit E       + More
Eukaryotic translation initiation factor 3 subunit E-2      
Eukaryotic translation initiation factor 3 subunit E-1      

Alternative Name

Eukaryotic translation initiation factor 3 subunit 6
Eukaryotic translation initiation factor 3 subunit 6-2
Eukaryotic translation initiation factor 3 subunit 6-1

Location in the cell

Cytoplasmic   Reliability : 2.418

CDS

ATGAGTTACTCAAAATTTGATTTAACGTTTAAAATAGGACAGTATCTTGATCGGCATCTCGTGTTTCCTTTACTAGAATTCTTAGCAGCAAAGGAGACATATGACCAGTCAGAGCTCCTGCAGGCAAAGTTGGAGATTTTGAGCAAAACTAACATGATAGATTATGTTACTGACATCAGAAGAATGCTCTATCCTGAAGAAGACACTCCTGAAGAAATTATACAGCGGAGAGGTGTAGTTCTTTCGGAACTGCAGGAACTTCAAGATGCAGTAGAGCCAGTATTGAGACTCATGCAAAGAGATGATGTAATGAAAACAATTGAAACCATGAGGGATCCTAAAACTCTTATAAACCATCTTTCGACAAACAAGGAGTATGAGTTTAAAATTGAAATGATCGATAGCATGTATCGTTTGGCCAAATATCGCTATGAATGTGGAAATTATGTGGAGTCAGCATCATATCTTTACTTTTGTCAACTGGTGATGTCGCCAACTGACAAGAATTATTTGTCGGTTCTTTGGGGTAAATTGGCTAGCGAAATTTTGGTACAAAATTGGGATGGCGCGCTCGATGATCTAACCAAACTTCGAGAGTTCATCGATAACGGTGGAGCCGGTTCCACTGCCAGCAACATGCAAGCCCTACAGCAACGGACCTGGCTGGTTCACTGGTCGCTATTCGTGTTCTTCAATCATGTCAAAGGACGTGATTTGATCATCGAAATGTTCCTGTATAAGCCTTTGTACTTGAACGCCATCCAGACGATGTGTCCCCACATCCTCCGCTACTTGGCTACTGCAGTAATCATAAACAGGTCTCGCAGAAATGCCTTGAAGGACCTTGTGAAAGTTATTCAACAAGAAGCTTACACCTATAGAGATCCTATCACAGAGTTCATTGAACATCTTTACGTTAATTTTGACTTTGAAGCGGCCCGTCGAAAATTGAATCAATGCCAAGCTGTACTTTTGACTGACTTTTTCTTAATCGCCTGTTTGGAAGAGTTTGTCGAAAATGCTCGACTGATGATCTTTGAAACTTTCTGCCGTATTCATCAAGTCATTAGTATTGGAATGTTAGCCGAGAACTTAAACATGCAGCCTGATGAAGCGGAATGCTGGATCGTGAACTTAATCCGTAATGCGCGCCTGGACGCGAAGATCGATTCCAAGTTAGGTCACGTGGTGATGGGTGCACAACCTCTTTCGCCATATCAACAATTAGTTGAGAGAATCGATTCACTGGCAGTGAGATCCGAAGCTCTGACTTCATTAGTGGAAAGGAAACATAAAGCACGCAATCAAGATATACGTTGGGGTGCTCAAGAGTTTTAA

Protein

MSYSKFDLTFKIGQYLDRHLVFPLLEFLAAKETYDQSELLQAKLEILSKTNMIDYVTDIRRMLYPEEDTPEEIIQRRGVVLSELQELQDAVEPVLRLMQRDDVMKTIETMRDPKTLINHLSTNKEYEFKIEMIDSMYRLAKYRYECGNYVESASYLYFCQLVMSPTDKNYLSVLWGKLASEILVQNWDGALDDLTKLREFIDNGGAGSTASNMQALQQRTWLVHWSLFVFFNHVKGRDLIIEMFLYKPLYLNAIQTMCPHILRYLATAVIINRSRRNALKDLVKVIQQEAYTYRDPITEFIEHLYVNFDFEAARRKLNQCQAVLLTDFFLIACLEEFVENARLMIFETFCRIHQVISIGMLAENLNMQPDEAECWIVNLIRNARLDAKIDSKLGHVVMGAQPLSPYQQLVERIDSLAVRSEALTSLVERKHKARNQDIRWGAQEF

Description

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation (PubMed:18493598). In addition to its role in the eIF-3 complex, also functions in protein ubiquitination and degradation (PubMed:18493598, PubMed:28505193). During mitosis required for regulating mitotic microtubule growth and kinetochore formation, and consequently is required for satisfying the spindle assembly checkpoint (SAC) during metaphase to prevent delays in mitotic progression (PubMed:28505193). This is likely by promoting the ubiquitination and degradation of Klp67A, a kinesin-like protein that suppresses microtubule polymerization at plus ends (PubMed:28505193). Acts in the COP9 signalosome (CSN) mediated regulation of cullin neddylation by promoting Cul1 and Cul3 neddylation and negatively regulating the CSN complex subunit CSN5 (PubMed:18493598).

Subunit

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. The eIF-3 complex interacts with pix.
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. The eIF-3 complex interacts with pix. Interacts with mxt (By similarity).
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. The eIF-3 complex interacts with pix. Interacts with mxt (PubMed:23716590).

Similarity

Belongs to the eIF-3 subunit E family.

Keywords

Complete proteome   Cytoplasm   Initiation factor   Protein biosynthesis   Reference proteome   Endoplasmic reticulum   Microsome  

Feature

chain  Eukaryotic translation initiation factor 3 subunit E

Uniprot

Q2F5R8   A0A2H1X346   A0A2W1BNG4   A0A2A4JZX2   H9J2D2   S4P8A8   + More
I4DMU6   A0A194PPR8   A0A194QUQ5   A0A212F206   I4DK47   A0A1Y1MTV3   A0A0T6B9V8   J3JUK5   N6T086   D6WDP3   A2I3X8   E0VAQ3   A0A2J7Q730   E2B6R7   A0A2P8YI35   E9IE19   A0A2A3EJE1   A0A0N0U3K1   V9IDL6   V9ID46   A0A067QKC5   A0A088AQJ3   A0A0L7REG9   F4WZD3   A0A158NFZ9   A0A026VUL6   E2A736   A0A151X1Q8   A0A195E4T7   A0A154P999   A0A195ETF1   A0A0C9RKF9   A0A2S2QKQ2   A0A151INM3   A0A0A9WN05   J9JWC3   A0A0K8TAP5   A0A2H8TRR1   J9JQV1   A0A336LLF3   A0A1L8DSH0   R4FMF3   A0A1I8Q843   A0A1B6ML62   A0A0M4EFH4   B4KY00   B3M4D9   A0A224XCN5   A0A1L8ECF5   B4LG58   A0A069DUD6   W8C2T4   A0A3B0KQQ4   A0A0V0G6R7   B4IXG1   Q1HQY6   B4N3B0   A0A1A9XQY9   A0A1A9UP23   A0A1B0C2Q0   A0A023F8K5   D3TM41   A0A0J9RXZ4   B4QMY7   Q29EX2   O77410   A0A023ES59   A0A1A9W4Y9   T1PGM9   B4H5N1   A0A0K8V0R4   A0A034VN85   A0A0C9QXH5   A0A084W146   A0A1W4UGS6   B4PK98   B3NDH5   A0A0P4VKZ9   A0A182IUV8   T1E833   A0A2M3YYL0   A0A2M4BPD5   U5EMI3   A0A182FEM0   B4MYA1   B0WAM5   A0A2M4A1B0   W5JQD6   A0A2M4A0U5   B4HK67   A0A0L0C7H4   A0A1Q3F7W4   A0A182N9A3   A0A182PII8  

Pubmed

28756777    19121390    23622113    22651552    26354079    22118469    + More
28004739    22516182    23537049    18362917    19820115    20566863    20798317    29403074    21282665    24845553    21719571    21347285    24508170    30249741    25401762    26823975    17994087    26334808    24495485    17204158    17510324    25474469    20353571    22936249    15632085    10375641    10731132    12537572    10731138    18493598    23716590    28505193    24945155    26483478    25315136    25348373    24438588    27129103    20920257    23761445    26108605   

EMBL

DQ667966    DQ311355    ODYU01013029    SOQ59656.1    KZ150007    PZC75165.1    + More
NWSH01000356    PCG77063.1    BABH01007739    BABH01007740    GAIX01004249    JAA88311.1    AK402614    BAM19236.1    KQ459597    KPI94968.1    KQ461150    KPJ08710.1    AGBW02010786    OWR47743.1    AK401665    BAM18287.1    GEZM01027192    JAV86807.1    LJIG01002910    KRT84030.1    BT126920    AEE61882.1    APGK01057462    KB741280    KB632033    ENN70923.1    ERL88203.1    KQ971322    EEZ99942.1    EF070481    ABM55547.1    AAZO01000492    DS235012    EEB10459.1    NEVH01017447    PNF24392.1    GL446000    EFN88651.1    PYGN01000579    PSN43925.1    GL762556    EFZ21185.1    KZ288227    PBC31820.1    KQ435875    KOX70202.1    JR039144    AEY58551.1    JR039145    AEY58552.1    KK853239    KDR09513.1    KQ414611    KOC69225.1    GL888479    EGI60377.1    ADTU01001539    KK107847    QOIP01000005    EZA47488.1    RLU22792.1    GL437252    EFN70768.1    KQ982585    KYQ54329.1    KQ979609    KYN20200.1    KQ434849    KZC08489.1    KQ981979    KYN31436.1    GBYB01007356    JAG77123.1    GGMS01009114    MBY78317.1    KQ976932    KYN07035.1    GBHO01037369    GDHC01013388    JAG06235.1    JAQ05241.1    ABLF02034552    GBRD01003199    JAG62622.1    GFXV01005078    MBW16883.1    ABLF02010956    ABLF02010957    ABLF02010958    ABLF02047343    UFQS01000040    UFQT01000040    SSW98149.1    SSX18535.1    GFDF01004760    JAV09324.1    ACPB03012056    GAHY01001028    JAA76482.1    GEBQ01003368    JAT36609.1    CP012525    ALC43002.1    CH933809    CH902618    GFTR01006241    JAW10185.1    GFDG01002381    JAV16418.1    CH940647    GBGD01001498    JAC87391.1    GAMC01003017    JAC03539.1    OUUW01000012    SPP87551.1    GECL01003143    JAP02981.1    CH916366    DQ440308    CH477239    CH964062    JXJN01024608    GBBI01001027    JAC17685.1    CCAG010022578    EZ422493    ADD18769.1    CM002912    KMZ00110.1    CM000363    CH379070    U89162    AE014296    AF132551    JXUM01122305    GAPW01001520    KQ566589    JAC12078.1    KXJ69995.1    KA647018    AFP61647.1    CH479211    GDHF01019941    JAI32373.1    GAKP01015737    JAC43215.1    GBYB01005367    JAG75134.1    ATLV01019208    KE525264    KFB43940.1    CM000159    CH954178    GDKW01001538    JAI55057.1    GAMD01002547    JAA99043.1    GGFM01000595    MBW21346.1    GGFJ01005507    MBW54648.1    GANO01001014    JAB58857.1    CH963894    DS231873    GGFK01001285    MBW34606.1    ADMH02000413    ETN66627.1    GGFK01001115    MBW34436.1    CH480815    JRES01000810    KNC28207.1    GFDL01011399    JAV23646.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000053240    UP000007151    UP000019118    + More
UP000030742    UP000007266    UP000009046    UP000235965    UP000008237    UP000245037    UP000242457    UP000053105    UP000027135    UP000005203    UP000053825    UP000007755    UP000005205    UP000053097    UP000279307    UP000000311    UP000075809    UP000078492    UP000076502    UP000078541    UP000078542    UP000007819    UP000015103    UP000095300    UP000092553    UP000009192    UP000007801    UP000008792    UP000268350    UP000001070    UP000008820    UP000007798    UP000092443    UP000078200    UP000092460    UP000092444    UP000000304    UP000001819    UP000000803    UP000069940    UP000249989    UP000091820    UP000095301    UP000008744    UP000030765    UP000192221    UP000002282    UP000008711    UP000075880    UP000069272    UP000002320    UP000000673    UP000001292    UP000037069    UP000075884    UP000075885   

PRIDE

Q2F5R8    H9J2D2    A0A088AQJ3    O77410   

Pfam

PF09440   eIF3_N        + More
PF01399   PCI
PF13359   DDE_Tnp_4

Interpro

IPR036390   WH_DNA-bd_sf        + More
IPR000717   PCI_dom       
IPR019010   eIF3e_N       
IPR016650   eIF3e       
IPR027806   HARBI1_dom       

SUPFAM

SSF46785   SSF46785       

ProteinModelPortal

Q2F5R8   A0A2H1X346   A0A2W1BNG4   A0A2A4JZX2   H9J2D2   S4P8A8   + More
I4DMU6   A0A194PPR8   A0A194QUQ5   A0A212F206   I4DK47   A0A1Y1MTV3   A0A0T6B9V8   J3JUK5   N6T086   D6WDP3   A2I3X8   E0VAQ3   A0A2J7Q730   E2B6R7   A0A2P8YI35   E9IE19   A0A2A3EJE1   A0A0N0U3K1   V9IDL6   V9ID46   A0A067QKC5   A0A088AQJ3   A0A0L7REG9   F4WZD3   A0A158NFZ9   A0A026VUL6   E2A736   A0A151X1Q8   A0A195E4T7   A0A154P999   A0A195ETF1   A0A0C9RKF9   A0A2S2QKQ2   A0A151INM3   A0A0A9WN05   J9JWC3   A0A0K8TAP5   A0A2H8TRR1   J9JQV1   A0A336LLF3   A0A1L8DSH0   R4FMF3   A0A1I8Q843   A0A1B6ML62   A0A0M4EFH4   B4KY00   B3M4D9   A0A224XCN5   A0A1L8ECF5   B4LG58   A0A069DUD6   W8C2T4   A0A3B0KQQ4   A0A0V0G6R7   B4IXG1   Q1HQY6   B4N3B0   A0A1A9XQY9   A0A1A9UP23   A0A1B0C2Q0   A0A023F8K5   D3TM41   A0A0J9RXZ4   B4QMY7   Q29EX2   O77410   A0A023ES59   A0A1A9W4Y9   T1PGM9   B4H5N1   A0A0K8V0R4   A0A034VN85   A0A0C9QXH5   A0A084W146   A0A1W4UGS6   B4PK98   B3NDH5   A0A0P4VKZ9   A0A182IUV8   T1E833   A0A2M3YYL0   A0A2M4BPD5   U5EMI3   A0A182FEM0   B4MYA1   B0WAM5   A0A2M4A1B0   W5JQD6   A0A2M4A0U5   B4HK67   A0A0L0C7H4   A0A1Q3F7W4   A0A182N9A3   A0A182PII8  

PDB

6FEC     E-value=9.92765e-152,     Score=1377

KEGG

692936    K03250 translation initiation factor 3 subunit E | (RefSeq) eIF3-S6, eIF3e; eukaryotic translation i

PATHWAY

03013    RNA transport - Bombyx mori (domestic silkworm)

GO

GO:0033290   GO:0071540   GO:0016282   GO:0003743   GO:0001732   GO:0005852   GO:0006413   GO:0005634   GO:0043231   GO:0005783   GO:0005515   GO:0005737   GO:0006241   GO:0030286   GO:0005216   GO:0045211   GO:0006281   GO:0048384  

PANTHER

PTHR10317  

Subcellular location

Cytoplasm  
Microsome   Uniformly distributed in interphase and mitotic cells.   With evidence from 6 publications.
Endoplasmic reticulum   Uniformly distributed in interphase and mitotic cells.   With evidence from 6 publications.

Length:

445

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.3631

Exp number, first 60 AAs:

0.00033

Total prob of N-in:

0.00399

outside

1  -  445

 

 

Pi

195.824562

Theta

169.687051

Tajima's D

-2.27017

CLR

10.403136

CSRT

0.00359982000899955

Interpretation

Possibly Positive selection